HLA Population Genetics in Solid Organ Transplantation.

abstract：:Antihuman lymphocyte rabbit (or horse) gamma globulins used in recipients of organ transplantation are prepared against thymocytes or immortalized cell lines, the only two sources so far allowing enough antigen preparation. These cells lack, however, the surface determinants characteristic of alloreactive blasts invol...

journal_title：Transplantation

authors： Bonneville M,Carcagne J,Vie H,Moreau JF,Chevalier S,Latour M,Carosella E,Soulillou JP

更新日期：1989-08-01 00:00:00

abstract：:Pancreas transplantation utilizing portal venous and enteric exocrine drainage has potential benefits over the standard systemic venous and bladder exocrine drainage method. Unfortunately, technical difficulties are often experienced with the arterial anastomosis after the portal venous anastomosis is completed. We ha...

journal_title：Transplantation

authors： Bigam DL,Hemming AW,Sanabria JR,Cattral MS

更新日期：1999-07-27 00:00:00

abstract：:A panel of ethicists, organ procurement organization executives, physicians, and surgeons was convened by the sponsorship of the American Society of Transplant Surgeons to determine whether an ethically acceptable pilot trial could be proposed to provide a financial incentive for a family to consent to the donation of...

journal_title：Transplantation

authors： Arnold R,Bartlett S,Bernat J,Colonna J,Dafoe D,Dubler N,Gruber S,Kahn J,Luskin R,Nathan H,Orloff S,Prottas J,Shapiro R,Ricordi C,Youngner S,Delmonico FL

更新日期：2002-04-27 00:00:00

abstract：:Programmed cell death (PCD) is currently one of the most intensively studied areas in cell biology. Substantial evidence now exists demonstrating the integral role of PCD in many fundamental immunologic processes; therefore, understanding the mechanisms of PCD may provide advances with broad implications in immunobiol...

journal_title：Transplantation

authors： Woodle ES,Kulkarni S

更新日期：1998-09-27 00:00:00

abstract：BACKGROUND:Most transplant centers in the United States, including our own, use creatinine clearance (Ccr) to estimate glomerular filtration rate (GFR) in potential living kidney donors. The purpose of this study was to evaluate our experience with estimation of donor GFR by Ccr and to explore other potential strategie...

journal_title：Transplantation

authors： Bertolatus JA,Goddard L

更新日期：2001-01-27 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) induction on hepatocytes was investigated in relation to acute liver allograft rejection, CMV infection, and systemic bacterial infections. Twenty-four liver transplant recipients underwent an episode of acute rejection, 13 developed a symptomatic clinical CMV infection, and ...

journal_title：Transplantation

authors： Lautenschlager IT,Höckerstedt KA

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Prophylactic ganciclovir (GCV) is used in high-risk renal transplant patients to prevent acute cytomegalovirus (CMV) disease, but its impact on inflammation within the allograft itself remains undefined. METHODS:To study the effect of GCV prophylaxis on allograft inflammation, murine CMV (MCMV)-infected all...

journal_title：Transplantation

authors： Shimamura M,Saunders U,Rha B,Guo L,Cassady KA,George JF,Britt WJ

更新日期：2011-10-15 00:00:00

abstract：BACKGROUND:Chronic allograft nephropathy (CAN) is the most common cause of long-term renal-allograft dysfunction and the second most common cause of transplant loss. There are concerns that prolonged patient exposure to calcineurin inhibitors (CNIs) exacerbates or promotes the process of CAN. METHODS:In our unit, we c...

journal_title：Transplantation

authors： Afzali B,Shah S,Chowdhury P,O'sullivan H,Taylor J,Goldsmith D

更新日期：2005-02-15 00:00:00

abstract：:With advances in microsurgery and molecular biology, the mouse model for organ transplantation has become increasingly popular. However, knowledge about these models is limited, as only a small number of centers have experience with murine models. In this study, we compared the rejection pattern after liver, kidney, h...

journal_title：Transplantation

authors： Zhang Z,Zhu L,Quan D,Garcia B,Ozcay N,Duff J,Stiller C,Lazarovits A,Grant D,Zhong R

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:Human islet transplantation is a great potential therapy for type I diabetes. To investigate islet graft survival and function, we recently showed the improved effects after co-culture and co-transplantation with vascular endothelial cells (ECs) in diabetic rats. METHODS:ECs were isolated, and the viability...

journal_title：Transplantation

authors： Pan X,Xue W,Li Y,Feng X,Tian X,Ding C

更新日期：2011-12-15 00:00:00

abstract：:One of the most powerful influences on cadaveric renal graft survival is the enhancing effect of blood transfusions from unrelated individuals (1, 2). However, the optimum number of transfusions required to achieve this effect remains controversial. Enhanced graft survival following only one or two transfusions has be...

