Predictive role of pretransplant serum CXCL10 for cardiac acute rejection.

abstract：OBJECTIVES:Recent studies demonstrated that prolactin (PRL) has beneficial effects on beta cells for islet transplantation. We examined the effect of human recombinant PRL (rhPRL) supplementation to the culture media to determine its potential use in the context of clinical islet transplantation. MATERIALS AND METHODS...

journal_title：Transplantation

authors： Yamamoto T,Mita A,Ricordi C,Messinger S,Miki A,Sakuma Y,Timoneri F,Barker S,Fornoni A,Molano RD,Inverardi L,Pileggi A,Ichii H

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:Circulation of leukocytes via blood, tissue and lymph is integral to adaptive immunity. Afferent lymphatics form CCL21 gradients to guide dendritic cells and T cells to lymphatics and then to draining lymph nodes (dLN). Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 (V...

journal_title：Transplantation

authors： Iwami D,Brinkman CC,Bromberg JS

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Better preservation strategies for the storage of donation after circulatory death grafts are essential to improve graft function and to increase the kidney donor pool. We compared continuous normothermic ex vivo kidney perfusion (NEVKP) with hypothermic anoxic machine perfusion (HAMP) and static cold storag...

journal_title：Transplantation

authors： Urbanellis P,Hamar M,Kaths JM,Kollmann D,Linares I,Mazilescu L,Ganesh S,Wiebe A,Yip PM,John R,Konvalinka A,Mucsi I,Ghanekar A,Bagli DJ,Robinson LA,Selzner M

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Liver transplantation (LT) represents a curative treatment for small hepatocellular carcinoma (HCC). Potentially curable higher-stage HCC patients are denied LT due to the lack of cancer markers that predict progression and recurrence. METHODS:Thirty-eight candidates for LT with hepatitis C virus (HCV) cirr...

journal_title：Transplantation

authors： Mas VR,Fisher RA,Archer KJ,Yanek KC,Williams B,Dumur CI,Maluf DG

更新日期：2007-04-15 00:00:00

abstract：:Unstimulated whole saliva and serum samples were collected from ten allogeneic bone marrow transplant recipients before and after bone marrow transplantation, seven donors, and from twenty healthy individuals. Two patterns with regard to salivary IgA were found after transplantation. In five patients, a short-lasting ...

journal_title：Transplantation

authors： Norhagen-Engström G,Hammarström L,Lönnqvist B,Söder PO,Smith CI

更新日期：1988-11-01 00:00:00

abstract：:A 44-year-old man was maintained on prednisone and azathioprine after renal transplantation. One and a half years after transplantation, he developed multiple perianal Escherichia coli abscesses. These became chronic and resisted antibiotic therapy. Histologically, the lesions were typical of malakoplakia. Peripheral ...

journal_title：Transplantation

authors： Biggar WD,Keating A,Bear RA

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) play a key role in extracellular matrix remodeling events associated with hepatic regeneration after partial hepatectomy. We therefore hypothesized that urinary MMPs and their endogenous tissue inhibitors of matrix metalloproteinases (TIMPs) might also provide important infor...

journal_title：Transplantation

authors： Greene AK,Puder M,Roy R,Kilroy S,Louis G,Folkman J,Moses MA

更新日期：2004-10-27 00:00:00

abstract：:The early detection of allograft rejection remains elusive after solitary pancreas transplantation (PTX). We have previously described a modified technique of cystoscopic transduodenal PTX biopsy using the Biopty gun under ultrasound guidance. During the last 2 years, we performed 24 solitary PTXs with prospective pro...

journal_title：Transplantation

authors： Stratta RJ,Taylor RJ,Grune MT,Sindhi R,Sudan D,Castaldo P,Cushing KA,Radio SJ,Wisecarver JL,Matamoros A

更新日期：1995-12-27 00:00:00

abstract：:Prominent components of vascularized xenograft rejection such as platelet activation and microvascular thrombosis may be dependent upon thrombin generation in vivo. To study potential therapeutic benefits of a synthetic low-molecular-weight thrombin inhibitor, SDZ MTH 958, in hyperacute porcine heart rejection by huma...

journal_title：Transplantation

authors： Robson SC,Young VK,Cook NS,Metternich R,Kasper-Konig W,Lesnikoski BA,Pierson RN 3rd,Hancock WW,Candinas D,White DJ,Bach FH

