Plasma exchange for recurrent nephrotic syndrome following renal transplantation.


:Patients with steroid-resistant nephrotic syndrome and focal segmental glomerulosclerosis (FGS) who develop end-stage renal disease are at risk for recurrence of the disease following renal transplantation. Recurrence of the nephrotic syndrome in renal allografts of two children with primary FGS was successfully controlled by plasma exchange. This report suggests that plasma exchange instituted early in the course of recurrent nephrotic syndrome may be beneficial in some patients with steroid-resistant nephrotic syndrome and FGS.






Laufer J,Ettenger RB,Ho WG,Cohen AH,Marik JL,Fine RN




Has Abstract


1988-10-01 00:00:00












  • Impact of simultaneous pancreas and kidney transplantation on cardiovascular risk factors in patients with type 1 diabetes mellitus.

    abstract::We retrospectively investigated the impact of pancreas transplantation on cardiovascular disease risk factors in patients with type 1 diabetic end-stage renal disease (ESRD). Two cohorts of patients, 44 simultaneous pancreas and kidney transplant patients (SPK) and 30 kidney transplant-alone patients (KTA), were inclu...


    pub_type: 杂志文章


    authors: Luan FL,Miles CD,Cibrik DM,Ojo AO

    更新日期:2007-08-27 00:00:00

  • Deceased Organ Donors and PHS Risk Identification: Impact on Organ Usage and Outcomes.

    abstract:BACKGROUND:In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization...


    pub_type: 杂志文章


    authors: Pruett TL,Clark MA,Taranto SE

    更新日期:2017-07-01 00:00:00

  • T cell depletion of human bone marrow. Comparison of Campath-1 plus complement, anti-T cell ricin A chain immunotoxin, and soybean agglutinin alone or in combination with sheep erythrocytes or immunomagnetic beads.

    abstract::The aim of this study was to compare the extent of in vitro T cell depletion and recovery of hematopoietic progenitor cells achieved with five methods of T cell depletion. Bone marrow samples from the same source were treated with monoclonal antibody Campath-1 (CP1) and human complement, XomaZyme-H65 (anti-T cell rici...


    pub_type: 杂志文章


    authors: Frame JN,Collins NH,Cartagena T,Waldmann H,O'Reilly RJ,Dupont B,Kernan NA

    更新日期:1989-06-01 00:00:00

  • TNF-alpha signaling is not required for in vivo transcriptional reactivation of latent murine cytomegalovirus.

    abstract:BACKGROUND:Reactivation of cytomegalovirus (CMV) is frequently observed in recipients of solid organs and bone marrow transplants and is associated with increased risk of acute and chronic allograft rejection, opportunistic infection, graft failure, and patient mortality. The molecular mechanisms by which reactivation ...


    pub_type: 杂志文章


    authors: Zhang Z,Li Z,Yan S,Wang X,Abecassis M

    更新日期:2009-09-15 00:00:00

  • Increased transplant arteriosclerosis in the absence of CCR7 is associated with reduced expression of Foxp3.

    abstract:BACKGROUND:The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs and the migration of dendritic cells into afferent lymphatic vessels. Antigen presentation, T cell recruitment, and expansion of regulatory cells are crucial events in establish...


    pub_type: 杂志文章


    authors: Ensminger SM,Helm SN,Ohl L,Spriewald BM,Abele S,Wollin M,Wood KJ,Weyand M,Förster R

    更新日期:2008-08-27 00:00:00

  • Clinical and economic impact of flow cytometry crossmatching in primary cadaveric kidney and simultaneous pancreas-kidney transplant recipients.

    abstract::We retrospectively compared the clinical and financial impact of a final cross-match by T cell flow cytometry (FXM) versus conventional complement-dependent cytotoxicity (CXM) in consecutive primary cadaveric kidney (K) and primary simultaneous cadaveric pancreas-kidney (SPK) transplant recipients. Mean follow-up was ...


    pub_type: 杂志文章


    authors: Pelletier RP,Orosz CG,Adams PW,Bumgardner GL,Davies EA,Elkhammas EA,Henry ML,Ferguson RM

    更新日期:1997-06-15 00:00:00

  • Bovine islets are less susceptible than human islets to damage by human cytokines.

