Abstract:
BACKGROUND:Immunotherapy given post-autologous stem cell transplantation may eliminate residual tumor cells escaping the conditioning protocol. METHODS:Five children suffering from stage IV neuroblastoma were treated by recombinant interleukin-2 (IL-2) post-autologous peripheral blood stem cell transplantation. The patients' peripheral mononuclear cells were monitored for CD3+ and CD56+ levels, their proliferative response and killing of various cell lines targets. RESULTS:An increase in the level of total lymphocytes, mainly due to expansion of T cells, and enhanced proliferative response to phytohemaglutinin were observed. Elevated cytotoxicity against K562 and neuroblastoma target cells was detected in four patients and against K562 targets in one patient. Toxicity included mild thrombocytopenia, and fever in four patients and mild to moderate encephalopathy which necessitated withdrawing one patient from the protocol. Three of five patients studied are alive today, one of them whose IL-2 was stopped, is in relapse. Two patients have died. CONCLUSIONS:Immunotherapy with s.c. intermediate-high dose IL-2 is feasible and results in expansion of T cells and in stimulation of killing activity against several targets including in some cases, neuroblastoma tumor cells.
journal_name
Transplantationjournal_title
Transplantationauthors
Toren A,Nagler A,Rozenfeld-Granot G,Levanon M,Davidson J,Bielorai B,Kaplinsky C,Meitar D,Mandel M,Ackerstein A,Ballin A,Attias D,Biniaminov M,Rosenthal E,Brok-Simoni F,Rechavi G,Kaufmann Ydoi
10.1097/00007890-200010150-00019subject
Has Abstractpub_date
2000-10-15 00:00:00pages
1100-4issue
7eissn
0041-1337issn
1534-6080journal_volume
70pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Seasonal variation in blood pressure (BP) has been described in the general and dialysis populations, with higher recordings noted in the winter than in the summer. This difference has been attributed to changes in weight, ambient temperature, and length of daylight. In this study, we sought to determine whether such ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200112150-00014
更新日期:2001-12-15 00:00:00
abstract:BACKGROUND:We hypothesized that solitary pancreas transplants could be performed successfully even in the presence of poor HLA matching if an aggressive approach were taken with regard to immunosuppressive protocol and the performance of allograft biopsy. METHODS:Seven pancreas-after-kidney transplants and seven pancr...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/00007890-200007270-00028
更新日期:2000-07-27 00:00:00
abstract::The use of real-time reverse transcription polymerase chain reaction to compare gene expression in different tissues and conditions requires normalization to an internal control that must be expressed at a constant level. Although a previous validation step is required to confirm that an internal control is appropriat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173790.12227.7b
更新日期:2005-09-15 00:00:00
abstract::The calcineurin inhibitors (CNIs) have been the cornerstone of immunosuppressive therapy in recent years, though their association with dose-related nephrotoxicity is a major factor in the development of chronic allograft nephropathy in kidney transplant recipients. The novel proliferation signal inhibitor everolimus ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000162434.62591.f3
更新日期:2005-05-15 00:00:00
abstract:BACKGROUND:Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation in more than 30% of cases and can lead to allograft loss. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS. METHODS:We conducted a retrospective stu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829eda4f
更新日期:2013-10-15 00:00:00
abstract:BACKGROUND:There is an increasing appreciation of the deleterious effects of antibody and B cells on acute and chronic transplant outcomes. Many effector functions of antibody are mediated by a family of receptors (FcγRs) that are expressed on most immune cells, including neutrophils, natural killer cells, and B cells....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000287
更新日期:2014-08-15 00:00:00
abstract:BACKGROUND:Scarring can greatly impact quality of life for individuals (ie, causing depression posttraumatic stress disorder, body image issues). Those who wish to be anonymous live liver donors are warned of the potential negative psychological impacts associated with the large scar left from liver donation surgery. G...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003333
更新日期:2020-05-25 00:00:00
