Predictive role of pretransplant serum CXCL10 for cardiac acute rejection.


BACKGROUND:The detection of acute rejection in heart transplantation remains an important feature of transplant management, especially in the early phase. Frequent surveillance with endomyocardial biopsy is necessary, even though it is an invasive procedure and carries a certain risk. Hence, noninvasive biomarkers able to predict acute rejection could be a further helpful tool in patient management. The interferon-gamma-inducible chemokine CXCL10 is required for initiation and development of graft failure caused by acute or chronic rejection. It has been reported that CXCL10 serum level is predictive of graft loss in kidney graft recipients. In the present study, we investigated whether pretransplant CXCL10 serum level may be a predictive noninvasive biomarker in heart transplant (HTx) recipients, as well. METHODS:Sera from 143 patients undergoing orthotopic heart transplantation were collected before surgery and tested for CXCL10 and CCL22 and compared with serum samples from healthy subjects. RESULTS:We found that basal CXCL10 serum levels in HTx recipients were significantly higher than in healthy subjects, whereas no difference was seen in CCL22 levels. Among HTx recipients, CXCL10 serum levels of rejectors were significantly higher than in nonrejectors. Our results showed that CXCL10 was a significant independent risk factor of several variables and had the highest predictive value for early acute heart rejection, with 160 pg/mL cutoff value. CONCLUSIONS:In HTx recipients, measurement of pretransplant CXCL10 serum levels could be a clinically useful tool for predicting cardiac acute rejection, especially in the early posttransplant period.






Crescioli C,Buonamano A,Scolletta S,Sottili M,Francalanci M,Giomarelli P,Biagioli B,Lisi G,Pradella F,Serio M,Romagnani P,Maccherini M




Has Abstract


2009-01-27 00:00:00














  • OSAKA trial: a randomized, controlled trial comparing tacrolimus QD and BD in kidney transplantation.

    abstract:BACKGROUND:The once-daily (QD), prolonged-release formulation of tacrolimus has been shown to improve adherence versus twice-daily (BD) tacrolimus. Treatment nonadherence in transplant recipients has been associated with poor graft outcomes. METHODS:This open-label, parallel-group study randomized adults with end-stag...


    pub_type: 杂志文章,随机对照试验


    authors: Albano L,Banas B,Klempnauer JL,Glyda M,Viklicky O,Kamar N,Optimising immunoSuppression After Kidney transplantation with ADVAGRAF Study Group.

    更新日期:2013-11-27 00:00:00

  • Ability of cyclosporine to promote the growth of transplanted ultraviolet radiation-induced tumors in mice.

    abstract::The use of immunosuppressive agents (primarily azathioprine and prednisone) to promote human allograft survival is known to be associated with an enhanced rate of skin cancer development by ultraviolet radiation (UVR). These observations raise the question of whether the immunosuppressive agents are functioning as coc...


    pub_type: 杂志文章


    authors: Servilla KS,Burnham DK,Daynes RA

    更新日期:1987-08-01 00:00:00

  • Thromboembolism in heart transplantation: role of prothrombin G20210A and factor V Leiden.

    abstract:BACKGROUND:Thromboembolism has been reported as a frequent complication after cardiac transplantation. Many risk factors for thrombosis may explain this, such as metabolic alterations and the use of cyclosporine. In the general population, two single nucleotide polymorphisms (SNPs), factor V Leiden and prothrombin G202...


    pub_type: 杂志文章


    authors: Miriuka SG,Langman LJ,Evrovski J,Miner SE,Kozuszko S,D'Mello N,Delgado DH,Wong BY,Ross HJ,Cole DE

    更新日期:2005-09-15 00:00:00

  • Galectin-3-mediated xenoactivation of human monocytes.

    abstract:BACKGROUND:Delayed xenograft rejection (DXR) remains a roadblock to successful xenotransplantation. A feature of DXR is early recruitment of monocytes to the xenograft. Naïve human monocytes can recognize and adhere to unstimulated porcine aortic endothelial cells (PAEC) more than human aortic endothelial cells, partly...


