Abstract:
:In a canine model of dog leukocyte antigen (DLA)-identical nonmyeloablative marrow transplantation including postgrafting immunosuppression with cyclosporine (CSP) and mycophenolate mofetil (MMF), engraftment was only transient with 100 cGy total body irradiation (TBI) conditioning, indicating suboptimal pretransplant immunosuppression. In contrast, grafts after 200 cGy TBI were durable in 11/12 recipients. We hypothesized that addition of pentostatin before transplantation could, in part, substitute for 100 cGy TBI. Pharmacokinetic studies showed pentostatin significantly inhibited adenosine deaminase in canine lymphocytes. Eight dogs were conditioned with 6x4 mg/m pentostatin and 100 cGy TBI, whereas two dogs received 3x4 mg/m pentostatin plus 100 cGy TBI. All were given MMF/CSP posttransplant. All showed initial engraftment; four remained stable mixed chimeras for >32 weeks. The median duration of engraftment was 13 (range 9 to >39) weeks, which was significantly longer than in six historical controls conditioned with 100 cGy TBI alone (median 10, range 3-12 weeks) (P=0.01).
journal_name
Transplantationjournal_title
Transplantationauthors
Panse JP,Storb R,Storer B,Santos EB,Wentzel C,Sandmaier BMdoi
10.1097/01.tp.0000181168.42461.0bsubject
Has Abstractpub_date
2005-11-27 00:00:00pages
1518-21issue
10eissn
0041-1337issn
1534-6080pii
00007890-200511270-00026journal_volume
80pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::To evaluate the efficacy of University of Wisconsin (UW) solution for lung preservation, we performed canine lung allotransplantation with lungs preserved in UW solution. Donor lungs from eight dogs were flushed with UW solution and lungs from four dogs with Euro-Collins solution, and these were preserved for 24 hr in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199301000-00004
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:We developed a nonviral gene transfer method using rapid injection of naked DNA targeting the liver and applied it in a rat model of liver transplantation. METHODS:Inbred Dark Agouti and Lewis rats were used. To test the efficacy and adverse effects of systemic or local (catheter-based) injection, different...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000118404.66106.e8
更新日期:2004-04-15 00:00:00
abstract::Immunomodulatory properties are attributed to apoptotic cells. These properties have been used to modulate allogeneic immune responses in experimental transplantation settings. In independent studies, apoptotic cell infusion has been shown to favor hematopoietic cell engraftment, to increase heart graft survival, and ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000269113.59857.d6
更新日期:2007-07-15 00:00:00
abstract::Longitudinal studies over an eight-month period have been performed to follow the T killer response restoration after allogeneic bone marrow transplantation (BMT). The capacity of the patient's peripheral blood mononuclear cells (PBM) to develop cytotoxic effector cells directed either against allogeneic cells or agai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198708000-00024
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Liver transplant recipients for hepatitis C virus (HCV)-related cirrhosis usually remain anti-HCV-seropositive after transplantation. The aim of this study was to characterize, longitudinally, the profile of HCV-specific antibodies and cryoglobulins in liver transplant recipients with recurrent HCV infection...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199901150-00013
更新日期:1999-01-15 00:00:00
abstract:BACKGROUND:Natural antibodies that react with galactose-alpha(1,3)galactose [galalpha(1,3)gal] carbohydrate epitopes exist in humans and Old World primates because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species and the subsequent production of antibodies to environmental mi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200107150-00028
更新日期:2001-07-15 00:00:00
abstract::Two technical modifications have been suggested for whole-pancreas transplantation with bladder drainage. The duodenal button technique (DB [Madison]) and the duodenal segment technique (DS [Iowa]) are the most commonly performed procedures (1,2). From December 1985 until May 1988 we performed 32 combined pancreas-kid...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198901000-00026
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Dysregulation of the coagulation system due to inflammatory responses and cross-species molecular incompatibilities represents a major obstacle to successful xenotransplantation. We hypothesized that complement inhibition mediated by transgenic expression of human CD46 in pigs might also regulate the coagula...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000746
