Mediators involved in the immunomodulatory effects of apoptotic cells.

abstract：BACKGROUND:Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. METHODS:We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 doub...

journal_title：Transplantation

authors： Berglund S,Le Blanc K,Remberger M,Gertow J,Uzunel M,Svenberg P,Winiarski J,Ljungman P,Ringdén O,Uhlin M,Mattsson J

更新日期：2012-11-27 00:00:00

abstract：BACKGROUND:Although the value of duodenal histology as a means to diagnose acute rejection in pancreaticoduodenal allografts has been validated, it is not known how the duodenum responds to antirejection treatment in comparison with the pancreas. METHODS:Diabetic Lewis rats received a pancreaticoduodenal allograft. Cy...

journal_title：Transplantation

authors： Mark W,Hechenleitner P,Dietze O,Klima G,Schneeberger S,Steurer W,Candinas D,Margreiter R,Königsrainer A

更新日期：2002-01-27 00:00:00

abstract：:Imaging methods such as nuclear medicine (including positron emission tomography), magnetic resonance imaging, ultrasound, and optical imaging can be used to provide information about the expression of genes, and the location of molecules and cells in intact animals or patients. In the setting of transplantation, this...

journal_title：Transplantation

authors： George AJ,Bhakoo KK,Haskard DO,Larkman DJ,Reynolds PR

更新日期：2006-11-15 00:00:00

abstract：:Patients receiving allogeneic marrow transplantation for hematologic malignancies commonly are conditioned with total body irradiation (TBI) and given methotrexate (MTX) in an attempt to prevent graft-versus-host disease. To study the effects of TBI with or without MTX on bronchoalveolar cells and proteins, we perform...

journal_title：Transplantation

authors： Springmeyer SC,Kopecky KJ,Deeg HJ,Whitehead J,Altman LC,Storb R

更新日期：1984-04-01 00:00:00

abstract：:T cell surface proteins involved in transmembrane signalling resulting in the activation of T cells were investigated utilizing as probes monoclonal antibodies directed at T cell surface antigens. Here we report that mAbs that react with a framework determinant of alpha/beta heterodimer of T cell receptor for antigen,...

journal_title：Transplantation

authors： Suthanthiran M

更新日期：1989-02-01 00:00:00

abstract：:If transplantation of endocrine tissue is to become a therapy for a significant number of insulin-dependent diabetic individuals, tissue sources other than adult human islets will be required. Because human fetal pancreatic cells may offer that alternative, we have tried to find the optimal combination of tissue cultu...

journal_title：Transplantation

authors： Beattie GM,Otonkoski T,Lopez AD,Hayek A

更新日期：1993-12-01 00:00:00

abstract：:Intestinal transplantation has become the treatment of choice for patients who are experiencing life-threatening complications of intestinal failure. Early attempts with intestinal transplantation were unsuccessful as a consequence of both technical and immunologic failures. The introduction of tacrolimus provided the...

journal_title：Transplantation

authors： Langnas AN

更新日期：2004-05-15 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion injury (IRI) plays key roles in graft viability and posttransplantation function. Caspase-3 associated with apoptosis and inflammation is up-regulated by IRI. We propose that naked small interfering RNA (siRNA) targeting caspase-3 may prevent IRI and improve kidney preservation. METHODS...

journal_title：Transplantation

authors： Yang B,Hosgood SA,Nicholson ML

更新日期：2011-03-15 00:00:00

abstract：:Anti-CD3 monoclonal antibody (mAb) OKT3 is immunosuppressive, but causes severe adverse effects during the first administration ("first-dose reaction"). These adverse effects are presumably caused by cytokine release that results from T-cell activation. In vitro, T-cell activation by anti-CD3 mAb requires interaction ...

journal_title：Transplantation

authors： Tax WJ,Tamboer WP,Jacobs CW,Frenken LA,Koene RA

更新日期：1997-01-15 00:00:00

abstract：BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...

journal_title：Transplantation

authors： Wang H,Hosiawa KA,Garcia B,Shum JB,Dutartre P,Kelvin DJ,Zhong R

更新日期：2003-05-15 00:00:00

abstract：BACKGROUND:In an effort to define reliable assays that might predict postimmunosuppressant-withdrawal development of chronic rejection (CR), despite conditioning for tolerance induction, we evaluated various immunological responses in nonhuman primate renal allograft recipients. METHODS:Fourteen Cynomolgus monkeys rec...

