Postirradiation recovery of lymphoid cells in the rat.

abstract：BACKGROUND:Activation of the renin angiotensin system may contribute to the development of delayed graft function after renal transplantation. We, therefore, examined the impact of pretransplant treatment with blockers of the renin angiotensin system on early graft function after renal transplantation. METHOD:The case...

journal_title：Transplantation

authors： Stevens KK,Patel RK,Clancy M,Jardine AG

更新日期：2010-03-27 00:00:00

abstract：:Significant extended survival of C3H/He skin grafts in antilymphocyte serum (ALS)-treated B6AF1 mice can be brought about by the injection of donor-strain bone marrow on day 6 or 7 after grafting. In the present study, survival of the active graft-prolonging bone marrow cells under several storage conditions was inves...

journal_title：Transplantation

authors： De Fazio SR,Hartner WC,Monaco AP,Gozzo JJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Both discordant and concordant xenogeneic responses are dominated by humoral immunity. Recent advances in molecular engineering approaches may largely prevent rejection by means of this pathway, leaving the cellular arm of the immune response as the principal remaining barrier to successful engraftment. MET...

journal_title：Transplantation

authors： Trani JL,Song HK,Lerner SM,Markmann JW,Barker CF,Naji A,Markmann JF

更新日期：2001-08-15 00:00:00

abstract：BACKGROUND:Both number and origin (donor vs. host) of dendritic cells (DC) are associated with acute graft-versus-host disease (aGvHD), relapse and graft failure after human allogeneic hematopoietic cell transplantation (aHCT). METHODS:We prospectively and simultaneously investigated skin and blood DC subtypes, their ...

journal_title：Transplantation

authors： Auffermann-Gretzinger S,Eger L,Bornhäuser M,Schäkel K,Oelschlaegel U,Schaich M,Illmer T,Thiede C,Ehninger G

更新日期：2006-03-27 00:00:00

abstract：:Human herpesvirus type 6 (HHV-6) causes roseola infantum (exanthema subitum) upon primary infection in young children. Thereafter it persists lifelong in the organism. Like other herpesviruses, HHV-6 can be reactivated in periods of immunosuppression - e.g., after organ transplantation. In order to study the incidence...

journal_title：Transplantation

authors： Schmidt CA,Wilbron F,Weiss K,Brinkmann V,Oettle H,Lohmann R,Langrehr JM,Neuhaus P,Siegert W

更新日期：1996-02-27 00:00:00

abstract：BACKGROUND:Composite tissue allotransplantation (CTA) has been recently introduced as a potential treatment for tissue loss secondary to burns, injuries, or resections. However, the optimal strategies to prevent CTA rejection remain undefined. Presently, no CTA model exists to evaluate human-specific immunosuppressants...

journal_title：Transplantation

authors： Cendales LC,Xu H,Bacher J,Eckhaus MA,Kleiner DE,Kirk AD

更新日期：2005-11-27 00:00:00

abstract：BACKGROUND:Hemodynamic monitoring using transesophageal echocardiography (TEE) in patients with signs of portal hypertension undergoing orthotopic liver transplantation (OLT) carries potential risk of esophageal and gastric variceal hemorrhage. The aim of our retrospective analysis was to evaluate the safety of intraop...

journal_title：Transplantation

authors： Burger-Klepp U,Karatosic R,Thum M,Schwarzer R,Fuhrmann V,Hetz H,Bacher A,Berlakovich G,Krenn CG,Faybik P

更新日期：2012-07-27 00:00:00

abstract：BACKGROUND:The delayed allograft rejection in C6-deficient PVG C6- rats compared with normal PVG rats has been attributed to the lack of alloantibody activation of the membrane attack complex of complement. As T cells alone have been shown to effect graft rejection, we examined T-cell responses in PVG C6- rats. METHOD...

journal_title：Transplantation

authors： Merten S,Chen JC,Ha H,Plain K,Boyd RA,Penny MJ,Leenaerts P,Hall BM

更新日期：1998-05-15 00:00:00

abstract：BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...

journal_title：Transplantation

authors： Wang H,Hosiawa KA,Garcia B,Shum JB,Dutartre P,Kelvin DJ,Zhong R

更新日期：2003-05-15 00:00:00

abstract：:A group of 170 patients having functional renal allografts were evaluated at least six months after renal transplantation. They were assessed for symptoms and signs of tendinitis in the Achilles and Supraspinatus tendons. Of the 170 patients, 34 had tendinitis. Four patients (11.8%) had spontaneous rupture of the Achi...

journal_title：Transplantation

authors： Murison MS,Eardley I,Slapak M

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Whether cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) at prophylaxis cessation predicts D+/R+ kidney transplants at risk of late-onset CMV infection after receiving distinct induction therapies is still not well characterized. METHODS:We prospectively assessed CMV-specific CMI predicting late-...

