Hepatic tolerance to hypotension as assessed by the changes in arterial ketone body ratio in the state of brain death.

abstract：BACKGROUND:A recent clinical study demonstrated that in renal allografts preserved in the cold apoptosis occurred soon after reperfusion. The mode of cell death during cold storage is generally considered necrotic. Whether apoptosis occurs as a part of cold storage is uncertain. The objective was to determine in human ...

journal_title：Transplantation

authors： Salahudeen AK,Joshi M,Jenkins JK

更新日期：2001-09-15 00:00:00

abstract：BACKGROUND:One of the alternative options to simultaneous pancreas-kidney transplantation (SPKT) for type I diabetics with renal failure is sequential transplant of a living donor kidney followed by a deceased donor pancreas transplant (pancreas after living donor kidney transplant [PALK]). We retrospectively compared ...

journal_title：Transplantation

authors： Poommipanit N,Sampaio MS,Cho Y,Young B,Shah T,Pham PT,Wilkinson A,Danovitch G,Bunnapradist S

更新日期：2010-06-27 00:00:00

abstract：BACKGROUND:Graft vascular disease, a major cause of late graft failure in cardiac transplant patients, is associated with the presence of class II major histocompatibility complex molecules on the endothelium. 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, e.g., simvastatin, have been shown to reduce the in...

journal_title：Transplantation

authors： Sadeghi MM,Tiglio A,Sadigh K,O'Donnell L,Collinge M,Pardi R,Bender JR

更新日期：2001-05-15 00:00:00

abstract：:The antibody response to the pregnancy-associated (Pa) antigen in the pregnant female segregated with the major histocompatibility complex (MHC) when the female progeny in the (PVG x WF)F1 x PVG testcross, in which the PVG strain is a low responder to Pa and the WF strain is a high responder, were mated to DA male rat...

journal_title：Transplantation

authors： Kunz HW,Gill TJ 3rd

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:To optimize the methods used for human islet isolation for transplantation, it is important to improve our understanding of the structure of the islet-exocrine interface. In this study, the composition of collagen subtypes in the interface have been characterized and quantified in human pancreas. METHODS:Hu...

journal_title：Transplantation

authors： Hughes SJ,Clark A,McShane P,Contractor HH,Gray DW,Johnson PR

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:Recently, sirolimus (SRL) was introduced as an immunosuppressant in solid-organ transplantation. This study evaluated combinations of SRL and tacrolimus (Tac). METHODS:This 6-month study investigated the safety and efficacy of Tac and steroids in combination with three different doses of SRL in renal-transp...

journal_title：Transplantation

authors： van Hooff JP,Squifflet JP,Wlodarczyk Z,Vanrenterghem Y,Paczek L

更新日期：2003-06-27 00:00:00

abstract：BACKGROUND:The influence of donor hematopoietic cell microchimerism on organ allograft survival has been studied largely in vascularized transplant models. Here, we examine the impact of donor bone marrow (BM) cells administered intravenously together with transient systemic tacrolimus therapy on microchimerism, the su...

journal_title：Transplantation

authors： Khanna A,Steptoe RJ,Antonysamy MA,Li W,Thomson AW

更新日期：1998-02-27 00:00:00

abstract：:Many severe metabolic deficiencies in children are caused by a single gene defect with a resultant single gene product deficiency. These diseases may be amenable to permanent cure using new techniques of gene transfer and cell transplantation. In many in vivo models of retroviral mediated gene therapy, a significant l...

journal_title：Transplantation

authors： Gilbert JC,Takada T,Stein JE,Langer R,Vacanti JP

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Donor hepatectomy and liver implantation time reduce long-term graft and patient survival after liver transplantation. It is not known whether these surgical times influence early outcomes after liver transplantation. METHODS:This single-center study evaluated the effect of donor hepatectomy and implantatio...

journal_title：Transplantation

authors： Gilbo N,Fieuws S,Meurisse N,Nevens F,van der Merwe S,Laleman W,Verslype C,Cassiman D,van Malenstein H,Roskams T,Sainz-Barriga M,Pirenne J,Jochmans I,Monbaliu D

更新日期：2020-05-28 00:00:00

abstract：:The purpose of this study was to investigate two promising immunosuppressive agents, didemnin B (DB) and FK506 (FK), during pregnancy to assess potential adverse maternal or fetal effects. Pregnant C3H mice were randomized into control and high- and low-dose treatment groups for each drug. Animals received daily injec...

journal_title：Transplantation

authors： Farley DE,Shelby J,Alexander D,Scott JR

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Preemptive therapy of human cytomegalovirus (HCMV) infections has gained popularity in transplantation centers. However, standardized protocols are not available. In particular, whether a qualitative molecular assay for detection of a late (pp67) HCMV mRNA represents a valuable alternative to quantitative an...