    pub_type: 杂志文章


    authors: Greenwald AG,Jin R,Waddell TK

    更新日期:2009-01-15 00:00:00

  • Liver transplantation using an organ donor with HELLP syndrome.

    abstract:BACKGROUND:The shortage of organs for liver transplantation has forced transplant centers to expand the donor pool by using donors traditionally labeled as marginal. One such example is liver transplantation using a donor with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), a disorder of late pre...


    pub_type: 杂志文章


    authors: Briceno PJ,Ortiz JA,Manzarbeitia C,Jeon H,Munoz SJ,Rothstein KD,Araya V,Gala I,Reich DJ

    更新日期:2004-01-15 00:00:00

  • Differentiation of class I- and class II-directed donor-specific alloreactivity in bronchoalveolar lavage lymphocytes from lung transplant recipients.

    abstract::Previous studies have demonstrated that donor antigen-specific primed-lymphocyte-test (PLT) reactivity of bronchoalveolar lavage lymphocytes is strongly associated with acute pulmonary rejection and with obliterative bronchiolitis (OB); however, a systematic analysis of PLT reactivity as being class I-or II-directed h...


    pub_type: 杂志文章


    authors: Reinsmoen NL,Bolman RM,Savik K,Butters K,Hertz M

    更新日期:1992-01-01 00:00:00

  • Resource utilization associated with procurement of transplantable organs from donors that do not meet OPTN eligible death criteria.

    abstract:BACKGROUND:The strategy of evaluating every donation opportunity warrants an investigation into the financial feasibility of this practice. The purpose of this investigation is to measure resource utilization required for procurement of transplantable organs in an organ procurement organization (OPO). METHODS:Donors w...


    pub_type: 杂志文章


    authors: DuBay DA,Redden DT,Bryant MK,Dorn DP,Fouad MN,Gray SH,White JA,Locke JE,Meeks CB,Taylor GC,Kilgore ML,Eckhoff DE

    更新日期:2014-05-27 00:00:00

  • Alterations in chemokine receptor CCR5 expression on blood dendritic cells correlate with acute graft-versus-host disease.

    abstract:BACKGROUND:Dendritic cells (DC) are important in the development of acute graft-versus-host disease (GVHD) after allogeneic hemopoietic cell transplantation (alloHCT). The trafficking of immature DC from blood to GVHD target organs is likely to be regulated by chemokine receptors. METHODS:We performed flow cytometry t...


    pub_type: 杂志文章


    authors: Shahin K,Sartor M,Hart DN,Bradstock KF

    更新日期:2013-10-27 00:00:00

  • Combined liver-intestine grafts compared with isolated intestinal transplantation in children: a single-center experience.

    abstract:BACKGROUND:Intestinal transplantation is known to be associated with a high risk of early complications and mortality. METHODS:We analyzed prospective data of 51 primary small bowel transplantations from December 1999 to August 2009 and identified perioperative factors that impact on early mortality (≤6 months after t...


    pub_type: 杂志文章


    authors: Dopazo C,Gupte GL,Sharif K,Perera MT,Hartley J,Muiesan P,Mayer DA,Bromley P,Bennett J,Kelly DA,van Mourik I,McKiernan P,Beath SV,Mirza DF

    更新日期:2012-10-27 00:00:00

  • Pharmacokinetic Study of Conversion Between 2 Formulations of Once-daily Extended-release Tacrolimus in Stable Lung Transplant Patients.

    abstract:BACKGROUND:The aim of this study was to compare the pharmacokinetic profile, tolerability, and safety of a novel once-daily extended-release formulation of tacrolimus (LCPT) with that of once-daily prolonged-release tacrolimus (ODT) in stable adult lung transplant (LT) recipients. METHODS:Phase II, open-label, single-...


    pub_type: 杂志文章


    authors: Sintes H,Sáez-Giménez B,Berastegui C,López-Meseguer M,Monforte V,Bravo C,Vima J,Gómez-Ollés S,Roman A

