Abstract:
:We have demonstrated that DA hearts grafted into PVG rats were completely protected from rejection by simultaneous liver transplantation from the same donor. In subsequent experiments PVG animals were given DA hearts followed 5 or 6 days later by livers from the same donor strain. Instead of the expected rapid rejection, all the grafts survived for at least 18 days, despite showing definite graft-swelling, a reliable clinical sign of early rejection, immediately prior to liver transplantation. In all 13 rats the heart size returned to normal and a strong beat returned within a few days. 6 animals survived indefinitely with healthy, beating heart grafts and the remaining 7 animals died of liver transplant rejection, but in these animals also the hearts were beating normally immediately prior to death. Histological examination of the hearts revealed no active rejection, but there was extensive myocardial scarring, compatible with resolution of a rejection reaction. It seems, therefore, that the liver grafts had entirely absorbed the vigorous immune response, terminating that which had already begun in the heart. This immunosuppressive effect was donor-specific and far more powerful than that of the immunosuppressive agent cyclosporine.
journal_name
Transplantationjournal_title
Transplantationauthors
Kamada N,Wight DGdoi
10.1097/00007890-198409000-00004subject
Has Abstractpub_date
1984-09-01 00:00:00pages
217-21issue
3eissn
0041-1337issn
1534-6080journal_volume
38pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::The CD154-CD40 pathway is one of the critical costimulatory pathways that are required for full activation of T cells during alloimmune responses. Blockade of this pathway with anti-CD154 antibodies has been reported to prolong allograft survival in experimental transplantation models and to induce tolerance in some i...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-200201151-00012
更新日期:2002-01-15 00:00:00
abstract::In liver allograft rejection, interlobular bile ducts are thought to be the main target of rejection. In contrast, in other organ allografts the capillary bed of the graft appears to be the primary target. To determine whether portal tract microvasculature is destroyed in liver allografts during rejection, we have ide...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199307000-00012
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Frequencies of alloreactive T cells determined by limiting dilution assays (LDA) may not adequately reflect the donor-reactive immune status in transplant recipients. To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200208270-00023
更新日期:2002-08-27 00:00:00
abstract::Antibody-mediated rejection (AMR) is an important cause of graft loss and continues to present a formidable obstacle to successful transplantation. Unresolved problems continue to be the absence of effective strategies to ablate the donor-specific antibody (DSA) response as well as to attenuate the antibody-mediated g...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003298
更新日期:2021-02-01 00:00:00
abstract::In a canine model of dog leukocyte antigen (DLA)-identical nonmyeloablative marrow transplantation including postgrafting immunosuppression with cyclosporine (CSP) and mycophenolate mofetil (MMF), engraftment was only transient with 100 cGy total body irradiation (TBI) conditioning, indicating suboptimal pretransplant...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000181168.42461.0b
更新日期:2005-11-27 00:00:00
abstract::The interactions of rapamycin (Rapa), CsA, and donor-specific transfusion (DST) were examined in an ACI to Lewis rat heterotopic cardiac allograft model. Survival data were truncated at 175 days for the purpose of statistical comparisons. Vehicle (Veh)-treated animals rejected at a mean of 7.3 +/- 0.2 days. Treatment ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199305000-00033
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Normothermic perfusion is an alternative but little studied method of organ preservation. Herein, we report the first case of ex vivo normothermic renal transplant perfusion in man. METHODS:The 62-year-old extended criteria donor died of an intracranial hemorrhage and had undergone cardiopulmonary resuscita...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31822d4e04
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:Current desensitization (DES) methods are not always effective. Thus, novel, more effective approaches are desirable. Interleukin (IL)-6 is an attractive target as it promotes B-cell differentiation to plasma cells, is important for immunoglobulin production, and induces Th17 cells. Here, we undertook a phas...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000741
更新日期:2015-11-01 00:00:00
abstract::The interactions of steroid hormones and human peripheral blood lymphocytes (PBLs) have been investigated following glass-wool column separation of PBLs and incubation in a serum-free medium in the presence of phytohemagglutinin (PHA). Addition of hydrocortisone or progesterone above physiological concentrations resul...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197905000-00004
更新日期:1979-05-01 00:00:00
abstract::Transcription factors of the nuclear factor of activated T cells (NFAT) family regulate both immune activation and insulin production. Calcineurin inhibitors (CNIs) target NFAT activation. Hence, CNIs not only prevent organ transplant rejection but also contribute to the development of new-onset diabetes after transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823f7f26
更新日期:2012-02-15 00:00:00
abstract:BACKGROUND:In chronic graft-versus-host disease (cGvHD), skin fibrosis, contractures, and an increase in collagen content form the hallmark. We report a successful treatment of a cGvHD patient by topical application of halofuginone, an inhibitor of collagen alpha1(I) gene expression. METHODS:Halofuginone-containing oi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199912150-00027
更新日期:1999-12-15 00:00:00
abstract::Pseudoaneurysms of the hepatic artery are a rare complication of liver transplantation. Early diagnosis and treatment are essential to avoid life-threatening hemorrhage. Conventional treatment consists of surgical resection and vascular reconstruction or transarterial coil embolization. More recently, percutaneous thr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000063936.94587.10
更新日期:2003-05-27 00:00:00
abstract::It has been reported that cultured keratinocyte (CK) allografts are not rejected in mice, unlike in other species. Several reports have suggested that mouse CK allografts are incapable of stimulating a primary alloresponse, including sensitization of recipients to alloantigens. In this study, we investigated the immun...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-07-15 00:00:00
