Effect of preprocurement ventilation on lungs donated after cardiac death in a canine lung transplantation model.

abstract：BACKGROUND:DBA/2J kidney allografts, but not heart allografts, are spontaneously accepted indefinitely in C57BL/6 (B6) mice, through regulatory tolerance mechanism dependent on Foxp3 cells. In contrast, B6 kidneys are rejected within a week in DBA/2J recipients. We hypothesized that the tolerogenic difference of the ki...

journal_title：Transplantation

authors： Oh NA,O'Shea T,Ndishabandi DK,Yuan Q,Hong S,Gans J,Ge J,Gibney S,Chase C,Yang C,Rosales I,Shinoda K,Drew B,Kojima L,Russell PS,Madsen JC,Colvin RB,Alessandrini A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Historically, ex vivo physiological evaluation of cadaveric renal allografts has been limited to assessing perfusate flow (PF) during hypothermic perfusion preservation (HPP). Using a small animal model, we have previously described a method for continuous monitoring of glomerular filtration rate (GFR) durin...

journal_title：Transplantation

authors： Inman SR,Osgood RW,Plott WK,Richardson BF,Lewis RM

更新日期：1999-11-27 00:00:00

abstract：:Nonmajor histocompatibility complex (non-MHC) antigens are important targets of graft rejection and graft-versus-host disease in clinical transplantation. Little is known regarding immunity to non-MHC antigens. To study this problem we evaluated the effect of antihuman thymocyte globulin (ATG) on reactivity in autolog...

journal_title：Transplantation

authors： Harada M,Gale RP

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...

journal_title：Transplantation

authors： Arnault I,Bao YM,Sebagh M,Anjo A,Dimicoli JL,Lemoine A,Delvart V,Adam R

更新日期：2003-07-15 00:00:00

abstract：:We have analyzed HLA data from the UNOS registry on 20,230 patients on the renal waiting list in 1991 and 18,708 donors from 1988-1992. Significant differences were found in the distribution of HLA antigens for comparisons of the total donor pool and the various racial groups of patients as well as for inter- and intr...

journal_title：Transplantation

authors： Leffell MS,Steinberg AG,Bias WB,Machan CH,Zachary AA

更新日期：1994-11-27 00:00:00

abstract：:The applicability of laparoscopic donor nephrectomy (LDN) has not been assessed in the obese donor. We hypothesized that obesity is not a technical contraindication to LDN. From May 1998 to February 1999, 40 patients underwent LDN at the Georgetown Transplant Institute with the transperitoneal technique. Prophylaxis a...

journal_title：Transplantation

authors： Kuo PC,Plotkin JS,Stevens S,Cribbs A,Johnson LB

更新日期：2000-01-15 00:00:00

abstract：BACKGROUND:Solitary pancreas transplants, both pancreas transplant alone (PTA) and pancreas after kidney (PAK), have higher rejection rates and lower graft survivals than simultaneous pancreas-kidney transplants (SPK). The aim of this study is to compare three different antibody induction regimens in solitary pancreas ...

journal_title：Transplantation

authors： Stegall MD,Kim DY,Prieto M,Cohen AJ,Griffin MD,Schwab TR,Nyberg SL,Velosa JA,Gloor JM,Innocenti F,Bohorquez H,Dean PG,Carpenter HA,Leontovich ON,Sterioff S,Larson TS

更新日期：2001-11-27 00:00:00

abstract：:Prominent components of vascularized xenograft rejection such as platelet activation and microvascular thrombosis may be dependent upon thrombin generation in vivo. To study potential therapeutic benefits of a synthetic low-molecular-weight thrombin inhibitor, SDZ MTH 958, in hyperacute porcine heart rejection by huma...

journal_title：Transplantation

authors： Robson SC,Young VK,Cook NS,Metternich R,Kasper-Konig W,Lesnikoski BA,Pierson RN 3rd,Hancock WW,Candinas D,White DJ,Bach FH

更新日期：1996-03-27 00:00:00

abstract：:Adhesion of leukocytes to vascular endothelium is a necessary step leading to the migration of cells into underlying tissues. Vascular adhesion molecules regulate this process and may play an important role in graft rejection. Immunocytochemical studies have been used to investigate the expression of vascular adhesion...

journal_title：Transplantation

authors： Taylor PM,Rose ML,Yacoub MH,Pigott R

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Cidofovir has antiviral activity against a wide spectrum of DNA viruses. Several small studies have focused on the efficacy of topical cidofovir in various viral-induced diseases. We report a systemic complication of such therapy. CASE REPORT:A bone marrow transplant recipient with chronic renal failure dev...

