Abstract:
:The reactions of a number of LEW anti-ACI allospecific rat monoclonal antibodies were examined in a series of breeding studies. Analysis of (LEW X ACI) F2 progeny demonstrated concordance of the monoclonal class I and class II specificities with results of conventional alloantisera typing. In addition, a "gene dosage" effect was noted, with a/a homozygotes showing approximately twice the reactivity as a/l heterozygotes. The previously noted crossreaction of antibody 36.3 (anti-RT1.Aa) with WF and RP strains segregated with RT1.Au in (WF X ACI) F2 and (LEW X RP) F2 progeny suggesting structural similarity of these two allelic products. Finally, an apparent decreased reaction of two (WF X ACI) F2 offspring with antibody 36.3 was shown to be heritable to the F5 generation and may represent an example of genetic control of level of expression of a class I antigen.
journal_name
Transplantationjournal_title
Transplantationauthors
Fuks A,Guttmann RDsubject
Has Abstractpub_date
1983-11-01 00:00:00pages
568-71issue
5eissn
0041-1337issn
1534-6080journal_volume
36pub_type
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