    abstract:BACKGROUND:The potential benefits of islet xenografting in type 1 diabetes include the intriguing, but still unanswered, possibility that the grafted xenoislets may be less subjected to human autoimmune attack. Cytokines may play a major role in the pathogenesis of autoimmune diabetes by causing impairment of insulin r...


    pub_type: 杂志文章


    authors: Piro S,Lupi R,Dotta F,Patanè G,Rabuazzo MA,Marselli L,Santangelo C,Realacci M,Del Guerra S,Purrello F,Marchetti P

    更新日期:2001-01-15 00:00:00

  • Male-restricted expression of H-Y antigen on preimplantation mouse embryos.

    abstract::The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indica...


    pub_type: 杂志文章


    authors: Shelton JA,Goldberg EH

    更新日期:1984-01-01 00:00:00

  • The specificity of nephritogenic antibodies. IV. Binding of monoclonal antithymocyte antibodies to rat kidney.

    abstract::Polyclonal rabbit antirat thymocyte serum (ATS) has been shown to form in situ glomerular immune aggregates following perfusion into normal rat kidney ex vivo. This may be due to the presence of T-cell-like epitopes in the rat kidney, or it may be a result of contaminating anti-connective-tissue antibodies in ATS. To ...


    pub_type: 杂志文章


    authors: Bagchus WM,Donga J,Rozing J,Hoedemaeker PJ,Bakker WW

    更新日期:1986-06-01 00:00:00

  • Detection of alloreactive T cells by flow cytometry: a new test compared with limiting dilution assay.

    abstract:BACKGROUND:Frequencies of alloreactive T cells determined by limiting dilution assays (LDA) may not adequately reflect the donor-reactive immune status in transplant recipients. To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared the...


    pub_type: 杂志文章


    authors: De Haan A,Van Der Gun I,Van Der Bij W,De Leij LF,Prop J

    更新日期:2002-08-27 00:00:00

  • A possible explanation for anemia in patients treated with mycophenolic acid.

    abstract:BACKGROUND:Clinical studies suggest that the immunosuppressant mycophenolate mofetil is associated with anemia. However, the mechanism for this is not known. Here, we studied the effect of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, on erythropoiesis in vitro. METHODS:Both UT-7 cells and p...


    pub_type: 杂志文章


    authors: Pile T,Kieswich J,Harwood S,Yaqoob MM

    更新日期:2011-12-27 00:00:00

  • Resolution and relapse of osteopetrosis in mice transplanted with myeloid tissue of variable histocompatibility.

    abstract::Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was ini...


    pub_type: 杂志文章


    authors: Nisbet NW,Menage J,Loutit JF

    更新日期:1979-10-01 00:00:00

  • Impaired revascularization of transplanted mouse pancreatic islets is chronic and glucose-independent.

    abstract:BACKGROUND:Pancreatic islets are avascular immediately after transplantation and depend on revascularization. Recently, the authors found decreased vascular density in mouse islets 1 month after implantation into nondiabetic recipients. This study investigated possible differences in revascularization between islets im...


    pub_type: 杂志文章


    authors: Mattsson G,Jansson L,Nordin A,Carlsson PO

    更新日期:2003-03-15 00:00:00

  • New mixed lymphocyte microculture test harvested by a simple device developed for this purpose.

    abstract::The methodology of the conventional mixed lymphocyte culture test has been simplified and miniaturized by developing a micromethod employing Terasaki trays with a final culture volume of 20 mul containing between 10,000 and 20,000 responding and stimulating cells each/culture. This represents one-tenth the cell concen...


    pub_type: 杂志文章


    authors: Péna-Martinez J,Festenstein H

    更新日期:1975-07-01 00:00:00

  • Accept or Decline? An Analytics-Based Decision Tool for Kidney Offer Evaluation.

    abstract:BACKGROUND:When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for futu...


    pub_type: 杂志文章


    authors: Bertsimas D,Kung J,Trichakis N,Wojciechowski D,Vagefi PA

    更新日期:2017-12-01 00:00:00

  • Favorable nutritional outcome after isolated liver transplantation for liver failure in a child with short bowel syndrome.

