Peripheral monitoring of direct and indirect alloantigen presentation pathways in clinical heart transplant recipients.

abstract：:Survival of skin allografts made to antilymphocyte serum (ALS)-treated recipients is prolonged by posttransplant intravenous injection of donor strain bone marrow cells (BMC). If asialofetuin (ASF) is coinjected with the BMC, the prolonged graft survival is augmented (e.g., median survival time increased from 43 days ...

journal_title：Transplantation

authors： Khouri W,Masli S,De Fazio SR,Gozzo JJ

更新日期：1994-02-01 00:00:00

abstract：:Cultured neonatal rat islets were transplanted across six strain combinations into nonimmunosuppressed allogeneic recipients. Islets were isolated nonenzymatically by an in vitro method and were cultured at 37 degrees C in 5% CO2 in air for 10 days prior to transplant. Transplants to nondiabetic recipients across four...

journal_title：Transplantation

authors： Serie JR,Hegre OD,Eide CR,Weinhaus AJ,Marshall S

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Macroencapsulated islets can reverse hyperglycemia in diabetic animals when transplanted i.p. or into the fat pad. The s.c. space is an attractive site for such transplantation because macrocapsules can be implanted with local anesthesia and be easily removed or reloaded with fresh islets. METHODS:Immunopro...

journal_title：Transplantation

authors： Tatarkiewicz K,Hollister-Lock J,Quickel RR,Colton CK,Bonner-Weir S,Weir GC

更新日期：1999-03-15 00:00:00

abstract：BACKGROUND:Previous studies have identified more morbidity in simultaneous pancreas-kidney (SPK) transplant recipients compared with kidney alone (KA) recipients. With the development of novel immunosuppressive drugs, studies are needed to determine optimal treatment regimens in specific patient populations. METHODS:W...

journal_title：Transplantation

authors： Lee CM,Scandling JD,Krieger NR,Dafoe DC,Alfrey EJ

更新日期：1997-11-15 00:00:00

abstract：:Allotransplantation into immunosuppressed individuals results in long-term survival of grafts. However, the grafts are damaged, probably at many stages before, during and after implantation. The hypothesis to be presented is that release of antigens and autoantigens from the chronically damaged graft results in breaki...

journal_title：Transplantation

authors： Rose ML

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:Skin-autofluorescence (skin-AF) noninvasively measures the tissue accumulation of advanced glycation end products (AGEs). AGEs are nephrotoxic and potential effectors of cardiovascular mortality. We investigated whether skin-AF predicted graft loss after kidney transplantation. METHODS:A total of 302 renal ...

journal_title：Transplantation

authors： Hartog JW,Gross S,Oterdoom LH,van Ree RM,de Vries AP,Smit AJ,Schouten JP,Nawroth PP,Gans RO,van Son WJ,Bierhaus A,Bakker SJ

更新日期：2009-04-15 00:00:00

abstract：:The utility of bile cytology (BC) in the diagnosis of hepatic graft rejection was assessed in 21 liver transplantations in 18 patients. A total of 307 BC specimens were studied; cell density and relative contribution of different cell types were monitored in 130 specimens. The findings in 62 fine-needle aspiration bio...

journal_title：Transplantation

authors： Kubota K,Ericzon BG,Barkholt L,Reinholt FP

更新日期：1989-12-01 00:00:00

abstract：:After measurement of normal renal function, dog kidneys (n = 52) were subjected to 3, 15, or 30 min of normothermic warm ischemia (WI). After 24 hr of preservation by simple hypothermic storage (SHS) in a modified Collins solution, autotransplant was done and renal function was again measured beginning at 1 hr. Compar...

journal_title：Transplantation

authors： Gregg CM,Lai MK,Mandour WA,Linke CA

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:After transplantation, donor dendritic cells (DC) migrating to the draining lymph node of the recipient are thought to play an important role in the initiation of graft rejection. In this study, we compared the in vivo migration of DC after allogeneic skin transplantation with that after congeneic skin trans...

journal_title：Transplantation

authors： Richters CD,van Gelderop E,du Pont JS,Hoekstra MJ,Kreis RW,Kamperdijk EW

更新日期：1999-03-27 00:00:00

abstract：:Orthotopic liver allografts from BN donors to LEW recipients are spontaneously accepted, and the recipients develop donor-specific immunological unresponsiveness. This unresponsiveness may be mediated by suppressor T cells. Immunomagnetically purified splenic T cells from LEW rats bearing BN liver grafts were shown to...