abstract:INTRODUCTION:Celsior (CEL) was formulated specifically for heart preservation. Recently some preliminary reports have suggested that CEL is also effective for liver preservation. In this study liver preservation with CEL was compared to colloid-free University of Wisconsin solution (MUW). METHODS:Arterialized rat live...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200010270-00002
更新日期:2000-10-27 00:00:00
abstract::Osteopetrotic microphthalmic mice (mi/mi) were treated by injections of suspensions of myeloid tissue, newborns i.p., and weanlings i.v. Donated syngeneic material effected permanent cure of oteopetrosis provided that the dose was large enough (10(8) cells of bone marrow). H-2-compatible allogeneic bone marrow was ini...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197910000-00004
更新日期:1979-10-01 00:00:00
abstract::The effect of the quinoline-3-carboxamide LS-2616 (Linomide), given alone or together with cyclosporine, was studied in the first set cardiac allograft transplantation model in the rat. PVG rat hearts were transplanted heterotopically to Wistar/Kyoto rat recipients on day 0. The recipients were given LS-2616 orally on...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198902000-00003
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Renal allograft rejection is associated with the expression of adhesion molecules on vascular endothelial and tubular epithelial cells. METHODS:To assess whether the number of cell adhesion molecules expressed in donor kidneys can predict early rejection or delayed graft function, kidney biopsies from 20 li...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200106150-00028
更新日期:2001-06-15 00:00:00
abstract::Sprague-Dawley rats were treated for 14 days with rapamycin (RAP; 1.5 mg/kg/day i.p.), cyclosporine (15 mg/kg/day by gavage), both drugs in combination, or appropriate drug vehicles. Hematological parameters and biochemical indices of renal and hepatic function were determined throughout the experimental period, at th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199108000-00004
更新日期:1991-08-01 00:00:00
abstract::The psychosocial and psychiatric impact of donating bone marrow (BM) has received little study. This mail questionnaire study of bone marrow donors whose recipient had survived more than one year post-BMT was undertaken to document the psychosocial consequences of donation on "successful" BM donors. Demographic, mood ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198604000-00014
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:Most transplant centers in the United States, including our own, use creatinine clearance (Ccr) to estimate glomerular filtration rate (GFR) in potential living kidney donors. The purpose of this study was to evaluate our experience with estimation of donor GFR by Ccr and to explore other potential strategie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200101270-00016
更新日期:2001-01-27 00:00:00
abstract:BACKGROUND:The authors have previously demonstrated that inhibition of CD28 and CD40 ligand (CD40L) co-stimulatory signals by adenovirus-mediated cytotoxic T-lymphocyte-associated (CTL) antigen 4 (A4) immunoglobulin (Ig) and CD40Ig gene therapies induces tolerance or long-term acceptance in rat liver and heart allograf...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000144324.83846.a9
更新日期:2004-11-27 00:00:00
abstract::Natural killer (NK) cells effect hybrid resistance, in which parental hematopoietic cell grafts are rejected by F1 recipients. NK cells can also resist engraftment of fully MHC-mismatched allogeneic marrow. However, studies of NK cell-mediated alloresistance have relied on short-term proliferation, colony, or survival...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601150-00024
更新日期:1996-01-15 00:00:00
abstract:BACKGROUND:Prophylactic administration of anti-HBs intravenous immunoglobulins (IVIg) in hepatitis B infected-liver transplant patients protects against acute rejection. To explore the suitability of intravenous immunoglobulins (IVIg) as prophylaxis of acute rejection and graft-versus-host disease (GVHD) after allograf...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000226073.20185.b1
更新日期:2006-06-27 00:00:00
abstract::Using antisera to human beta2-microglobulin and an immunofluorescent technique, beta2-microglobulin was found to be localized along tubular and glomerular basement membranes of renal bipsies studied. Since beta2-microglobulin is a subunit of HLA preparations, it may also serve as an indirect marker for the presence of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197707000-00001
更新日期:1977-07-01 00:00:00
abstract::In the USA approximately 10% of candidates for renal transplantation have serum antibodies to hepatitis C (HCV). To assess the possible impact of HCV infection on early posttransplant events we assessed allograft complications during the first 6 months following renal transplantation in three groups of adult renal all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199610270-00004