    abstract::A patient with short gut syndrome presented with end-stage liver disease. She underwent an isolated liver transplantation at the age of 3.5 years. Parenteral nutrition was discontinued 1.5 years after surgery. At 7 years of age, the patient has maintained normal nutritional indices and growth while on a normal oral di...


    pub_type: 杂志文章


    authors: Gottrand F,Michaud L,Bonnevalle M,Dubar G,Pruvot FR,Turck D

    更新日期:1999-02-27 00:00:00

  • The effect of cyclosporine on agonist-stimulated glomerular and mesangial cell vasodilatory prostaglandin production.

    abstract::Cyclosporine A administration produces an increase in renal vascular resistance and a decrease in glomerular filtration rate in both human and animal models. CsA usage in humans has also been shown to alter the ability of the kidney to adapt to alterations in renal hemodynamics. CsA alters the production of prostaglan...


    pub_type: 杂志文章


    authors: Bunke M,Wilder L,Martin A

    更新日期:1991-10-01 00:00:00

  • APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors.

    abstract:BACKGROUND:Two apolipoprotein L1 gene (APOL1) renal-risk variants in donors and African American (AA) recipient race are associated with worse allograft survival in deceased-donor kidney transplantation (DDKT) from AA donors. To detect other factors impacting allograft survival from deceased AA kidney donors, APOL1 ren...


    pub_type: 杂志文章


    authors: Freedman BI,Pastan SO,Israni AK,Schladt D,Julian BA,Gautreaux MD,Hauptfeld V,Bray RA,Gebel HM,Kirk AD,Gaston RS,Rogers J,Farney AC,Orlando G,Stratta RJ,Mohan S,Ma L,Langefeld CD,Bowden DW,Hicks PJ,Palmer ND,Pala

    更新日期:2016-01-01 00:00:00

  • Finding a place for public preferences in liver allocation decisions.

    abstract::Over the last decade there have been major advances in all aspects of liver transplantation with the consequence that the number of patients who could benefit from the procedure is increasing. As a result, the number of patients listed for liver transplantation is growing while the donor pool is remaining constant or ...


    pub_type: 杂志文章,评审


    authors: Neuberger J,Ubel PA

    更新日期:2000-11-27 00:00:00

  • Enhancement of tumor growth in allogeneic mice following impairment of macrophage function.

    abstract::Teratoma 402 AX is an embryo-like tumor cell line originally derived from the testicles of strain 129/J mice. This teratocarcinoma grows well in males and pregnant females but poorly in virgin females when given in small doses. Induction of growth of this tumor is syngeneic and allogeneic virgin females was achieved b...


    pub_type: 杂志文章


    authors: Isa AM,Sanders BR

    更新日期:1975-10-01 00:00:00

  • Transplantation of DLA-compatible and incompatible fetal liver hematopoietic cells in dogs.

    abstract::Requirements for sustained engraftment of fetal liver hematopoietic stem cells were evaluated in 45 dogs. Pretransplant preparative treatment with total-body irradiation, 14.7 Gy, permitted engraftment of DLA-compatible fetal liver cells. Radiation alone was inadequate in DLA-haploidentical or DLA-mismatched transplan...


    pub_type: 杂志文章


    authors: Cain G,Stitzel K,Gale R,Champlin R

    更新日期:1987-12-01 00:00:00

  • The effect of limited courses of cyclosporine on survival and immunocompetence of allogeneic bone marrow chimeras.

    abstract::Isolator-maintained CBH/Ola (Rtlc) rats were lethally irradiated and reconstituted with spleen and bone marrow cells from fully allogeneic WAG or Wistar (Rtlu) donors. Hematopoietically reconstituted rats were treated with cyclosporine (CsA)4 as prophylaxis for graft-versus-host disease (GVHD) for periods ranging from...


    pub_type: 杂志文章


    authors: Denham S,Attridge SR,Barfoot RK

    更新日期:1985-11-01 00:00:00

  • Cardiac allograft vasculopathy: central role of endothelial injury leading to transplant "atheroma".

    abstract::Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...


    pub_type: 杂志文章,评审


    authors: Valantine HA

    更新日期:2003-09-27 00:00:00

  • Using biomarkers of tolerance and rejection to identify high- and low-risk patients following kidney transplantation.