journal_title：Transplantation

authors： Gassel HJ,Hutchinson IV,Engemann R,Morris PJ

更新日期：1992-12-01 00:00:00

abstract：:Renal transplant recipients are at risk of severe morbidity and mortality from CMV disease. We have undertaken routine surveillance for CMV shedding on 133 transplant recipients, using a rapid culture technique, in order to assess the incidence of CMV infection and disease in these patients and to assess the prognosti...

journal_title：Transplantation

authors： Pillay D,Ali AA,Liu SF,Kops E,Sweny P,Griffiths PD

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) and mechanical ventilation (MV) can be used as a bridge to heart-lung transplantation (HLT). The goal of this study was to determine if pretransplantation ECMO or MV affects survival in HLT. METHODS:The United Network for Organ Sharing database was reviewed for all...

journal_title：Transplantation

authors： Jayarajan SN,Taghavi S,Komaroff E,Brann S,Horai T,Cordova F,Patel N,Guy TS,Toyoda Y

更新日期：2014-01-15 00:00:00

abstract：BACKGROUND:Calcineurin inhibitors (CNIs) are the first-line immunosuppressive agents administered after liver transplantation, but they cause renal impairment. Two recent randomized trials report cellular rejection and liver graft loss when mycophenolate mofetil (MMF) monotherapy was used as a renal-sparing agent. Our ...

journal_title：Transplantation

authors： Raimondo ML,Dagher L,Papatheodoridis GV,Rolando N,Patch DW,Davidson BR,Rolles K,Burroughs AK

更新日期：2003-01-27 00:00:00

abstract：BACKGROUND:Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with survival in HC...

journal_title：Transplantation

authors： Velidedeoglu E,Mange KC,Frank A,Abt P,Desai NM,Markmann JW,Reddy R,Markmann JF

更新日期：2004-06-27 00:00:00

abstract：:Ultraviolet (UV)-irradiated mice were compared with unirradiated mice for their susceptibility to primary and transplanted tumors etiologically unrelated to UV radiation. Although UV-irradiated mice are unable to reject transplants of highly antigenic syngeneic tumors induced by UV light, the growth of syngeneic, non-...

journal_title：Transplantation

authors： Kripke ML,Thorn RM,Lill PH,Civin CI,Pazmiño NH,Fisher MS

更新日期：1979-09-01 00:00:00

abstract：:Living donor renal allograft survival is superior to that achieved from deceased donors, although graft outcome is suboptimal in some of these patients. In an effort to identify the subset of patients at high risk for poor outcomes we studied donor risk factors in 248 living kidney donor-recipient pairs. Unadjusted do...

journal_title：Transplantation

authors： Issa N,Stephany B,Fatica R,Nurko S,Krishnamurthi V,Goldfarb DA,Braun WE,Dennis VW,Heeger PS,Poggio ED

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:We hypothesized that solitary pancreas transplants could be performed successfully even in the presence of poor HLA matching if an aggressive approach were taken with regard to immunosuppressive protocol and the performance of allograft biopsy. METHODS:Seven pancreas-after-kidney transplants and seven pancr...

journal_title：Transplantation

authors： Gruber SA,Katz S,Kaplan B,Clark JH 3rd,Chen PC,El-Sabrout R,Kerman RH

更新日期：2000-07-27 00:00:00

abstract：BACKGROUND:Impaired pretransplant performance status (PS) is associated with chronic liver disease (CLD). We studied its impact on hospital length of stay (LOS), complications and readmissions in the first year after liver transplantation. METHOD:The Standard National Liver Transplant Registry was linked to a hospital...

journal_title：Transplantation

authors： Wallace D,Cowling TE,Walker K,Suddle A,Gimson A,Rowe I,Callaghan C,Heaton N,van der Meulen J,Bernal W

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:Solid organ xenograft rejection is associated with vascular injury resulting at least in part in platelet activation, and rejected xenografts invariably demonstrate intravascular thrombosis and interstitial hemorrhage. Complement activation plays a prominent role in platelet-endothelial interaction. We teste...

journal_title：Transplantation

authors： Brandl U,Jöckle H,Erhardt M,Michel S,Burdorf L,Brenner P,Bittmann I,Rössle M,Mordstein V,Hammer C,Thein E,Reichart B,Schmoeckel M

