Selection of a suitable internal control gene for expression studies in pancreatic islet grafts.

abstract：:To investigate whether graft-versus-host reactivity (GVHR) and the graft-versus-leukemia (GVL) effect can be differentiated, C3H-->AKR mixed bone marrow (BM) chimeras were prepared using two different conditioning regimens. Total body irradiation (TBI) chimeras were induced by infusing 5 x 1O(6) T cell depleted syngen...

journal_title：Transplantation

authors： Salam A,Waer M

更新日期：1996-03-15 00:00:00

abstract：:The value of percutaneous core needle biopsy in the immunohistological evaluation of renal allograft dysfunction was studied in 72 consecutive biopsies performed in 42 patients. The phenotypes of infiltrating cells mediating graft destruction were identified with monoclonal antibodies and immunoperoxidase staining tec...

journal_title：Transplantation

authors： Waltzer WC,Miller F,Arnold A,Anaise D,Rapaport FT

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The influence of donor hematopoietic cell microchimerism on organ allograft survival has been studied largely in vascularized transplant models. Here, we examine the impact of donor bone marrow (BM) cells administered intravenously together with transient systemic tacrolimus therapy on microchimerism, the su...

journal_title：Transplantation

authors： Khanna A,Steptoe RJ,Antonysamy MA,Li W,Thomson AW

更新日期：1998-02-27 00:00:00

abstract：BACKGROUND:Isolated transient elevation of alkaline phosphatase (ALP) in the absence of bone or liver disease has been reported in children including liver transplant patients. Specific isoenzyme patterns have been associated with this phenomenon in healthy children but have not been reported after liver transplantatio...

journal_title：Transplantation

authors： O'Riordan S,Baker AJ,Sherwood RA

更新日期：2002-10-15 00:00:00

abstract：:Blocking activity of mouse pregnancy serum was investigated using a well defined one-way mixed lymphocyte culture and a cell-mediated microcytotoxicity test. Allogeneic (C57BL (H-2b) X CBA/Ca (H-2k)) and syngeneic (C57BL (H-2b) X C57BL (H-2b)) pregnancy and postpartum sera were found to stimulate rather than inhibit t...

journal_title：Transplantation

authors： Smith G

更新日期：1978-11-01 00:00:00

abstract：BACKGROUND:One method of countering chronic lung donor shortages is the practice of donation after cardiac death (DCD). However, this technique inevitably leads to pulmonary dysfunction related to warm ischemia. One promising method of alleviating this problem is ventilation. However, it can rarely be initiated from th...

journal_title：Transplantation

authors： Sakamoto J,Chen F,Yamada T,Nakajima D,Ohsumi A,Kikuchi R,Zhao X,Fujinaga T,Shoji T,Sakai H,Bando T,Date H

更新日期：2011-10-27 00:00:00

abstract：:Acute rejection is a frequent cause of early graft dysfunction in renal transplantation, and serum creatinine is the most important measure of clinical response. However, there is little information on serum creatinine during rejection episodes. In this study, the determinants that might influence the clinical respons...

journal_title：Transplantation

authors： Nankivell BJ,Allen RD,O'Connell PJ,Chapman JR

更新日期：1995-07-15 00:00:00

abstract：:To determine if cold preservation time continues to affect renal transplant outcome, prospectively collected data from 17,937 cadaveric renal transplants performed between 1982 and 1991 were analyzed. Cold preservation intervals of 1-16, 16-32, 32-48, and greater than 48 hr were studied by multi- and univariate method...

journal_title：Transplantation

authors： Peters TG,Shaver TR,Ames JE 4th,Santiago-Delpin EA,Jones KW,Blanton JW

更新日期：1995-01-27 00:00:00

abstract：BACKGROUND:De novo donor HLA-specific (dnDSA) and non-HLA antibodies including antiangiotensin type 1 receptor antibodies (AT1R-abs) have been associated with antibody-mediated rejection (AMR) and decreased graft survival as well as cellular-mediated rejection (CMR) and early onset of microvasculopathy in heart transpl...

journal_title：Transplantation

authors： Reinsmoen NL,Lai CH,Mirocha J,Cao K,Ong G,Naim M,Wang Q,Haas M,Rafiei M,Czer L,Patel J,Kobashigawa J

更新日期：2014-03-15 00:00:00

abstract：:We initiated a policy of using RSLT in critically ill patients in June of 1988. Since that time we have performed 30 RSLTs in 29 patients, including 28 children and 1 adult. The mean age of the children was 27 months (range 1 month to 10 years) with 14 (52%) being 1 year of age or less. The mean weight was 11.3 kg (ra...