更新日期:2015-10-01 00:00:00
abstract:INTRODUCTION:Statins are an established therapy after cardiac transplantation. Sirolimus (Srl) has been used successfully in cardiac transplant patients. However, potential side effects are hyperlipidemia and interactions with statins. The aim of the study was to evaluate the safety and efficacy of statin therapy after...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181910eb2
更新日期:2008-12-27 00:00:00
abstract:BACKGROUND:Rat lung allograft rejection is mediated by collagen type V (col(V)) specific T-helper-cell 17 (Th17) cells. Adoptive transfer of these cells is sufficient to induce rejection pathology in isografts, whereas tolerance to col(V) suppresses allograft rejection. Therefore, we tested whether regulatory T cells f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181bcde7b
更新日期:2009-12-27 00:00:00
abstract:BACKGROUND:The authors investigated the relationship between therapeutic blood transfusion before renal transplantation and rejection rates in cyclosporine- and tacrolimus-treated patients. METHODS:In one center, 265 consecutive recipients were studied. Protocol induction was with azathioprine, prednisolone, and cyclo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000111756.83834.A7
更新日期:2004-02-15 00:00:00
abstract:BACKGROUND:Immunomodulatory protocols including intravenous immunoglobulin/rituximab (IVIG/R) are employed to decrease anti-human leukocyte antigen (HLA) antibody levels for patients broadly sensitized to HLA and increase chances for transplantation with a compatible deceased donor (DD). The aim of our study was to ide...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31821eab8a
更新日期:2011-07-15 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the efficacy of cariporide (a sodium-hydrogen exchanger inhibitor), BMS180448 (a pharmacologic ischemic preconditioning agent), and the combination thereof, as adjuvant therapies for extended cardiac allograft preservation. METHODS:A porcine model of donor brain death ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000079254.81264.6D
更新日期:2003-09-15 00:00:00
abstract:BACKGROUND:Deep venous thrombosis (DVT) is a common problem with potentially devastating results in patients undergoing major surgical procedures. Certain renal transplant recipients are particularly at risk for allograft loss as a consequence of renal vein and artery thrombosis. Over the past few years, low molecular ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199808270-00020
更新日期:1998-08-27 00:00:00
abstract::Nonadherence to immunosuppressants in renal transplant recipients is a major factor affecting graft survival, but it is difficult to detect accurately in clinical practice. Adherence was measured in 153 adult renal transplant recipients using self-report questionnaires and interview, clinician rating, and cyclosporine...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.tp.0000110412.20050.36
更新日期:2004-03-15 00:00:00
abstract:BACKGROUND:There is a debate about the relative contribution of immunologic (rejection) and nonimmunologic (limited nephron mass) factors in long-term graft survival. METHODS:Using multivariate analysis, we studied the association of the following variables with outcome: delayed graft function (DGF), acute rejection, ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200001150-00011
更新日期:2000-01-15 00:00:00
abstract::Rabbit antisera to rat thoracic duct lymphocytes were examined by absorption analysis with quantitative radioimmunoassays to determine the tissue distribution of the antigens recognised and the amount of antibody against different specificities. Seven of eight sera were remarkably specific for leucocytes and one serum...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00009
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:Bone marrow transplantation (BMT) for class 3 patients with thalassemia is challenging due to high rates of graft rejection and transplant-related mortality. Since the first studies of BMT in the late 1980s, a number of conditioning regimens have been designed to improve outcomes, but with suboptimal results...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000928
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:BK virus-associated nephropathy (BKVN) is associated with an increased risk of graft failure. METHODS:Levels of mRNAs encoding proteins implicated in inflammation and fibrosis were measured in urine collected at the time of biopsy diagnosis of BKVN in 29 kidney graft recipients and analyzed for prognosticat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829acb38