更新日期：2007-12-27 00:00:00

abstract：:Infectious complications in patients with recurrent hepatitis C virus (HCV) hepatitis after liver transplantation were prospectively assessed and compared with those of all other liver transplant recipients without HCV hepatitis operated on during the same period. Major infections occurred in 64% (14/22) of the patien...

journal_title：Transplantation

authors： Singh N,Gayowski T,Wagener MM,Marino IR

更新日期：1996-02-15 00:00:00

abstract：:The response to IL-2 and IL-4 of several functionally defined lymphoid cell types was assessed at the individual responding cell level in limiting dilution experiments in which exogenous IL-2 or IL-4 was used to promote cellular activation and expansion. Splenic precursors that give rise to alloreactive CTL in LDA sup...

journal_title：Transplantation

authors： Widmer MB,Voice RF,Conlon PJ,Grabstein KH

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Immunotherapy given post-autologous stem cell transplantation may eliminate residual tumor cells escaping the conditioning protocol. METHODS:Five children suffering from stage IV neuroblastoma were treated by recombinant interleukin-2 (IL-2) post-autologous peripheral blood stem cell transplantation. The pa...

journal_title：Transplantation

authors： Toren A,Nagler A,Rozenfeld-Granot G,Levanon M,Davidson J,Bielorai B,Kaplinsky C,Meitar D,Mandel M,Ackerstein A,Ballin A,Attias D,Biniaminov M,Rosenthal E,Brok-Simoni F,Rechavi G,Kaufmann Y

更新日期：2000-10-15 00:00:00

abstract：BACKGROUND:The effective use of new steroid-sparing immunosuppressive regimens may lower cumulative glucocorticoid use among renal transplant recipients. However, it is unknown what effect this therapeutic trend has had on bone disease. METHODS:Unselected newly transplanted inpatients (n=45) were identified and compre...

journal_title：Transplantation

authors： Mikuls TR,Julian BA,Bartolucci A,Saag KG

更新日期：2003-01-15 00:00:00

abstract：:Induction immunosuppression is intense, prophylactic therapy used at the time of transplantation based on the empiric observation that more powerful immunosuppression is required to prevent acute rejection early. In the past decade, there has been a growing trend towards the use of specialized agents such as antibody ...

journal_title：Transplantation

authors： Kirk AD

更新日期：2006-09-15 00:00:00

abstract：:A novel, water-soluble metabolite of cyclosporine, a sulphate conjugate, present in high concentrations in human bile and plasma was evaluated for its immunosuppressive properties. The direct binding of the conjugate to surface molecules on lymphocytes was studied. The effect of the metabolite was tested in several in...

journal_title：Transplantation

authors： Johansson A,Henricsson S,Möller E

更新日期：1990-03-01 00:00:00

abstract：:Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was ini...

journal_title：Transplantation

authors： Nisbet NW,Menage J,Loutit JF

更新日期：1979-10-01 00:00:00

abstract：:Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...

journal_title：Transplantation

authors： Valantine HA

更新日期：2003-09-27 00:00:00

abstract：:The monoclonal antibodies (MoAb) CR11-351 and KS1 are secreted by hybridomas generated with splenocytes from BALB/c mice immunized with the cultured human B lymphoid cells LG-2 (HLA-A2,A2,B27,B27). The 2 monoclonal antibodies immunoprecipitated components with a superimposable 2-dimensional gel electrophoretic profile...

journal_title：Transplantation

authors： Tsujisaki M,Sakaguchi K,Igarashi M,Richiardi P,Perosa F,Ferrone S

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:We sought to compare the immunoreactive potential of human cord blood (CB) versus normal adult bone marrow (BM) versus mobilized blood (peripheral blood stem cells; PBSC) from cancer patients. METHODS:Forty mice were randomized to receive a range of doses of T cell-replete cell preparations from one of the ...

journal_title：Transplantation

authors： Leung W,Ramírez M,Mukherjee G,Perlman EJ,Civin CI

更新日期：1999-09-15 00:00:00

abstract：:Agarose is known to inhibit nonspecifically the cytotoxic effects of normal sera on xenogeneic lymphoid cells. To find an explanation for this agarose effect we have studied its requirements using guinea pig and human sera as the source of activity and rat thymocytes as target cells. Control assays were performed usin...

journal_title：Transplantation

authors： Budzko DB,Kierszenbaum F

更新日期：1977-04-01 00:00:00