journal_title：Transplantation

authors： Martin S,Dyer PA,Harris R,Manos J,Mallick NP,Gokal R,Johnson RW

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:To investigate the transparency, biocompatibility, and safety of human-derived acellular dermal matrix for application in corneal stromal transplantation. METHODS:Twenty-four patients (24 eyes) with pellucid marginal corneal degeneration were enrolled, and intrastromal keratoplasty was performed with human-...

journal_title：Transplantation

authors： Jiang X,Wang Y,Qiu W,Huang C,Liu Z,Ding T,Shi D,Li X

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Donor hepatectomy with maximal safety while preserving graft viability is of principal concern in living donor liver transplantation. There are compelling reasons for avoiding blood transfusion, even with autologous blood, to avoid the potential risks it imposes on healthy donors. This study aims to describe...

journal_title：Transplantation

authors： Chen CL,Chen YS,de Villa VH,Wang CC,Lin CL,Goto S,Wang SH,Cheng YF,Huang TL,Jawan B,Cheung HK

更新日期：2000-06-27 00:00:00

abstract：:The proliferation and differentiation of donor hematopoietic progenitor cells in bone marrow transplantation (BMT) recipients is influenced by hematopoietic growth factors, which could derive from either T cells or adherent stromal bone marrow cells, or both. In this study of 20 BMT recipients, we asked whether T lymp...

journal_title：Transplantation

authors： Thomas S,Clark SC,Rappeport JM,Nathan DG,Emerson SG

更新日期：1990-04-01 00:00:00

abstract：:The role of TNF in the expression of GVHD and GVHD-related immunodeficiency was studied in a well-established murine GVHD model of bone marrow transplantation across minor histocompatibility barriers (B10.BR-->GBA/J) both in vitro and in vivo. Splenocytes from animals with GVHD profoundly inhibited the proliferation o...

journal_title：Transplantation

authors： Wall DA,Sheehan KC

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:This is a follow-up of a withdrawal study that we previously performed on 104 liver transplant patients in which immunosuppression was gradually withdrawn over a period of 3 years. Eighty-one patients were not able to be withdrawn (rejectors), and 23 patients were successfully weaned off immunosuppression ...

journal_title：Transplantation

authors： Tryphonopoulos P,Ruiz P,Weppler D,Nishida S,Levi DM,Moon J,Tekin A,Velez M,Neuman DR,Island E,Selvaggi G,Tzakis AG

更新日期：2010-12-27 00:00:00

abstract：BACKGROUND:Human ehrlichiosis, a newly described zoonotic infection, can be classified as human monocytic ehrlichiosis (HME) or human granulocytic ehrlichiosis (HGE). Although the clinical manifestations of HME and HGE are similar, the type of leukocyte infected, the etiologic agent, and the tick vector are distinct. ...

journal_title：Transplantation

authors： Adachi JA,Grimm EM,Johnson P,Uthman M,Kaplan B,Rakita RM

更新日期：1997-10-27 00:00:00

abstract：BACKGROUND:The role of asymptomatic bacteriuria in kidney transplant recipients is unknown. There is no clear evidence of its effect on transplanted kidney. METHODS:We studied urine cytokines profile among kidney transplant recipients with bacteriuria found in screening examination. Urine cultures were collected in 26...

journal_title：Transplantation

authors： Ciszek M,Paczek L,Bartłomiejczyk I,Mucha K

更新日期：2006-06-27 00:00:00

abstract：:Endothelial damage has been implicated in the pathogenesis of chronic rejection. Conversely, expression of protective genes [including A20, A1, bcl-xl, and hemoxygenase-1 (HO-1)] in the endothelium has been associated with long-term graft survival. Overexpression of protective genes in cultured endothelial cells confe...

journal_title：Transplantation

authors： Evans PC,Taylor ER,Kilshaw PJ

更新日期：2001-02-15 00:00:00

abstract：BACKGROUND:All-cause mortality is high after kidney transplantation (KT), but no prognostic index has focused on predicting mortality in KT using baseline and emergent comorbidity after KT. METHODS:A total of 4928 KT recipients were used to derive a risk score predicting mortality. Patients were randomly assigned to t...

journal_title：Transplantation

authors： Hernández D,Sánchez-Fructuoso A,González-Posada JM,Arias M,Campistol JM,Rufino M,Morales JM,Moreso F,Pérez G,Torres A,Serón D,Spanish Late Allograft Dysfunction Study Group.