journal_title：Transplantation

authors： Gerna G,Baldanti F,Lilleri D,Parea M,Torsellini M,Castiglioni B,Vitulo P,Pellegrini C,Viganò M,Grossi P,Revello MG

更新日期：2003-04-15 00:00:00

abstract：OBJECTIVE:We compared the enzyme release from preserved and ex vivo reperfused livers after acute injury or inflammatory stimulus with organ function. METHODS:Acute injury was induced by carbon tetrachloride and inflammation was induced by turpentine oil treatments. Livers were exsanguinated and preserved for 8 or 24 ...

journal_title：Transplantation

authors： Gioli-Pereira L,Coradin K,Nagaoka MR,Borges DR,Kouyoumdjian M

更新日期：2002-10-27 00:00:00

abstract：:Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide. This overview examines current DCD practices, identifies problems and challenges, and suggests clinical strategies for possible improvement. Although there is uniform agreement on DCD donor candi...

journal_title：Transplantation

authors： Morrissey PE,Monaco AP

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:Dysregulation of the coagulation system due to inflammatory responses and cross-species molecular incompatibilities represents a major obstacle to successful xenotransplantation. We hypothesized that complement inhibition mediated by transgenic expression of human CD46 in pigs might also regulate the coagula...

journal_title：Transplantation

authors： Bongoni AK,Kiermeir D,Schnider J,Jenni H,Garimella P,Bähr A,Klymiuk N,Wolf E,Ayares D,Voegelin E,Constantinescu MA,Seebach JD,Rieben R

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Neonatal primates have been reported to receive pig hearts without hyperacute rejection (HAR). We examined the ontogeny of the anti-pig xenoantibody (XenoAb) and HAR in the neonatal and infant monkeys. METHODS:Twenty-six serum samples from 15 monkeys ages 14-192 days were subjected to hemagglutination titra...

journal_title：Transplantation

authors： Kawauchi M,Nakajima J,Endoh M,Oka T,Takamoto S

更新日期：2000-08-27 00:00:00

abstract：:A study was designed to determine if cold preservation induces an increase in lymphocyte adherence to liver sinusoids on reperfusion. Rat livers were stored at 1 degree C in University of Wisconsin solution for 45 min, 8 hr, or 30 hr, and then reperfused for 90 min at 37 degrees C in an isolated perfused rat liver app...

journal_title：Transplantation

authors： Clavien PA,Morgan GR,Sanabria JR,Petrunka C,Levy GA,Robert P,Harvey C,Strasberg SM

更新日期：1991-09-01 00:00:00

abstract：:Pulmonary endothelium is considered the compartment most susceptible to preservation damage. This investigation was designed to analyze the efficacy of an original, University of Parma low-potassium-albumin solution (SPAL UP) on cultured human pulmonary artery endothelial cells (HPAEC) and to compare its effects with ...

journal_title：Transplantation

authors： Spaggiari L,Rusca M,Carbognani P,Alfieri R,Urbani S,Cattelani L,Petronini P,Solli P,Borghetti AF,Bobbio P

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:As opposed to most solid-organ transplant recipients, patients with acute liver failure exhibit a pretransplant health status more comparable with the general population, and any posttransplant cardiovascular risk excess should thus be more attributable to transplantation-related factors alone. METHODS:This...

journal_title：Transplantation

authors： Aberg F,Jula A,Höckerstedt K,Isoniemi H

更新日期：2010-01-15 00:00:00

abstract：BACKGROUND:Recurrent hepatitis C virus (HCV) after liver transplantation (OLT) is a major cause of graft loss in HCV-positive patients. In this study, we evaluated the efficacy and safety of pegylated interferon alfa-2b (peginterferon) and ribavirin treatment for recurrent HCV after OLT and analyzed the influence of an...

journal_title：Transplantation

authors： Neumann U,Puhl G,Bahra M,Berg T,Langrehr JM,Neuhaus R,Neuhaus P

更新日期：2006-07-15 00:00:00

abstract：:A sensitive micromethod for generating and assaying allogeneically induced cytotoxic human lymphocytes in vitro is described. Responding lymphocytes are cultured with mitomycin-C treated allogeneic stimulating cells in wells of replicate microtrays for both one-way mixed leukocyte culture (MLC) and cell-mediated lymph...

journal_title：Transplantation

authors： Zarling JM,McKeough M,Bach FH

更新日期：1976-06-01 00:00:00

abstract：:Sixty-two adults who underwent orthotopic liver transplantations between February 1981 and June 1983 were followed for a mean of 170 days after the operation. Twenty-six patients developed 30 episodes of significant fungal infection. Candida species and Torulopsis glabrata were responsible for 22 episodes and Aspergil...

