Abstract:
:Glutathione and glyoxalase II levels were evaluated in cytosolic and mitochondrial compartments of rat liver after 7 and 24 hr of cold storage in University of Wisconsin (UW) and Euro-Collins solutions. 1-4 A similar time-dependent depletion of cytosolic glutathione up to about 60% of control values was observed in both Euro-Collins and UW solutions. Cytosolic glyoxalase II showed activity oscillations in livers stored in Euro-Collins but not in UW. Mitochondrial glutathione and glyoxalase II were severely depleted soon after 7 hr of cold storage in Euro-Collins, whereas the same parameters did not change in liver stored in UW after 24 hr. UW is confirmed to be the most suitable solution for liver cold storage and we conclude that mitochondrial glutathione and glyoxalase II can be important parameters in assessing mitochondrial and cell function.
journal_name
Transplantationjournal_title
Transplantationauthors
Jassem W,Ciarimboli C,Cerioni PN,Saba V,Norton SJ,Principato Gdoi
10.1097/00007890-199605150-00026subject
Has Abstractpub_date
1996-05-15 00:00:00pages
1416-20issue
9eissn
0041-1337issn
1534-6080journal_volume
61pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract::Mus caroli blastocysts transferred to pseudopregnant Mus musculus implant but die about midgestation. Death of the M caroli embryos is associated with infiltration of the fetoplacental units by M musculus lymphocytes, including functional cytotoxic T lymphocytes (CTL). To determine if specific maternal antifetal immun...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198806000-00021
更新日期:1988-06-01 00:00:00
abstract::BK polyoma virus causes allograft dysfunction as a result of tubulo-interstitial nephritis in 2% to 5% of renal transplant recipients. The incidence of BK virus infection among renal transplant recipients in India is unknown. We used routine histologic examination, immunohistochemistry, and electron microscopy to retr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000113163.02039.30
更新日期:2004-02-15 00:00:00
abstract::Incompatibility for DBA/2 (D2) minor histocompatibility antigens (MiHA) alone leads to a severe lethal graft-versus-host reaction (GVHR) in irradiated (D2 X B10.D2)F1 mice receiving a bone-marrow-plus-spleen-cell graft from B10.D2 donors. This mortality is abrogated when the donors are preimmunized simultaneously agai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198309000-00016
更新日期:1983-09-01 00:00:00
abstract::Hepatic tolerance to hypotension was assessed by changes in arterial ketone body ratio (KBR) and hepatic energy charge levels in experimental brain death induced by epidural ballooning in dogs, and compared with the hemorrhagic shock model. Systolic arterial blood pressure was significantly decreased from 182 mmHg to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00008
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001716
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:In an effort to improve outcomes associated with living kidney donation, the Kidney Diseases Improving Global Outcomes (KDIGO) assembled a Work Group to develop comprehensive guidelines addressing the evaluation and care of living kidney donors. We conducted this systematic review to inform guideline develop...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001252
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Scarring can greatly impact quality of life for individuals (ie, causing depression posttraumatic stress disorder, body image issues). Those who wish to be anonymous live liver donors are warned of the potential negative psychological impacts associated with the large scar left from liver donation surgery. G...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003333
更新日期:2020-05-25 00:00:00
abstract::CD18 antibodies react with the common beta chain of the human leukocyte function antigen (LFA1)* and thus block the functions mediated by the three identified molecules in humans. A murine CD18 monoclonal antibody was infused in 8 leukemic patients receiving allogeneic T-depleted bone marrow transplantation in order t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00014
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:We previously reported that no cytotoxic T-lymphocyte precursor frequencies (CTLpf) were found in 60% of patients on azathioprine or mycophenolate mofetil+Pred long after kidney transplantation. We questioned whether the absence of donor-specific CTLpf was associated with low levels of stimulatory Th1 (tumor...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a36c85
更新日期:2009-05-27 00:00:00
abstract:BACKGROUND:Calcineurin is a ubiquitously expressed calcium-dependent phosphatase that is inhibited by the immunosuppressant drugs cyclosporine and tacrolimus. Measuring calcineurin activity in transplant patients has been complicated by a lack of consistent correlation between drug level and enzyme activity, particular...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829acb64
更新日期:2013-08-15 00:00:00
abstract::The combination of pharmacokinetic and pharmacodynamic (measurement of the biological effect) monitoring of immunosuppressive drugs provides a method for the optimization of drug dosing. We chose to investigate this using mycophenolic acid (MPA), an immunosuppressive drug that mediates its effect by the inhibition of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601150-00018
更新日期:1996-01-15 00:00:00
abstract:BACKGROUND:Small-for-size grafts often cause persistent conjugated hyperbilirubinemia in the recipient after adult-to-adult living donor liver transplantation, but the cause has not yet been clarified. In physiologic status, bilirubin is excreted from hepatocytes to the bile canaliculus by means of multidrug resistance...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000089234.93366.6D
更新日期:2004-01-15 00:00:00
abstract:BACKGROUND:LCP-Tacro is an extended-release formulation of tacrolimus designed for once-daily dosing. Phase 1 studies demonstrated greater bioavailability to twice-daily tacrolimus capsules and no new safety concerns. METHODS:In this phase 2 study, adult stable kidney transplant patients on tacrolimus capsules (Progra...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/TP.0b013e3182962cc1
更新日期:2013-07-27 00:00:00
abstract::Antigenic requirements for the induction of T cell-independent primary splenic IgM antibody responses (plaque-forming cell responses) to H-2Dd alloantigens were studied. Results show that some functional activity or structural property of the donor cells is required for immunogenicity, because antigens are not active ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198302000-00014
更新日期:1983-02-01 00:00:00
