Abstract:
BACKGROUND:FTY720 prevents allograft rejection with remarkable potency without inducing generalized immunosuppression. We determined the effect of FTY720 on development of autoimmune diabetes in nonobese diabetic (NOD) mice. METHODS:NOD mice were given FTY720 (0.5 mg/kg, orally) five times per week starting from 4 weeks of age. RESULTS:Daily FTY720 prevented development of diabetes in 15 of 16 treated mice, whereas 70% of untreated NOD mice became diabetic by 35 weeks of age. Withdrawal of FTY720 at 35 weeks of age led to development of diabetes within 2 weeks in five mice, whereas the remaining mice maintained diabetes-free conditions for up to 44 weeks of age. No side effect of the drug was seen throughout the treatment period. FTY720 also prevented cyclophosphamide-induced diabetes in NOD mice. CONCLUSIONS:FTY720 is a safe and benign therapeutic agent that may be used chronically in prediabetic individuals.
journal_name
Transplantationjournal_title
Transplantationauthors
Maki T,Gottschalk R,Monaco APdoi
10.1097/00007890-200212270-00006subject
Has Abstractpub_date
2002-12-27 00:00:00pages
1684-6issue
12eissn
0041-1337issn
1534-6080journal_volume
74pub_type
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