Transplantomics: Toward Precision Medicine in Transplantation Research.


:Precision medicine is an emerging integrative approach for disease prevention, early detection, and treatment which takes into account individual variability in genetic and other molecular measurements, medical history, environmental exposures, and lifestyle. The development and availability of genomic and other molecular profiling technologies provide an unprecedented opportunity to apply precision medicine strategies in transplantation research. Developing integrative computational methods to analyze these diverse types of data provides new opportunities to impact diagnostics and therapeutics. In this article, we discuss ways we can leverage molecular data sets to develop new hypotheses for disease mechanisms, identify new disease biomarkers, and reposition drugs for diseases with unmet needs. We specifically discuss computational methods that can be applied to achieve these goals in the context of organ transplant.






Sirota M,Sarwal MM




Has Abstract


2017-08-01 00:00:00












  • Donor Hepatectomy and Implantation Time Are Associated With Early Complications After Liver Transplantation: A Single-center Retrospective Study.

    abstract:BACKGROUND:Donor hepatectomy and liver implantation time reduce long-term graft and patient survival after liver transplantation. It is not known whether these surgical times influence early outcomes after liver transplantation. METHODS:This single-center study evaluated the effect of donor hepatectomy and implantatio...


    pub_type: 杂志文章


    authors: Gilbo N,Fieuws S,Meurisse N,Nevens F,van der Merwe S,Laleman W,Verslype C,Cassiman D,van Malenstein H,Roskams T,Sainz-Barriga M,Pirenne J,Jochmans I,Monbaliu D

    更新日期:2020-05-28 00:00:00

  • Population pharmacokinetics of tacrolimus in children who receive cut-down or full liver transplants.

    abstract:BACKGROUND:The aim of this study was to investigate the population pharmacokinetics of tacrolimus in pediatric liver transplant recipients and to identify factors that may explain pharmacokinetic variability. METHODS:Data were collected retrospectively from 35 children who received oral immunosuppressant therapy with ...


    pub_type: 杂志文章


    authors: Staatz CE,Taylor PJ,Lynch SV,Willis C,Charles BG,Tett SE

    更新日期:2001-09-27 00:00:00

  • Possible role of extracellularly released phagocyte proteinases in coagulation disorder during liver transplantation.

    abstract::Orthotopic liver transplantation is frequently associated with a complex coagulation disorder, influencing the outcome of the procedure. In this respect, disseminated intravascular coagulation (DIC) had been suggested to be of causative importance for bleeding complications after reperfusion of the liver graft. In 10 ...


    pub_type: 杂志文章


    authors: Riess H,Jochum M,Machleidt W,Himmelreich G,Blumhardt G,Roissaint R,Neuhaus P

    更新日期:1991-09-01 00:00:00

  • Psychological adjustment of adult bone marrow transplant donors whose recipient survives.

    abstract::The psychosocial and psychiatric impact of donating bone marrow (BM) has received little study. This mail questionnaire study of bone marrow donors whose recipient had survived more than one year post-BMT was undertaken to document the psychosocial consequences of donation on "successful" BM donors. Demographic, mood ...


    pub_type: 杂志文章


    authors: Wolcott DL,Wellisch DK,Fawzy FI,Landsverk J

    更新日期:1986-04-01 00:00:00

  • Characterization of immunoreactive trypsin as a means of differentiating graft pancreatitis and allograft rejection after porcine pancreatic transplantation.

    abstract::Graft pancreatitis and allograft rejection were both accompanied by increased serum levels of immunoreactive anionic trypsin (irAT) in a porcine pancreatic allograft transplantation model. Characterization of this immunoreactivity by gel filtration revealed different elution profiles in these conditions that can be he...


    pub_type: 杂志文章


    authors: Källén R,Borgström A

    更新日期:1992-01-01 00:00:00

  • Incidence, predictors, costs, and outcome of renal cell carcinoma after kidney transplantation: USRDS experience.

    abstract:INTRODUCTION:We carried out an analysis of the United States Renal Data System to determine the incidence, risk factors, prognosis, and costs associated with the diagnosis of renal cell carcinoma (RCC) after kidney transplantation. METHODS:This is a retrospective cohort of 40,821 Medicare primary renal transplant reci...


    pub_type: 杂志文章


    authors: Hurst FP,Jindal RM,Graham LJ,Falta EM,Elster EA,Stackhouse GB,Agodoa LY,Lentine KL,Salifu MO,Abbott KC

    更新日期:2010-10-27 00:00:00

  • Effects of a short course of leflunomide on T-independent B-lymphocyte xenoreactivity and on susceptibility of xenografts to acute or chronic rejection.

