Abstract:
BACKGROUND:Tacrolimus (Tac) has immunosuppressant properties similar to those of cyclosporine A (CsA), but it is more potent. At present, however, its immunosuppressive activity in renal transplant recipients with ongoing chronic rejection has not been clarified. METHODS:We studied changes in kidney function, mixed lymphocyte culture, cell-mediated lympholysis, cytotoxic antibodies, lymphocyte population, and cytokine response before and after the conversion from CsA to Tac in 14 pediatric renal transplant recipients with chronic rejection. CsA (5.9+/-0.2 mg/kg/d) was replaced by Tac (0.1+/-0.004 mg/kg/d). RESULTS:Serum creatinine decreased (2.3+/-0.2-1.9+/-0.2 mg/dL, P <0.005), creatinine clearance increased (36.8+/-2.5-46.1+/-4.4 mL/min/1.73 m, P <0.005), and urinary protein excretion decreased (0.4+/-0.01-0.2+/-0.04 g/24 hr, P <0.03) after 6 months, and these values were maintained after 2 years with Tac treatment. During Tac therapy, anti-donor and anti-control mixed lymphocyte culture decreased 38% and 31% (P <0.05), respectively. Cell-mediated lympholysis did not change. CD3 decreased from 87%+/-2% to 80%+/-2% (P <0.005), and CD8 decreased from 34%+/-3% to 27%+/-2% (P <0.005). The switch to Tac decreased the interferon-gamma production in vitro (P <0.05) and increased tumor necrosis factor-alpha levels (P <0.05). The release of interleukin-10 was strikingly augmented with CsA or Tac therapy (P <0.01), but transforming growth factor-beta secretion was similar. CONCLUSIONS:Our data indicate that conversion from CsA to Tac therapy leads to an improvement in renal function without altering key elements of the immunosuppression in children with ongoing chronic rejection.
journal_name
Transplantationjournal_title
Transplantationauthors
Ferraris JR,Tambutti ML,Cardoni RL,Prigoshin Ndoi
10.1097/01.tp.0000112438.46472.38subject
Has Abstractpub_date
2004-02-27 00:00:00pages
532-7issue
4eissn
0041-1337issn
1534-6080pii
00007890-200402270-00011journal_volume
77pub_type
临床试验,杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Small-for-size grafts often cause persistent conjugated hyperbilirubinemia in the recipient after adult-to-adult living donor liver transplantation, but the cause has not yet been clarified. In physiologic status, bilirubin is excreted from hepatocytes to the bile canaliculus by means of multidrug resistance...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000089234.93366.6D
更新日期:2004-01-15 00:00:00
abstract::Survival times of allogeneic fetal pancreases were determined across various immunogenetic barriers using several inbred rat strains. Pancreases from 17-day-old embryos transplanted beneath the kidney capsule of normal, nonimmunosuppressed recipients were richly vascularized within a short period regardless of histoin...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198001000-00008
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Infections are a major cause of morbidity and mortality in kidney allograft recipients. In this post hoc analysis of a randomized clinical trial which tested the effect of denosumab on bone mineral density, we assessed the impact of this drug on the incidence and severity of infections in the first year afte...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000001547
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND/AIM:It remains uncertain whether autoimmune hepatitis (AIH), as an original indication for orthotopic liver transplantation (OLTX), predisposes to the development of chronic rejection (CR) after surgery and published reports on heterogeneous groups of patients provided conflicting data. In this work we analy...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200008150-00014
更新日期:2000-08-15 00:00:00
abstract::Arterial ketone body ratio (AKBR [acetoacetate/beta-hydroxybutyrate]) was measured in nineteen patients under medical supportive therapy for fulminant hepatic failure (FHF), in order to evaluate its predictive value relative to liver transplantation. Of the 19 patients 8 (42%) were salvaged and 11 (58%) died. Seven of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199104000-00009
更新日期:1991-04-01 00:00:00
abstract::Heterologous anti-immunoglobulin is a potent immunosuppressive agent that prolongs H-2- and H-3-incompatible skin graft survival. In conjunction with antithymocyte serum, anti-immunoglobulin promotes greater graft life than either antiserum used alone, without evidence of toxicity to recipient animals. Combination tre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197711000-00007
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND:Chronic cyclosporine (CsA) nephropathy, which has been unequivocally documented in recipients of heart, heart-lung, liver, or bone marrow transplants, as well as in nontransplant situations, usually results in a progressive deterioration of renal function. In this study, we assessed the potential reversibili...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199803150-00010
