Favorable Kidney Function in Pediatric Liver Transplant Recipients: Results of a Single-center Cohort Study.

Abstract:

BACKGROUND:Although chronic kidney disease (CKD) is still a common complication, the prognosis of kidney function after liver transplantation (LT) is not well known. Moreover, kidney function after LT in children with renal involvement is unknown. METHODS:We retrospectively analyzed patients aged <20 years who underwent LT between November 2005 and March 2015 at our institute. RESULTS:The cohort included 313 pediatric LT recipients (135 males). The median age at LT was 1.1 years (interquartile range, 0.6 to 4.8 y), and the median duration of follow-up was 3.8 years (interquartile range, 1.7 to 6.2 y). We divided the patients by their primary disease into BA (biliary atresia), non-BA (other liver disease without primary renal involvement), or KD (patients with a pre-existing kidney disease) group, which comprised 141, 141, and 31 patients, respectively. Eight-year renal survival with stage 3 CKD (estimated glomerular filtration rate < 60 mL/min/1.73 m) as the event was 99.2%, 92.4%, and 47.7% for the BA, non-BA, and KD group, respectively. Multivariate analysis disclosed primary kidney disease and multiple acute rejections as independent predictors of renal survival. The KD group showed no increase in the rate of kidney function deterioration after LT. CONCLUSIONS:Eight-year renal survival with stage 3 CKD, particularly in patients with non-pre-existing KD, exceeded 92.0%, and end-stage kidney disease developed in only one patient. Kidney function can be highly preserved following LT even in patients with KD, provided that LT is not contraindicated in patients with renal involvement receiving optimal immunosuppressive management.

journal_name

Transplantation

journal_title

Transplantation

authors

Sato M,Kaneko T,Ogura M,Kamei K,Ito S,Fukuda A,Sakamoto S,Kasahara M,Ishikura K

doi

10.1097/TP.0000000000002548

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

1655-1662

issue

8

eissn

0041-1337

issn

1534-6080

journal_volume

103

pub_type

杂志文章
  • Trends in Lung Transplantation Practices Across the United States During the COVID-19 Pandemic.

    abstract:BACKGROUND:The purpose of this study is to examine the effects of the coronavirus disease 2019 (COVID-19) pandemic on adult lung transplants and report practice changes in the United States. METHODS:A retrospective analysis of a public dataset from the United Network for Organ Sharing was performed regarding adult lun...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000003522

    authors: Chan EG,Chan PG,Harano T,Ryan JP,Morrell MR,Sanchez PG

    更新日期:2021-01-01 00:00:00

  • Results of conversion from cyclosporine to azathioprine in cadaveric renal transplantation.

    abstract::Between December 1983 and August 1985, 110 cadaver transplants were performed at our institution. All were started on cyclosporine (CsA) and prednisone (P) for immunosuppressive therapy. Of the 110 patients, 46 were converted from CsA to azathioprine (AZA) for a variety of reasons (cost, toxicity, patient preference, ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198702000-00012

    authors: Gonwa TA,Nghiem DD,Schulak JA,Corry RJ

    更新日期:1987-02-01 00:00:00

  • Thrombotic microangiopathy in living-donor liver transplantation.

    abstract:BACKGROUND:Thrombotic microangiopathy (TMA) is a fatal complication characterized by microvascular occlusive disorder resulting in systemic or intrarenal platelet aggregation, severe thrombocytopenia, and microangiopathic hemolytic anemia. Only sporadic case reports of TMA after cadaveric or living-donor liver transpla...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000165048.00487.8e

    authors: Tamura S,Sugawara Y,Matsui Y,Kishi Y,Akamatsu N,Kaneko J,Makuuchi M

    更新日期:2005-07-27 00:00:00

  • The effect of idarubicin monoclonal antibody treatment of first-set rejection of murine skin allografts.

