Abstract:
BACKGROUND:The purpose of this study is to examine the effects of the coronavirus disease 2019 (COVID-19) pandemic on adult lung transplants and report practice changes in the United States. METHODS:A retrospective analysis of a public dataset from the United Network for Organ Sharing was performed regarding adult lung transplantation (January 19, 2020-June 30, 2020). Data were stratified into 3 periods: pre-COVID-19 (January 19, 2020-March 14, 2020), first COVID-19 era (March 15, 2020-May 8, 2020), and second COVID-19 era (May 9, 2020-June 30, 2020). Weekly changes in waitlist inactivations (COVID-19 precautions or not), waitlist additions, transplant volume, and donor recovery were examined across eras and changes across era were correlated. RESULTS:During the first COVID-19 era, 301 patients were added to the waitlist, representing a 40% decrease when compared to the prior 8-week period. This was followed by a significant increase in listing during the second COVID-19 era (t = 2.16, P = 0.032). Waitlist inactivations decreased in the second COVID-19 era from the first COVID-19 era (t = 3.60, P < 0.001). There was no difference in waitlist inactivations between the pre-COVID era and the second COVID-19 era (P = 0.10). Weekly volume was not associated with trends in COVID-19 cases across any era, but was negatively associated with waitlist inactivations due to COVID-19 precautions entering the first COVID-19 era (r = -0.73, P = 0.04) and second COVID-19 era (r = -0.89, P = 0.003). CONCLUSIONS:Due to the COVID-19 pandemic, the United States experienced a decrease in lung transplant volume. While overall volume has returned to normal, additional studies are needed to identify areas of improvement to better prepare for future pandemics.
journal_name
Transplantationjournal_title
Transplantationauthors
Chan EG,Chan PG,Harano T,Ryan JP,Morrell MR,Sanchez PGdoi
10.1097/TP.0000000000003522subject
Has Abstractpub_date
2021-01-01 00:00:00pages
187-192issue
1eissn
0041-1337issn
1534-6080pii
00007890-202101000-00028journal_volume
105pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::BK polyoma virus causes allograft dysfunction as a result of tubulo-interstitial nephritis in 2% to 5% of renal transplant recipients. The incidence of BK virus infection among renal transplant recipients in India is unknown. We used routine histologic examination, immunohistochemistry, and electron microscopy to retr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000113163.02039.30
更新日期:2004-02-15 00:00:00
abstract:BACKGROUND:Epitopes are the sites to which antibodies bind. Both alpha and beta peptide chains of the human leukocyte antigen-DQ heterodimers (DQA1 and DQB1, respectively) contain polymorphic regions. We can identify DQA1 and DQB1 epitopes by DQ single antigen beads assay of the antibodies, correlating the beads' react...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181804cd2
更新日期:2008-08-15 00:00:00
abstract:BACKGROUND:Mycophenolate mofetil (MMF), compared to azathioprine (AZA), reduces acute rejection and treatment failure in cyclosporine (CsA) and steroid regimens, but its effect on graft survival is unproven from prospective studies and prolonged use is costly. This study evaluated the efficacy and tolerability of repla...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00007890-200208270-00013
更新日期:2002-08-27 00:00:00
abstract::Graft pancreatitis and allograft rejection were both accompanied by increased serum levels of immunoreactive anionic trypsin (irAT) in a porcine pancreatic allograft transplantation model. Characterization of this immunoreactivity by gel filtration revealed different elution profiles in these conditions that can be he...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199201000-00004
更新日期:1992-01-01 00:00:00
abstract::Liver transplantation is the most effective treatment for selected patients with hepatocellular carcinoma. However, cancer recurrence, posttransplantation, remains to be the critical issue that affects the long-term outcome of hepatocellular carcinoma recipients. In addition to tumor biology itself, increasing evidenc...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001844
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The inflammatory reaction that occurs during the 5 days after transplantation led at 3 days to the death of 70% of injected myoblasts. Use of anti-inflammatory agents appeared to be a possible way to increase myoblast survival. The application of gene transfer techniques to cell transplantation offers the po...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199803270-00005
更新日期:1998-03-27 00:00:00
