T-cell receptor beta-chain usage in directly activated alloreactive CD4+ T cells: unrestricted Vbeta gene usage with CDR3 size limitations.

abstract：BACKGROUND:Delayed graft function and acute rejections adversely affect the long-term survival of kidney transplantation. To decrease the incidences of these phenomena, we changed the initial immunosuppressive protocol in pediatric kidney transplantation in The Netherlands. METHODS:We compared a cohort (n=123) treated...

journal_title：Transplantation

authors： Cransberg K,Bouts AH,Cornelissen EA,Lilien MR,Van Hoeck KJ,Hop WC,Nauta J

更新日期：2008-11-15 00:00:00

abstract：:Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patien...

journal_title：Transplantation

authors： Singh N,Gayowski T,Wagener MM,Marino IR

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:Recent studies have described submandibular gland allografts in animal models; however, the amount of saliva secretion or nervous regeneration in those animals have not been reported. Herein, we investigated saliva secretion from submandibular gland allografts in beagle dogs. METHODS:Using a vascularized su...

journal_title：Transplantation

authors： Isomura ET,Yoshitomi K,Hamaguchi M,Kogo M

更新日期：2007-03-27 00:00:00

abstract：:The generation of Gal knockout (KO) pigs is likely to be an important advance in xenotransplantation. However, recent reports suggesting that expression of Gal may not be completely eliminated raise the possibility of a continuing anti-Gal immune response. The authors used a Gal-mismatched skin graft model to study ce...

journal_title：Transplantation

authors： Gock H,Murray-Segal L,Salvaris E,Cowan P,D'Apice AJ

更新日期：2004-03-15 00:00:00

abstract：BACKGROUND:Hemophagocytic syndrome (HPS) is a serious hematological disorder caused by activated T lymphocytes in immunologically compromised patients. There is no report of HPS in liver transplant recipients. METHODS:Among 135 patients who underwent living-related liver transplantation between June 1990 and October 2...

journal_title：Transplantation

authors： Chisuwa H,Hashikura Y,Nakazawa Y,Kamijo T,Nakazawa K,Nakayama J,Oh-Ishi T,Ikegami T,Terada M,Kawasaki S

更新日期：2001-12-15 00:00:00

abstract：:To determine the nature and sequence of the histologic changes in the early rejection of pancreaticoduodenal allografts and to assess the correlation between pancreaticoduodenal biopsy findings and the pathologic changes in the graft, we performed serial cystoscopically directed needle biopsies of pancreaticoduodenal ...

journal_title：Transplantation

authors： Carpenter HA,Barr D,Marsh CL,Miller AR,Perkins JD

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Natural antibodies (NAbs) against a terminal alpha1-3 galactosyl (alphaGal) epitope have been identified as the major human anti-pig NAbs. METHODS AND RESULTS:We used two synthetic alphaGal trisaccharides--type 6 (alphaGal6) and type 2(alphaGal2)--linked to an inert matrix to remove NAbs from human plasma i...

journal_title：Transplantation

authors： Xu Y,Lorf T,Sablinski T,Gianello P,Bailin M,Monroy R,Kozlowski T,Awwad M,Cooper DK,Sachs DH

更新日期：1998-01-27 00:00:00

abstract：BACKGROUND:Cyclosporine A (CsA)-induced chronic nephrotoxicity is characterized by renal dysfunction and interstitial fibrosis. Early and progressive renal macrophage influx, correlating with latter interstitial fibrotic areas, has been associated with CsA treatment. This study investigated the role of macrophages, the...

journal_title：Transplantation

authors： Carlos CP,Mendes GE,Miquelin AR,Luz MA,da Silva CG,van Rooijen N,Coimbra TM,Burdmann EA

更新日期：2010-06-15 00:00:00

abstract：:Cyclosporine (CsA) is an immunosuppressive drug requiring dose individualization and regular control due to its highly variable pharmacokinetics. Since gastroparesis may influence the absorption of CsA, a randomized cross-over study was performed to assess the pharmacokinetics and tolerability of a novel microemulsion...

journal_title：Transplantation

authors： van der Pijl JW,Srivastava N,Denouël J,Burggraaf J,Schoemaker RC,van der Woude FJ,Cohen AF

更新日期：1996-08-27 00:00:00

abstract：:World Kidney Day on March 8, 2012, provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and better, but ...

journal_title：Transplantation

authors： Garcia GG,Harden P,Chapman J,World Kidney Day Steering Committee 2012.

