Abstract:
BACKGROUND:There is an increasing appreciation of the deleterious effects of antibody and B cells on acute and chronic transplant outcomes. Many effector functions of antibody are mediated by a family of receptors (FcγRs) that are expressed on most immune cells, including neutrophils, natural killer cells, and B cells. Most FcγRs are activating and controlled by a single inhibitory receptor, FcγRIIB (CD32B), which also regulates some aspects of B-cell activation and antibody production. FcγRIIB-deficient mice develop severe chronic arteriopathy in a murine cardiac allograft model. A single nucleotide polymorphism in human FcγRIIB (rs1050501) results in profound receptor dysfunction and is associated with systemic lupus erythematosus. The frequency of this FcγRIIB-I/T232 polymorphism also shows significant racial variation. METHODS:In the present study, we sought to determine whether the FcγRIIB-I/T232 single nucleotide polymorphism rs1050501 affected susceptibility to renal allograft rejection or loss and transplant recipient survival. FcγRIIB-I/T232 genotype was determined in 2,851 Caucasian and 570 Afro-Caribbean renal transplant recipients, and in 236 transplant recipients with a primary diagnosis of systemic lupus erythematosus, all of whom were enrolled into the Collaborative Transplant Study. RESULTS:We found no significant difference in pretransplant panel reactive antibodies, acute rejection at 1-year nor in 10-year transplant or patient survival in individuals with differing FcγRIIB-I/T232 genotype. CONCLUSION:This negative result is surprising, given the importance of this receptor in modulating antibody effector function.
journal_name
Transplantationjournal_title
Transplantationauthors
Clatworthy MR,Matthews RJ,Doehler B,Willcocks LC,Opelz G,Smith KGCdoi
10.1097/TP.0000000000000287subject
Has Abstractpub_date
2014-08-15 00:00:00pages
285-291issue
3eissn
0041-1337issn
1534-6080journal_volume
98pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Malnutrition is common in patients with end-stage liver disease considered for transplantation, but it is unclear whether this affects the outcome after transplantation. AIM.: To determine whether the severity of malnutrition in liver transplant candidates affects outcome after transplantation. METHODS:We d...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000150022.64564.c2
更新日期:2005-02-15 00:00:00
abstract::A patient with end-stage renal disease and known benign monoclonal gammopathy underwent kidney transplantation at Westchester County Medical Center, Valhalla, NY. After surgery, during routine follow-up, the patient had laboratory evidence of frank multiple myeloma. However, she did not show any clinical signs or symp...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/00007890-199612150-00008
更新日期:1996-12-15 00:00:00
abstract::The aim of this study was to analyze, in heart transplant patients, if renal function improvement after cyclosporine replacement by everolimus persists at the middle term and its predictors. We studied prospectively 56 patients in whom conversion was consecutively made. Forty-five patients completed the follow-up peri...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31819452ce
更新日期:2009-02-27 00:00:00
abstract::It has been reported that the response to alloantigens presented by the direct and indirect pathway may be of differential relevance after human kidney transplantation. Accordingly, we monitored these routes in peripheral blood mononuclear cells (PBMC) of heart transplant patients from before transplantation and up to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601150-00033
更新日期:1996-01-15 00:00:00
abstract:BACKGROUND:Preemptive therapy of human cytomegalovirus (HCMV) infections has gained popularity in transplantation centers. However, standardized protocols are not available. In particular, whether a qualitative molecular assay for detection of a late (pp67) HCMV mRNA represents a valuable alternative to quantitative an...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.TP.0000057239.32192.B9
更新日期:2003-04-15 00:00:00
abstract:BACKGROUND:Urothelial carcinoma (UC) is a common complication after renal replacement therapy (RRT) among Chinese end-stage renal disease (ESRD) patients. It is unclear whether there are any differences in the clinicopathologic characteristics of UC between renal transplantation (RT) and dialysis patients; such differe...
