Prolongation of allograft survival in diabetic rats treated with cyclosporine by deoxyguanosine pretreatment of pancreatic islets of Langerhans.

abstract：:The potent immunosuppressive action of rabbit antithymocyte globulin (RATG) in allotransplant recipients has been recognized for many years. Some of the antibody specificities and immunoregulatory effects of RATG have been described, but a comprehensive definition of RATG components has not been reported previously. I...

journal_title：Transplantation

authors： Rebellato LM,Gross U,Verbanac KM,Thomas JM

更新日期：1994-03-15 00:00:00

abstract：:Because of the inherent difficulties in allele assignment with HLA-DR serological typing, in 1993 our organ procurement organization-based HLA laboratory replaced serology with the molecular method of polymerase chain reaction using sequence-specific primer mixes (PCR-SSP) to type for DR and DQ at a resolution level e...

journal_title：Transplantation

authors： Bryan CF,Harrell KM,Nelson PW,Pierce GE,Ross G,Shield CF 3rd,Warady BA,Aeder MI,Helling TS,Landreneau MD,Luger AM

更新日期：1996-12-27 00:00:00

abstract：:A new method of thymus transplantation is introduced, in which the graft is directly connected with the recipient's vascular system. This procedure was used both in euthymic rats and congenitally athymic nude rats. At all tested intervals after transplantation thymus grafts hardly differed from the recipient's own thy...

journal_title：Transplantation

authors： Kampinga J,Schuurman HJ,Pol GH,Bartels H,Broekhuizen R,Vaessen LM,Tielen FJ,Rozing J,Blaauw EH,Roser B

更新日期：1990-10-01 00:00:00

abstract：:Diarrhea is a frequent but overlooked complication of kidney transplantation. Diarrhea is repeatedly neglected, often considered by patients and clinicians an unavoidable side effect of immunosuppressive regimens. It is, however, associated with a significant impairment in life quality. Severe and chronic posttranspla...

journal_title：Transplantation

authors： Aulagnon F,Scemla A,DeWolf S,Legendre C,Zuber J

更新日期：2014-10-27 00:00:00

abstract：:The recent introduction of a variety of techniques for removing T cells from bone marrow grafts has reduced the incidence of graft-versus-host disease (GVHD)-associated morbidity and mortality. Whether this advance will be translated into improved patient survival is unclear at present, mainly because these procedures...

journal_title：Transplantation

authors： Bunjes D,Heit W,Arnold R,Schmeiser T,Wiesneth M,Carbonell F,Porzsolt F,Raghavachar A,Heimpel H

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization...

journal_title：Transplantation

authors： Pruett TL,Clark MA,Taranto SE

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Long-term acceptance of semi-identical orthotopic liver transplants (OLTs) in inbred swine is induced by a 12-day course of FK506. To study whether acceptance is attributable to central or peripheral immune mechanisms, the effect of complete thymectomy was determined. METHODS:Total thymectomy was performed ...

journal_title：Transplantation

authors： Uryuhara K,Ambiru S,Dehoux JP,Oike F,Talpe S,Gianello P

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:We examined whether oral administration of alloantigen could induce the prolonged survival of cardiac allografts. METHODS:Hearts from CBK (H2k+Kb) transgenic or (C57BL/10xCBA)F1 (H2bxH2k) mice were transplanted into CBA (H2k) recipients pretreated orally with 1 x 10(7) donor splenocytes in the presence or a...

journal_title：Transplantation

authors： Niimi M,Witzke O,Bushell A,Hara M,Morris PJ,Wood KJ

更新日期：2000-11-27 00:00:00

abstract：:The use of real-time reverse transcription polymerase chain reaction to compare gene expression in different tissues and conditions requires normalization to an internal control that must be expressed at a constant level. Although a previous validation step is required to confirm that an internal control is appropriat...

journal_title：Transplantation

authors： Rodriguez-Mulero S,Montanya E

更新日期：2005-09-15 00:00:00

abstract：BACKGROUND:Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, transplantation with DCD livers results in inferior graft survival. In this study, we examined donor and recipient characteristics that are associated with...

journal_title：Transplantation

authors： Lee KW,Simpkins CE,Montgomery RA,Locke JE,Segev DL,Maley WR

更新日期：2006-12-27 00:00:00

abstract：:We are participating in a multicenter trial testing the efficacy of a murine monoclonal antihuman peripheral T lymphocyte antibody (OKT3.PAN) as immunosuppressive therapy for the treatment of acute cadaveric renal allograft rejection. Although clinical data indicate that administration of this antibody clears the circ...