journal_title：Transplantation

authors： Bienvenu B,Martinez F,Devergie A,Rybojad M,Rivet J,Bellenger P,Morel P,Gluckman E,Lebbé C

更新日期：2002-02-27 00:00:00

abstract：:Gliotoxin is an immunosuppressive secondary metabolite produced by several pathogenic fungi. It has previously been shown to prevent graft-versus-host disease in transplantation of allogeneic mouse bone marrow and to reduce the immunogenicity of human fetal pancreas. We here report on the effect of gliotoxin on the pr...

journal_title：Transplantation

authors： Sutton P,Moreland A,Hutchinson IV,Müllbacher A

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:Infections and acute graft-versus-host disease (GvHD) represent major complications of allogeneic stem-cell transplantation (SCT). Dendritic cells (DCs) display an extraordinary capacity to induce innate and adaptive immune responses. Therefore, they play a crucial role in the elimination of pathogens and in...

journal_title：Transplantation

authors： Mager K,Wehner R,Bahr F,Oelschlägel U,Platzbecker U,Wermke M,Shayegi N,Middeke JM,Radke J,Röllig C,Schetelig J,Thiede C,Ehninger G,Schmitz M,Bornhäuser M,Tuve S

更新日期：2012-06-27 00:00:00

abstract：:Until 1996, living kidney donation had been neglected in Germany. To encourage potential donors and to convince them that nephrectomy is not too risky for a healthy person, the author decided to set an example with a personal nondirected donation. This donation, controversially discussed in the public domain, neverthe...

journal_title：Transplantation

authors： Hoyer J

更新日期：2003-10-27 00:00:00

abstract：BACKGROUND:Cardiac allograft vasculopathy (CAV) has an incidence of 43% at 8 years after heart transplantation with extremely limited treatment options and unclear pathogenesis. CAV constitutes a significant complication that limits the long-term survival of heart recipients. Insulin-like growth factor-1 (IGF-1) is ass...

journal_title：Transplantation

authors： Aharinejad S,Salama M,Rödler S,Ehrlich M,Zuckermann A,Laufer G

更新日期：2012-02-15 00:00:00

abstract：:The lung is one of the primary targets of acute graft-versus-host disease (GVHD), which is the principal complication that occurs after allogeneic intestinal transplantation. The purpose of this study is to investigate the involvement of Fas/Fas ligand system in pulmonary injury after rat semi-allogeneic intestinal tr...

journal_title：Transplantation

authors： Hiroyasu S,Shiraishi M,Koji T,Mamadi T,Sugawa H,Tomori H,Muto Y

更新日期：1999-10-15 00:00:00

abstract：:CD18 antibodies react with the common beta chain of the human leukocyte function antigen (LFA1)* and thus block the functions mediated by the three identified molecules in humans. A murine CD18 monoclonal antibody was infused in 8 leukemic patients receiving allogeneic T-depleted bone marrow transplantation in order t...

journal_title：Transplantation

authors： Baume D,Kuentz M,Pico JL,Beaujean F,Cordonnier C,Vernant JP,Hayat M,Bernard A

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:The growing number of patients awaiting a kidney transplant raises questions about allocation of kidneys to the elderly and about the use of elderly donors. In all reported studies analyzing the influence of age on the outcome after renal transplantation, age is investigated as a categorical variable. METHO...

journal_title：Transplantation

authors： Roodnat JI,Zietse R,Mulder PG,Rischen-Vos J,van Gelder T,IJzermans JN,Weimar W

更新日期：1999-02-27 00:00:00

abstract：:The rat aortic transplant model was modified to investigate whether the vascular wall changes on chronic rejection are reversible. DA (RT1a) aortas were first transplanted to WF (RT1a) recipients. The first transplantation was accompanied, as described earlier, by an increase in intimal cellularity and thickness and t...

journal_title：Transplantation

authors： Mennander A,Häyry P

更新日期：1996-08-27 00:00:00

abstract：:The use of real-time reverse transcription polymerase chain reaction to compare gene expression in different tissues and conditions requires normalization to an internal control that must be expressed at a constant level. Although a previous validation step is required to confirm that an internal control is appropriat...

journal_title：Transplantation

authors： Rodriguez-Mulero S,Montanya E

更新日期：2005-09-15 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) induction on hepatocytes was investigated in relation to acute liver allograft rejection, CMV infection, and systemic bacterial infections. Twenty-four liver transplant recipients underwent an episode of acute rejection, 13 developed a symptomatic clinical CMV infection, and ...