journal_title:Transplantation
pub_type: 杂志文章,收录出版
doi:10.1097/TP.0000000000000112
更新日期:2014-09-15 00:00:00
abstract::Unilateral, intraorganal injection of parental lymph node cells into thyroid lobes of F1 hybrid rats elicited an intense, local graft-versus-host reaction within the injected lobes containing massive numbers of lymphocytes. Surprisingly, significant mononuclear cell infiltration was also seen within the contralateral ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197805000-00003
更新日期:1978-05-01 00:00:00
abstract::The aim of this study was to investigate the combined effect of DLA matching and immunosuppressive therapy on the survival of segmental small-bowel allografts in dogs. Orthotopic segmental small-bowel transplantations (25 to 30% of total small bowel length) were performed in two stages: first a heterotopic segmental s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199311000-00002
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:In France, the need for continuous monitoring of transplant center performance has recently become apparent. Cumulative sum (CUSUM) monitoring of transplantation is already been used to monitor transplant outcomes in the United Kingdom and in the United States. Because CUSUM monitoring can be applied by diff...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002591
更新日期:2019-09-01 00:00:00
abstract::Hamster hearts transplanted into stable rat recipients of hamster livers (OLT rats) were hyperacutely rejected after transfer with unaltered rat antihamster hyperimmune serum (HS). This was followed by immediate liver xenograft rejection in 4 of 5 rats. In contrast, simple heat inactivation of the rat HS resulted in p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199403270-00025
更新日期:1994-03-27 00:00:00
abstract::Using C1q binding, Kg binding, and Raji cell radioimmunoassays, the relationship between renal allograft rejection and the circulating immune complexes was examined in 90 patients with renal transplants. The data showed that there was a significant quantitative correlation between C1q-binding and Raji-cell-binding act...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198308000-00009
更新日期:1983-08-01 00:00:00
abstract::HLAs are fundamental to the adaptive immune response and play critical roles in the cellular and humoral response in solid organ transplantation. The genes encoding HLA proteins are the most polymorphic within the human genome, with thousands of different allelic variants known within the population. Application of th...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001830
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Translational research in a relevant preclinical model is recommended before Treg-inducing protocols can be implemented in humans. We have characterized rhesus monkey CD25 cells phenotypically and functionally. METHODS:The phenotype of CD4(+)CD25(high) cells was determined by FACS, focusing on established m...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31816b15b9
更新日期:2008-04-27 00:00:00
abstract:BACKGROUND:Preconditioning protects against both liver and lung damage after hepatic ischemia-reperfusion (I/R). Xanthine and xanthine oxidase (XOD) may contribute to the development of hepatic I/R. OBJECTIVE:To evaluate whether preconditioning could modulate the injurious effects of xanthine/XOD on the liver and lung...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200204270-00004
更新日期:2002-04-27 00:00:00
abstract:BACKGROUND:Strong alloreactive T cell responses are a menace in transplantation surgery and their menagement requires understanding the basis of alloreactivity. Alloantigen recognition can be peptide independent, peptide specific, or peptide dependent. The mechanisms influencing each recognition pattern are largely unk...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200203150-00024
更新日期:2002-03-15 00:00:00
abstract::Rabbit antisera to rat thoracic duct lymphocytes were examined by absorption analysis with quantitative radioimmunoassays to determine the tissue distribution of the antigens recognised and the amount of antibody against different specificities. Seven of eight sera were remarkably specific for leucocytes and one serum...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00009
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:Generation of non-human primate regulatory T cells (Treg) with alloantigen (alloAg) specificity would allow their testing in preclinical transplant models. Low recovery of Treg from peripheral blood limits their potential utility. In small animals and humans, conventional myeloid dendritic cells (DC) have be...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181ba6b1f
更新日期:2009-11-15 00:00:00
abstract::Apoptotic cells are endowed with immunomodulatory properties. The authors propose infusing apoptotic cells as a cell-based therapy product to facilitate allogeneic hematopoietic engraftment after a nonmyeloablative conditioning regimen. Such an approach may be used to obtain macrochimerism in combined hematopoietic ce...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000067951.90241.54
