The importance of the effect of underlying disease on rejection outcomes following orthotopic liver transplantation.

abstract：BACKGROUND:Nephrotoxicity is a major side effect of calcineurin inhibitors (CNI). Earlier we reported 8% of our heart transplant recipients reaching end-stage renal failure (ESRF). Now, with an extended follow up of 20 years, we re-evaluated the development of ESRF and studied its influence on survival and the impact o...

journal_title：Transplantation

authors： van de Wetering J,Weimar CH,Balk AH,Roodnat JI,Holweg CT,Baan CC,van Domburg RT,Weimar W

更新日期：2006-12-27 00:00:00

abstract：BACKGROUND:Intrathymic events undergoing allograft rejection remain undefined. The present study investigated the role of tumor necrosis factor-beta on acute thymic involution in rat hepatic allograft recipients during rejection. METHODS:Apoptosis and cellular phenotypic changes in the thymus were studied after hepati...

journal_title：Transplantation

authors： Yamaguchi Y,Okabe K,Miyanari N,Matsumura F,Ichiguchi O,Akizuki E,Matsuda T,Liang J,Ohshiro H,Miyayama Y,Yamada S,Mori K,Ogawa M

更新日期：1998-10-15 00:00:00

abstract：:Influenza vaccination has been strongly recommended for immunosuppressed renal transplant recipients. However, immunosuppression may lead to impaired antibody responses. We studied the antibody response to an inactivated trivalent influenza vaccine in 59 renal transplant recipients with life-sustaining kidney function...

journal_title：Transplantation

authors： Versluis DJ,Beyer WE,Masurel N,Wenting GJ,Weimar W

更新日期：1986-10-01 00:00:00

abstract：:Numerous studies have reported successful allotransplantation of hepatocytes. However, none have shown long-term correction of a liver-related metabolic defect. In this study, we used a method of regional hepatocyte transplantation and subsequent induction of transplanted cell proliferation by regeneration response in...

journal_title：Transplantation

authors： Eguchi S,Rozga J,Lebow LT,Chen SC,Wang CC,Rosenthal R,Fogli L,Hewitt WR,Middleton Y,Demetriou AA

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:Clinical studies suggest that the immunosuppressant mycophenolate mofetil is associated with anemia. However, the mechanism for this is not known. Here, we studied the effect of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, on erythropoiesis in vitro. METHODS:Both UT-7 cells and p...

journal_title：Transplantation

authors： Pile T,Kieswich J,Harwood S,Yaqoob MM

更新日期：2011-12-27 00:00:00

abstract：:The case studies of four patients with post-transplantation calcinosis are presented. Three of the four patients died of inanition and sepsis secondary to infection of extensive soft tissue ulcers and diffuse cutaneous vascular calcification with gangrene. The fourth patient survived following removal of all four para...

journal_title：Transplantation

authors： Perloff LJ,Spence RK,Grossman RA,Barker CF

更新日期：1979-01-01 00:00:00

abstract：:Comparative experiments were performed on 41 allogenic rat kidney transplants to determine the mitotic behaviour and proliferative metabolism (application of 3H-thymidine) in the first 6 days after recirculation. Three days after transplantation, DNA synthesis in the tubular epithelial cells of the cortex and the medu...

journal_title：Transplantation

authors： Lauschke H

更新日期：1978-07-01 00:00:00

abstract：:Fine-needle aspiration biopsies were used for clinical monitoring of liver allografts; 21 patients with an inflammatory episode of acute rejection (12.0 +/- 3.3 CIU at the peak) were studied; all episodes were reversible. The inflammatory infiltrate consisted mainly of lymphoid cells, including lymphoid blasts, with i...

journal_title：Transplantation

authors： Lautenschlager I,Höckerstedt K,Salmela K,Isoniemi H,Holmberg C,Jalanko H,Häyry P

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Graft thrombosis immediately after surgery remains a problem for successful pancreas transplantation. The present study evaluated the efficacy of computed tomography (CT) angiography for monitoring of graft patency in the immediate postoperative period. METHODS:The study involved 119 patients who underwent ...

journal_title：Transplantation

authors： Kim YH,Park JB,Lee SS,Byun JH,Kim SC,Han DJ

更新日期：2012-11-15 00:00:00

abstract：:OKT3 is a murine monoclonal antibody to the CD3 antigen of human T lymphocytes. The production of human antimurine antibodies after treatment with OKT3 has been perceived as a major limitation to its extended use and reuse. Treatment of 142 patients with 168 courses of OKT3 resulted in the development of antimouse ant...