更新日期：1996-03-27 00:00:00

abstract：BACKGROUND:Previously, we identified an antimitogenic IgG antibody separated from sera of patients with known kidney transplant chronic rejection. This antibody inhibits individual patients' own unprimed T helper cell responses to alloantigens as well as a third-party mixed lymphocyte response, but does not inhibit aut...

journal_title：Transplantation

authors： Shoker AS,Okasha K,Sheridan DP,Kappel JE,Baltzan MA

更新日期：1997-09-27 00:00:00

abstract：:Using C1q binding, Kg binding, and Raji cell radioimmunoassays, the relationship between renal allograft rejection and the circulating immune complexes was examined in 90 patients with renal transplants. The data showed that there was a significant quantitative correlation between C1q-binding and Raji-cell-binding act...

journal_title：Transplantation

authors： Fukuda M

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:The inflammation response is modulated by the elaborated chemokine-chemokine receptor system, which also plays an important role in the development of acute rejection (AR). In this study, we hypothesized that functional genetic variants of some of these modulatory proteins might influence the outcome of AR. ...

journal_title：Transplantation

authors： Simeoni E,Vassalli G,Seydoux C,Ramsay D,Noll G,von Segesser LK,Fleury S

更新日期：2005-11-15 00:00:00

abstract：BACKGROUND:When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for futu...

journal_title：Transplantation

authors： Bertsimas D,Kung J,Trichakis N,Wojciechowski D,Vagefi PA

更新日期：2017-12-01 00:00:00

abstract：:The results of kidney retransplantation in the cyclosporine era remain to be determined. Over a 42-month period, 76 nonprimary renal transplants (66 second, 7 third, 3 fourth allografts) were performed in 73 recipients under cyclosporine immunosuppression. The patient population was predominantly white (90.4%) with a ...

journal_title：Transplantation

authors： Stratta RJ,Oh CS,Sollinger HW,Pirsch JD,Kalayoglu M,Belzer FO

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Recently, sirolimus (SRL) was introduced as an immunosuppressant in solid-organ transplantation. This study evaluated combinations of SRL and tacrolimus (Tac). METHODS:This 6-month study investigated the safety and efficacy of Tac and steroids in combination with three different doses of SRL in renal-transp...

journal_title：Transplantation

authors： van Hooff JP,Squifflet JP,Wlodarczyk Z,Vanrenterghem Y,Paczek L

更新日期：2003-06-27 00:00:00

abstract：BACKGROUND:Proteinuria is associated with endothelial dysfunction (ED) and increased mortality. We investigated whether urinary protein excretion (UPE) is correlated with markers of ED and whether these markers affect the association of proteinuria with mortality in renal transplant recipients (RTR). METHODS:Six hundr...

journal_title：Transplantation

authors： van Ree RM,Oterdoom LH,de Vries AP,Homan van der Heide JJ,van Son WJ,Navis G,Gans RO,Bakker SJ

更新日期：2008-12-27 00:00:00

abstract：:The complement system plays a major role in hyperacute rejection of discordant xenografts. In an immediately vascularized xenograft of a porcine organ to a primate, natural antibodies bind to the vascular endothelium of the graft, triggering activation of complement via the classical pathway. One consequence of antibo...

journal_title：Transplantation

authors： Dalmasso AP,Platt JL

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Our goal was to test the intragraft mRNA expression and production of two chemokines that are potent chemoattractants for antigen-primed T cells, interferon-gamma inducible protein 10 (IP-10) and monokine-induced by IFN-gamma, (Mig), in allogeneic heart grafts. METHODS:Syngeneic or allogeneic A/J (H-2a) hea...

journal_title：Transplantation

authors： Kapoor A,Morita K,Engeman TM,Koga S,Vapnek EM,Hobart MG,Fairchild RL

更新日期：2000-03-27 00:00:00

abstract：:Increased susceptibility to bacterial infection is a recognized side-effect of sirolimus treatment after transplantation, which could be caused by inhibition of neutrophil activation. Blood from 24 healthy subjects was equilibrated with 0 to 50 ng/mL sirolimus or 60 microg/mL propofol. Blood was also collected from 23...

journal_title：Transplantation

authors： Gee I,Trull AK,Charman SC,Alexander GJ

更新日期：2003-12-27 00:00:00

abstract：BACKGROUND:The functional relevance of HLA-C mismatches in an alloresponse is still much debated, putting into doubt the relevance of matching for this antigen in selection of an allogeneic bone marrow donor. In addition to presenting peptides to T cells, HLA-C also functions as a ligand for killing inhibitory receptor...