更新日期:2003-05-15 00:00:00
abstract:BACKGROUND:Human leukocyte antigen (HLA) antibodies produced after transplantation are frequently measured in transplant recipients, because they are strongly associated with humoral rejection and graft loss. However, antibodies can be induced by posttransplant blood transfusions rather than by the graft, casting doubt...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a24b96
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:Both chemokines and adhesion molecules mediate allograft rejection by recruiting leukocytes into the allograft. We investigated the association of six single nucleotide polymorphisms (SNPs) located in interleukin (IL)-8, CXCR1, CXCR2, and selectin with kidney allograft outcomes. METHODS:The promoter regions...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/tp.0b013e3181fd0195
更新日期:2011-01-15 00:00:00
abstract:BACKGROUND:Composite tissue allotransplantation (CTA) is a recently introduced option for limb replacement and reconstruction of other nonreconstructible tissue defects. As with recipients of other allotransplants, CTA recipients can experience rejection episodes that are presumed to be mediated by immune mechanisms si...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2005-12-27 00:00:00
abstract:BACKGROUND:Sensitization to human leukocyte antigens (HLA) is a significant barrier to transplantation. Currently, no proven therapy exists to improve access to transplantation for highly sensitized patients. Here, we report a novel approach using intravenous immune globulin to modulate anti-HLA antibody and improve th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000080685.31697.FC
更新日期:2003-08-27 00:00:00
abstract:BACKGROUND:Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000054619.13962.30
更新日期:2003-03-15 00:00:00
abstract::In a cross-sectional survey of the quality of life of 45 liver transplant recipients, physical and psychological status, physical complaints, capability to participate in daily life, social support, and global quality of life were assessed. The average time of follow-up was 9 months after transplantation. Nine patient...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199309000-00013
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Intracellular concentration of reactive oxygen species is held within tight physiological limits by enzymes with scavenging and repair functions. Under extreme conditions such as prolonged cold ischemia, these enzymes may be unable to adequately protect the organ, resulting in reperfusion injury that renders...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200209270-00013
更新日期:2002-09-27 00:00:00
abstract:BACKGROUND:In a pilot trial we evaluated the toxicity and efficacy of sirolimus (rapamycin) as second-line therapy for the treatment of acute graft-versus-host disease (GVHD) in 21 patients (1-46 years of age) after allogeneic hematopoietic stem cell transplantation (HSCT). METHODS:All patients were treated with methy...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200112270-00010
更新日期:2001-12-27 00:00:00
abstract::We have recently shown that a single intrathymic injection of synthetic 25mer peptides, representing full sequences of the hypervariable domain of RT1.BuB (4 peptides) and RT1.Du beta (4 peptides) WF class II MHC molecules, 48 hr before transplantation induces donor-specific unresponsiveness to WF rat renal allografts...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1994-07-27 00:00:00
abstract:BACKGROUND:Some statins have been reported to suppress the immune system and increase the expression of bone morphogenetic protein-2 gene that plays a pivotal role in bone regeneration. METHODS:The effects of cerivastatin on skeletal reconstruction by vascularized bone allograft were investigated in a rat tibia-fibula...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000074992.49236.58
更新日期:2003-09-15 00:00:00
abstract:BACKGROUND:Bioluminescence imaging (BLI) modalities are being developed to monitor islet transplant mass and function in vivo. The aim of this study was to use the BLI system to determine how the change in functional islet mass correlated to metabolic abnormalities during the course of alloimmune rejection in a murine ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000206109.71181.bf
更新日期:2006-05-27 00:00:00
abstract::Cyclosporine (CsA) is an immunosuppressive drug requiring dose individualization and regular control due to its highly variable pharmacokinetics. Since gastroparesis may influence the absorption of CsA, a randomized cross-over study was performed to assess the pharmacokinetics and tolerability of a novel microemulsion...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007890-199608270-00006
更新日期:1996-08-27 00:00:00