journal_title：Transplantation

authors： First MR,Schroeder TJ,Hurtubise PE,Mansour ME,Penn I,Munda R,Balistreri WF,Alexander JW,Melvin DB,Fidler JP

更新日期：1989-01-01 00:00:00

abstract：:The stability of HLA alloantibodies was studied in 128 antibody-positive, potential kidney transplant recipients over an average period of 3 years. Antibody detection was performed using an anti-human globulin-complement-dependent cytotoxicity technique. In this study, the specificity of antibodies was categorized as ...

journal_title：Transplantation

authors： Rodey GE,Revels K,Fuller TC

更新日期：1997-03-27 00:00:00

abstract：:The mixed lymphocyte culture tests between one patient with acute lymphocytic leukemia and her mother and between another patient with aplastic anemia and his mother were found nonreactive, despite a one-haplotype difference for HL-A. Two crossovers in each family at the MLC locus or a specific defect in lymphocyte r...

journal_title：Transplantation

authors： Opelz G

更新日期：1975-01-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a major pathogen in transplant recipients and AIDS patients, and the virus may also play a role in allograft rejection. Previous work from this laboratory demonstrated increased cell surface expression of the adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) following CMV infection in vitro. W...

journal_title：Transplantation

authors： Craigen JL,Grundy JE

更新日期：1996-10-27 00:00:00

abstract：:Weight gain following renal transplantation occurs frequently but has not been investigated quantitatively. A retrospective chart review of 115 adult renal transplant recipients was used to describe patterns of weight gain during the first 5 years after transplantation. Only 23 subjects (21%) were overweight before th...

journal_title：Transplantation

authors： Johnson CP,Gallagher-Lepak S,Zhu YR,Porth C,Kelber S,Roza AM,Adams MB

更新日期：1993-10-01 00:00:00

abstract：:We retrospectively investigated the impact of pancreas transplantation on cardiovascular disease risk factors in patients with type 1 diabetic end-stage renal disease (ESRD). Two cohorts of patients, 44 simultaneous pancreas and kidney transplant patients (SPK) and 30 kidney transplant-alone patients (KTA), were inclu...

journal_title：Transplantation

authors： Luan FL,Miles CD,Cibrik DM,Ojo AO

更新日期：2007-08-27 00:00:00

abstract：:We have demonstrated that DA hearts grafted into PVG rats were completely protected from rejection by simultaneous liver transplantation from the same donor. In subsequent experiments PVG animals were given DA hearts followed 5 or 6 days later by livers from the same donor strain. Instead of the expected rapid rejecti...

journal_title：Transplantation

authors： Kamada N,Wight DG

更新日期：1984-09-01 00:00:00

abstract：:Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that c...

journal_title：Transplantation

authors： Hebert MF,Zheng S,Hays K,Shen DD,Davis CL,Umans JG,Miodovnik M,Thummel KE,Easterling TR

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:The role of combined liver-kidney transplantation (CLKT) for cirrhotic patients with renal failure (RF) is controversial. Since the model for end-stage liver disease era, there has been a rise in the number of CLKT. Using the Organ Procurement Transplant Network/United Network for Organ Sharing database, thi...

journal_title：Transplantation

authors： Fong TL,Khemichian S,Shah T,Hutchinson IV,Cho YW

更新日期：2012-08-27 00:00:00

abstract：:Survival times of allogeneic fetal pancreases were determined across various immunogenetic barriers using several inbred rat strains. Pancreases from 17-day-old embryos transplanted beneath the kidney capsule of normal, nonimmunosuppressed recipients were richly vascularized within a short period regardless of histoin...

journal_title：Transplantation

authors： Mullen Y,Shintaku IP

更新日期：1980-01-01 00:00:00

abstract：:Of 113 cyclosporine-treated primary renal allograft recipients, 60 were randomized to receive standard therapy without diltiazem (ND) and 53 received standard therapy plus diltiazem (D). There was no difference in CsA blood levels between ND and D at all intervals between 3 and 24 months follow-up, yet the D group req...

journal_title：Transplantation

authors： Chrysostomou A,Walker RG,Russ GR,d'Apice AJ,Kincaid-Smith P,Mathew TH

更新日期：1993-02-01 00:00:00

abstract：:Precision medicine is an emerging integrative approach for disease prevention, early detection, and treatment which takes into account individual variability in genetic and other molecular measurements, medical history, environmental exposures, and lifestyle. The development and availability of genomic and other molec...

