Cardiotrophin-1 Improves Kidney Preservation, Graft Function, and Survival in Transplanted Rats.

abstract：:We studied the role of interleukin (IL)-8 during engraftment after hematopoietic stem cell transplantation. In 40 consecutive patients undergoing either allogeneic marrow (n=32) or autologous peripheral blood stem cell transplantation (n=8), IL-8 plasma levels were serially determined. Median IL-8 concentrations peake...

journal_title：Transplantation

authors： Schwabe M,Hartert AM,Bertz H,Finke J

更新日期：2004-10-15 00:00:00

abstract：BACKGROUND:In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points. ME...

journal_title：Transplantation

authors： Malinoski D,Patel MS,Axelrod DA,Broglio K,Lewis RJ,Groat T,Niemann CU

更新日期：2019-11-01 00:00:00

abstract：:The current shortage of donor organs has stimulated investigation of pig-to-human xenotransplantation as a practical alternative to allotransplantation. However, a major obstacle to this xenotransplantation is hyperacute rejection, which is believed to be initiated by the interaction of natural anti-alpha-galactosyl (...

journal_title：Transplantation

authors： Li SF,Neethling FA,Taniguchi S,Yeh JC,Kobayashi T,Ye Y,Koren E,Cummings RD,Cooper DK

更新日期：1996-11-15 00:00:00

abstract：:To determine the degree of graft versus host disease (GVHD) prophylaxis that might be necessary if cord blood (CB) transplantation is more widely applied, we compared human cord blood mononuclear cell (CBMC) and adult peripheral blood mononuclear cell (PBMC) proliferative responses and stimulatory capabilities; to exa...

journal_title：Transplantation

authors： Greenfeld JI,Noizat-Pirenne F,Hardy MA,Oluwole SF,Hesdorffer CA,Preti RA,De Groote D,Franchimont P

更新日期：1994-08-27 00:00:00

abstract：BACKGROUND:Existing data indicate that non-human leukocyte antigen (HLA) immunogenetic polymorphisms influence the risk of complications after allogeneic hemopoietic stem-cell transplantation. However, prior studies have been limited by small sample size and limited genotyping. METHODS:We examined 22 polymorphisms in ...

journal_title：Transplantation

authors： Mullighan C,Heatley S,Doherty K,Szabo F,Grigg A,Hughes T,Schwarer A,Szer J,Tait B,To B,Bardy P

更新日期：2004-02-27 00:00:00

abstract：BACKGROUND:Intrahepatic bile duct strictures are a serious complication after non-heart-beating (NHB) liver transplantation. Bile salt toxicity has been identified as an important factor in the pathogenesis of bile duct injury and cholangiopathies. The role of bile salt toxicity in the development of biliary strictures...

journal_title：Transplantation

authors： Yska MJ,Buis CI,Monbaliu D,Schuurs TA,Gouw AS,Kahmann ON,Visser DS,Pirenne J,Porte RJ

更新日期：2008-06-15 00:00:00

abstract：BACKGROUND:The use of liver allografts from an older donor (OD) (age>50 years) is a widespread strategy to manage the disparity between supply and demand of organs for liver transplantation. This study determines the effect of OD allografts on fibrosis progression and graft survival after liver transplantation in patie...

journal_title：Transplantation

authors： Machicao VI,Bonatti H,Krishna M,Aqel BA,Lukens FJ,Nguyen JH,Rosser BG,Satyanarayana R,Grewal HP,Hewitt WR,Harnois DM,Crook JE,Steers JL,Dickson RC

更新日期：2004-01-15 00:00:00

abstract：:We have proposed that the mechanisms of alloengraftment and variable acquired tolerance can be facilitated by minimum posttransplant immunosuppression. It was further suggested that the efficacy of minimalistic treatment could be enhanced by preoperative recipient conditioning with an antilymphoid antibody preparation...

journal_title：Transplantation

authors： Marcos A,Eghtesad B,Fung JJ,Fontes P,Patel K,Devera M,Marsh W,Gayowski T,Demetris AJ,Gray EA,Flynn B,Zeevi A,Murase N,Starzl TE

更新日期：2004-10-15 00:00:00

abstract：:Agarose is known to inhibit nonspecifically the cytotoxic effects of normal sera on xenogeneic lymphoid cells. To find an explanation for this agarose effect we have studied its requirements using guinea pig and human sera as the source of activity and rat thymocytes as target cells. Control assays were performed usin...

journal_title：Transplantation

authors： Budzko DB,Kierszenbaum F

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Bronchiolitis obliterans syndrome (BOS) is the major problem after lung and heart-lung transplantation (LTx/HLTx). Sirolimus (Sir) and Mycophenolate (MMF) showed a promising efficacy in the treatment of BOS in animal models. The first clinical experience in converting LTx/HLTx-recipients with BOS from calcin...