    abstract::Idarubicin was conjugated to anti-Ly-2.1 and anti-L3T4 monoclonal antibodies. These conjugates were used to investigate their effects on skin graft survival in mice. Several donor and recipient combinations were used so that the effect of individual or mixtures of conjugates on class I and class II antigenic differenc...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198907000-00018

    authors: Smyth MJ,McKenzie IF,Pietersz GA

    更新日期:1989-07-01 00:00:00

  • Induction of antiidiotypic antibodies by blood transfusions. Characterization of T cell alloantigen-specific receptors by sera from transfused mice.

    abstract::Balb/c (H-2d) mice were transfused weekly with 0.1 ml of whole blood from C3H (H-2k) mice. One week after 3 blood transfusions (BT), the mice were bled and the sera collected and pooled. The 3BT serum was absorbed twice with C3H lymphocytes and IgG isolated by ion-exchange chromatography. Balb/c anti-C3H, Balb/c anti-...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198612000-00011

    authors: Singal DP,Ludwin D,Joseph S,Blajchman MA,Ofosu FA,Liao SK

    更新日期:1986-12-01 00:00:00

  • Transplantation and 2-year follow-up of kidneys procured from a cadaver donor with a history of lupus nephritis.

    abstract:BACKGROUND:Two patients underwent cadaver transplantation with kidneys from a donor with a history of World Health Organization Class IV/V lupus nephritis, and we report their clinical and pathological outcome. METHODS:The donor had a diagnosis of lupus nephritis made by renal biopsy 5 years before donation. At the ti...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200003270-00030

    authors: Lipkowitz GS,Madden RL,Kurbanov A,Mulhern JG,O'Shea MH,Germain MJ,Freeman J,Braden GL

    更新日期:2000-03-27 00:00:00

  • Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients.

    abstract:BACKGROUND:Tacrolimus pharmacokinetic characteristics vary greatly among individuals. Tacrolimus is a substrate of cytochrome p450 (CYP), of subfamily CYP3A. CYP3A activity is the sum of the activities of the family of CYP3A genes, including CYP3A5. Subjects with the CYP3A5*1/*1 genotype express large amounts of CYP3A5...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000090753.99170.89

    authors: Thervet E,Anglicheau D,King B,Schlageter MH,Cassinat B,Beaune P,Legendre C,Daly AK

    更新日期:2003-10-27 00:00:00

  • FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation.

    abstract:BACKGROUND:In organ transplantation, several immunosuppressants are currently used to control graft rejection. Clinically, no single immunosuppressive agent can completely prevent posttransplantation immunoreaction; thus, combination therapy is usually performed. Novel agents with more powerful immunosuppressive activi...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000144312.08782.16

    authors: Yamamoto S,Okuda T,Yamasaki K,Tanaka H,Kubo S,Takemura S,Ikeda K,Minamiyama Y,Hirohashi K,Suehiro S

    更新日期:2004-12-15 00:00:00

  • Vascular thymus transplantation in rats. Technique, morphology, and function.

    abstract::A new method of thymus transplantation is introduced, in which the graft is directly connected with the recipient's vascular system. This procedure was used both in euthymic rats and congenitally athymic nude rats. At all tested intervals after transplantation thymus grafts hardly differed from the recipient's own thy...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199010000-00028

    authors: Kampinga J,Schuurman HJ,Pol GH,Bartels H,Broekhuizen R,Vaessen LM,Tielen FJ,Rozing J,Blaauw EH,Roser B

    更新日期:1990-10-01 00:00:00

  • Immunohistochemical study of actin binding protein (p55) in the human kidney.

    abstract:BACKGROUND:In clinical transplantation, "passenger" dendritic cells (DCs) in the allograft have been thought to induce allograft rejection. However, the presence of DCs in the normal human kidney is controversial. Most reports have relied on the examination of MHC class I and II antigen expression in combination with D...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199804150-00025

    authors: Sonderbye L,Meehan S,Palsson R,Ahsan N,Ladefoged J,Langhoff E

    更新日期:1998-04-15 00:00:00

  • Cardiac transplantation using extended-donor criteria organs for systemic amyloidosis complicated by heart failure.