abstract:BACKGROUND:It remains unknown whether low-grade hyperparathyroidism persisting beyond the first year postrenal transplantation has any impact on bone density. METHODS:Parathyroid hormone (PTH), glomerular filtration rate (GFR), and bone density (by dual-energy x-ray absorptiometry [DXA]) were monitored in the follow-u...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000230130.50451.78
更新日期:2006-09-27 00:00:00
abstract:BACKGROUND:Renal dysfunction early after kidney transplantation has multiple causes including ischemia-reperfusion (I/R) injury and drug-induced nephrotoxicity. This study assesses the acute nephrotoxicity of tacrolimus (Tac) and sirolimus (Sir) in a rat renal isograft model. METHODS:Lewis renal isografts and uninephr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000128837.07640.ae
更新日期:2004-08-15 00:00:00
abstract::This study compares two recently introduced radioimmunoassay kits involving specific monoclonal antibodies to cyclosporine. One kit (Sandimmun) involved 3H-labeled CsA (3H-CsA) as tracer and the other (CY-CLO-Trac-SP) involved a 125I-labeled conjugated derivative of CsA. The kits were nearly equivalent in method perfo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198904000-00019
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Pneumocystis jirovecii pneumonia (PJP) is an important infection-related complication, whose mode of transmission remains uncertain. METHODS:We investigated a nosocomial cluster of 14 PJP cases (11 confirmed and 3 probable) in kidney transplant recipients using epidemiological and genotyping methods. RESUL...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182384b57
更新日期:2011-12-27 00:00:00
abstract::Renal allograft recipients treated with cyclosporine (CsA) have increased renal vascular resistance that falls when CsA is stopped. With the aim of identifying whether CsA-treated patients with excellent renal function also have an alteration in renal vascular tone and to investigate which vessels are affected, we hav...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198807000-00014
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Early enteral nutrition with solutions containing prebiotics (fiber) and probiotics (Lactobacillus) is suggested to reduce bacterial translocation and minimize the incidence of infections after liver transplantation. METHODS:In a prospective, randomized placebo-controlled trial consisting of 95 patients, we...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-200207150-00021
更新日期:2002-07-15 00:00:00
abstract::To examine whether cyclosporine (CsA) has mutagenic potential against human cells, we analyzed sister chromatid exchange (SCE) induction by CsA using human lymphocytes in vitro. SCE frequencies increased significantly in the lymphocytes treated with 1 microgram/ml and 5 micrograms/ml CsA, though the frequencies seemed...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::A severe shortage of organs is one of the major barriers facing transplantation today. One of the proposals designed to overcome this serious problem is to increase the use of genetically unrelated living kidney donors. Excellent results have been achieved with these volunteers and cogent arguments have been made that...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200004270-00035
更新日期:2000-04-27 00:00:00
abstract::World Kidney Day on March 8, 2012, provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and better, but ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318245f186
更新日期:2012-02-27 00:00:00
abstract:BACKGROUND:Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CO releasing molecules (CORM)-401 has recently...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002201
更新日期:2018-07-01 00:00:00
abstract::Two technical modifications have been suggested for whole-pancreas transplantation with bladder drainage. The duodenal button technique (DB [Madison]) and the duodenal segment technique (DS [Iowa]) are the most commonly performed procedures (1,2). From December 1985 until May 1988 we performed 32 combined pancreas-kid...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00026
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The use of calcineurin inhibitors is associated with chronic nephrotoxicity and lower glomerular filtration rate (GFR). As a result, one strategy of transplant immunosuppression is calcineurin inhibitor elimination. METHODS:The aim of this study was to determine the outcome of a prospective randomized trial...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e31822805d7
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:The aim was to compare efficacy of multiple daily injections (MDI), continuous subcutaneous insulin infusion (CSII) and islet transplantation to reduce hypoglycemia and glycemic variability in type 1 diabetes subjects with severe hypoglycemia. METHODS:This was a within-subject, paired comparison of MDI and ...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000001381
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Gastrointestinal complications are common in patients who undergo kidney transplantation and may affect posttransplant outcomes. We examined the incidence and predictors of gastroesophageal reflux disease (GERD) and dyspepsia and their associations with graft survival and mortality after transplant. METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318160d4c4
更新日期:2008-02-15 00:00:00
abstract:BACKGROUND:A 35-year period of clinical development resulted in orthotopic liver transplantation (OLT) becoming a standardized surgical procedure. Despite this progress, the rate of technical complications is still high. Although the main problem in most analyses is vascular or bile duct failure, we observed a remarkab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005270-00018
更新日期:2000-05-27 00:00:00
abstract::The beneficial effect of deoxyspergualin (DSG, NKT-01) on lethal graft-versus-host disease in mice has been studied in a major histoincompatible donor-recipient combination. Suppression of the effector mechanisms responsible for the lethal outcome in this GVHD model is also noted. This study reveals: (1) DSG has a mar...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199103000-00032
更新日期:1991-03-01 00:00:00
abstract::In organ transplantation, blood borne cells and macromolecules (e.g., antibodies) of the host immune system are brought into direct contact with the endothelial cell lining of graft vessels. In this location, graft endothelial cells play several roles in allograft rejection, including the initiation of rejection respo...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e3181891d8b
更新日期:2008-11-27 00:00:00