    更新日期:2018-10-01 00:00:00

  • Prolongation of heterotropic heart allograft survival in rats by use of antigen-antibody complexes.

    abstract::Treatment of BN recipients with soluble WAG/Rij histocompatibility antigens (HCA) did not produce prolongation of (WAG/Rij X BN) F1 heart allografts but resulted in specific sensitization of the recipients in most cases. Three different anti-WAG/Rij sera (ADS) were tested, either alone or complexed in equivalence to 0...


    pub_type: 杂志文章


    authors: Marquet RL,Heystek GA,Tank B,van ES AA

    更新日期:1976-06-01 00:00:00

  • Improved results in pancreatic transplantation by avoidance of nonimmunological graft failures.

    abstract::Twenty eight consecutive combined renal and pancreatic transplantations with enteric exocrine diversion were performed between June 1984 and May 1986. The one-year actuarial patient survival and renal and pancreatic graft survival were 90%, 67%, and 69%, respectively. Nineteen pancreatic grafts and eighteen renal graf...


    pub_type: 杂志文章


    authors: Tydén G,Brattström C,Lundgren G,Ostman J,Gunnarsson R,Groth CG

    更新日期:1987-05-01 00:00:00

  • Immunity to Vaccine-preventable Viral Infections in Australians Being Evaluated for Liver Transplantation.

    abstract:BACKGROUND:Vaccine-preventable viral infections are associated with increased risk of morbidity and mortality in immunocompromised patients. Current guidelines recommend routine screening and vaccination of all patients before solid organ transplantation. We studied rates of immunity against vaccine-preventable viruses...


    pub_type: 杂志文章


    authors: Gardiner A,Liu K,Bonnichsen M,Joshi V,Davis RJ,Strasser SI

    更新日期:2019-11-01 00:00:00

  • Atrial anastomotic thrombus causes neurologic deficits in a lung transplant recipient.

    abstract::Pulmonary thrombus formation in the region of atrial anastomosis following lung transplantation has been reported by several authors. Such patients typically present immediately after surgery with significant hemodynamic compromise causing pulmonary edema and hypoxemia. We describe a patient who presented with bilater...


    pub_type: 杂志文章


    authors: Stang MR,Hinderliter AL,Gott KK,Paradowski LJ,Aris RM

    更新日期:1996-09-15 00:00:00

  • Long-term improvement in renal function after cyclosporine reduction in renal transplant recipients with histologically proven chronic cyclosporine nephropathy.

    abstract:BACKGROUND:Chronic cyclosporine (CsA) nephropathy, which has been unequivocally documented in recipients of heart, heart-lung, liver, or bone marrow transplants, as well as in nontransplant situations, usually results in a progressive deterioration of renal function. In this study, we assessed the potential reversibili...


    pub_type: 杂志文章


    authors: Mourad G,Vela C,Ribstein J,Mimran A

    更新日期:1998-03-15 00:00:00

  • CD4+ and B lymphocytes in transplantation immunity. II. Augmented rejection of tumor allografts by mice lacking B cells.

    abstract::To test the importance of B lymphocytes in immunity to major histocompatibility complex class I alloantigens, B cell-deficient mice were generated by reconstituting severe combined immunodeficiency mice, which lack functional B and T lymphocytes, with T cells or with both T and B cells. The reconstituted mice were cha...


    pub_type: 杂志文章


    authors: Monach PA,Schreiber H,Rowley DA

    更新日期:1993-06-01 00:00:00

  • What clinical alternatives to whole liver transplantation? Current status of artificial devices and hepatocyte transplantation.

    abstract::Shortage of organ donors limits the number of possible liver transplantations. Alternative therapies for treatment of liver failure are currently being developed: (i) extracorporeal artificial liver devices; (ii) bioartificial liver devices using hepatocytes; and (iii) hepatocyte transplantation. The objective of thes...