abstract:BACKGROUND:The consequences of a prior human herpesvirus-8 (HHV-8) infection in kidney-transplant recipients are still partially unknown. The aim of this monocentric study was to determine the prevalence of HHV-8-seropositive patients at the time of transplantation and to identify the main clinical events of these HHV-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005150-00008
更新日期:2000-05-15 00:00:00
abstract:BACKGROUND:Some statins have been reported to suppress the immune system and increase the expression of bone morphogenetic protein-2 gene that plays a pivotal role in bone regeneration. METHODS:The effects of cerivastatin on skeletal reconstruction by vascularized bone allograft were investigated in a rat tibia-fibula...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000074992.49236.58
更新日期:2003-09-15 00:00:00
abstract:BACKGROUND:The role of natural killer (NK) cells and macrophages (Møs) in the absence of T cell immunity in discordant xenograft (xg) rejection was investigated. METHODS:Guinea pig hearts were transplanted into athymic nude rats receiving no treatment or antixenoantibody (xAb), anticomplement (C), antinatural killer (...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2000-07-15 00:00:00
abstract::Cyclosporine (CsA) dose adjustment after renal transplantation is generally based on serum, plasma, or whole-blood trough level values. In the face of increased levels, the dosage is reduced in order to prevent CsA-induced nephrotoxicity. There is a paucity of data, however, on the kinetics of CsA in association with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198512000-00006
更新日期:1985-12-01 00:00:00
abstract::Despite previous attempts there is currently no suitable animal model available for xenogeneic graft versus host disease (XGVHD) mediated via human immunocompetent cells. Recently, we have developed an efficient protocol to engraft SCID mice with human peripheral blood lymphocytes (Hu-PBLs). The engraftment efficiency...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-07-27 00:00:00
abstract::The proliferation and differentiation of donor hematopoietic progenitor cells in bone marrow transplantation (BMT) recipients is influenced by hematopoietic growth factors, which could derive from either T cells or adherent stromal bone marrow cells, or both. In this study of 20 BMT recipients, we asked whether T lymp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199004000-00010
更新日期:1990-04-01 00:00:00
abstract::The use of cyclosporine has been associated with an increased incidence of thrombosis and endothelial cell perturbation. To explore possible mechanisms involved, we examined the effects of CSA on the activation of protein C by thrombomodulin. Cultured bovine aortic endothelial cell monolayers were incubated for 24 hr ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199103000-00030
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:The effect of cyclosporine A (CsA) on polyomavirus BK virus (BKV) replication remains unclear. The aim of this in vitro study was to investigate the effect of CsA on BKV replication in human uroepithelial cells. METHODS:After infection of a human renal proximal tubular cell line, HK-2 with BKV, BKV viral lo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c9b51c
更新日期:2010-02-15 00:00:00
abstract:BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199905150-00012
更新日期:1999-05-15 00:00:00
abstract::The dose-response effect of cyclosporine on rat limb transplant prolongation was investigated across the LBN-to-LEW histocompatibility barrier. This composite tissue allograft model has been shown to represent a strong transplantation barrier. Median limb allograft survival times increased in a dose-dependent manner w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198504000-00004
更新日期:1985-04-01 00:00:00
abstract::A prospective randomized trial was performed comparing survival of cadaveric grafts allocated by HLA-A+B matching and HLA-DR matching. The two allocation methods resulted in very similar graft survivals. HLA-A matching had no significant effect on graft survival. HLA-B and HLA-DR matching were shown to have approximat...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-198407000-00010
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Sensitization to human leukocyte antigens (HLA) is a significant barrier to transplantation. Currently, no proven therapy exists to improve access to transplantation for highly sensitized patients. Here, we report a novel approach using intravenous immune globulin to modulate anti-HLA antibody and improve th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000080685.31697.FC
更新日期:2003-08-27 00:00:00
