Abstract:
:Although the requirements for the induction of IL-2 receptor expression following lymphocyte stimulation in vitro have been well characterized, little information is available on the role of IL-2 and the IL-2 receptor in lymphocyte activation in vivo. We have established a quantitative assay for the measurement of IL-2-receptor-positive cells in the draining popliteal lymph node following the injection of allogeneic cells in the footpad. At the peak of the response more than 20% of the lymph node cells were IL-2-receptor-positive, and the majority of the IL-2-receptor-positive cells were Ly-2+ T cells and B cells. IL-2 receptor expression in vivo was closely associated with an increase in cell size and spontaneous and IL-2-driven proliferation, as well as with the induction of CTL activity specific for the donor strain. The model system described here should be useful in the further characterization of the mechanism of action in vivo of immunosuppressive drugs, antibodies, or lymphokines.
journal_name
Transplantationjournal_title
Transplantationauthors
Kroczek RA,Black CD,Barbet J,Edison LJ,Shevach EMdoi
10.1097/00007890-198710000-00018subject
Has Abstractpub_date
1987-10-01 00:00:00pages
547-53issue
4eissn
0041-1337issn
1534-6080journal_volume
44pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:The inflammation response is modulated by the elaborated chemokine-chemokine receptor system, which also plays an important role in the development of acute rejection (AR). In this study, we hypothesized that functional genetic variants of some of these modulatory proteins might influence the outcome of AR. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000178378.53616.ca
更新日期:2005-11-15 00:00:00
abstract:BACKGROUND:A combined liver and kidney transplantation (CLKT) is advocated for selected individuals with chronic kidney disease undergoing liver transplantation (LT). The aim was to develop a risk score to identify the patients whose estimated glomerular filtration rate (eGFR) would decline during the year post-LT to a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d9e195
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Aspartylglucosaminuria is a rare, inherited lysosomal disease characterized by a slowly progressive mental retardation and coarse facial and body features. With the intent to provide the deficient enzyme aspartylglucosaminidase, allogeneic stem-cell transplantation (ASCT) has been attempted. Only a few cases...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200408150-00015
更新日期:2004-08-15 00:00:00
abstract::Rat liver transplantation was utilized to study the effect of hepatic iron on the control of iron absorption. Six iron-loaded and six normal livers were transplanted into normal or iron-loaded animals. Iron absorption was measured pretransplant and 10 days posttransplant by total-body counting (59Fe). The animals were...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198907000-00005
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:After allogeneic hematopoietic stem-cell transplantation (HSCT), donor-derived T cells may elicit graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) responses. The main targets of GVHD and GVT responses after human leukocyte antigen (HLA)-identical HSCT are minor histocompatibility antigens (mHAgs...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181f5470c
更新日期:2010-11-15 00:00:00
abstract:BACKGROUND:The genetic modification of pigs is a powerful strategy that may ultimately enable successful xenotransplantation of porcine organs into humans. METHODS:Transgenic pigs were produced by microinjection of gene constructs for human complement regulatory proteins CD55 and CD59 and the enzyme alpha1,2-fucosyltr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200006270-00008
更新日期:2000-06-27 00:00:00
abstract:BACKGROUND:There are limited experimental data on the nature of the humoral response elicited in humans against pig antigens. In this study, we have examined the xenoantibody (XAb) response in eight patients with acute liver failure exposed to pig hepatocytes after treatment with the bioartificial liver (BAL). METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199901150-00003
更新日期:1999-01-15 00:00:00
abstract:BACKGROUND:Human CD58 is an adhesion molecule that interacts with CD2 on lymphocytes. We describe here an antibody that blocks responses of human peripheral blood mononuclear cells (PBMCs) to porcine cells and reacts with a porcine protein with homology to CD58. METHODS:Antibodies were isolated with a screen for inhib...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000120377.57543.d8
更新日期:2004-04-27 00:00:00
abstract::The effects of dietary (10% calories) safflower (SAF), evening primrose (EPO), and fish oil (F) as sources of linoleic acid (control), gamma-linolenic acid, and long-chain n-3 fatty acids, respectively, on cardiovascular and renal responses to chronic (5 weeks) cyclosporine administration were studied in male borderli...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199203000-00030
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Intestinal allograft mucosa undergoes repopulation with host immunocytes. However, critical changes within key immunocyte subsets are not known. METHODS:To explain acute cellular rejection after intestine transplantation (ITx) on the basis of altered mucosal immunocytes, rejecting and rejection-free ITx all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182708d9d
更新日期:2012-12-27 00:00:00
abstract:BACKGROUND:Preemptive therapy of human cytomegalovirus (HCMV) infections has gained popularity in transplantation centers. However, standardized protocols are not available. In particular, whether a qualitative molecular assay for detection of a late (pp67) HCMV mRNA represents a valuable alternative to quantitative an...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.TP.0000057239.32192.B9
更新日期:2003-04-15 00:00:00
abstract::To elucidate the time course of glomerular and arterial endothelial injury resulting from pulsatile perfusion preservation of human kidneys, we examined two kidneys, one at 16 and the other at 42 hr, for which no suitable recipient could be found. The scanning electron microscope revealed subtle changes at 16 hr in th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198504000-00012
更新日期:1985-04-01 00:00:00
abstract::Hepatocyte transplantation is an investigational alternative to orthotopic liver transplantation to treat liver based inborn errors of metabolism. We report successful hepatocyte transplantation in a 4-year-old girl with infantile Refsum disease. Hepatocytes were isolated from the left liver segment of two male donors...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000077420.81365.53
更新日期:2003-08-27 00:00:00