更新日期:2013-07-27 00:00:00
abstract:BACKGROUND:Recipient antidonor cytotoxic T-cell activity has been associated with graft loss and acute rejection in renal allograft recipients. The role of immunologic mechanisms in the development of chronic graft rejection is controversial. We analyzed all living related renal transplants performed at Children's Hosp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199706270-00009
更新日期:1997-06-27 00:00:00
abstract:METHODS:Two hundred twenty-three recipients of first cadaveric kidney allografts were randomized to receive tacrolimus (TAC) + mycophenolate mofetil (MMF), TAC + azathioprine (AZA), or cyclosporine (Neoral; CsA) + MMF. All regimens contained corticosteroids, and antibody induction was used only in patients who experien...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.TP.0000069831.76067.22
更新日期:2003-06-27 00:00:00
abstract::Conjugation of dextran-coated superparamagnetic iron oxide (SPIO) particles with transactivator protein (Tat)-peptide and fluorescein isothiocyanate (FITC) allows cells to readily uptake SPIO particles. This makes possible high-resolution, real-time imaging of these cells by magnetic resonance imaging (MRI). First, we...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000090164.42732.47
更新日期:2003-10-15 00:00:00
abstract:BACKGROUND:Neuromuscular blockade (NMB) reversal with neostigmine and glycopyrrolate has been reported to cause cardiac arrest in patients with a history of cardiac transplantation. The purpose of this study was to examine the safety of NMB reversal with acetylcholinesterase inhibitors and muscarinic anticholinergics i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001060
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Immunological unresponsiveness of T cells to alloantigen can be induced by intrathymic injection of donor-specific antigen in small-animal models. Intrathymic tolerance to vascularized grafts in large animals has not previously been reported. METHODS:Thirty-two dogs were allocated into dog leukocyte antigen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181910e67
更新日期:2008-12-27 00:00:00
abstract:BACKGROUND:Gene targeting in large animals has the potential to be useful in medicine as well as in agriculture. Previously, we reported the first successful targeting of the bovine alpha1,3-galactosyltransferase (alpha1,3GT) gene and establishment of a heterozygous knockout cell line. In this report, we generated both...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000190422.66657.f1
更新日期:2006-03-15 00:00:00
abstract:BACKGROUND:Donor-specific immune tolerance has been reported in isolated cases of kidney transplantation associated with bone marrow transplantation. The following is a description of a living donor liver transplantation for a hilar cholangiocarcinoma in a previous recipient of an allogeneic bone marrow transplant. ME...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000083981.82522.13
更新日期:2003-09-27 00:00:00
abstract:BACKGROUND:Previous reports have established the feasibility of using livers from controlled, non-heart-beating donors (CNHBD) with good immediate graft function. This has been largely borne out of necessity because of the donor shortage. METHODS:Retrospective database review for the last 7 years (1995-2002), encompas...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000128327.95311.e3
更新日期:2004-07-27 00:00:00
abstract:BACKGROUND:Gastrointestinal complications are common in patients after lung and heart transplantation. Endoscopy is a standard method for the assessment of gastrointestinal morbidities. The aim of this study was to analyze the number and type of complications during endoscopic procedures in patients before and after lu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000517
更新日期:2015-07-01 00:00:00
abstract::The proliferation and differentiation of donor hematopoietic progenitor cells in bone marrow transplantation (BMT) recipients is influenced by hematopoietic growth factors, which could derive from either T cells or adherent stromal bone marrow cells, or both. In this study of 20 BMT recipients, we asked whether T lymp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199004000-00010
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Delayed xenograft rejection (DXR) remains a roadblock to successful xenotransplantation. A feature of DXR is early recruitment of monocytes to the xenograft. Naïve human monocytes can recognize and adhere to unstimulated porcine aortic endothelial cells (PAEC) more than human aortic endothelial cells, partly...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318191e6b4
更新日期:2009-01-15 00:00:00