journal_title：Transplantation

authors： Boskovic S,Kawai T,Smith RN,Wee SL,Nadazdin O,Koyama I,Saidman S,Cardarelli F,Elias N,Sykes M,Strom T,Colvin RB,Sachs DH,Cosimi AB

更新日期：2006-09-27 00:00:00

abstract：:A patient with end-stage renal disease and known benign monoclonal gammopathy underwent kidney transplantation at Westchester County Medical Center, Valhalla, NY. After surgery, during routine follow-up, the patient had laboratory evidence of frank multiple myeloma. However, she did not show any clinical signs or symp...

journal_title：Transplantation

authors： Dagher F,Sammett D,Abbi R,Tomasula JR,Delaney V,Butt KM

更新日期：1996-12-15 00:00:00

abstract：BACKGROUND:The detection of acute rejection in heart transplantation remains an important feature of transplant management, especially in the early phase. Frequent surveillance with endomyocardial biopsy is necessary, even though it is an invasive procedure and carries a certain risk. Hence, noninvasive biomarkers able...

journal_title：Transplantation

authors： Crescioli C,Buonamano A,Scolletta S,Sottili M,Francalanci M,Giomarelli P,Biagioli B,Lisi G,Pradella F,Serio M,Romagnani P,Maccherini M

更新日期：2009-01-27 00:00:00

abstract：:Acute rejection (AR) remains the biggest challenge during the first year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the criterion standard for AR, endomyocardial biopsy has several li...

journal_title：Transplantation

authors： Chen Y,Zhang L,Liu J,Zhang P,Chen X,Xie M

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Accurate and rapid diagnosis of human cytomegalovirus (HCMV) disease in solid organ transplant patients remains a challenge. We evaluated the clinical utility of a quantitative polymerase chain reaction (QPCR) method to diagnose transplant patients with HCMV disease. METHODS:A total of 429 plasma samples fr...

journal_title：Transplantation

authors： Ferreira-Gonzalez A,Fisher RA,Weymouth LA,Langley MR,Wolfe L,Wilkinson DS,Garrett CT

更新日期：1999-10-15 00:00:00

abstract：BACKGROUND:Tacrolimus (Tac) has immunosuppressant properties similar to those of cyclosporine A (CsA), but it is more potent. At present, however, its immunosuppressive activity in renal transplant recipients with ongoing chronic rejection has not been clarified. METHODS:We studied changes in kidney function, mixed ly...

journal_title：Transplantation

authors： Ferraris JR,Tambutti ML,Cardoni RL,Prigoshin N

更新日期：2004-02-27 00:00:00

abstract：:Human epidermal cells were grown serially in surface culture by inoculation of suspensions of disaggregated cells. Single cells grew into colonies and the colonies fused to make a confluent epithelium. The epithelium was detached as a unit and transplanted onto a graft bed prepared in athymic mice. Such grafts formed ...

journal_title：Transplantation

authors： Banks-Schlegel S,Green H

更新日期：1980-04-01 00:00:00

abstract：:This study focuses upon two discrete components of posttransplant hepatic reticuloendothelial system (RES) function-phagocytosis and killing of bacteria-under various conditions of ischemic preservation. We had previously reported that, following intravenous injection of rats with 51Cr and 125I double-labeled Escheric...

journal_title：Transplantation

authors： Klein AS,Zhadkevich M,Wang D,Margolick JB,Winkelstein JA,Bulkley GB

更新日期：1996-04-27 00:00:00

abstract：BACKGROUND:Generation of non-human primate regulatory T cells (Treg) with alloantigen (alloAg) specificity would allow their testing in preclinical transplant models. Low recovery of Treg from peripheral blood limits their potential utility. In small animals and humans, conventional myeloid dendritic cells (DC) have be...

journal_title：Transplantation

authors： Zahorchak AF,Raimondi G,Thomson AW

更新日期：2009-11-15 00:00:00

abstract：BACKGROUND:The need for renal replacement therapy (RRT) either before or after orthotopic liver transplant (OLTX) has been reported to be a poor prognostic indicator for survival. Use of continuous veno-venous hemodialysis (CVVHD) for RRT has been reported in three series of OLTX patients with high 90-day mortality rat...

journal_title：Transplantation

authors： Gonwa TA,Mai ML,Melton LB,Hays SR,Goldstein RM,Levy MF,Klintmalm GB

更新日期：2001-05-27 00:00:00

abstract：BACKGROUND:The shortage of organs for liver transplantation has forced transplant centers to expand the donor pool by using donors traditionally labeled as marginal. One such example is liver transplantation using a donor with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), a disorder of late pre...