    abstract:BACKGROUND:Leflunomide is a novel immunosuppressive agent with promising activity for xenotransplantation. It is not clear yet which mechanisms of action of leflunomide are responsible for that. METHODS:In a hamster-to-C57BL/6 nude mouse heart transplantation model, a 2-week course of leflunomide was used after transp...


    pub_type: 杂志文章


    authors: Yan Y,Verbeken E,Yu L,Rutgeerts O,Goebels J,Segers C,Lin Y,Waer M

    更新日期:2005-01-27 00:00:00

  • Naked small interfering RNA of caspase-3 in preservation solution and autologous blood perfusate protects isolated ischemic porcine kidneys.

    abstract:BACKGROUND:Ischemia-reperfusion injury (IRI) plays key roles in graft viability and posttransplantation function. Caspase-3 associated with apoptosis and inflammation is up-regulated by IRI. We propose that naked small interfering RNA (siRNA) targeting caspase-3 may prevent IRI and improve kidney preservation. METHODS...


    pub_type: 杂志文章


    authors: Yang B,Hosgood SA,Nicholson ML

    更新日期:2011-03-15 00:00:00

  • CXCL9 Predicts Severity at the Onset of Chronic Graft-versus-host Disease.

    abstract:BACKGROUND:Chronic graft-versus-host disease (cGVHD) represents a double-edged sword. In its nonsevere form, cGVHD associates with better control of the malignant disease, thus highlighting graft-versus-leukemia effects. However, severe cGVHD leads to debilitating morbidity and increased nonrelapse mortality. The predi...


    pub_type: 杂志文章


    authors: Giesen N,Schwarzbich MA,Dischinger K,Becker N,Hummel M,Benner A,Radujkovic A,Müller-Tidow C,Dreger P,Luft T

    更新日期:2020-11-01 00:00:00

  • Allotransplantation of rat islets into the cisterna magna of streptozotocin-induced diabetic rats.

    abstract::Islets were isolated from the pancreata of Sprague-Dawley rats and transplanted into streptozotocin-induced diabetic outbred Wistar rats. The effect of transplantation of islets into the cisterna magna on the diabetic state of the recipients was compared with that of the conventional transplantation of islets into liv...


    pub_type: 杂志文章


    authors: Lee HC,Ahn KJ,Lim SK,Kim KR,Ahn YS,Lee KE,Huh KB

    更新日期:1992-03-01 00:00:00

  • Immunobiology of natural killer lymphocytes in transplantation.

    abstract::Natural killer (NK) lymphocytes are powerful effector cells of the peripheral immune system. NK cell functions are controlled by the expression of a variety of cell surface receptors with either inhibitory or activating roles. The genetic and functional diversity of this repertoire of receptors and the role of human l...


    pub_type: 杂志文章,评审


    authors: Young NT

    更新日期:2004-07-15 00:00:00

  • The use of a prostacyclin analog, iloprost, as an adjunct to pulmonary preservation with Euro-Collins solution.

    abstract::The addition of prostaglandin to the single-flush technique of lung preservation is considered to enhance subsequent graft function. We have evaluated the use of the prostacyclin analog, Iloprost, in an animal model of unilateral lung transplantation. Group 1 (n = 5) received Iloprost as a pretreatment intravenously (...


    pub_type: 杂志文章


    authors: Hooper TL,Fetherston GJ,Flecknell PA,Dark JH,McGregor CG

    更新日期:1990-03-01 00:00:00

  • Use of donor beta 2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts.

    abstract::Donor graft major histocompatibility complex class I antigens are targets for both allogeneic and xenogeneic rejection. Mice homozygous for beta 2-microglobulin gene disruption express reduced amounts of surface MHC class I antigens. Liver cells from such mutant mice were transplanted into isogeneic, allogeneic, and x...


    pub_type: 杂志文章


    authors: Li X,Faustman D

    更新日期:1993-04-01 00:00:00

  • HLA Population Genetics in Solid Organ Transplantation.

    abstract::HLAs are fundamental to the adaptive immune response and play critical roles in the cellular and humoral response in solid organ transplantation. The genes encoding HLA proteins are the most polymorphic within the human genome, with thousands of different allelic variants known within the population. Application of th...


    pub_type: 杂志文章,评审


    authors: Kransdorf EP,Pando MJ,Gragert L,Kaplan B

    更新日期:2017-09-01 00:00:00

  • Recurrent Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allografts Treated With Anti-CD20 Antibodies.

    abstract:BACKGROUND:Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a distinct form of glomerulonephritis that often recurs after kidney transplantation causing severe graft injury and often failure. METHODS:We describe post transplant outcomes and response to therapy in 20 recipients with ...


    pub_type: 杂志文章


    authors: Buxeda A,Said SM,Nasr SH,Leung N,El Ters M,Cosio FG

    更新日期:2019-07-01 00:00:00

  • Prolongation of rat kidney allograft survival by nematodes.