    abstract:BACKGROUND:Systemic amyloidosis complicated by heart failure is associated with high cardiovascular morbidity and mortality. Heart transplantation for patients with systemic amyloidosis is controversial due to recurrence of disease in the transplanted organ or progression of disease in other organs. METHODS:All patien...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000255567.80203.bd

    authors: Maurer MS,Raina A,Hesdorffer C,Bijou R,Colombo P,Deng M,Drusin R,Haythe J,Horn E,Lee SH,Marboe C,Naka Y,Schulman L,Scully B,Shapiro P,Prager K,Radhakrishnan J,Restaino S,Mancini D

    更新日期:2007-03-15 00:00:00

  • Pathophysiological Trends During Withdrawal of Life Support: Implications for Organ Donation After Circulatory Death.

    abstract:BACKGROUND:Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been l...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001396

    authors: Iyer A,Chew HC,Gao L,Villanueva J,Hicks M,Doyle A,Kumarasinghe G,Jabbour A,Jansz PC,Feneley MP,Harvey RP,Graham RM,Dhital KK,Macdonald PS

    更新日期:2016-12-01 00:00:00

  • The mechanism of anti-CD3 monoclonal antibodies. Mediation of cytolysis by inter-T cell bridging.

    abstract::OKT3, an anti-CD3 MAB, depletes T cells in vivo and is among the most potent inhibitors of acute allograft rejection. The mechanism of this inhibition is unknown. The present studies investigate whether anti-CD3 antibodies have the ability to crosslink CD3 on two different cells and induce TCR-dependent antibody-bridg...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199010000-00030

    authors: Wong JT,Eylath AA,Ghobrial I,Colvin RB

    更新日期:1990-10-01 00:00:00

  • Variations of the lymphocytotoxicity test. An evaluation of sensitivity and specificity.

    abstract::Multiple variations of the basic lymphocytotoxicity test have been reported to increase test sensitivity. Although these modifications are used routinely in crossmatch tests, as required by federal regulation, there has been no methodical assessment of the relative sensitivities and specificities of these techniques w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199509000-00016

    authors: Zachary AA,Klingman L,Thorne N,Smerglia AR,Teresi GA

    更新日期:1995-09-15 00:00:00

  • Nosocomial Pneumocystis jirovecii pneumonia: lessons from a cluster in kidney transplant recipients.

    abstract:BACKGROUND:Pneumocystis jirovecii pneumonia (PJP) is an important infection-related complication, whose mode of transmission remains uncertain. METHODS:We investigated a nosocomial cluster of 14 PJP cases (11 confirmed and 3 probable) in kidney transplant recipients using epidemiological and genotyping methods. RESUL...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182384b57

    authors: Phipps LM,Chen SC,Kable K,Halliday CL,Firacative C,Meyer W,Wong G,Nankivell BJ

    更新日期:2011-12-27 00:00:00

  • T suppressor cells induced by transfusions and cyclosporine. Studies in the murine cardiac allograft model.

    abstract::Pregraft transfusion combined with immunosuppression at the time of grafting improves the survival of clinical and experimental allografts. The mechanisms responsible for this effect were investigated in the murine model of cardiac transplantation, combining transfusions 7 to 30 days prior to transplantation with cycl...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199012000-00026

    authors: Mottram PL,Mirisklavos A,Dumble LJ,Clunie GJ

    更新日期:1990-12-01 00:00:00

  • Measurement of renovascular circulating volume during hypothermic organ perfusion.

    abstract:BACKGROUND:Kidney donation after cardiac death leads to vascular damage as a result of warm ischemia, affecting renovascular circulating volume. Novel ultrasound dilution techniques may be used to measure renovascular circulating volumes during hypothermic machine perfusion of donor kidneys. METHODS:Renovascular circu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31828a46f7

    authors: de Vries EE,van Smaalen TC,Boer J,Hoogland ER,Krivitski NM,Snoeijs MG,van Heurn LW