journal_title：Transplantation

authors： Lautenschlager IT,Höckerstedt KA

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Suppressive dendritic cells (DCs) are a promising tool for tolerance induction in transplantation. A human DCs subpopulation, which constitutively expresses indoleamine-2,3-dioxygenase (IDO), a molecule shown to prevent the rejection of fetus during pregnancy, has recently been described. This subset, charac...

journal_title：Transplantation

authors： Löb S,Ebner S,Wagner S,Weinreich J,Schäfer R,Königsrainer A

更新日期：2007-02-27 00:00:00

abstract：BACKGROUND:Currently, many transplantation centers do not follow former living kidney donors on a long-term basis. Several potential barriers have been identified to provide this follow-up of former living kidney donors, including concerns that donor insurance will not reimburse transplantation centers or primary care ...

journal_title：Transplantation

authors： Kher A,Rodrigue J,Ajaimy M,Wasilewski M,Ladin K,Mandelbrot D

更新日期：2012-11-27 00:00:00

abstract：:Graft-versus-host disease (GVHD)* is a frequent complication of allogeneic bone marrow transplantation. The potentially beneficial effect of phototherapy for treatment of cutaneous manifestations of GVHD led us to investigate retrospectively the effect of this therapy in a larger series of patients. Eleven patients wi...

journal_title：Transplantation

authors： Aubin F,Brion A,Deconinck E,Plouvier E,Hervé P,Humbert P,Cahn JY

更新日期：1995-01-15 00:00:00

abstract：:Enhancement of skin grafts in mice by passively administered alloantiserum was examined in conjunction with the simultaneous use of other immunosuppressive regimens. It could be clearly shown that when a "weak" antilymphocyte serum (ALS) was used, a significant further prolongation of graft survival occurred over that...

journal_title：Transplantation

authors： Koene RA,Gerlag PG,McKenzie IF,Hagemann JF,Wijdeveld PG

更新日期：1975-09-01 00:00:00

abstract：:The aim of this study was to assess the feasibility of detecting anti-HLA antibodies in eluates from needle core biopsies of renal transplants with chronic allograft nephropathy. Two methods of screening, the enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FlowPRA) were compared. Twenty renal transplants...

journal_title：Transplantation

authors： Martin L,Guignier F,Bocrie O,D'Athis P,Rageot D,Rifle G,Justrabo E,Mousson C

更新日期：2005-05-27 00:00:00

abstract：:Preformed recipient HLA-specific antibodies can cause hyperacute rejection of a transplanted kidney if they are directed against mismatched donor HLA antigens. To avoid hyperacute rejection it is essential that recipient antibodies be identified during patient workup for transplantation and HLA antigens to which a pat...

journal_title：Transplantation

authors： Martin S

更新日期：2001-05-27 00:00:00

abstract：BACKGROUND:It remains unknown whether low-grade hyperparathyroidism persisting beyond the first year postrenal transplantation has any impact on bone density. METHODS:Parathyroid hormone (PTH), glomerular filtration rate (GFR), and bone density (by dual-energy x-ray absorptiometry [DXA]) were monitored in the follow-u...

journal_title：Transplantation

authors： Akaberi S,Lindergård B,Simonsen O,Nyberg G

更新日期：2006-09-27 00:00:00

abstract：:The aim of this study was to assess the efficacy of an enteral diet fortified with arginine, RNA, and fish oil (Impact), alone and in combination with cyclosporine (CsA) and donor-specific transfusion (DST) on allograft survival in the ACI:Lewis rat cardiac transplant model. Animals were fed ad libitum with either sta...

journal_title：Transplantation

authors： Levy AE,Alexander JW

更新日期：1995-10-27 00:00:00

abstract：BACKGROUND:Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could...

journal_title：Transplantation

authors： Ryan JB,Hicks M,Cropper JR,Garlick SR,Kesteven SH,Wilson MK,Feneley MP,Macdonald PS

更新日期：2003-03-15 00:00:00

abstract：BACKGROUND:The short tolerable cold ischemia time and the importance of other risk factors have generally superseded the role of HLA matching in the allocation of donor hearts. Recent advances in the accuracy and time required to perform HLA typing and crossmatching, however, have led us to re-examine the United Networ...

journal_title：Transplantation

authors： Thompson JS,Thacker LR 2nd,Takemoto S

更新日期：2000-05-27 00:00:00