    abstract::Nippostrongylus infection strongly stimulates TH2 activity in vivo. Given the evidence of cross regulation between TH2 and TH1 cells, and the link between TH1 activity and graft rejection, we examined the effects of Nippostrongylus infection on the fate of kidney allografts in rats. Both prior Nippostrongylus infectio...


    pub_type: 杂志文章


    authors: Ledingham DL,McAlister VC,Ehigiator HN,Giacomantonio C,Theal M,Lee TD

    更新日期:1996-01-27 00:00:00

  • Cardiac allograft vasculopathy: central role of endothelial injury leading to transplant "atheroma".

    abstract::Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...


    pub_type: 杂志文章,评审


    authors: Valantine HA

    更新日期:2003-09-27 00:00:00

  • Lung transplantation after allogeneic marrow transplantation in pediatric patients: the Memorial Sloan-Kettering experience.

    abstract:BACKGROUND:Chronic lung disease and pulmonary failure are complications that can occur after bone marrow transplantation (BMT) and are associated with severe morbidity and mortality. METHODS:We report on four patients who developed chronic, progressive, and irreversible lung disease 1 to 3 years after allogeneic BMT i...


    pub_type: 杂志文章


    authors: Heath JA,Kurland G,Spray TL,Kernan NA,Small TN,Brochstein JA,Gillio AP,Boklan J,O'Reilly RJ,Boulad F

    更新日期:2001-12-27 00:00:00

  • Skin-autofluorescence is an independent predictor of graft loss in renal transplant recipients.

    abstract:BACKGROUND:Skin-autofluorescence (skin-AF) noninvasively measures the tissue accumulation of advanced glycation end products (AGEs). AGEs are nephrotoxic and potential effectors of cardiovascular mortality. We investigated whether skin-AF predicted graft loss after kidney transplantation. METHODS:A total of 302 renal ...


    pub_type: 杂志文章


    authors: Hartog JW,Gross S,Oterdoom LH,van Ree RM,de Vries AP,Smit AJ,Schouten JP,Nawroth PP,Gans RO,van Son WJ,Bierhaus A,Bakker SJ

    更新日期:2009-04-15 00:00:00

  • Transesophageal echocardiography during orthotopic liver transplantation in patients with esophagoastric varices.

    abstract:BACKGROUND:Hemodynamic monitoring using transesophageal echocardiography (TEE) in patients with signs of portal hypertension undergoing orthotopic liver transplantation (OLT) carries potential risk of esophageal and gastric variceal hemorrhage. The aim of our retrospective analysis was to evaluate the safety of intraop...


    pub_type: 杂志文章


    authors: Burger-Klepp U,Karatosic R,Thum M,Schwarzer R,Fuhrmann V,Hetz H,Bacher A,Berlakovich G,Krenn CG,Faybik P

    更新日期:2012-07-27 00:00:00

  • Cardiac transplantation using extended-donor criteria organs for systemic amyloidosis complicated by heart failure.

    abstract:BACKGROUND:Systemic amyloidosis complicated by heart failure is associated with high cardiovascular morbidity and mortality. Heart transplantation for patients with systemic amyloidosis is controversial due to recurrence of disease in the transplanted organ or progression of disease in other organs. METHODS:All patien...


    pub_type: 杂志文章


    authors: Maurer MS,Raina A,Hesdorffer C,Bijou R,Colombo P,Deng M,Drusin R,Haythe J,Horn E,Lee SH,Marboe C,Naka Y,Schulman L,Scully B,Shapiro P,Prager K,Radhakrishnan J,Restaino S,Mancini D

    更新日期:2007-03-15 00:00:00

  • Influence of HLA matching on rejections and short- and long-term primary cadaveric allograft survival.

    abstract::Distribution of cadaveric donor kidneys, based upon the donor-recipient HLA match grade, remains one of the major controversies in transplantation. To determine whether matching results in fewer rejection episodes and better graft survival, we retrospectively studied our single-center patient population of 683 cyclosp...


    pub_type: 杂志文章


    authors: Kerman RH,Kimball PM,Lindholm A,Van Buren CT,Katz SM,Lewis RM,McClain J,Podbielski J,Williams J,Kahan BD

    更新日期:1993-11-01 00:00:00

  • mTOR Inhibition Role in Cellular Mechanisms.

    abstract::The mammalian target of rapamycin inhibitors (mTOR-I), drugs widely used in transplant medicine and oncology, exert their function by inhibiting a serine/threonine kinase with a pivotal role in cellular metabolism and in a wide range of eukaryotic biological/cellular functions and signaling networks. Additionally, as ...