    abstract::Despite great improvements in renal allograft survival over the last 3 decades, long-term graft loss, particularly through antibody-mediated rejection, remains the bane of kidney transplantation. Interindividual patient variation means that a given immunosuppressive regimen may be inadequate in certain patients and ex...


    pub_type: 杂志文章,评审


    authors: Ashton-Chess J,Giral M,Soulillou JP,Brouard S

    更新日期:2009-05-15 00:00:00

  • Perfusion of kidneys with unformulated "naked" intercellular adhesion molecule-1 antisense oligodeoxynucleotides prevents ischemic/reperfusion injury.

    abstract:BACKGROUND:We have previously shown that phosphorothioate intercellular adhesion molecule (ICAM)-1 antisense oligodeoxynucleotide (oligo) IP-9125 blocks the expression of rat ICAM-1 mRNA in rat L2 cells. A single ex situ perfusion of grafts with unformulated IP-9125, suspended in Euro-Collins solution, prolonged the su...


    pub_type: 杂志文章


    authors: Chen W,Bennett CF,Wang ME,Dragun D,Tian L,Stecker K,Clark JH,Kahan BD,Stepkowski SM

    更新日期:1999-09-27 00:00:00

  • Apoptosis and chemokine induction after renal ischemia-reperfusion.

    abstract:BACKGROUND:One of the earliest prerequisites for the development of inflammation after ischemia-reperfusion (I/R) is local chemokine expression. We recently demonstrated that apoptosis, characterized by intracellular caspase-activation, contributes to the development of inflammation after I/R. METHODS:The contribution...


    pub_type: 杂志文章


    authors: Daemen MA,de Vries B,van't Veer C,Wolfs TG,Buurman WA

    更新日期:2001-04-15 00:00:00

  • Induction of epidermal fatty acid binding protein in intravascular monocytes of renal allografts.

    abstract::During acute rejection of rat renal allografts, numerous activated monocytes accumulate in the vasculature of the graft. These monocytes seem to be involved in allograft destruction. Proinflammatory and effector functions of monocytes and macrophages can be down-regulated by peroxisome proliferators, which are probabl...


    pub_type: 杂志文章


    authors: Grau V,Garn H,Bette M,Spener F,Steiniger B,Gemsa D,Stehling O

    更新日期:2003-03-15 00:00:00

  • Dominance of tissue-restricted cytotoxic T lymphocytes in the response to allogeneic renal epithelial cell lines.

    abstract::Our current knowledge of cytotoxic T lymphocytes (CTL) is largely derived from studies of effector populations generated in allogeneic mixed leukocyte cultures (MLC) and assayed for lytic activity to lymphoid cell (LC) targets. We herein report that the CTL response to allogeneic renal epithelial cell lines (REC) is d...


    pub_type: 杂志文章


    authors: Hadley GA,Rostapshova EA,Bartlett ST

    更新日期:1996-07-15 00:00:00

  • The management of T tube leaks in orthotopic liver transplant recipients with endoscopically placed nasobiliary catheters.

    abstract::Biliary tract problems remain an important cause of complication following orthotopic hepatic transplantation. We describe 12 liver transplantation patients who developed bile peritonitis secondary to a biliary leak after T tube removal. Each of these patients underwent an urgent ERCP that exhibited leakage outside th...


    pub_type: 杂志文章


    authors: Ostroff JW,Roberts JP,Gordon RL,Ring EJ,Ascher NL

    更新日期:1990-05-01 00:00:00

  • Hepatic stellate cells preferentially expand allogeneic CD4+ CD25+ FoxP3+ regulatory T cells in an IL-2-dependent manner.

    abstract:BACKGROUND:Organ transplantation has been successfully practiced for decades, but the outcome of cell transplantation remains disappointing. This is the case in animal models; liver allografts in mice are spontaneously accepted without requirement of immunosuppression, whereas hepatocyte transplants in the same combina...


    pub_type: 杂志文章


    authors: Jiang G,Yang HR,Wang L,Wildey GM,Fung J,Qian S,Lu L

    更新日期:2008-12-15 00:00:00