journal_title：Transplantation

authors： Bowen A,Edwards LC,Gailiunas P,Helderman JH

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical acute vascular rejection (AVR). The present study was undertaken to determine the efficacy of LF15-0195, a new analogue of 15-deoxyspergualin, in the prevention of AVR and to determine whether a combination of LF15-0...

journal_title：Transplantation

authors： Wang H,Hosiawa KA,Garcia B,Shum JB,Dutartre P,Kelvin DJ,Zhong R

更新日期：2003-05-15 00:00:00

abstract：:The dose-response effect of cyclosporine on rat limb transplant prolongation was investigated across the LBN-to-LEW histocompatibility barrier. This composite tissue allograft model has been shown to represent a strong transplantation barrier. Median limb allograft survival times increased in a dose-dependent manner w...

journal_title：Transplantation

authors： Hewitt CW,Black KS,Fraser LA,Howard EB,Martin DC,Achauer BM,Furnas DW

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned...

journal_title：Transplantation

authors： Appel JZ 3rd,Alwayn IP,Correa LE,Cooper DK,Robson SC

更新日期：2001-10-15 00:00:00

abstract：BACKGROUND:Neighborhood poverty has been associated with worse outcomes after live donor kidney transplantation (LDKT), and prior work suggests that women with kidney disease may be more susceptible to the negative influence of poverty than men. As such, our goal was to examine whether poverty differentially affects wo...

journal_title：Transplantation

authors： Purnell TS,Luo X,Crews DC,Bae S,Ruck JM,Cooper LA,Grams ME,Henderson ML,Waldram MM,Johnson M,Segev DL

更新日期：2019-10-01 00:00:00

abstract：:The Southeastern Regional Organ Procurement Program has developed a computerized system for the selection of organ transplant recipients. This system has proven to be a useful method for the rapid selection of histocompatible recipients for organ transplants from a large pool of potential recipients in a wide geograp...

journal_title：Transplantation

authors： Stulting RD,Ward FE

更新日期：1975-01-01 00:00:00

abstract：:Tolerance induction by CD45RB monoclonal antibody (mAb) in murine allograft models is associated with an alteration in the CD45RBlo/CD45RBhi T-cell ratio in favor of CD45RBlo T cells, which can function as regulatory cells and promote tolerance. It has been proposed that inversion of the CD45RBhi/CD45RBlo normal T-cel...

journal_title：Transplantation

authors： Luke PP,Deng JP,O'Brien CA,Everest M,Hall AV,Chakrabarti S,O'Connell PJ,Zhong R,Jevnikar AM

更新日期：2003-07-27 00:00:00

abstract：:Gliotoxin is an immunosuppressive secondary metabolite produced by several pathogenic fungi. It has previously been shown to prevent graft-versus-host disease in transplantation of allogeneic mouse bone marrow and to reduce the immunogenicity of human fetal pancreas. We here report on the effect of gliotoxin on the pr...

journal_title：Transplantation

authors： Sutton P,Moreland A,Hutchinson IV,Müllbacher A

更新日期：1995-11-15 00:00:00

abstract：:Cyclosporine extends kidney allograft survival in the chacma baboon, and this study explores various administration protocols to generate optimal serum concentrations of the drug, assessed by radioimmunoassay and by inhibition of lymphocyte transformation by phytohemagglutinin and allogeneic lymphocytes in culture. Se...

journal_title：Transplantation

authors： Smit JA,Drielsma RF,Myburgh JA,Laupacis A,Stiller CR

更新日期：1983-08-01 00:00:00

abstract：:Although extrinsic denervation is inevitable after intestinal transplantation and leads to poor intestinal function, little is known about the occurrence of extrinsic reinnervation. In this study, extrinsic sympathetic reinnervation was investigated morphologically following syngeneic intestinal transplantation perfor...

journal_title：Transplantation

authors： Kiyochi H,Ono A,Yamamoto N,Ohnishi K,Shimahara Y,Kobayashi N

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:It has been suggested that cytomegalovirus infection increases the risk of ischemic heart disease. Both cytomegalovirus and ischemic heart disease are common after renal transplantation, suggesting a possible causal association in this population. METHODS AND PATIENTS:We studied 1004 consecutive renal trans...