journal_title：Transplantation

authors： van der Meer A,Allebes WA,Paardekooper J,Ruiter J,Joosten I

更新日期：2001-09-15 00:00:00

abstract：:Hepatic grafts from non-heartbeating donors may alleviate the organ shortage, but they inherently suffer from warm ischemia. In the present study, we tested our hypothesis that augmentation of endogenous adenosine by inhibition of nucleoside transport with R75231 attenuates ischemic liver injury. Adult female beagle d...

journal_title：Transplantation

authors： Todo S,Zhu Y,Zhang S,Jin MB,Ishizaki N,Tanaka H,Subbotin V,Starzl TE

更新日期：1997-01-27 00:00:00

abstract：:The study purpose was to identify risks, benefits and costs associated with an expanded donor protocol. The protocol design evaluated organs rescued using expanded donor criteria and weighed all costs associated with doing so. Costs were measured against conditions experienced with expanded and traditional criteria an...

journal_title：Transplantation

authors： Jacobbi LM,McBride VA,Etheredge EE,McDonald JC,Cooper ES,Frey D,Boudreaux JP,Gonzalez F,Van Meter C,McMillan R

更新日期：1995-12-27 00:00:00

abstract：:Acute rejection (AR) remains the biggest challenge during the first year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the criterion standard for AR, endomyocardial biopsy has several li...

journal_title：Transplantation

authors： Chen Y,Zhang L,Liu J,Zhang P,Chen X,Xie M

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study is to examine the effects of the coronavirus disease 2019 (COVID-19) pandemic on adult lung transplants and report practice changes in the United States. METHODS:A retrospective analysis of a public dataset from the United Network for Organ Sharing was performed regarding adult lun...

journal_title：Transplantation

authors： Chan EG,Chan PG,Harano T,Ryan JP,Morrell MR,Sanchez PG

更新日期：2021-01-01 00:00:00

abstract：:Data of 32,000 donors were utilized for a computer simulation to analyze the effect of selection parameters on the outcome of kidney transplants. If the HLA match grade is considered for organ allocation, the overall 1-year graft survival rate is up to 7% higher for first cadaver transplants and up to 12% higher for s...

journal_title：Transplantation

authors： Wujciak T,Opelz G

更新日期：1993-03-01 00:00:00

abstract：:We studied major histocompatibility complex (MHC) and cytokine mRNA induction after renal injury in the absence of interferon-gamma (IFN-gamma) using IFN-gamma gene knockout (GKO) mice. The left renal pedicle of normal (wild-type) and GKO BALB/c mice was clamped for 60 minutes; cytokine and MHC mRNA expression were mo...

journal_title：Transplantation

authors： Goes N,Urmson J,Vincent D,Halloran PF

更新日期：1995-12-27 00:00:00

abstract：BACKGROUND:Black American heart transplant recipients receiving cyclosporine-based primary immunoprophylaxis suffer higher rates of allograft rejection with hemodynamic compromise, infections, and posttransplant coronary artery disease. We examined the hypothesis that a combination of tacrolimus and mycophenolate mofet...

journal_title：Transplantation

authors： Mehra MR,Uber PA,Scott RL,Park MH

更新日期：2002-12-15 00:00:00

abstract：BACKGROUND:Two patients underwent cadaver transplantation with kidneys from a donor with a history of World Health Organization Class IV/V lupus nephritis, and we report their clinical and pathological outcome. METHODS:The donor had a diagnosis of lupus nephritis made by renal biopsy 5 years before donation. At the ti...

journal_title：Transplantation

authors： Lipkowitz GS,Madden RL,Kurbanov A,Mulhern JG,O'Shea MH,Germain MJ,Freeman J,Braden GL

更新日期：2000-03-27 00:00:00

abstract：:Alemtuzumab is a humanized CD52-specific monoclonal antibody that is increasingly used off-label as an induction agent in solid organ transplantation, particularly in the setting of maintenance immunosuppression minimization protocols. In this review, we briefly discuss this agent's mechanisms of action and summarize ...

journal_title：Transplantation

authors： Weaver TA,Kirk AD

更新日期：2007-12-27 00:00:00

abstract：BACKGROUND:The comparative effectiveness of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) versus bare metal stents (BMS) has not been studied in the kidney transplant population. METHODS:Using the US Renal Data System, we identified 3245 kidney transplant patients who underwent PCI between Ap...

journal_title：Transplantation

authors： Lenihan CR,Montez-Rath ME,Winkelmayer WC,Chang TI

更新日期：2017-04-01 00:00:00