journal_title：Transplantation

authors： Groetzner J,Wittwer T,Kaczmarek I,Ueberfuhr P,Strauch J,Nagib R,Meiser B,Franke U,Reichart B,Wahlers T

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:Frequencies of alloreactive T cells determined by limiting dilution assays (LDA) may not adequately reflect the donor-reactive immune status in transplant recipients. To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared the...

journal_title：Transplantation

authors： De Haan A,Van Der Gun I,Van Der Bij W,De Leij LF,Prop J

更新日期：2002-08-27 00:00:00

abstract：:Cross sensitization between the products of the H-2K and H-2D loci has been demonstrated by an experimental design in which recipients were sensitized with tissue bearing determinants controlled by one locus (e.g., H-2K), and then challenged with skin grafts expressing determinants controlled by the other locus (e.g.,...

journal_title：Transplantation

authors： Murphy DB,Shreffler DC

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:Significant disparity exists in the United Kingdom between the need for organ transplant and supply of deceased donor organs. In the recent years, efforts to increase donation has improved the rate of mainly deceased donors after circulatory death and from older donors. The rate of donation from pediatric po...

journal_title：Transplantation

authors： Dave RV,Hakeem AR,Dawrant MJ,Ecuyer CL,Lewington AJ,Attia MS,Hostert L,Finlay E,Ahmad N

更新日期：2015-09-01 00:00:00

abstract：:Temperature is a key parameter in organ preservation that has been consistently linked to primary nonfunction (PNF). In this communication, and for the first time anywhere, continued and direct measurements of human liver intraparenchymal temperatures are reported in six clinical cases of orthotopic liver transplantat...

journal_title：Transplantation

authors： Villa R,Fondevila C,Erill I,Guimerà A,Bombuy E,Gómez-Suárez C,Sacristán JC,García-Valdecasas JC

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:Injection of neonatal BALB/c mice with semi-allogeneic splenocytes leads to antigen-specific tolerance lasting into adulthood. Tolerant mice accept A/J skin grafts and fail to generate CD8 cytotoxic T lymphocyte (CTL) activity against A/J targets. Anergic CD8 T cells are present in tolerant mice, and CD4 reg...

journal_title：Transplantation

authors： Gao Q,Rouse TM,Kazmerzak K,Field EH

更新日期：1999-12-27 00:00:00

abstract：BACKGROUND:Several technical modifications in portal vein (PV) reconstruction have shown excellent outcomes in pediatric liver transplantation (LT); however, which procedure is the best for PV reconstruction of the hypoplastic PV in pediatric LT remains unclear. METHODS:One hundred sixteen pediatric patients aged 1 or...

journal_title：Transplantation

authors： Sakamoto S,Uchida H,Kitajima T,Shimizu S,Yoshimura S,Takeda M,Hirata Y,Fukuda A,Kasahara M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:One of the main concerns after living donor liver transplantation is the risk of morbidity and/or mortality that it imposes on the donors. Respiratory postoperative complications in living liver donors have already been reported but their frequency seems to be underestimated. We designed a prospective study ...

journal_title：Transplantation

authors： Dondero F,Taillé C,Mal H,Sommacale D,Sauvanet A,Farges O,Francoz C,Durand F,Delefosse D,Denninger MH,Vilgrain V,Marrash-Chahla R,Fournier M,Belghiti J

更新日期：2006-01-27 00:00:00

abstract：BACKGROUND:Mixed allogeneic bone marrow chimerism induces tolerance to solid organ grafts. Although we previously reported that partially ablative conditioning with 700 cGy of total body irradiation (TBI) is sufficient to allow for bone marrow engraftment in mice, we determined that a minimum of 1000 cGy was required i...

journal_title：Transplantation

authors： Neipp M,Gammie JS,Exner BG,Li S,Chambers WH,Pham SM,Ildstad ST

更新日期：1999-08-15 00:00:00

abstract：:Forty-three human liver allograft biopsies and normal liver were directly analyzed for inflammatory and immunoregulatory cytokine gene expression by polymerase chain reaction (PCR). IL-5 gene expression was predominantly present in biopsies from liver allografts with histopathological evidence of acute rejection. IL-2...

journal_title：Transplantation

authors： Martinez OM,Krams SM,Sterneck M,Villanueva JC,Falco DA,Ferrell LD,Lake J,Roberts JP,Ascher NL

更新日期：1992-02-01 00:00:00

abstract：:Natural killer (NK) cells effect hybrid resistance, in which parental hematopoietic cell grafts are rejected by F1 recipients. NK cells can also resist engraftment of fully MHC-mismatched allogeneic marrow. However, studies of NK cell-mediated alloresistance have relied on short-term proliferation, colony, or survival...

