Abstract:
:It has been postulated that the establishment of acquired, neonatal immunologic tolerance is due to a "deficit" in interleukin 2 (IL-2). To test this hypothesis, chickens were made immunologically tolerant to both major and minor histocompatibility antigens by transplantation of skin grafts onto newly hatched recipients. In this study, we injected various doses of IL-2 and concanavalin A simultaneously with transplantation and in some cases, several days posttransplantation, and we failed to enhance graft rejection. These results may have practical importance in respect to the clinical use of recombinant IL-2. Injection of IL-2 in and around surviving skin grafts also failed to alter skin graft survival.
journal_name
Transplantationjournal_title
Transplantationauthors
Tempelis CH,Hála K,Krömer G,Schauenstein K,Wick Gdoi
10.1097/00007890-198802000-00041subject
Has Abstractpub_date
1988-02-01 00:00:00pages
449-51issue
2eissn
0041-1337issn
1534-6080journal_volume
45pub_type
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