    pub_type: 杂志文章,评审


    authors: Zaza G,Granata S,Caletti C,Signorini L,Stallone G,Lupo A

    更新日期:2018-02-01 00:00:00

  • Fetal liver transplantation in the dog. I. Restoration of hemopoiesis with cryopreserved fetal liver cells from DLA-identical siblings.

    abstract::Fetal liver cells (FLC) were obtained from beagle fetuses 52 days postconception, and were cryopreserved prior to transplantation into ten sibling recipients that had previously been exposed to total-body irradiation delivered in 3 fractions of 6 Gy each at 4 days, 2 days, and 2 hr before grafting. Donors and hosts we...


    pub_type: 杂志文章


    authors: Prümmer O,Raghavachar A,Werner C,Calvo W,Carbonell F,Steinbach I,Fliedner TM

    更新日期:1985-04-01 00:00:00

  • A potential immunosuppressive effect of anti-lymphocyte function-associated antigen-1 monoclonal antibody on islet transplantation.

    abstract::The immunosuppressive potentials of mAbs to lymphocyte function-associated antigen-1 (LFA-1) and CD2 molecules were examined in murine islet transplantation. Crude digested islets from BALB/c (H-2d) mice were transplanted into the renal subcapsular space of streptozotocin-induced diabetic C57BL/6 (H-2b) mice. The rat ...


    pub_type: 杂志文章


    authors: Gotoh M,Fukuzaki T,Monden M,Dono K,Kanai T,Yagita H,Okumura K,Mori T

    更新日期:1994-01-01 00:00:00

  • Outcomes of Liver Transplantation for Hepatocellular Carcinoma Beyond the University of California San Francisco Criteria: A Single-center Experience.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor. Currently, liver transplantation may be the optimal treatment for HCC in cirrhotic patients. Patient selection is currently based on tumor size. We developed a program to offer liver transplantation to selected patients with HCC...


    pub_type: 杂志文章


    authors: Victor DW 3rd,Monsour HP Jr,Boktour M,Lunsford K,Balogh J,Graviss EA,Nguyen DT,McFadden R,Divatia MK,Heyne K,Ankoma-Sey V,Egwim C,Galati J,Duchini A,Saharia A,Mobley C,Gaber AO,Ghobrial RM

    更新日期:2020-01-01 00:00:00

  • Randomized trial to evaluate the clinical benefits of serum alpha-glutathione S-transferase concentration monitoring after liver transplantation.

    abstract:BACKGROUND:An increase in serum alpha-glutathione S-transferase concentration (GST) has been shown to be a more sensitive and specific marker of hepatocellular damage than equivalent increases in transaminase activities. A randomized clinical trial of 60 liver transplants in 49 patients was carried out to assess the cl...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hughes VF,Trull AK,Gimson A,Friend PJ,Jamieson N,Duncan A,Wight DG,Prevost AT,Alexander GJ

    更新日期:1997-11-27 00:00:00

  • Characterization of naturally occurring CD4+CD25+ regulatory T cells in rhesus monkeys.

    abstract:BACKGROUND:Translational research in a relevant preclinical model is recommended before Treg-inducing protocols can be implemented in humans. We have characterized rhesus monkey CD25 cells phenotypically and functionally. METHODS:The phenotype of CD4(+)CD25(high) cells was determined by FACS, focusing on established m...


    pub_type: 杂志文章


    authors: Haanstra KG,van der Maas MJ,'t Hart BA,Jonker M

    更新日期:2008-04-27 00:00:00

  • In vivo immunoadsorption of antipig antibodies in baboons using a specific Gal(alpha)1-3Gal column.

    abstract::The major role of anti-alphaGal antibodies in the hyperacute rejection of pig organs by humans and baboons has been clearly demonstrated. Spacered alpha-galactose disaccharide (Gal(alpha1)-3Gal) hapten was produced by chemical synthesis and covalently attached to a flexible, hydrophilic polymer (PAA), which in turn wa...


    pub_type: 杂志文章


    authors: Taniguchi S,Neethling FA,Korchagina EY,Bovin N,Ye Y,Kobayashi T,Niekrasz M,Li S,Koren E,Oriol R,Cooper DK

    更新日期:1996-11-27 00:00:00

  • mTOR inhibition and its effect on cancer in transplantation.

    abstract::A considerable amount of data indicates that transplanted patients are at increased risk for de novo and recurrent cancer. Treatment of this population is difficult. It remains unclear if the immunosuppressive therapy should be continued, tapered or even stopped or if immunosuppressive drugs with antiproliferative pro...


    pub_type: 杂志文章,评审


    authors: Andrassy J,Graeb C,Rentsch M,Jauch KW,Guba M

    更新日期:2005-09-27 00:00:00