更新日期:1998-03-15 00:00:00
abstract::Predictors of survival after lung transplant were analyzed in a large cohort of 990 lung transplanted patients from a single center. The overall survival was 41.6%, (41.5% in males, and 41.8% in females), the average length of the follow up was 45.84+/-51.98 months (range 0-282.47 months). Females tend to live longer ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816c2fae
更新日期:2008-04-27 00:00:00
abstract::In a murine strain combination disparate in both H-2 antigens and minor histocompatibility antigens consisting of C57BL/6 (B6; H-2b, Mls-1b) mice as recipients and AKR/J (AKR; H-2k, Mls-1a) mice as donors, we reported that the administration of anti-TCR-alpha beta mAb nonspecifically suppresses the ability to reject a...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-02-15 00:00:00
abstract::The monoclonal antibodies (MoAb) CR11-351 and KS1 are secreted by hybridomas generated with splenocytes from BALB/c mice immunized with the cultured human B lymphoid cells LG-2 (HLA-A2,A2,B27,B27). The 2 monoclonal antibodies immunoprecipitated components with a superimposable 2-dimensional gel electrophoretic profile...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198803000-00026
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Operational tolerance is defined as long-term acceptance of a transplanted organ after complete cessation of immunosuppression (IS), but may not always protect against antigen-dependent changes in graft morphology. METHOD:IS free patients after living-donor liver transplantation (LDLT) underwent protocol bi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318195a7cb
更新日期:2009-02-27 00:00:00
abstract:BACKGROUND:Although islet xenotransplantation is a promising therapy for type 1 diabetes, its clinical application has been hampered by cellular rejection and the requirement for high levels of immunosuppression. The aim of this study was to determine the role of Foxp3 regulatory T (Treg) cells in costimulation blockad...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001482
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Donor-specific immune tolerance has been reported in isolated cases of kidney transplantation associated with bone marrow transplantation. The following is a description of a living donor liver transplantation for a hilar cholangiocarcinoma in a previous recipient of an allogeneic bone marrow transplant. ME...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000083981.82522.13
更新日期:2003-09-27 00:00:00
abstract::In human organ transplantation, the correct diagnosis of rejection may be difficult using clinical and/or histopathologic criteria, and immunologic assays should therefore be considered. We have applied monoclonal antibodies in 2-color flow cytometric (FACS) analysis to study phenotypic patterns of kidney-infiltrating...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198905000-00014
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Human cytomegalovirus (CMV) uses different strategies to escape from human host defense reactions. Previously we have observed that infection of endothelial cells with CMV in vitro leads to enhanced activity of endothelial ectonucleotidases. These ectoenzymes are responsible for hydrolysis of extracellular a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000287598.25493.a5
更新日期:2007-11-27 00:00:00
abstract::A monoclonal anti-Lyt-1.1 serum has been characterized in terms of its effect on various cell populations involved in cell-mediated immune responses. The monoclonal serum was compared to a conventionally prepared anti-Lyt-1.1 serum. Cytotoxic T cell precursors and effectors were found to be Lyt-1.1+. Helper T cells wh...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198101000-00013
更新日期:1981-01-01 00:00:00
abstract::IL-10 is a regulatory cytokine of both T cells and monocytes. We have investigated the ability of IL-10 to regulate responses to alloantigens in vitro and in vivo. Addition of IL-10 to mixed lymphocyte cultures profoundly decreased the proliferation and IL-2 production by donor B10.BR cells stimulated with CBA cells e...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-12-15 00:00:00
abstract:BACKGROUND:Immunogenicity of a graft depends on its expression of major histocompatability complex (MHC) antigens and adhesion molecules and on the amount of intragraft leukocytes, the so-called passenger leukocytes. Although long-term culture reduces passenger leukocytes, permanent acceptance is not necessarily observ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200208270-00003
更新日期:2002-08-27 00:00:00