journal_title：Transplantation

authors： Wajszczuk CP,Dummer JS,Ho M,Van Thiel DH,Starzl TE,Iwatsuki S,Shaw B Jr

更新日期：1985-10-01 00:00:00

abstract：:Most alloreactive T cells specifically recognize peptides bound to donor MHC molecules. In addition to peptides, solvent accessible MHC residues also may stimulate alloreactive T cells. We studied T cell receptor (TCR) usage by 16 independent anti-HLA-B7 alloreactive cytolytic T lymphocyte (CTL) clones. Most or all of...

journal_title：Transplantation

authors： Li YY,Smith KD,Shi Y,Lutz CT

更新日期：1996-10-15 00:00:00

abstract：:The development of organ preservation solutions has been primarily accomplished in whole organ animal models. This study examines the toxicity of commonly used organ preservation solutions on endothelial cells in vitro. Primary human umbilical-vein endothelial cell cultures were incubated at 4 degrees C in solutions o...

journal_title：Transplantation

authors： Killinger WA Jr,Dorofi DB,Keagy BA,Johnson G Jr

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:This study aimed to determine factors associated with body composition changes shortly after liver transplantation (LTx), including the influence of immunosuppressive agents. The combined resting energy expenditure (REE) and handgrip strength provided a valuable assessment in data interpretation of body comp...

journal_title：Transplantation

authors： Brito-Costa A,Pereira-da-Silva L,Papoila AL,Alves M,Mateus É,Nolasco F,Barroso E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Nonspecific inflammatory damages occurring prior to organ transplantation reduce long-term graft survival. Here, we tested the beneficial effects of carbon monoxide (CO) induction by methylene chloride (MC). METHODS:Fischer-344 (F-344 Rat) or Dark Agouti (DA Rat) donor animals were either treated with MC fo...

journal_title：Transplantation

authors： Martins PN,Reutzel-Selke A,Jurisch A,Denecke C,Attrot K,Pascher A,Kotsch K,Pratschke J,Neuhaus P,Volk HD,Tullius SG

更新日期：2006-10-15 00:00:00

abstract：BACKGROUND:The aging of liver transplant (LT) recipients, the weighting of the model for end-stage liver disease score, and the increased prevalence of nonalcoholic steatohepatitis has led to an increased number of older LT recipients with pre-LT chronic kidney disease (CKD). There are limited data on the impact of inc...

journal_title：Transplantation

authors： Goldberg DS,Vianna RM,Martin EF,Martin P,Arosemena Benitez LR,O'Brien CB,Bhamidimarri KR

更新日期：2020-12-01 00:00:00

abstract：:Tolerance induction by CD45RB monoclonal antibody (mAb) in murine allograft models is associated with an alteration in the CD45RBlo/CD45RBhi T-cell ratio in favor of CD45RBlo T cells, which can function as regulatory cells and promote tolerance. It has been proposed that inversion of the CD45RBhi/CD45RBlo normal T-cel...

journal_title：Transplantation

authors： Luke PP,Deng JP,O'Brien CA,Everest M,Hall AV,Chakrabarti S,O'Connell PJ,Zhong R,Jevnikar AM

更新日期：2003-07-27 00:00:00

abstract：:In vitro pretreatment of islets of Langerhans with deoxyguanosine (dGuo) has been shown to be effective for the prolongation of islet allograft survival in rats. [This study evaluates the effect of pretreatment of islets with dGuo transplanted into CsA-treated recipients.] Transplantation of dGuo-treated islets from W...

journal_title：Transplantation

authors： al-Abdullah IH,Kumar AM,al-Adnani MS,Abouna GM

更新日期：1991-05-01 00:00:00

abstract：:We have proposed that the mechanisms of alloengraftment and variable acquired tolerance can be facilitated by minimum posttransplant immunosuppression. It was further suggested that the efficacy of minimalistic treatment could be enhanced by preoperative recipient conditioning with an antilymphoid antibody preparation...

journal_title：Transplantation

authors： Marcos A,Eghtesad B,Fung JJ,Fontes P,Patel K,Devera M,Marsh W,Gayowski T,Demetris AJ,Gray EA,Flynn B,Zeevi A,Murase N,Starzl TE

更新日期：2004-10-15 00:00:00

abstract：BACKGROUND:Recently, peptides derived from the heavy chain of HLA-B2702 have been shown to modulate immune responses. In this study, we examined the use of these peptides for immunosuppression in a pig to mouse islet xenograft model. METHODS:Purified porcine islets were transplanted in autoimmune (non-obese diabetic) ...

journal_title：Transplantation

authors： Squiers EC,Hodell M,Tice D,Buelow R

更新日期：1998-12-15 00:00:00