    pub_type: 社论,评审


    authors: Sgroi A,Serre-Beinier V,Morel P,Bühler L

    更新日期:2009-02-27 00:00:00

  • CMV-specific Cell-mediated Immunity at 3-month Prophylaxis Withdrawal Discriminates D+/R+ Kidney Transplants at Risk of Late-onset CMV Infection Regardless the Type of Induction Therapy.

    abstract:BACKGROUND:Whether cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) at prophylaxis cessation predicts D+/R+ kidney transplants at risk of late-onset CMV infection after receiving distinct induction therapies is still not well characterized. METHODS:We prospectively assessed CMV-specific CMI predicting late-...


    pub_type: 杂志文章


    authors: Jarque M,Melilli E,Crespo E,Manonelles A,Montero N,Torras J,Cruzado JM,Luque S,Gil-Vernet S,Grinyó JM,Bestard O

    更新日期:2018-11-01 00:00:00

  • Severe acute renal failure after exposure to sirolimus-tacrolimus in two living donor kidney recipients.

    abstract:BACKGROUND:We began a clinical trial in African Americans comparing sirolimus-tacrolimus to standard immunosuppression. We report two African American male living donor kidney recipients who developed acute renal failure after exposure to sirolimus-tacrolimus. METHODS:Both patients received similar doses of sirolimus ...


    pub_type: 杂志文章


    authors: Lawsin L,Light JA

    更新日期:2003-01-15 00:00:00

  • Treatment of chronic renal allograft rejection in rats with a low-molecular-weight heparin (reviparin).

    abstract:BACKGROUND:Low-molecular-weight heparin (LMWH) has been shown to prolong survival of rat cardiac allografts independently from immunosuppressive treatment. Furthermore, long-term treatment reduces the development of chronic graft vascular disease after experimental heart transplantation. The aim of the present study wa...


    pub_type: 杂志文章


    authors: Braun C,Schultz M,Fang L,Schaub M,Back WE,Herr D,Laux V,Rohmeiss P,Schnuelle P,van der Woude FJ

    更新日期:2001-07-27 00:00:00

  • Concentration-controlled everolimus (Certican): combination with reduced dose calcineurin inhibitors.

    abstract::The calcineurin inhibitors (CNIs) have been the cornerstone of immunosuppressive therapy in recent years, though their association with dose-related nephrotoxicity is a major factor in the development of chronic allograft nephropathy in kidney transplant recipients. The novel proliferation signal inhibitor everolimus ...


    pub_type: 杂志文章,评审


    authors: Pascual J

    更新日期:2005-05-15 00:00:00

  • Detection of alloreactive T cells by flow cytometry: a new test compared with limiting dilution assay.

    abstract:BACKGROUND:Frequencies of alloreactive T cells determined by limiting dilution assays (LDA) may not adequately reflect the donor-reactive immune status in transplant recipients. To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared the...


    pub_type: 杂志文章


    authors: De Haan A,Van Der Gun I,Van Der Bij W,De Leij LF,Prop J

    更新日期:2002-08-27 00:00:00

  • Acute nephrotoxicity of tacrolimus and sirolimus in renal isografts: differential intragraft expression of transforming growth factor-beta1 and alpha-smooth muscle actin.

    abstract:BACKGROUND:Renal dysfunction early after kidney transplantation has multiple causes including ischemia-reperfusion (I/R) injury and drug-induced nephrotoxicity. This study assesses the acute nephrotoxicity of tacrolimus (Tac) and sirolimus (Sir) in a rat renal isograft model. METHODS:Lewis renal isografts and uninephr...


    pub_type: 杂志文章


    authors: Ninova D,Covarrubias M,Rea DJ,Park WD,Grande JP,Stegall MD

    更新日期:2004-08-15 00:00:00

  • Synergistic effects of mycophenolate mofetil and losartan in a model of chronic cyclosporine nephropathy.

    abstract:BACKGROUND:Combined treatments of mycophenolate mofetil (MMF) and losartan (LSRT) have synergistic effects on various renal diseases through their hemodynamic and anti-inflammatory effects. This study investigated whether MMF treatment is effective in inhibiting inflammatory processes in chronic cyclosporine A (CsA) ne...