    更新日期:2013-05-15 00:00:00

  • Comparison of sirolimus-based calcineurin inhibitor-sparing and calcineurin inhibitor-free regimens in cadaveric renal transplantation.

    abstract:INTRODUCTION:This study examines the efficacy and toxicity of sirolimus used as primary immunosuppression in combination with reduced dose tacrolimus (calcineurin inhibitor [CI]-sparing regimen) or mycophenolate mofetil (CI-free regimen) in high-risk cadaveric renal transplantation. METHODS:Seventy subjects were treat...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.tp.0000121504.69676.5e

    authors: Lo A,Egidi MF,Gaber LW,Amiri HS,Vera S,Nezakatgoo N,Gaber AO

    更新日期:2004-04-27 00:00:00

  • Association of polymorphisms of interleukin-8, CXCR1, CXCR2, and selectin with allograft outcomes in kidney transplantation.

    abstract:BACKGROUND:Both chemokines and adhesion molecules mediate allograft rejection by recruiting leukocytes into the allograft. We investigated the association of six single nucleotide polymorphisms (SNPs) located in interleukin (IL)-8, CXCR1, CXCR2, and selectin with kidney allograft outcomes. METHODS:The promoter regions...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/tp.0b013e3181fd0195

    authors: Ro H,Hwang YH,Kim H,Jeong JC,Lee H,Doh YS,Park HC,Oh KH,Park MH,Ha J,Yang J,Ahn C

    更新日期:2011-01-15 00:00:00

  • A delay in bone marrow transplantation after partial conditioning improves engraftment.

    abstract:BACKGROUND:In the present study we examined the effect of the timing of marrow infusion on engraftment in nonmyeloablatively conditioned mice. METHODS:B10 mice were conditioned with decreasing doses of total body irradiation (TBI) and reconstituted with bone marrow cells (BMCs) from major histocompatibility complex-di...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.tp.0000116414.66171.81

    authors: Xu H,Exner BG,Chilton PM,Tanner MK,Mueller YM,Rezzoug F,Ildstad ST

    更新日期:2004-03-27 00:00:00

  • Contrasted blood and intragraft toll-like receptor 4 mRNA profiles in operational tolerance versus chronic rejection in kidney transplant recipients.

    abstract:BACKGROUND:Deciphering the mechanisms of tolerance and chronic rejection (CR) remains a major goal in transplantation. Data in rodents suggest that Toll-like receptors (TLR), regulators of innate immune responses, play a role in determining graft outcome. However, few studies have focused on TLR expression in human kid...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31817b8dc5

    authors: Braudeau C,Ashton-Chess J,Giral M,Dugast E,Louis S,Pallier A,Braud C,Moreau A,Renaudin K,Soulillou JP,Brouard S

    更新日期:2008-07-15 00:00:00

  • Successful retreatment of allograft rejection with OKT3.

    abstract::OKT3 is a murine monoclonal antibody to the CD3 antigen of human T lymphocytes. The production of human antimurine antibodies after treatment with OKT3 has been perceived as a major limitation to its extended use and reuse. Treatment of 142 patients with 168 courses of OKT3 resulted in the development of antimouse ant...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198901000-00020

    authors: First MR,Schroeder TJ,Hurtubise PE,Mansour ME,Penn I,Munda R,Balistreri WF,Alexander JW,Melvin DB,Fidler JP

    更新日期:1989-01-01 00:00:00

  • Innominate artery interposition graft simplifies the portal venous drainage method of pancreas transplantation.

