Abstract:
:By using the lysostrip and the blocking of cytotoxicity by Fab2 fragments, HLA-A and B antibodies were detected in sera from rabbits and goats immunized with human high-density lipoprotein (HDL)-associated HLA antigens isolated from sera and from cultured lymphoid cells. After appropriate absorptions, the xenoantisera became specific for HLA-A and B alloantigens, reacted with the same structures as alloantisera, and displayed the same patterns of cross-reactions as alloantisera; however, several xenoantisera contained antibodies cross-reactive with antigens coded by the A and B loci. Our data indicate that HDL-associated HLA antigens isolated from lymphoid cells and from serum efficiently elicit xenoantibodies to allotypic specificities of the human histocompatibility system.
journal_name
Transplantationjournal_title
Transplantationauthors
Richiardi P,Pellegrino MA,Ferrone Sdoi
10.1097/00007890-197910000-00014subject
Has Abstractpub_date
1979-10-01 00:00:00pages
333-8issue
4eissn
0041-1337issn
1534-6080journal_volume
28pub_type
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