Abstract:
BACKGROUND:In chronic graft-versus-host disease (cGvHD), skin fibrosis, contractures, and an increase in collagen content form the hallmark. We report a successful treatment of a cGvHD patient by topical application of halofuginone, an inhibitor of collagen alpha1(I) gene expression. METHODS:Halofuginone-containing ointment was applied daily on the left side of the neck and shoulder of a cGvHD patient. Collagen alpha1(I) gene expression and collagen content in skin biopsy specimens were evaluated by in situ hybridization and sirius red staining, respectively. RESULTS:After 3 and 6 months, a marked reduction in skin collagen synthesis was observed, accompanied with increase neck rotation on the treated side. After cessation of treatment, the sclerosis, skin tightness, and collagen alpha1(I) gene expression returned to baseline level. No adverse effects were observed, and no plasma levels of halofuginone could be detected. CONCLUSIONS:Halofuginone may provide a promising novel and safe therapy for cGvHD patients.
journal_name
Transplantationjournal_title
Transplantationauthors
Nagler A,Pines Mdoi
10.1097/00007890-199912150-00027subject
Has Abstractpub_date
1999-12-15 00:00:00pages
1806-9issue
11eissn
0041-1337issn
1534-6080journal_volume
68pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Gastrointestinal complications are common in patients who undergo kidney transplantation and may affect posttransplant outcomes. We examined the incidence and predictors of gastroesophageal reflux disease (GERD) and dyspepsia and their associations with graft survival and mortality after transplant. METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318160d4c4
更新日期:2008-02-15 00:00:00
abstract:BACKGROUND:Although chronic kidney disease (CKD) is still a common complication, the prognosis of kidney function after liver transplantation (LT) is not well known. Moreover, kidney function after LT in children with renal involvement is unknown. METHODS:We retrospectively analyzed patients aged <20 years who underwe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002548
更新日期:2019-08-01 00:00:00
abstract::Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide. This overview examines current DCD practices, identifies problems and challenges, and suggests clinical strategies for possible improvement. Although there is uniform agreement on DCD donor candi...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000437178.48174.db
更新日期:2014-02-15 00:00:00
abstract:BACKGROUND:Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation has not been described. METHODS:Intestinal samples were taken from 4 isolated intestine and 3 multivisceral transplant recipients at the time of any operativ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001593
更新日期:2017-10-01 00:00:00
abstract::In an effort to determine the influence of immunosuppressive therapy and other clinical variables on posttransplant osteopenia, vertebral bone density was measured at least 6 months after transplantation in 65 adult primary renal transplant recipients receiving a variety of immunosuppressive regimens. Fifteen of the 6...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-12-15 00:00:00
abstract:BACKGROUND:In patients with acute liver failure (ALF) of unknown cause, viral infections are believed to be involved. This study investigates the involvement of human herpesvirus-6 (HHV-6). METHODS:Thirty-two patients with ALF who underwent transplantations during a 6-year period were studied for viruses in biopsies f...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000069233.13409.DF
更新日期:2003-08-15 00:00:00
abstract:BACKGROUND:Increasing long-term allograft survival is the main challenge in organ transplantation, and allograft loss due to chronic rejection has been found to correlate with episodes of early acute rejection. It is important to understand the mechanisms that maintain the donor-specific hyporesponsive state. This stud...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0b013e3181af20fd
更新日期:2009-08-15 00:00:00
abstract:INTRODUCTION:Posttransplant anemia and its association with transplant outcomes have not been properly studied. METHODS:We examined 530 renal allograft recipients transplanted at our center and followed up for 31.0±14.1 months. Hemoglobin (Hb), serum bicarbonate, and creatinine; use of erythropoiesis-stimulating agent...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31824b36fa
更新日期:2012-05-15 00:00:00
abstract:BACKGROUND:Few studies have directly compared preemptive therapy (PET) and antiviral prophylaxis (AP) for prevention of cytomegalovirus (CMV) disease in CMV seropositive (R+) orthotopic liver transplant (OLT) recipients. METHODS:We prospectively assessed CMV disease and clinical outcomes among 160 consecutive R+ OLT r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002029
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Endomyocardial biopsy (EMB) remains the gold standard for acute cellular rejection (ACR) diagnosis in cardiac transplantation yet is subject to interobserver variability. A method that could avoid discordant EMB analysis would be desirable. The apoptosis rate in EMB correlates with ACR severity. Apollon inhi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181c3c690
更新日期:2010-01-27 00:00:00
abstract::Acute graft-versus-host disease (GVHD) has recently been associated with endothelial cell injury. The potential clinical significance was explored here in an autopsy review. Thirty-seven allogeneic bone marrow recipients were identified in the autopsy files at The Johns Hopkins Hospital with no evidence of systemic in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199401000-00016
更新日期:1994-01-01 00:00:00
abstract::In a cross-sectional survey of the quality of life of 45 liver transplant recipients, physical and psychological status, physical complaints, capability to participate in daily life, social support, and global quality of life were assessed. The average time of follow-up was 9 months after transplantation. Nine patient...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199309000-00013
更新日期:1993-09-01 00:00:00
abstract::The aim of our study was to sensitize cells in vitro, follow their proliferative and cytotoxic responses, and determine their ability to cause lethal graft-versus-host disease (GVHD). C57BL/6 (H2b) spleen cells were incubated with irradiated BALB/C (H2d) Moloney lymphoma cells (LSTRA) in mixed leukocyte culture condit...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197612000-00008
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:At our institution, increased kidney donation from unrelated donors accounts for a steady rise in live donor kidney transplantation rates. We compared outcomes of living related (LRT) versus living unrelated kidney transplants (LURT) and analyzed the effect of early rejection upon graft survival. METHODS:A ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000135464.11616.5a