更新日期:1996-10-27 00:00:00
abstract:BACKGROUND:Airway complications continue to be an important source of morbidity and mortality after lung transplantation (LTx). Different approaches have been used for their nonsurgical management. We describe our experience using self-expandable metallic stents (SEMSs) in patients with airway complications post-LTx. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000061229.83500.A0
更新日期:2003-05-15 00:00:00
abstract:BACKGROUND:Although used for more than 20 years, optimal dosing strategies of most immunosuppressants have never been determined. Tacrolimus, one of the newer agents used in solid-organ transplantation, is gaining increasing popularity because of its ability to reverse refractory rejection in cyclosporine-treated patie...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-200210270-00014
更新日期:2002-10-27 00:00:00
abstract::We performed a multicenter study to investigate the problem of cadaver kidney transplants that never achieve function, or that recover after a period of delayed function, and we used multivariate techniques to model the results. Sixty-nine patients who received cadaver kidney transplants that never functioned (NF) wer...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198801000-00027
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:FK506-binding proteins (FKBP) are immunophilins that interact with the immunosuppressive drugs FK506 and rapamycin. Several FKBP family members such as FKBP12, FKBP12.6, and FKBP51 are expressed in T cells. It has been speculated that these FKBPs are possibly redundant in the immunosuppressant-induced T-cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200206150-00023
更新日期:2002-06-15 00:00:00
abstract:BACKGROUND:We hypothesized that tissue-engineered contractile cardiomyocyte sheets without a scaffold would show histological and electrical integration with impaired myocardium, leading to the regeneration of infarcted myocardium. METHODS:Neonatal rat cardiomyocytes were cultured on Poly(N-isopropylacrylamide)-grafte...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000181163.69108.dd
更新日期:2005-12-15 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MS) is a known cardiovascular risk factor in the general population. We explored the influence of MS on the occurrence of atherosclerotic events (AEs) after renal transplantation. METHODS:Three hundred thirty-seven renal transplant recipients were included in the study. Various parameter...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000266898.93894.3d
更新日期:2007-06-27 00:00:00
abstract:BACKGROUND:Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have an increased risk of rejection. METHODS:We have related polymorphisms that influence cytokine production in the tumor n...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199709150-00021
更新日期:1997-09-15 00:00:00
abstract:BACKGROUND:Donation after cardiac death (DCD) increases the number of donor kidneys but is associated with more primary nonfunction (PNF) and delayed graft function (DGF). It has been suggested that biomarkers in the preservation solution of machine perfused kidneys may predict PNF, although evidence is lacking. METHO...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31827908e6
更新日期:2013-02-27 00:00:00
abstract::Uncontrolled donation after circulatory death (uDCD) refers to donation from persons who die following an unexpected and unsuccessfully resuscitated cardiac arrest. Despite the large potential for uDCD, programs of this kind only exist in a reduced number of countries with a limited activity. Barriers to uDCD are of a...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000003139
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:It is unclear to what extent cancer history affects posttransplantation mortality in solid organ transplant recipients. METHODS:We identified a Swedish population-based cohort of solid organ transplant recipients in the National Patient Register 1970 to 2008 and linked it to the Cancer and Cause-of-Death Re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829854b7
更新日期:2013-08-15 00:00:00
abstract:BACKGROUND:Immunosuppressive drugs that target T cells are useful for prolonging allograft survival. The anti-CD3 immunotoxin FN18-CRM9 has been shown to effectively prolong renal allograft survival in a rhesus monkey model of transplantation. However, immunotoxin-treated monkeys showed increased levels of inflammatory...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199909150-00016
更新日期:1999-09-15 00:00:00