更新日期：2012-02-27 00:00:00

abstract：BACKGROUND:Deciphering the mechanisms of tolerance and chronic rejection (CR) remains a major goal in transplantation. Data in rodents suggest that Toll-like receptors (TLR), regulators of innate immune responses, play a role in determining graft outcome. However, few studies have focused on TLR expression in human kid...

journal_title：Transplantation

authors： Braudeau C,Ashton-Chess J,Giral M,Dugast E,Louis S,Pallier A,Braud C,Moreau A,Renaudin K,Soulillou JP,Brouard S

更新日期：2008-07-15 00:00:00

abstract：:The individual effects of verapamil and 2 antioxidants on perfused rat liver nucleoside triphosphate (NTP) recovery following cold storage in University of Wisconsin (UW) solution was assessed using 31P nuclear magnetic resonance spectroscopy. The pharmacological agents were added to UW solution and were present only ...

journal_title：Transplantation

authors： Bowers JL,Neymark E,Cook CU,Clouse ME

更新日期：1994-06-15 00:00:00

abstract：:After the progressive improvement in the results of organ transplantation we now face the challenge of shortage in organ supply. The decreasing number of organ retrievals performed in 1990 at our hospital has raised questions concerning loss of potential organ donors and opposition to donation by the next of kin. We i...

journal_title：Transplantation

authors： Faltin DL,Jeannet M,Suter PM

更新日期：1992-07-01 00:00:00

abstract：INTRODUCTION:The use of liver allografts from elderly donors (≥70 years) has increased because of organ shortage and increased life expectancy. The aim of this study is to evaluate the current utilization of elderly donors in United States, recipient selection, and their posttransplant outcomes. METHODS:A linkage betw...

journal_title：Transplantation

authors： Paterno F,Wima K,Hoehn RS,Cuffy MC,Diwan TS,Woodle SE,Abbott DE,Shah SA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Primary hyperoxaluria is a rare autosomal recessive metabolic disease that often progresses to end-stage renal disease (ESRD). Liver transplantation is curative for patients with the alanine: glyoxylate aminotransferase deficiency. For oxalosis patients with minor enzyme deficiencies, renal transplantation m...

journal_title：Transplantation

authors： Cibrik DM,Kaplan B,Arndorfer JA,Meier-Kriesche HU

更新日期：2002-09-15 00:00:00

abstract：BACKGROUND:Mycophenolic acid, the active metabolite of mycophenolate mofetil, inhibits the glycosylation of cell membrane glycoproteins. We hypothesized that impaired glycosylation of cell adhesion molecules on endothelial cells in vivo results in decreased susceptibility to inflammation or immunogenicity after allogen...

journal_title：Transplantation

authors： Valentin JF,Bruijn JA,Paul LC

更新日期：2000-02-15 00:00:00

abstract：BACKGROUND:An elevated terminal creatinine is frequently used as a reason for organ refusal in pediatric kidney transplantation. There is increasing evidence that adults who receive kidneys from donors with moderate to severe acute kidney injury (AKI) have similar outcomes to recipients who receive kidneys from donors ...

journal_title：Transplantation

authors： Solomon S,Hayde N

更新日期：2020-03-01 00:00:00

abstract：:In a DBA/2 (H-2d) pancreatic islet-to-B6AF1 (H-2b/k.d) recipient combination, the graft survival of hand-picked islets was compared with that of "crude digested" islets that were prepared simply by collagenase digestion and Ficoll gradient separation and were contaminated with lymph nodes and vascular and ductal tissu...

journal_title：Transplantation

authors： Gotoh M,Maki T,Satomi S,Porter J,Monaco AP

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Activation of the renin angiotensin system may contribute to the development of delayed graft function after renal transplantation. We, therefore, examined the impact of pretransplant treatment with blockers of the renin angiotensin system on early graft function after renal transplantation. METHOD:The case...

journal_title：Transplantation

authors： Stevens KK,Patel RK,Clancy M,Jardine AG

更新日期：2010-03-27 00:00:00

abstract：BACKGROUND:Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). METHODS:We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We com...