journal_title：Transplantation

authors： Sirota M,Sarwal MM

更新日期：2017-08-01 00:00:00

abstract：:A new method of thymus transplantation is introduced, in which the graft is directly connected with the recipient's vascular system. This procedure was used both in euthymic rats and congenitally athymic nude rats. At all tested intervals after transplantation thymus grafts hardly differed from the recipient's own thy...

journal_title：Transplantation

authors： Kampinga J,Schuurman HJ,Pol GH,Bartels H,Broekhuizen R,Vaessen LM,Tielen FJ,Rozing J,Blaauw EH,Roser B

更新日期：1990-10-01 00:00:00

abstract：:Experimental evidence suggests storing lungs inflated with oxygen and with oxidizable substrate improves results of lung transplantation. Glucose is included in the low-potassium-dextran (LPD) solution Perfadex to achieve this goal. The authors hypothesized that other substrates might be more effective. Rat lungs were...

journal_title：Transplantation

authors： Peltz M,He TT,Adams GA 4th,Chao RY,Meyer DM,Jessen ME

更新日期：2005-08-15 00:00:00

abstract：BACKGROUND:Infectious complications still represent a major cause of morbidity and mortality in patients with organ transplantation. In particular, small bowel or multivisceral transplantation is complicated to a greater extent than other grafts as a consequence of infectious complications including sepsis. METHODS:Th...

journal_title：Transplantation

authors： Guaraldi G,Cocchi S,Codeluppi M,Di Benedetto F,De Ruvo N,Masetti M,Venturelli C,Pecorari M,Pinna AD,Esposito R

更新日期：2005-12-27 00:00:00

abstract：INTRODUCTION:Immune privilege provides a natural paradigm for potentially down-regulating allogeneic and xenogeneic inflammatory immune responses. Fas ligand has been suggested as a general underlying mechanism of immune privilege; the human Fas ligand has been shown to ligate murine Fas in vitro. METHODS:In this stud...

journal_title：Transplantation

authors： Kimmel SG,Ohbatake M,Kushida M,Merguerian P,Clarke ID,Kim PC

更新日期：2000-03-27 00:00:00

abstract：BACKGROUND:A previous donor intervention trial found that induction of mild therapeutic hypothermia in the brain-dead donor reduced the dialysis requirement after kidney transplantation. Consequences on the performance of cardiac allografts after transplantation were not explored to date. METHODS:Cohort study investig...

journal_title：Transplantation

authors： Schnuelle P,Benck U,Krämer BK,Yard BA,Zuckermann A,Wagner F,Szabo G,Borggrefe M,Karck M,Gummert J

更新日期：2018-11-01 00:00:00

abstract：:A murine IgG1 antibody specific for the IL-2-binding site on the human lymphocyte IL-2 receptor beta chain (CD25) was evaluated in 11 patients who developed acute graft-versus-host disease following allogeneic marrow transplantation. All patients had received cyclosporine and methotrexate for prophylaxis of GVHD, eith...

journal_title：Transplantation

authors： Anasetti C,Martin PJ,Hansen JA,Appelbaum FR,Beatty PG,Doney K,Harkonen S,Jackson A,Reichert T,Stewart P

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Bone marrow (BM) is an excellent source of mesenchymal stem cells (MSC) which can be expanded in vitro for further use. However, large volumes of BM specimens are not routinely available. We hypothesized that the normally discarded BM collection kits might be a convenient source of large numbers of MSC. MET...

journal_title：Transplantation

authors： Mageed AS,Pietryga DW,DeHeer DH,West RA

更新日期：2007-04-27 00:00:00

abstract：BACKGROUND:A recent proposal supports the elimination of allocation points for human leukocyte antigen (HLA) mismatches (MM) in cadaveric kidney transplantation. The intent is to increase access for some racial groups that might be disadvantaged by the representation of race-specific HLA in a largely white donor pool. ...

journal_title：Transplantation

authors： Rebellato LM,Arnold AN,Bozik KM,Haisch CE

更新日期：2002-12-15 00:00:00

abstract：BACKGROUND:Alpha-glutathione-S-transferase (alphaGST) has been suggested as a sensitive marker of acute cellular rejection in liver transplantation. This study evaluated the usefulness of alphaGST as a marker of acute rejection in comparison with standard liver function tests. METHODS:Daily measurements of liver funct...

journal_title：Transplantation

authors： Nagral A,Butler P,Sabin CA,Rolles K,Burroughs AK

更新日期：1998-02-15 00:00:00