journal_title：Transplantation

authors： Lee LA,Sergio JJ,Sykes M

更新日期：1996-01-15 00:00:00

abstract：:Two patients with Fanconi's anemia treated for 5 years with oxymetholone developed hepatic function abnormalities in association with hepatic tumors demonstrated by isotope liver-spleen scan or abdominal echogram. The lesions resolved over a period of 26 months after allogeneic marrow transplantation, and the patients...

journal_title：Transplantation

authors： Schmidt E,Deeg HJ,Storb R

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examined correlates and outcomes associated with low PA (ie, not meeting individual study's definition of being physically acti...

journal_title：Transplantation

authors： Berben L,Engberg SJ,Rossmeissl A,Gordon EJ,Kugler C,Schmidt-Trucksäss A,Klem ML,Sereika SM,De Simone P,Dobbels F,De Geest SM,B-SERIOUS consortium.

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Assays of drug blood levels are used for therapeutic immunosuppressive drug monitoring (pharmacokinetics, PK). We monitored lymphocyte functions (pharmacodynamics, PD) in allograft recipients treated with mycophenolic acid (MPA) to determine its mechanisms and the relationships among dose levels, PK, PD, and...

journal_title：Transplantation

authors： Gummert JF,Barten MJ,van Gelder T,Billingham ME,Morris RE

更新日期：2000-10-15 00:00:00

abstract：:Increased QT dispersion (QTd), predicting patients with risk of malignant arrhythmia, have recently been reported in hemodialysis patients (HDp). In this prospective study, we aimed to investigate changes in QTd and signal averaged-ECG (SAECG) in HDp after transplantation. Twenty-seven HDp (M/F:18/9, mean age 30+/-8 y...

journal_title：Transplantation

authors： Yildiz A,Akkaya V,Tükek T,Sahin S,Sever MS,Bozfakioğlu S,Korkut F

更新日期：2001-11-15 00:00:00

abstract：:Injecting semiallogeneic CAF1 spleen into BALB/c newborn mice renders mice tolerant, and the majority of mice show prolonged survival of tolerogen-bearing A/J skin grafts. Moreover, graft survival is associated with enhanced Th2 cytokine responses and graft rejection with Th1 cytokine responses. To further delineate t...

journal_title：Transplantation

authors： Gao Q,Chen N,Field EH

更新日期：1995-12-15 00:00:00

abstract：BACKGROUND:Human ehrlichiosis, a newly described zoonotic infection, can be classified as human monocytic ehrlichiosis (HME) or human granulocytic ehrlichiosis (HGE). Although the clinical manifestations of HME and HGE are similar, the type of leukocyte infected, the etiologic agent, and the tick vector are distinct. ...

journal_title：Transplantation

authors： Adachi JA,Grimm EM,Johnson P,Uthman M,Kaplan B,Rakita RM

更新日期：1997-10-27 00:00:00

abstract：BACKGROUND:After pancreas transplantation, endocrine function is determined by the insulin secretory capacity of the transplanted pancreas. The authors evaluated the predictive value of postoperative oral glucose tolerance test (OGTT) and stimulated insulin secretion on long-term endocrine function. METHODS:Forty-one ...

journal_title：Transplantation

authors： Pfeffer F,Nauck MA,Drognitz O,Benz S,von Dobschuetz E,Hopt UT

更新日期：2003-11-27 00:00:00

abstract：BACKGROUND:Gene targeting in large animals has the potential to be useful in medicine as well as in agriculture. Previously, we reported the first successful targeting of the bovine alpha1,3-galactosyltransferase (alpha1,3GT) gene and establishment of a heterozygous knockout cell line. In this report, we generated both...

journal_title：Transplantation

authors： Sendai Y,Sawada T,Urakawa M,Shinkai Y,Kubota K,Hoshi H,Aoyagi Y

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:We have previously shown successful engraftment of allogeneic hematopoietic stem cells (HSCs) when transplanted across the major histocompatibility antigen barriers if transplanted along with a preparation of facilitator cells (osteoblasts). We have investigated whether or not fully allogeneic HSCs from heal...

journal_title：Transplantation

authors： El-Badri NS,Wang BY,Steele A,Cherry,Marikar Y,Mizobe K,Good RA

更新日期：2000-09-27 00:00:00

abstract：:Although the requirements for the induction of IL-2 receptor expression following lymphocyte stimulation in vitro have been well characterized, little information is available on the role of IL-2 and the IL-2 receptor in lymphocyte activation in vivo. We have established a quantitative assay for the measurement of IL-...

journal_title：Transplantation

authors： Kroczek RA,Black CD,Barbet J,Edison LJ,Shevach EM

更新日期：1987-10-01 00:00:00