journal_title：Transplantation

authors： Langnas AN,Marujo WC,Inagaki M,Stratta RJ,Wood RP,Shaw BW Jr

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Long-term results of prospective randomized trials comparing triple immunosuppressive strategies combining tacrolimus (TAC) or cyclosporine A (CsA) with mycophenolate mofetil (MMF) and steroids after heart transplantation (HTX) are rarely published. Therefore, we collected long-term follow-up data of an inte...

journal_title：Transplantation

authors： Guethoff S,Meiser BM,Groetzner J,Eifert S,Grinninger C,Ueberfuhr P,Reichart B,Hagl C,Kaczmarek I

更新日期：2013-02-27 00:00:00

abstract：:Sprague-Dawley rats were treated for 14 days with rapamycin (RAP; 1.5 mg/kg/day i.p.), cyclosporine (15 mg/kg/day by gavage), both drugs in combination, or appropriate drug vehicles. Hematological parameters and biochemical indices of renal and hepatic function were determined throughout the experimental period, at th...

journal_title：Transplantation

authors： Whiting PH,Woo J,Adam BJ,Hasan NU,Davidson RJ,Thomson AW

更新日期：1991-08-01 00:00:00

abstract：:A technique for orthotopic bone transplantation in mice has been developed. A section of recipient tibia was removed and replaced by a similar section from the donor animal. The graft was held in place by internal fixation. Bone healing was assessed clinically, histologically, radiologically, and by torsion testing. T...

journal_title：Transplantation

authors： Halloran PF,Ziv I,Lee EH,Langer F,Pritzker KP,Gross AE

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:Although the outcome of islet transplantation has improved, there remains a major obstacle in isolating viable islets from prolonged preserved pancreas. We previously reported that the two-layer cold storage method (TLM) improved the yield and in vitro function. In this study, we performed in vivo accurate f...

journal_title：Transplantation

authors： Kakinoki K,Fujino Y,Suzuki Y,Li S,Tanioka Y,Sakai T,Kuroda Y

更新日期：2005-06-15 00:00:00

abstract：:Pre-existing alloantibodies against the mismatched HLA-A and HLA-B antigens of the donor, when present in current sera, are believed to be detrimental to kidney graft survival. When these antibodies are present only in historical sera, their immunoglobulin class has reported to be important with respect to the expecte...

journal_title：Transplantation

authors： Roelen DL,van Bree J,Witvliet MD,Habraken I,van Beelen E,van't Sant PH,de Waal LP,van Rood JJ,Claas FH

更新日期：1994-05-15 00:00:00

abstract：:Natural suppressor (NS) activity is detected in tissues undergoing intense hematopoietic regeneration. This includes the spleens of mice recovering from total lymphoid irradiation or cyclophosphamide treatment, or after induction of chronic graft-versus-host disease against minor histocompatibility antigens. NS cells ...

journal_title：Transplantation

authors： Schreiber KL,Forman J

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Tacrolimus pharmacokinetic characteristics vary greatly among individuals. Tacrolimus is a substrate of cytochrome p450 (CYP), of subfamily CYP3A. CYP3A activity is the sum of the activities of the family of CYP3A genes, including CYP3A5. Subjects with the CYP3A5*1/*1 genotype express large amounts of CYP3A5...

journal_title：Transplantation

authors： Thervet E,Anglicheau D,King B,Schlageter MH,Cassinat B,Beaune P,Legendre C,Daly AK

更新日期：2003-10-27 00:00:00

abstract：BACKGROUND:PG490-88, a semisynthetic derivative of a novel compound PG490 (triptolide) purified from a Chinese herb (Tripterygium wilfordii Hook F), is effective in prevention of murine graft-versus-host disease (GVHD). METHODS:PG490-88 was administrated into recipients in a model (B10.D2 [H2d, Mls-2b, Mls-3b]-->BALB/...

journal_title：Transplantation

authors： Chen BJ,Chen Y,Cui X,Fidler JM,Chao NJ

更新日期：2002-01-15 00:00:00

abstract：:The effect of FK506 and cyclosporine on NK and ADCC activity was evaluated. Cytotoxic cells mediating both activities are resistant to FK506. In contrast, preincubation of ADCC and NK effectors with cyclosporine decreases their cytotoxic potential, while adding the drug to the assays is without effect. ...

journal_title：Transplantation

authors： Wasik M,Gorski A,Stepien-Sopniewska B,Lagodzinski Z

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:CD154 mediates key facets of humoral and cellular immunity to alloantigens, and is tolerogenic to influenza antigens in primates. Barriers to CD154-based tolerance induction for primate cardiac allografts have not previously been defined. METHODS:Heterotopic cardiac allograft outcomes in cynomolgus monkeys ...

journal_title：Transplantation

authors： Azimzadeh AM,Pfeiffer S,Wu G,Schröder C,Zorn GL 3rd,Kelishadi SS,Ozkaynak E,Kehry M,Atkinson JB,Miller GG,Pierson RN 3rd