    abstract::Pancreas transplantation utilizing portal venous and enteric exocrine drainage has potential benefits over the standard systemic venous and bladder exocrine drainage method. Unfortunately, technical difficulties are often experienced with the arterial anastomosis after the portal venous anastomosis is completed. We ha...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199907270-00029

    authors: Bigam DL,Hemming AW,Sanabria JR,Cattral MS

    更新日期:1999-07-27 00:00:00

  • Urine cytologic profile in renal allograft recipients determined by monoclonal antibodies. Diagnosis of allograft rejection.

    abstract::Controversy exists as to the type of cells present in the urine during renal allograft rejection. In order to resolve this controversy as well as to evaluate the value of urine sediment examination as a means of detecting AR, we quantitated the different cells present in urine during AR using an immunoperoxidase techn...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198903000-00017

    authors: Segasothy M,Birch DF,Fairley KF,Kincaid-Smith P

    更新日期:1989-03-01 00:00:00

  • Combined liver-kidney transplantation is preferable to liver transplant alone for cirrhotic patients with renal failure.

    abstract:BACKGROUND:The role of combined liver-kidney transplantation (CLKT) for cirrhotic patients with renal failure (RF) is controversial. Since the model for end-stage liver disease era, there has been a rise in the number of CLKT. Using the Organ Procurement Transplant Network/United Network for Organ Sharing database, thi...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e3182590d6b

    authors: Fong TL,Khemichian S,Shah T,Hutchinson IV,Cho YW

    更新日期:2012-08-27 00:00:00

  • Inverse correlation of cyclosporine binding with sensitivity and resistance.

    abstract::The primary effects of CsA on human lymphocyte responses in vitro appear to be the inhibition of IL-2 production and the inhibition of cytotoxic T cell activation. Induction of suppressor T cell activity is resistant to the effects of CsA. These data imply two distinct subsets of lymphocytes: CsA-resistant and CsA-sen...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198808001-00012

    authors: Hess AD,Colombani PM

    更新日期:1988-08-01 00:00:00

  • Pulmonary and blood stream infections in adult living donor and cadaveric liver transplant patients.

    abstract:BACKGROUND:Infectious complications occur in approximately 50% of cadaveric liver transplant (CDLT) recipients. Living-donor liver transplantation (LDLT) is an established alternative to shorten the waiting time. Currently, the incidence of pulmonary infections after LDLT and the microbiologic causes are unknown. In th...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31816f61a6

    authors: Saner FH,Olde Damink SW,Pavlakovic G,van den Broek MA,Rath PM,Sotiropoulos GC,Radtke A,Canbay A,Paul A,Nadalin S,Malagó M,Broelsch CE

    更新日期:2008-06-15 00:00:00

  • Recovery of liver perfusion after focal outflow obstruction and liver resection.

    abstract:BACKGROUND:Live liver donation requires extended liver resection in the donor with transection of the middle hepatic vein. This leads to focal outflow obstruction in the remnant liver or the partial graft. This study was designed to characterize the pathophysiological correlate of focal outflow obstruction in a small-f...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31816631f9

    authors: Dirsch O,Madrahimov N,Chaudri N,Deng M,Madrahimova F,Schenk A,Dahmen U

    更新日期:2008-03-15 00:00:00

  • Cardiac allograft vasculopathy: central role of endothelial injury leading to transplant "atheroma".

    abstract::Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/01.TP.0000080981.90718.EB

    authors: Valantine HA

    更新日期:2003-09-27 00:00:00

  • Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients.

    abstract::The mission of the recently established Immune Tolerance Network includes the development of protocols for the induction of transplant tolerance in organ allograft recipients and the development of assays that correlate with and may be predictive of the tolerant state. The state of clinical organ transplant tolerance ...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Thomson AW,Mazariegos GV,Reyes J,Donnenberg VS,Donnenberg AD,Bentlejewski C,Zahorchak AF,O'Connell PJ,Fung JJ,Jankowska-Gan E,Burlingham WJ,Heeger PS,Zeevi A

    更新日期:2001-10-27 00:00:00