journal_title：Transplantation

authors： Heilman RL,Cortese C,Geiger XJ,Younan K,Wadei HM,Mai ML,Reddy KS,Gonwa TA

更新日期：2012-01-15 00:00:00

abstract：BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...

journal_title：Transplantation

authors： Wang H,Hosiawa KA,Garcia B,Shum JB,Dutartre P,Kelvin DJ,Zhong R

更新日期：2003-05-15 00:00:00

abstract：:We reviewed the results of all percutaneous fine needle aspirations (FNA) and open lung biopsies (OLB) after bone marrow transplantation at our center (1984-1987) for the evaluation of focal lung lesions that developed or persisted despite antibiotic administration. We sought to determine the prevalence and types of i...

journal_title：Transplantation

authors： Crawford SW,Hackman RC,Clark JG

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Infectious complications still represent a major cause of morbidity and mortality in patients with organ transplantation. In particular, small bowel or multivisceral transplantation is complicated to a greater extent than other grafts as a consequence of infectious complications including sepsis. METHODS:Th...

journal_title：Transplantation

authors： Guaraldi G,Cocchi S,Codeluppi M,Di Benedetto F,De Ruvo N,Masetti M,Venturelli C,Pecorari M,Pinna AD,Esposito R

更新日期：2005-12-27 00:00:00

abstract：:Endothelial damage has been implicated in the pathogenesis of chronic rejection. Conversely, expression of protective genes [including A20, A1, bcl-xl, and hemoxygenase-1 (HO-1)] in the endothelium has been associated with long-term graft survival. Overexpression of protective genes in cultured endothelial cells confe...

journal_title：Transplantation

authors： Evans PC,Taylor ER,Kilshaw PJ

更新日期：2001-02-15 00:00:00

abstract：:The aim of this study was to assess the efficacy of an enteral diet fortified with arginine, RNA, and fish oil (Impact), alone and in combination with cyclosporine (CsA) and donor-specific transfusion (DST) on allograft survival in the ACI:Lewis rat cardiac transplant model. Animals were fed ad libitum with either sta...

journal_title：Transplantation

authors： Levy AE,Alexander JW

更新日期：1995-10-27 00:00:00

abstract：BACKGROUND:Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients. METHODS:Retrospective cohort study, including all actual deceased dono...

journal_title：Transplantation

authors： Coll E,Torre-Cisneros J,Calvo R,Garrido G,Matesanz R

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:Mycophenolic acid (MPA) is an inhibitor of lymphocyte proliferation and is well established as an immunosuppressive agent in solid organ transplantation. The initial formulation of the drug was a prodrug formulation, mycophenolate mofetil (MMF, Cellcept), which is well absorbed and rapidly converted to mycop...

journal_title：Transplantation

authors： Johnston A,He X,Holt DW

更新日期：2006-12-15 00:00:00

abstract：:In liver allograft rejection, interlobular bile ducts are thought to be the main target of rejection. In contrast, in other organ allografts the capillary bed of the graft appears to be the primary target. To determine whether portal tract microvasculature is destroyed in liver allografts during rejection, we have ide...

journal_title：Transplantation

authors： Matsumoto Y,McCaughan GW,Painter DM,Bishop GA

更新日期：1993-07-01 00:00:00

abstract：:Hepatic grafts from non-heartbeating donors may alleviate the organ shortage, but they inherently suffer from warm ischemia. In the present study, we tested our hypothesis that augmentation of endogenous adenosine by inhibition of nucleoside transport with R75231 attenuates ischemic liver injury. Adult female beagle d...

journal_title：Transplantation

authors： Todo S,Zhu Y,Zhang S,Jin MB,Ishizaki N,Tanaka H,Subbotin V,Starzl TE

更新日期：1997-01-27 00:00:00

abstract：:Despite major advances in immunopharmacology, virtually all patients receive the same center-specific immunosuppressive regimen following orthotopic liver transplantation (OLT). The present analysis was performed on the hypothesis that the original disease representing the indication for OLT leads to a different initi...

journal_title：Transplantation

authors： Berlakovich GA,Imhof M,Karner-Hanusch J,Gotzinger P,Gollackner B,Gnant M,Hanelt S,Laufer G,Muhlbacher F,Steininger R

更新日期：1996-02-27 00:00:00