journal_title：Transplantation

authors： Jarque M,Melilli E,Crespo E,Manonelles A,Montero N,Torras J,Cruzado JM,Luque S,Gil-Vernet S,Grinyó JM,Bestard O

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Clinical and epidemiological data of pandemic influenza A H1N1 infection in solid-organ transplant recipients have been described, but scarce data compare these outcomes with nonimmunocompromised patients. METHODS:We retrospectively reviewed and compared the clinical presentation, morbidity, and mortality o...

journal_title：Transplantation

authors： Camargo LF,de Sandes-Freitas TV,Silva CD,Bittante CD,Ono G,Corrêa L,Silva M Jr,Bellei NC,Goto JM,Medeiros EA,Gomes PS,Medina-Pestana JO

更新日期：2012-01-15 00:00:00

abstract：BACKGROUND:Sirolimus (rapamycin) is a potent immunosuppressant with a mechanism of action different from cyclosporine (CsA) or tacrolimus. METHODS:In 11 European centers, first cadaveric renal allograft recipients were randomized to CsA (n=42) or sirolimus (n=41). Dosing of these agents was concentration-controlled an...

journal_title：Transplantation

authors： Groth CG,Bäckman L,Morales JM,Calne R,Kreis H,Lang P,Touraine JL,Claesson K,Campistol JM,Durand D,Wramner L,Brattström C,Charpentier B

更新日期：1999-04-15 00:00:00

abstract：BACKGROUND:Identification of risk factors for BK virus (BKV) replication may improve transplant outcome. We investigated the impact of immunosuppressive drugs on the prevalence of BKV replication in recipients of human renal allografts. METHODS:One hundred twenty renal allograft recipients were studied prospectively a...

journal_title：Transplantation

authors： Dadhania D,Snopkowski C,Ding R,Muthukumar T,Chang C,Aull M,Lee J,Sharma VK,Kapur S,Suthanthiran M

更新日期：2008-08-27 00:00:00

abstract：BACKGROUND:LCP-Tacro is an extended-release formulation of tacrolimus designed for once-daily dosing. Phase 1 studies demonstrated greater bioavailability to twice-daily tacrolimus capsules and no new safety concerns. METHODS:In this phase 2 study, adult stable kidney transplant patients on tacrolimus capsules (Progra...

journal_title：Transplantation

authors： Gaber AO,Alloway RR,Bodziak K,Kaplan B,Bunnapradist S

更新日期：2013-07-27 00:00:00

abstract：:The mixed leukocyte culture (MLC) of peripheral blood lymphocytes (PBLs) from two prospective kidney transplant recipients and their respective donors, produced a primed cell population that functioned as suppressors. The primed cells suppressed the primary and secondary MLC when added as third components, without dem...

journal_title：Transplantation

authors： Fuller L,Kyriakides G,Flaa C,Esquenazi V,Miller J

更新日期：1980-01-01 00:00:00

abstract：:Glutathione and glyoxalase II levels were evaluated in cytosolic and mitochondrial compartments of rat liver after 7 and 24 hr of cold storage in University of Wisconsin (UW) and Euro-Collins solutions. 1-4 A similar time-dependent depletion of cytosolic glutathione up to about 60% of control values was observed in bo...

journal_title：Transplantation

authors： Jassem W,Ciarimboli C,Cerioni PN,Saba V,Norton SJ,Principato G

更新日期：1996-05-15 00:00:00

abstract：:The use of cyclosporine has been associated with an increased incidence of thrombosis and endothelial cell perturbation. To explore possible mechanisms involved, we examined the effects of CSA on the activation of protein C by thrombomodulin. Cultured bovine aortic endothelial cell monolayers were incubated for 24 hr ...

journal_title：Transplantation

authors： Garcia-Maldonado M,Kaufman CE,Comp PC

更新日期：1991-03-01 00:00:00

abstract：:The humoral theory states that antibodies cause the rejection of allografts. From 1917 to 1929, extensive efforts were made to produce antibodies against tumors. It was finally realized that the antibodies were produced against the transplant antigens present on transplantable tumors, not against the tumor-specific an...

journal_title：Transplantation

authors： Terasaki PI

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:Chronic allograft nephropathy (CAN) has become the predominant limiting factor for long-term transplant survival. A cardinal histomorphologic correlate for CAN is interstitial fibrosis. Currently, no method has been established in routine use that reliably quantifies the extent of interstitial fibrosis in re...

journal_title：Transplantation

authors： Pape L,Henne T,Offner G,Strehlau J,Ehrich JH,Mengel M,Grimm PC

更新日期：2003-09-27 00:00:00

abstract：BACKGROUND:Post-lung transplant infection is one of the leading causes of morbidity and mortality. The cause and incidence are similar in many series; however, infections such as Mycobacterium tuberculosis are influenced by the epidemiologic situation. The authors present a prospective and observational study to define...