abstract::The reactions of a number of LEW anti-ACI allospecific rat monoclonal antibodies were examined in a series of breeding studies. Analysis of (LEW X ACI) F2 progeny demonstrated concordance of the monoclonal class I and class II specificities with results of conventional alloantisera typing. In addition, a "gene dosage"...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the pharmacokinetic profile, tolerability, and safety of a novel once-daily extended-release formulation of tacrolimus (LCPT) with that of once-daily prolonged-release tacrolimus (ODT) in stable adult lung transplant (LT) recipients. METHODS:Phase II, open-label, single-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002348
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:We hypothesized that tissue-engineered contractile cardiomyocyte sheets without a scaffold would show histological and electrical integration with impaired myocardium, leading to the regeneration of infarcted myocardium. METHODS:Neonatal rat cardiomyocytes were cultured on Poly(N-isopropylacrylamide)-grafte...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000181163.69108.dd
更新日期:2005-12-15 00:00:00
abstract:BACKGROUND:Although clinical data suggest its existence, little is known about the effect of rapamycin derivatives on wound repair. This study aims to delineate the influence of the mammalian target of rapamycin inhibitor everolimus on wound healing in the rat intestine. METHODS:Four groups of 26 male Wistar rats rece...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000246078.09845.9c
更新日期:2006-12-15 00:00:00
abstract:BACKGROUND:Two patients with end-stage renal disease secondary to multiple myelomas were treated with combined kidney and bone marrow transplantation in an effort to achieve donor-specific allotolerance through the induction of mixed lymphohematopoietic chimerism. METHODS:Two female patients (55 and 50 years of age) w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200211270-00011
更新日期:2002-11-27 00:00:00
abstract:BACKGROUND:The current shortage of organ donors has led many centers to use marginal and nonheart-beating donors (NHBDs). Recent research has implicated the infiltration of lymphocytes as an important mediator of ischemia-reperfusion injury (IRI). FTY720 is an immunosuppressant that promotes lymphocyte sequestration in...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000269794.74990.da
更新日期:2007-07-27 00:00:00
abstract::Hepatic tolerance to hypotension was assessed by changes in arterial ketone body ratio (KBR) and hepatic energy charge levels in experimental brain death induced by epidural ballooning in dogs, and compared with the hemorrhagic shock model. Systolic arterial blood pressure was significantly decreased from 182 mmHg to ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00008
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:One of the earliest prerequisites for the development of inflammation after ischemia-reperfusion (I/R) is local chemokine expression. We recently demonstrated that apoptosis, characterized by intracellular caspase-activation, contributes to the development of inflammation after I/R. METHODS:The contribution...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200104150-00032
更新日期:2001-04-15 00:00:00
abstract:BACKGROUND:To investigate the transparency, biocompatibility, and safety of human-derived acellular dermal matrix for application in corneal stromal transplantation. METHODS:Twenty-four patients (24 eyes) with pellucid marginal corneal degeneration were enrolled, and intrastromal keratoplasty was performed with human-...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0000000000002681
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Donor T cells are primarily responsible for graft-versus-host disease (GVHD). Three effector pathways have been described for T-cell cytotoxicity: granzyme B/perforin, Fas/Fas ligand (FasL), and secreted molecules such as tumor necrosis factor (TNF)-alpha. Therefore, this study evaluates the gene expression ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000100465.83529.42
更新日期:2004-01-27 00:00:00
abstract:BACKGROUND:Centrilobular necrosis is not an uncommon finding after isolated liver transplantation. In this study, we sought to describe hepatic centrilobular necrosis in children after combined liver and small bowel transplantation (LSBT), and to assess the predictive factors, possible causes, and prognosis. METHODS:S...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200201270-00018
更新日期:2002-01-27 00:00:00
abstract::Rat, hamster, and rabbit islets were transplanted into diabetic C57BL/B6 mice. The effect on islet xenograft survival of low-temperature culture of the donor islets, alpha L3T4 treatment of the recipients for seven days, and transplantation of the grafts either in the renal capsule or in the liver via the portal vein ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198905000-00002
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been l...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001396
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Early and late complications related to the pancreas after simultaneous kidney-pancreas transplantation (SKPT) frequently result in graft loss. The authors describe a surgical rescue technique that allows salvage of the pancreatic graft when surgical complications appear after the transplant. METHODS:Of 158...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000041784.27763.A9
更新日期:2003-01-27 00:00:00
abstract:BACKGROUND:Hepatic transplantation is a highly effective but costly treatment for end-stage hepatic dysfunction. One approach to improve efficiency in the use of scarce organs for transplantation is to identify preoperative factors that are associated with poor outcome posttransplantation. This may assist both in selec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200109270-00023
更新日期:2001-09-27 00:00:00
abstract:BACKGROUND:Recent data indicate that factors other than erythropoietin (EPO), such as insulin-like growth factor 1 (IGF-1), can promote erythropoiesis in vitro and correct the anemia of chronic renal failure in vivo. IGF-1 is produced by the liver under growth hormone control, as well as by other sources, including the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199709270-00021
更新日期:1997-09-27 00:00:00
abstract:BACKGROUND:In live donor liver transplantation portal flush only of the graft is done on the bench. There are no data on antegrade arterial flush along with portal flush of the graft. METHODS:Consecutive patients undergoing elective right lobe live donor liver transplantation were block-randomized to receive either po...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000002088
更新日期:2018-04-01 00:00:00