Abstract:
:Cultured BALB/c (H-2d) thyroid, adult pancreatic islet and fetal proislet tissues can be accepted permanently in CBA/H (H-2k) recipients until rejection is triggered by the transfer of antidonor strain activated immune T cells. Class II MHC antigens are not expressed on the accepted grafts and are induced following immune cell transfer, but expression is quantitatively and qualitatively different for the different tissues. Thyroid allografts show intense class II MHC antigen expression early after immune cell transfer and before extensive tissue destruction has occurred. In contrast, adult islet and fetal proislet allografts show patchy and cytoplasmic staining usually associated with areas of tissue destruction. Gamma-interferon treatment of tissues in vitro showed that proislet tissue has a greater capacity for class II MHC antigen induction than adult islet tissue. The differences in the capacity for class II MHC induction by fetal and adult islet tissue may be important in relation to the pathogenesis of autoimmune disease.
journal_name
Transplantationjournal_title
Transplantationauthors
Warren HS,Hodder MJ,Allan W,Hume DA,Simeonovic CJdoi
10.1097/00007890-199204000-00025subject
Has Abstractpub_date
1992-04-01 00:00:00pages
834-40issue
4eissn
0041-1337issn
1534-6080journal_volume
53pub_type
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