abstract::Rat recipients of renal allografts and unilaterally nephrectomized control rats were studied to evaluate the response in blood pressure to prednisolone in diverse doses, and to determine the dosage required to achieve adequate immunosuppression without undue complication of hypertension. While a continuous infusion of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198703000-00007
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:A previous donor intervention trial found that induction of mild therapeutic hypothermia in the brain-dead donor reduced the dialysis requirement after kidney transplantation. Consequences on the performance of cardiac allografts after transplantation were not explored to date. METHODS:Cohort study investig...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002337
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Currently, the severity of veno-occlusive disease (VOD) is graded retrospectively on the basis of the evolution of clinical and biological criteria. The objective of this study was to describe a noninvasive method capable of predicting the severity of this disease at the time of the diagnosis. METHODS:Seven...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200207150-00011
更新日期:2002-07-15 00:00:00
abstract:BACKGROUND:Blockade of the inducible costimulator (ICOS) pathway has been shown to prolong allograft survival; however, its utility in xenotransplantation is unknown. We hypothesize that local expression of ICOS-Ig by the xenograft will suppress the T-cell response resulting in significant prolonged graft survival. ME...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31821774e0
更新日期:2011-05-27 00:00:00
abstract::Dendritic cell (DC) progenitors were propagated in liquid culture from nonparenchymal cells resident in normal mouse (B10.BR; H-2k, I-E+) liver in response to granulocyte-macrophage colony stimulating factor (GM-CSF). The liver-derived DC progenitors were MHC class II-/dim and did not express counter receptors for CTL...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199502270-00019
更新日期:1995-02-27 00:00:00
abstract::One of the most powerful influences on cadaveric renal graft survival is the enhancing effect of blood transfusions from unrelated individuals (1, 2). However, the optimum number of transfusions required to achieve this effect remains controversial. Enhanced graft survival following only one or two transfusions has be...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198503000-00008
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND:We investigated a novel immunosuppressive protocol including thymoglobulin induction in combination with sirolimus and corticosteroids, followed by introduction of markedly reduced exposures to cyclosporine to prevent pancreas-transplant rejection. METHODS:A 7-day course of thymoglobulin (1.5 mg/kg per day)...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000061768.98058.EC
更新日期:2003-04-27 00:00:00
abstract:BACKGROUND:Accelerated arteriosclerosis limits the survival of transplanted hearts. We hypothesized that insulin-like growth factor-I (IGF-I) is crucial in accelerating transplant arteriosclerosis. Recently, we reported that exposure to IGF-I prior to transplantation accelerates transplant arteriosclerosis in the rat a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199804270-00003
更新日期:1998-04-27 00:00:00
abstract:BACKGROUND:Organs for transplantation are a scarce community resource but community preferences and how they are incorporated into allocation policies are unclear. This systematic review aimed to ascertain community preferences for organ allocation and the principles underpinning these preferences. METHODS:Medline, Em...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e3181cf1ee1
更新日期:2010-04-15 00:00:00
abstract::Posttransplant lymphoproliferative disorders (PTLD) are EBV-associated lymphoid neoplasms that are caused by the uncontrolled growth of EBV-infected B lymphocytes. The clinical presentation of PTLD can range from benign polygonal lymphoproliferative disorders to aggressive monoclonal immunoblastic lymphomas. In this r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199606270-00010
更新日期:1996-06-27 00:00:00
abstract::The purpose of this study was to investigate the effect of prostaglandin E1 on rabbit heart preservation. The hearts were arrested with cardioplegia (CP) solution, followed by intracoronary infusion of Euro-Collins (E-C) solution. They were immersed in E-C solution at 4 degrees C for 9 hr, flushed with terminal warm C...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199209000-00006
更新日期:1992-09-01 00:00:00
abstract::Despite great improvements in renal allograft survival over the last 3 decades, long-term graft loss, particularly through antibody-mediated rejection, remains the bane of kidney transplantation. Interindividual patient variation means that a given immunosuppressive regimen may be inadequate in certain patients and ex...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e3181a2e295
更新日期:2009-05-15 00:00:00
abstract:BACKGROUND:Cold ischemia-reperfusion injury is unavoidable during organ transplantation, and prolonged preservation is associated with poorer function recovery. Cardiotrophin-1 (CT-1) is an IL-6 family cytokine with cytoprotective properties. This preclinical study in rats tested whether CT-1 mitigates cold renal ische...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002313
更新日期:2018-10-01 00:00:00
abstract::A monoclonal anti-Lyt-1.1 serum has been characterized in terms of its effect on various cell populations involved in cell-mediated immune responses. The monoclonal serum was compared to a conventionally prepared anti-Lyt-1.1 serum. Cytotoxic T cell precursors and effectors were found to be Lyt-1.1+. Helper T cells wh...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198101000-00013
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:The leflunomide analog, FK778, is a selective pyrimidine synthesis inhibitor. In rodent models, FK778 is efficacious in the prevention of allograft and xenograft rejection, and a combination of FK778 and cyclosporine has synergistic immunosuppressive efficacy. METHODS:Heterotopic renal transplantation was p...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000061789.97072.12
更新日期:2003-04-27 00:00:00
abstract:BACKGROUND:Socioeconomic variables including low income and noncompliance impact negatively upon long-term renal allograft survival, especially in African Americans. We sought to determine whether other socioeconomic variables contributed to noncompliance and allograft survival. METHODS:A detailed history of socioecon...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200107270-00017
更新日期:2001-07-27 00:00:00