abstract::Clinical as well as experimental studies have shown a great interindividual variability in the immunosuppressive efficacy of CsA. Evaluating previous in vitro findings of a correlation between sensitivity of alloresponsiveness to CsA and the HLA-DR phenotype CsA levels were compared in kidney transplant recipients wit...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199204000-00010
更新日期:1992-04-01 00:00:00
abstract::The antibody response to the pregnancy-associated (Pa) antigen in the pregnant female segregated with the major histocompatibility complex (MHC) when the female progeny in the (PVG x WF)F1 x PVG testcross, in which the PVG strain is a low responder to Pa and the WF strain is a high responder, were mated to DA male rat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198608000-00022
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Current grading systems in acute graft-versus-host disease (GVHD) are not able to identify patients with poor prognosis at time of onset, because they take into account maximal grade. The aim of this study was to evaluate potential predictors for overall survival at disease onset. METHODS:The study sample w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181bc2583
更新日期:2009-11-15 00:00:00
abstract::Seventy-two dog kidneys were stored under hypothermia as described by Collins and Sacks between 24 and 72 hr and then transplanted. The immediate function of the kidneys was measured by p-aminohippuric acid and inulin clearances. Twenty-four hr proved to be the maximum safe preservation time with both methods. The imm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197705000-00009
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Pneumocystis jiroveci pneumonia may be a life-threatening opportunistic infection in immunosuppressed solid organ transplant recipients. Despite effective treatment with high-dose trimethoprim-sulfamethoxazole and steroids, morbidity is often severe and lethality remains high. New therapeutic approaches are ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000280546.91617.6c
更新日期:2007-09-27 00:00:00
abstract::In vitro studies have shown that calcium channel blockers (CCB) exert inhibitory effects on immunocompetent cells but conflicting results have been reported as to the translation of these effects into significant in vivo immunosuppression. In this study we evaluated the effects of the benzothiazepine-like calcium bloc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199307000-00033
更新日期:1993-07-01 00:00:00
abstract::Renal allografts were performed in miniature swine that were identical at their major histocompatibility locus and were presensitized by skin grafts from their prospective renal donors. All of these renal grafts were rejected in a hyperacute or markedly accelerated manner compared to the survival of comparable grafts ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:Preoperative mapping of the hepatic venous system of the partial liver graft is indispensable to the success of living-related liver transplantation. We assessed the accuracy of magnetic resonance (MR) venography with angular reconstruction in depicting the tributaries of the middle hepatic vein and left hep...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199907270-00019
更新日期:1999-07-27 00:00:00
abstract::We report the management of a patient with the late onset of chronic graft-versus-host disease (GVHD) after orthotopic liver transplantation. GVHD is a rare complication of solid organ transplants that usually presents early after transplantation and is fatal in the majority of cases. Our patient differs from the typi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200105270-00022
更新日期:2001-05-27 00:00:00
abstract::Cultured BALB/c (H-2d) thyroid, adult pancreatic islet and fetal proislet tissues can be accepted permanently in CBA/H (H-2k) recipients until rejection is triggered by the transfer of antidonor strain activated immune T cells. Class II MHC antigens are not expressed on the accepted grafts and are induced following im...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199204000-00025
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:The comparative effectiveness of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) versus bare metal stents (BMS) has not been studied in the kidney transplant population. METHODS:Using the US Renal Data System, we identified 3245 kidney transplant patients who underwent PCI between Ap...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001446
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Although inactivated vaccines are recommended for immunocompromized patients, efficacy and safety of diphtheria and tetanus immunization in renal transplant recipients have received little attention so far. The aim of the study was to investigate the response to a standard diphtheria and tetanus booster vacc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199707270-00010
更新日期:1997-07-27 00:00:00