journal_title：Transplantation

authors： Hernández D,Hanson E,Kasiske MK,Danielson B,Roel J,Kasiske BL

更新日期：2001-10-27 00:00:00

abstract：BACKGROUND:Transplant medicine's impact on America's public health is seriously limited by acute shortage of transplantable organs. Consequently, the United Sates has witnessed considerable investment in the promotion of organ donor registries. Although there is no evidence to support that donor registry promotion alle...

journal_title：Transplantation

authors： Razdan M,Smith KJ,Bryce CL,Degenholtz HB

更新日期：2016-06-01 00:00:00

abstract：:The ability of concanavalin-A (Con-A) to activate lymphocytes to secrete human lymphotoxin (LT) was tested in the presence of agents known to modify the intracellular levels of cyclic nucleotides (cAMP and cGMP). Lymphocytes were treated with these agents at different stages of activation: (1) during the first encount...

journal_title：Transplantation

authors： Prieur AM,Granger GA

更新日期：1975-10-01 00:00:00

abstract：:The use of immunosuppressive agents (primarily azathioprine and prednisone) to promote human allograft survival is known to be associated with an enhanced rate of skin cancer development by ultraviolet radiation (UVR). These observations raise the question of whether the immunosuppressive agents are functioning as coc...

journal_title：Transplantation

authors： Servilla KS,Burnham DK,Daynes RA

更新日期：1987-08-01 00:00:00

abstract：:Lethally irradiated (850 rads) DBA/2 mice which had been transplanted 10 months previously with 2 times 10-6 bone marrow cells from 3-week-old donors of the H-2-histocompatible NZB, BALB/c and DBA/2 strains were examined for manifestations of autoimmune disease. Also studied were lethally irradiated (950 rads) NZB mic...

journal_title：Transplantation

authors： Morton JI,Siegel BV,Moore RD

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:Immunotherapy given post-autologous stem cell transplantation may eliminate residual tumor cells escaping the conditioning protocol. METHODS:Five children suffering from stage IV neuroblastoma were treated by recombinant interleukin-2 (IL-2) post-autologous peripheral blood stem cell transplantation. The pa...

journal_title：Transplantation

authors： Toren A,Nagler A,Rozenfeld-Granot G,Levanon M,Davidson J,Bielorai B,Kaplinsky C,Meitar D,Mandel M,Ackerstein A,Ballin A,Attias D,Biniaminov M,Rosenthal E,Brok-Simoni F,Rechavi G,Kaufmann Y

更新日期：2000-10-15 00:00:00

abstract：:Hematopoietic growth factors (HGF) mobilize potential tolerogenic cells in transplant donors. Fms-like tyrosine kinase 3 ligand (Flt3L) mobilizes stem cells and dendritic cells (DCs) in human and nonhuman primate blood. Blood and renal and liver biopsies were obtained from untreated and Flt3L-mobilized rhesus macaques...

journal_title：Transplantation

authors： Morelli AE,Coates PT,Shufesky WJ,Barratt-Boyes SM,Fung JJ,Demetris AJ,Thomson AW

更新日期：2007-03-15 00:00:00

abstract：:Living donor renal allograft survival is superior to that achieved from deceased donors, although graft outcome is suboptimal in some of these patients. In an effort to identify the subset of patients at high risk for poor outcomes we studied donor risk factors in 248 living kidney donor-recipient pairs. Unadjusted do...

journal_title：Transplantation

authors： Issa N,Stephany B,Fatica R,Nurko S,Krishnamurthi V,Goldfarb DA,Braun WE,Dennis VW,Heeger PS,Poggio ED

更新日期：2007-03-15 00:00:00

abstract：:Published data on the guinea pig-to-rat hepatic xenotransplant model describe problems concerning poor graft reperfusion. To further investigate this phenomenon, orthotopic liver xenotransplantation between weight-matched guinea pigs and rats were performed using Kamada's technique. On reperfusion, all cases had porta...

journal_title：Transplantation

authors： Delriviere LD,Havaux X,Gibbs P,Gianello PR

更新日期：1998-07-15 00:00:00

abstract：BACKGROUND:The inflammation response is modulated by the elaborated chemokine-chemokine receptor system, which also plays an important role in the development of acute rejection (AR). In this study, we hypothesized that functional genetic variants of some of these modulatory proteins might influence the outcome of AR. ...

journal_title：Transplantation

authors： Simeoni E,Vassalli G,Seydoux C,Ramsay D,Noll G,von Segesser LK,Fleury S

更新日期：2005-11-15 00:00:00