更新日期:2004-10-15 00:00:00
abstract::Antibodies against B lymphocytes were found in the serum of the majority of 59 kidney transplant recipients and of 22 eluates obtained from kidney allografts undergoing rejection. To characterize these B cell lymphocytotoxins we have used a mouse monoclonal anti-DR antibody (L227) that inhibits cytotoxicity of antibod...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198305000-00011
更新日期:1983-05-01 00:00:00
abstract::Fetal liver cells (FLC) were obtained from beagle fetuses 52 days postconception, and were cryopreserved prior to transplantation into ten sibling recipients that had previously been exposed to total-body irradiation delivered in 3 fractions of 6 Gy each at 4 days, 2 days, and 2 hr before grafting. Donors and hosts we...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::Endothelial cells serve an important role in augmenting immune responses through enhanced expression of MHC class II antigens. Immune-mediated vascular injury associated with rejection requires reendothelialization to restore vascular integrity. The origin of the reparative endothelial cells can be determined when ABO...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199102000-00033
更新日期:1991-02-01 00:00:00
abstract::Cyclosporine (CsA) dose adjustment after renal transplantation is generally based on serum, plasma, or whole-blood trough level values. In the face of increased levels, the dosage is reduced in order to prevent CsA-induced nephrotoxicity. There is a paucity of data, however, on the kinetics of CsA in association with ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198512000-00006
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:As T-cell receptor-major histocompatibility complex (MHC) class I/self peptide interaction regulates T-cell development in the thymus, we reasoned that presentation of peptides by self dendritic cells (DC) to developing T cells in the thymus might induce acquired thymic tolerance. This hypothesis is based on...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200001270-00005
更新日期:2000-01-27 00:00:00
abstract::Over the decade between 2003 and 2012, the UK has seen major changes in how organ donation and transplantation is delivered. The number of deceased organ donors has increased from 709 (12.0 per million population [pmp]) to 1,164 (18.3 pmp); this increase has been predominantly a result of an increase in donors after c...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000438215.16737.68
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) infection after liver transplantation may occur in patients previously not exposed to the virus, but who receive an organ from a surface antigen (HBsAg)-negative, core antibody (HBcAb)-positive donor. The risk of HBV reactivation after liver transplantation in recipients that are HBsA...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200202150-00027
更新日期:2002-02-15 00:00:00
abstract::Previous studies have demonstrated that donor antigen-specific primed-lymphocyte-test (PLT) reactivity of bronchoalveolar lavage lymphocytes is strongly associated with acute pulmonary rejection and with obliterative bronchiolitis (OB); however, a systematic analysis of PLT reactivity as being class I-or II-directed h...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199201000-00036
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The spleen is considered to be an important secondary lymphoid organ where acute graft-versus-host disease (GVHD) is initiated by donor T cells that recognize host alloantigens after allogeneic bone-marrow transplantation (BMT). The influence of splenectomy on the development of GVHD prior to BMT has yet to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200205270-00027
更新日期:2002-05-27 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate purine nucleotide metabolism in peripheral blood mononuclear cells (PBMC) of cardiac transplant recipients switched from azathioprine to mycophenolate mofetil (MMF). METHODS:Concentrations of guanosine 5'triphosphate (GTP) and adenosine 5'triphosphate (ATP), th...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000225759.54343.23
更新日期:2006-07-15 00:00:00
abstract::Antibody-mediated injury is a major cause of allograft dysfunction and loss. Antibodies to ABH(O) blood group antigens are classic mediators of ABO-incompatible graft rejection, whereas donor-specific anti-HLA antibodies and, more recently, autoantibodies are appreciated as important contributors to allograft inflamma...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001872
更新日期:2018-02-01 00:00:00
abstract::Nuclear imaging is used to evaluate renal allografts demonstrating delayed function after transplantation. Interpretation of the nuclear scan in the context of clinical data, provides helpful information in the management of the transplant recipient. The better quality of images obtained with technetium-99m mercaptoac...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199711270-00023
更新日期:1997-11-27 00:00:00
abstract:BACKGROUND:Gastrointestinal complications are common in patients after lung and heart transplantation. Endoscopy is a standard method for the assessment of gastrointestinal morbidities. The aim of this study was to analyze the number and type of complications during endoscopic procedures in patients before and after lu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000517
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:In an effort to define reliable assays that might predict postimmunosuppressant-withdrawal development of chronic rejection (CR), despite conditioning for tolerance induction, we evaluated various immunological responses in nonhuman primate renal allograft recipients. METHODS:Fourteen Cynomolgus monkeys rec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000234786.26511.a4
更新日期:2006-09-27 00:00:00
abstract::Transcription factors of the nuclear factor of activated T cells (NFAT) family regulate both immune activation and insulin production. Calcineurin inhibitors (CNIs) target NFAT activation. Hence, CNIs not only prevent organ transplant rejection but also contribute to the development of new-onset diabetes after transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31823f7f26
更新日期:2012-02-15 00:00:00
abstract:BACKGROUND:Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplants to how to conduct them ethically. METHODS:Leaders of each program performing and/or evaluating VCA ...
journal_title:Transplantation
pub_type: 共识发展会议,杂志文章,评审
doi:10.1097/TP.0000000000002478
更新日期:2019-06-01 00:00:00