journal_title：Transplantation

authors： Bravo C,Roldán J,Roman A,Degracia J,Majo J,Guerra J,Monforte V,Vidal R,Morell F

更新日期：2005-01-15 00:00:00

abstract：BACKGROUND:FK506-binding proteins (FKBP) are immunophilins that interact with the immunosuppressive drugs FK506 and rapamycin. Several FKBP family members such as FKBP12, FKBP12.6, and FKBP51 are expressed in T cells. It has been speculated that these FKBPs are possibly redundant in the immunosuppressant-induced T-cell...

journal_title：Transplantation

authors： Xu X,Su B,Barndt RJ,Chen H,Xin H,Yan G,Chen L,Cheng D,Heitman J,Zhuang Y,Fleischer S,Shou W

更新日期：2002-06-15 00:00:00

abstract：BACKGROUND:The aim of this single-center study was to investigate whether trough level adjusted mycophenolate mofetil (MMF) is more efficacious in combination with tacrolimus (TAC) or cyclosporine (CsA) and to evaluate the impact of either drug on MMF dosage. METHODS:Sixty patients (TAC, n = 30; CsA, n = 30) undergoin...

journal_title：Transplantation

authors： Meiser BM,Groetzner J,Kaczmarek I,Landwehr P,Müller M,Jung S,Uberfuhr P,Fraunberger P,Stempfle HU,Weis M,Reichart B

更新日期：2004-08-27 00:00:00

abstract：:Single amino acid disparities in MHC class I molecules can elicit transplantation responses. Since beta 2 microglobulin (beta 2m) is noncovalently associated with class I antigens on the cell membrane we investigated whether the single amino acid polymorphism at position 85 (Asp-->Ala) in the mouse beta 2m molecule ca...

journal_title：Transplantation

authors： Hederer RA,Chandler PR,Dyson PJ,Antoniou AN,Millrain MM,Mellor AL,Simpson E,Robinson PJ

更新日期：1996-01-27 00:00:00

abstract：BACKGROUND:FTY720 prevents allograft rejection with remarkable potency without inducing generalized immunosuppression. We determined the effect of FTY720 on development of autoimmune diabetes in nonobese diabetic (NOD) mice. METHODS:NOD mice were given FTY720 (0.5 mg/kg, orally) five times per week starting from 4 wee...

journal_title：Transplantation

authors： Maki T,Gottschalk R,Monaco AP

更新日期：2002-12-27 00:00:00

abstract：BACKGROUND:Previous reports have established the feasibility of using livers from controlled, non-heart-beating donors (CNHBD) with good immediate graft function. This has been largely borne out of necessity because of the donor shortage. METHODS:Retrospective database review for the last 7 years (1995-2002), encompas...

journal_title：Transplantation

authors： Manzarbeitia CY,Ortiz JA,Jeon H,Rothstein KD,Martinez O,Araya VR,Munoz SJ,Reich DJ

更新日期：2004-07-27 00:00:00

abstract：BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...

journal_title：Transplantation

authors： Uchida H,Kobayashi E,Matsuda K,Mizuta K,Sugimoto K,Kawarasaki H,Hashizume K,Fujimura A

更新日期：1999-05-15 00:00:00

abstract：BACKGROUND:Sirolimus (Rapamune, rapamycin, RAPA) is a potent immunosuppressive drug that has reduced the rate of acute rejection episodes by more than 40% in phase III trials when added to an immunosuppression regimen of cyclosporine (CsA) and prednisone. However, RAPA treatment tends to increase lipid levels, particul...

journal_title：Transplantation

authors： Hoogeveen RC,Ballantyne CM,Pownall HJ,Opekun AR,Hachey DL,Jaffe JS,Oppermann S,Kahan BD,Morrisett JD

更新日期：2001-10-15 00:00:00

abstract：:OKT3 is considered to be effective in the prophylaxis and treatment of rejection. However, anti-OKT3 immunization is still a major side-effect. Only the IgG antiidiotypic component of the response is responsible for neutralization of OKT3 therapeutic activity by inhibiting OKT3's binding to T cells (i.e., blocking ant...

journal_title：Transplantation

authors： Legendre C,Kreis H,Bach JF,Chatenoud L

更新日期：1992-01-01 00:00:00

abstract：:A panel of ethicists, organ procurement organization executives, physicians, and surgeons was convened by the sponsorship of the American Society of Transplant Surgeons to determine whether an ethically acceptable pilot trial could be proposed to provide a financial incentive for a family to consent to the donation of...

journal_title：Transplantation

authors： Arnold R,Bartlett S,Bernat J,Colonna J,Dafoe D,Dubler N,Gruber S,Kahn J,Luskin R,Nathan H,Orloff S,Prottas J,Shapiro R,Ricordi C,Youngner S,Delmonico FL

更新日期：2002-04-27 00:00:00