更新日期：2009-09-27 00:00:00

abstract：:OKT3, an anti-CD3 MAB, depletes T cells in vivo and is among the most potent inhibitors of acute allograft rejection. The mechanism of this inhibition is unknown. The present studies investigate whether anti-CD3 antibodies have the ability to crosslink CD3 on two different cells and induce TCR-dependent antibody-bridg...

journal_title：Transplantation

authors： Wong JT,Eylath AA,Ghobrial I,Colvin RB

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. ...

journal_title：Transplantation

authors： Molnar MZ,Ravel V,Streja E,Kovesdy CP,Mehrotra R,Kalantar-Zadeh K

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Accurate and rapid diagnosis of human cytomegalovirus (HCMV) disease in solid organ transplant patients remains a challenge. We evaluated the clinical utility of a quantitative polymerase chain reaction (QPCR) method to diagnose transplant patients with HCMV disease. METHODS:A total of 429 plasma samples fr...

journal_title：Transplantation

authors： Ferreira-Gonzalez A,Fisher RA,Weymouth LA,Langley MR,Wolfe L,Wilkinson DS,Garrett CT

更新日期：1999-10-15 00:00:00

abstract：BACKGROUND:The impact of nutritional status on outcome of allogeneic stem cell transplantation (alloSCT) is controversial. This study investigates the influence of pretransplant weight loss and serologic indicators of nutritional homeostasis on relapse and death of acute myeloid leukemia (AML) after alloSCT. METHODS:P...

journal_title：Transplantation

authors： Dietrich S,Radujkovic A,Stölzel F,Falk CS,Benner A,Schaich M,Bornhäuser M,Ehninger G,Krämer A,Hegenbart U,Ho AD,Dreger P,Luft T

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Deciphering the mechanisms of tolerance and chronic rejection (CR) remains a major goal in transplantation. Data in rodents suggest that Toll-like receptors (TLR), regulators of innate immune responses, play a role in determining graft outcome. However, few studies have focused on TLR expression in human kid...

journal_title：Transplantation

authors： Braudeau C,Ashton-Chess J,Giral M,Dugast E,Louis S,Pallier A,Braud C,Moreau A,Renaudin K,Soulillou JP,Brouard S

更新日期：2008-07-15 00:00:00

abstract：OBJECTIVE:Exact knowledge of biliary anatomy is essential in living donor liver transplantation. The purpose of this study was to evaluate the accuracy of pretransplant magnetic resonance cholangiography (MRC) in depicting the biliary anatomy in comparison with intraoperative cholangiography (IOC). MATERIALS AND METHO...

journal_title：Transplantation

authors： Hsu HW,Tsang LL,Yap A,Huang TL,Chen TY,Lin TS,Concejero AM,Ou SY,Yu CY,Chen CL,Cheng YF

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:Bioluminescence imaging (BLI) modalities are being developed to monitor islet transplant mass and function in vivo. The aim of this study was to use the BLI system to determine how the change in functional islet mass correlated to metabolic abnormalities during the course of alloimmune rejection in a murine ...

journal_title：Transplantation

authors： Chen X,Zhang X,Larson CS,Baker MS,Kaufman DB

更新日期：2006-05-27 00:00:00

abstract：:Blocking activity of mouse pregnancy serum was investigated using a well defined one-way mixed lymphocyte culture and a cell-mediated microcytotoxicity test. Allogeneic (C57BL (H-2b) X CBA/Ca (H-2k)) and syngeneic (C57BL (H-2b) X C57BL (H-2b)) pregnancy and postpartum sera were found to stimulate rather than inhibit t...

journal_title：Transplantation

authors： Smith G

更新日期：1978-11-01 00:00:00

abstract：BACKGROUND:Patients with von Hippel-Lindau (VHL) disease are at risk for the development of end-stage renal failure from the treatment of localized renal cell carcinoma. Transplantation with its attendant immunosuppression may predispose patients to tumor recurrence; however, there is little information regarding the o...

journal_title：Transplantation

authors： Goldfarb DA,Neumann HP,Penn I,Novick AC

更新日期：1997-12-27 00:00:00

abstract：BACKGROUND:While previous surveys have demonstrated the psychological impact on living-related liver transplantation (LRLT) donors, such as anxiety, depression, ambivalence and anger, the details regarding the relevant factors that affect donors' psychological status have not been well described. METHODS:To evaluate e...

journal_title：Transplantation

authors： Hayashi A,Noma S,Uehara M,Kuwabara H,Tanaka S,Furuno Y,Hayashi T

更新日期：2007-11-27 00:00:00