abstract:BACKGROUND:We hypothesized that solitary pancreas transplants could be performed successfully even in the presence of poor HLA matching if an aggressive approach were taken with regard to immunosuppressive protocol and the performance of allograft biopsy. METHODS:Seven pancreas-after-kidney transplants and seven pancr...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/00007890-200007270-00028
更新日期:2000-07-27 00:00:00
abstract:BACKGROUND:The role of human herpesvirus (HHV)-8 in the pathogenesis of multiple myeloma and its pre-malignant state of monoclonal gammopathy is unclear. HHV-8 is transmitted by organ transplantation, representing a unique model with which to investigate primary HHV-8 infection. METHODS:The authors studied the inciden...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000129065.31427.96
更新日期:2004-05-27 00:00:00
abstract:BACKGROUND:Combined lung and liver transplantation (Lu-LTx) is a therapeutic option for selected patients with coexisting lung and liver disease. For several reasons, Lu-LTx is performed in few centers and information about the technical issues, posttransplant management and long-term outcomes associated with this proc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181636f3f
更新日期:2008-02-27 00:00:00
abstract:BACKGROUND:Calcineurin-inhibitor therapy is a contributing factor to the origin of interstitial fibrosis and tubular atrophy (IFTA). METHODS:We conducted a prospective randomized trial of conversion of tacrolimus to sirolimus at 1-month posttransplant in kidney transplant recipients on rapid steroid withdrawal. We com...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e3182394cb3
更新日期:2012-01-15 00:00:00
abstract::Cyclosporine, but not its nonimmunosuppressive analog cyclosporine H (CsH), caused in a variety of hematopoietic cell types a growth arrest in the G0/G1 phase of the cell cycle. This arrest was associated with a significant reduction in the c-myc mRNA levels, which could be observed already 1 hr following CsA treatmen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199106000-00025
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Scarring can greatly impact quality of life for individuals (ie, causing depression posttraumatic stress disorder, body image issues). Those who wish to be anonymous live liver donors are warned of the potential negative psychological impacts associated with the large scar left from liver donation surgery. G...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003333
更新日期:2020-05-25 00:00:00
abstract::The following findings were noted among 45 bone marrow transplant recipients. The patients without cytomegalovirus (CMV) infection or chronic graft-versus-host disease (GVHD) showed normal lymphocyte stimulation in vitro by concanavalin A (Con A) more than 3 months after transplantation, and normal stimulation by phyt...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198504000-00008
更新日期:1985-04-01 00:00:00
abstract::Two hundred twenty-eight patients from a total of 466 (49%) receiving renal allografts under cyclosporine/prednisone (CsA/Pred) immunosuppression experienced at least one episode of posttransplant hepatotoxicity. All patients were documented to have normal serum bilirubin, serum glutamic oxaloacetic transaminase (SGOT...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198701000-00009
更新日期:1987-01-01 00:00:00
abstract::We evaluated the influence of dialysis requiring acute tubular necrosis on patient survival, and kidney survival and function in all 182 patients who needed dialysis immediately after transplantation at the University of Minnesota Hospitals. When compared to matched control patients not requiring dialysis, there was n...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198003000-00016
更新日期:1980-03-01 00:00:00
abstract:BACKGROUND:Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000054619.13962.30
更新日期:2003-03-15 00:00:00
abstract::Orthotopic liver transplantation is frequently associated with a complex coagulation disorder, influencing the outcome of the procedure. In this respect, disseminated intravascular coagulation (DIC) had been suggested to be of causative importance for bleeding complications after reperfusion of the liver graft. In 10 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199109000-00018
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Recent evidence suggests that living kidney donors are at an increased risk of end-stage renal disease. However, predicting which donors will have renal dysfunction remains challenging, particularly among those with no clinical evidence of disease at the time of donation. Although renal biopsies are not rout...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001236
更新日期:2016-06-01 00:00:00