    pub_type: 杂志文章


    authors: Yang CW,Ahn HJ,Kim WY,Li C,Jung JY,Yoon SA,Kim YS,Cha JH,Kim J,Bang BK

    更新日期:2003-02-15 00:00:00

  • Glomerular sclerosis in a renal isograft and identical twin donor. A family study.

    abstract::Loss of renal mass has been associated with the development of glomerular sclerosis in animals and human beings. The pathophysiology of this renal injury is unknown, but glomerular sclerosis in animals can be aggravated or accelerated following exposure to nephrotoxic antibodies, puromycin aminoglycoside or renal irra...


    pub_type: 杂志文章


    authors: Parfrey PS,Hollomby DJ,Gilmore NJ,Knaack J,Schur PH,Guttmann RD

    更新日期:1984-10-01 00:00:00

  • Abrogation of baboon natural xenoantibody to pig splenocytes by DL-penicillamine.

    abstract::Natural xenoantibodies are believed to be IgM in nature and are known to play a critical role in the hyperacute rejection of distantly related xenografts. The purpose of this study was to determine whether the reducing agent DL-penicillamine could inactivate baboon natural xenoantibodies to pig splenocytes. Pooled bab...


    pub_type: 杂志文章


    authors: Xu H,Kwiatkowski P,Chen JM,Kaplon RJ,Edwards NM,Dong X,Berger C,Michler RE

    更新日期:1994-12-27 00:00:00

  • A New Life: Motherhood After Heart Transplantation. A Single-center Experience and Review of Literature.

    abstract:BACKGROUND:Pregnancy after heart transplantation (HTx) may expose the recipient to hemodynamic and immunologic risks and the newborn to toxic effects of immunosuppressive therapy. Adequate preconception counseling is crucial to identify optimal timing and to modify immunosuppressive therapy to minimize risks for both t...


    pub_type: 杂志文章,评审


    authors: Macera F,Occhi L,Masciocco G,Varrenti M,Frigerio M

    更新日期:2018-09-01 00:00:00

  • Murine sera cytotoxicity toward human B cells and their effect on human mixed lymphocyte reactions.

    abstract::Seven murine anti-H-2 and three nonimmune mouse sera were tested for cytotoxicity toward B and T lymphocytes from a panel of human donors. One group of sera, including two anti-H-2.33 sera, exhibited cytotoxicity directed exclusively toward human B but not T cells from all donors. Absorption studies on human lymphobla...


    pub_type: 杂志文章


    authors: Verghese MW,Ward FE

    更新日期:1979-08-01 00:00:00

  • Effects of combination cyclosporine/mizoribine immunosuppression on canine renal allograft recipients.

    abstract::Heterotopic renal allografts following bilateral nephrectomies were placed in 21 healthy mongrel dogs. One group of 11 dogs received cyclosporine (5 mg/kg/24 hr, orally), and 1 group of 10 dogs received cyclosporine and mizoribine (5 mg/kg and 3 mg/kg/24 hr, orally). Body weights, blood cell counts, serum chemistry pr...


    pub_type: 杂志文章


    authors: Gregory CR,Gourley IM,Cain GR,Broaddus TW,Cowgill LD,Willits NH,Patz JD,Ishizaki G

    更新日期:1988-05-01 00:00:00

  • Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia-Reperfusion Injury via Increased Linkage With Gα12.

    abstract:BACKGROUND:Renal ischemia-reperfusion (I/R) injury causes renal tubular necrosis, apoptosis, and inflammation leading to acute renal dysfunction. Recent studies have revealed that deletion of Gα12 mitigates the renal damage due to I/R injury. Our previous study showed that activation of dopamine D3 receptor (D3R) incre...


    pub_type: 杂志文章


    authors: Wang Z,Guan W,Han Y,Ren H,Tang X,Zhang H,Liu Y,Fu J,He D,Asico LD,Jose PA,Zhou L,Chen L,Zeng C

    更新日期:2015-11-01 00:00:00