更新日期：2006-01-27 00:00:00

abstract：BACKGROUND:This study addresses the question of the mechanism for maintaining tolerance to donor alloantigen in the absence of antigen and the role of secondary lymphoid tissues. METHODS:Depleting anti-CD4 antibody administration in conjunction with allogeneic heart transplantation generates donor-specific operational...

journal_title：Transplantation

authors： Chosa E,Hara M,Watanabe A,Matsuzaki Y,Nakamura K,Hamano K,Wood KJ,Onitsuka T

更新日期：2007-05-15 00:00:00

abstract：:The aim of this study was to analyze, in heart transplant patients, if renal function improvement after cyclosporine replacement by everolimus persists at the middle term and its predictors. We studied prospectively 56 patients in whom conversion was consecutively made. Forty-five patients completed the follow-up peri...

journal_title：Transplantation

authors： Moro López JA,Almenar L,Martínez-Dolz L,Sánchez-Lázaro I,Agüero J,Buendía F,Ortiz V,Salvador A

更新日期：2009-02-27 00:00:00

abstract：:Renal transplantation is the preferred treatment for end-stage renal disease in children. Most transplant failures are due to allograft rejection. To date, only histopathological findings on renal biopsy can establish this diagnosis. Prior to the availability of cyclosporine, technetium-99m sulfur colloid nuclear scan...

journal_title：Transplantation

authors： Massengill SF,Pena DR,Drane WE,Fennell RS,Richard GA

更新日期：1992-12-01 00:00:00

abstract：:Serum IgA levels were monitored at 3, 6, 12, and 24 months after BMT in 131 allogeneic and 3 syngeneic bone marrow transplant recipients. In general, IgA levels were low during the first 6 months and did not return to normal levels until 1-2 years after transplantation. Children (less than 15 years) had lower IgA leve...

journal_title：Transplantation

authors： Abedi MR,Hammarström L,Ringdén O,Smith CI

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:The long-term outcome of simultaneous kidney pancreas transplant recipients is not well established. METHODS:We retrospectively reviewed all patients who underwent simultaneous kidney-pancreas transplantation with bladder drainage at our center between January 1989 and December 1991. A total of 57 patients ...

journal_title：Transplantation

authors： Sudan D,Sudan R,Stratta R

更新日期：2000-02-27 00:00:00

abstract：:The CD154-CD40 pathway is one of the critical costimulatory pathways that are required for full activation of T cells during alloimmune responses. Blockade of this pathway with anti-CD154 antibodies has been reported to prolong allograft survival in experimental transplantation models and to induce tolerance in some i...

journal_title：Transplantation

authors： Yamada And A,Sayegh MH

更新日期：2002-01-15 00:00:00

abstract：OBJECTIVE:The aim of this prospective, multicenter, noncomparative, open-label trial was to evaluate the prophylactic use of caspofungin in adult liver transplant recipients at high risk of developing invasive fungal infections (IFI). METHODS:Patients received caspofungin for at least 21 days. A successful treatment o...

journal_title：Transplantation

authors： Fortún J,Martín-Dávila P,Montejo M,Muñoz P,Cisneros JM,Ramos A,Aragón C,Blanes M,San Juan R,Gavaldá J,Llinares P,GESITRA Study Group.

更新日期：2009-02-15 00:00:00

abstract：:Patients undergoing primary cadaveric kidney transplantation were followed for 1 year as part of a phase II, multicenter, open-label concentration-ranging trial of FK506 and cyclosporine. One hundred twenty patients were randomly assigned to a cyclosporine-based regimen or one of three FK506-based regimens designed to...

journal_title：Transplantation

authors： Vincenti F,Laskow DA,Neylan JF,Mendez R,Matas AJ

更新日期：1996-06-15 00:00:00

abstract：BACKGROUND:Waiting time to deceased donor kidney transplant varies greatly across the United States. This variation violates the final rule, a federal mandate, which demands geographic equity in organ allocation for transplantation. METHODS:Retrospective analysis of the United States Renal Data System and United Netwo...

journal_title：Transplantation

authors： Davis AE,Mehrotra S,McElroy LM,Friedewald JJ,Skaro AI,Lapin B,Kang R,Holl JL,Abecassis MM,Ladner DP

更新日期：2014-05-27 00:00:00

abstract：:Significant extended survival of C3H/He skin grafts in antilymphocyte serum (ALS)-treated B6AF1 mice can be brought about by the injection of donor-strain bone marrow on day 6 or 7 after grafting. In the present study, survival of the active graft-prolonging bone marrow cells under several storage conditions was inves...

journal_title：Transplantation

authors： De Fazio SR,Hartner WC,Monaco AP,Gozzo JJ

更新日期：1986-01-01 00:00:00