Abstract:
:Significant extended survival of C3H/He skin grafts in antilymphocyte serum (ALS)-treated B6AF1 mice can be brought about by the injection of donor-strain bone marrow on day 6 or 7 after grafting. In the present study, survival of the active graft-prolonging bone marrow cells under several storage conditions was investigated. The bone marrow cells retained their effectiveness if stored at 4 degrees C in 10% fetal calf serum for 18 hr prior to injection, but not if maintained at 37 degrees C under standard lymphocyte culture conditions. Freezing the cells for 10 days in a cryoprotective medium preserved the ability of the cells to prolong graft survival. In fact, freeze-thawed cells were more effective than fresh cells. Extension of the ALS-bone marrow treatment protocol to human transplantation is expected to be facilitated by frozen and short-term refrigerated storage of the donor bone marrow.
journal_name
Transplantationjournal_title
Transplantationauthors
De Fazio SR,Hartner WC,Monaco AP,Gozzo JJdoi
10.1097/00007890-198601000-00004subject
Has Abstractpub_date
1986-01-01 00:00:00pages
26-8issue
1eissn
0041-1337issn
1534-6080journal_volume
41pub_type
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