journal_title：Transplantation

authors： Briceno PJ,Ortiz JA,Manzarbeitia C,Jeon H,Munoz SJ,Rothstein KD,Araya V,Gala I,Reich DJ

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND:Pediatric liver transplant recipients have traditionally been grouped according to age. Age-based classification schemes are useful in identifying clinical problems in selected age groups and also for developing solutions to these problems. Although infants in the first 3 months of life have not traditionall...

journal_title：Transplantation

authors： Woodle ES,Millis JM,So SK,McDiarmid SV,Busuttil RW,Esquivel CO,Whitington PF,Thistlethwaite JR

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:In this report, we compare the long-term outcome of pediatric liver transplantation (LTx) patients maintained with tacrolimus-based and with cyclosporine (CsA)-based immunosuppressive therapy. We examine long-term patient and graft survival, the incidence of rejection, and immunosuppression-related complicat...

journal_title：Transplantation

authors： Jain A,Mazariegos G,Kashyap R,Green M,Gronsky C,Starzl TE,Fung J,Reyes J

更新日期：2000-08-27 00:00:00

abstract：BACKGROUND:Immunosuppressive drugs that target T cells are useful for prolonging allograft survival. The anti-CD3 immunotoxin FN18-CRM9 has been shown to effectively prolong renal allograft survival in a rhesus monkey model of transplantation. However, immunotoxin-treated monkeys showed increased levels of inflammatory...

journal_title：Transplantation

authors： Hamawy MM,Tsuchida M,Manthei ER,Dong Y,Fechner JE,Knechtle JS

更新日期：1999-09-15 00:00:00

abstract：BACKGROUND:Clinical and hematological profile of chronic anemia in children after orthotopic liver transplantation (OLT) is unknown. METHODS:We prospectively studied children after orthotopic liver transplantation (OLT) with hemoglobin levels < 2 standard deviation of age appropriate mean for > 6 months. Investigation...

journal_title：Transplantation

authors： Misra S,Moore TB,Ament ME,Vargas JH,Busutill RW,McDiarmid SV

更新日期：2000-11-27 00:00:00

abstract：:Cyclosporine (CsA) administration and nitric oxide (NO) blockade promote similar chronic renal hemodynamic alterations in rats. We evaluated various clinical CsA doses under conditions of NO blockade using L-NAME (N-nitro L-arginine methyl ester). Groups of Sprague-Dawley rats kept on a normal salt (+NaCl) or low-salt...

journal_title：Transplantation

authors： Gardner MP,Houghton DC,Andoh TF,Lindsley J,Bennett WM

更新日期：1996-05-27 00:00:00

abstract：:Nine recombinant H-2 mouse strains with crossovers in the I region between I-E-negative haplotypes f,q and I-E-positive haplotypes p,k were examined for I-E expression by microcytotoxicity dye exclusion assay. These recombinants were found to be negative for I-E expression. There are two possible genotypes in these re...

journal_title：Transplantation

authors： Lafuse WP,Savarirayan S,McCormick JF,David CS

更新日期：1987-02-01 00:00:00

abstract：:A study was designed to determine if cold preservation induces an increase in lymphocyte adherence to liver sinusoids on reperfusion. Rat livers were stored at 1 degree C in University of Wisconsin solution for 45 min, 8 hr, or 30 hr, and then reperfused for 90 min at 37 degrees C in an isolated perfused rat liver app...

journal_title：Transplantation

authors： Clavien PA,Morgan GR,Sanabria JR,Petrunka C,Levy GA,Robert P,Harvey C,Strasberg SM

更新日期：1991-09-01 00:00:00

abstract：:The requirement for effective, minimally toxic immunosuppression remains a major obstacle to performing human composite tissue allotransplantation. The skin component of composite tissue (e.g., limb) allografts is especially antigenic, necessitating toxic immunosuppressant doses to prevent or reverse acute rejection. ...

journal_title：Transplantation

authors： van den Helder TB,Benhaim P,Anthony JP,McCalmont TH,Mathes SJ

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with survival in HC...

journal_title：Transplantation

authors： Velidedeoglu E,Mange KC,Frank A,Abt P,Desai NM,Markmann JW,Reddy R,Markmann JF

更新日期：2004-06-27 00:00:00