Abstract:
:Islets were isolated using neutral red as a dye to exclude lymphatic and acinar impurities in the transplant preparation. In a one donor-one recipient model, intraportally transplanted isogeneic islets survived indefinitely. Mean graft survival could be prolonged from 5 to 90 days, using a 3-dose rejection prophylaxis with CsA in allografts of (DA [RT1a]----Lew (RT 1l). Histological examination revealed intact islets in the grafted normoglycemic animals. Immunohistochemical staining of these islets showed B cells with insulin-rich cytoplasma. Blood glucose levels and the results of i.v. glucose tolerance tests 50 days after transplantation are presented. The different outcomes of our experiments are discussed.
journal_name
Transplantationjournal_title
Transplantationauthors
Dibelius A,Königsberger H,Walter P,Permanetter W,Brendel W,von Specht BUdoi
10.1097/00007890-198604000-00003subject
Has Abstractpub_date
1986-04-01 00:00:00pages
426-31issue
4eissn
0041-1337issn
1534-6080journal_volume
41pub_type
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