Time course of glomerular endothelial injury related to pulsatile perfusion preservation.

abstract：BACKGROUND:The growing number of patients awaiting a kidney transplant raises questions about allocation of kidneys to the elderly and about the use of elderly donors. In all reported studies analyzing the influence of age on the outcome after renal transplantation, age is investigated as a categorical variable. METHO...

journal_title：Transplantation

authors： Roodnat JI,Zietse R,Mulder PG,Rischen-Vos J,van Gelder T,IJzermans JN,Weimar W

更新日期：1999-02-27 00:00:00

abstract：BACKGROUND:ABO-incompatible organ transplantation typically induces hyperacute rejection. A2-to-O liver transplantations have been successful. This study compared overall and graft survival in O recipients of A2 and O grafts based on Organ Procurement and Transplantation Network data. METHODS:Scientific Registry of Tr...

journal_title：Transplantation

authors： Kluger MD,Guarrera JV,Olsen SK,Brown RS Jr,Emond JC,Cherqui D

更新日期：2012-09-15 00:00:00

abstract：:Seventy-two dog kidneys were stored under hypothermia as described by Collins and Sacks between 24 and 72 hr and then transplanted. The immediate function of the kidneys was measured by p-aminohippuric acid and inulin clearances. Twenty-four hr proved to be the maximum safe preservation time with both methods. The imm...

journal_title：Transplantation

authors： Grundmann R,Strümper R,Eichmann J,Pichlmaier H

更新日期：1977-05-01 00:00:00

abstract：:Increased QT dispersion (QTd), predicting patients with risk of malignant arrhythmia, have recently been reported in hemodialysis patients (HDp). In this prospective study, we aimed to investigate changes in QTd and signal averaged-ECG (SAECG) in HDp after transplantation. Twenty-seven HDp (M/F:18/9, mean age 30+/-8 y...

journal_title：Transplantation

authors： Yildiz A,Akkaya V,Tükek T,Sahin S,Sever MS,Bozfakioğlu S,Korkut F

更新日期：2001-11-15 00:00:00

abstract：BACKGROUND:Oral ingestion of potassium dichromate produces a complex spectrum of complications. It has an extremely poor prognosis and usually leads to rapid death. METHODS:We report the case of a 16-year-old male patient who was admitted to hospital after oral ingestion of potassium dichromate with suicidal intention...

journal_title：Transplantation

authors： Stift A,Friedl J,Längle F,Berlakovich G,Steininger R,Mühlbacher F

更新日期：2000-06-15 00:00:00

abstract：:Chronic graft-versus-host disease often results in a combined deficiency of humoral and cell-mediated immunity. Clinical and experimental studies have suggested that the decrease in B cell responsiveness is due to a failure of B cell production in the bone marrow, intrinsic B cell defects, excessive suppressor T cell ...

journal_title：Transplantation

authors： Schreiber KL,Forman J

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Diagnosing acute rejection (AR) in kidney transplant recipients typically requires an invasive kidney biopsy. A previous study has suggested that expression of five genes in peripheral blood can indicate the presence of AR in American pediatric kidney transplant recipients. This study aims to validate if the...

journal_title：Transplantation

authors： Lee A,Jeong JC,Choi YW,Seok HY,Kim YG,Jeong KH,Moon JY,Lee TW,Ihm CG,Jeon HJ,Koo TY,Ahn C,Lim SJ,Yang J,Lee SH

更新日期：2014-10-15 00:00:00

abstract：BACKGROUND:Tolerogenic dendritic cells (Tol-DCs) play a critical role in inducing and maintaining tolerance. Recognizing that both T-cell inactivation and activation are contingent on signals provided by DCs and that graft-specific activated T cells are major mediators of transplant rejection, we aimed to create an env...

journal_title：Transplantation

authors： Lan Z,Ge W,Arp J,Jiang J,Liu W,Gordon D,Healey D,DeBenedette M,Nicolette C,Garcia B,Wang H

更新日期：2010-12-27 00:00:00

abstract：BACKGROUND:Infectious complications occur in approximately 50% of cadaveric liver transplant (CDLT) recipients. Living-donor liver transplantation (LDLT) is an established alternative to shorten the waiting time. Currently, the incidence of pulmonary infections after LDLT and the microbiologic causes are unknown. In th...

journal_title：Transplantation

authors： Saner FH,Olde Damink SW,Pavlakovic G,van den Broek MA,Rath PM,Sotiropoulos GC,Radtke A,Canbay A,Paul A,Nadalin S,Malagó M,Broelsch CE

更新日期：2008-06-15 00:00:00

abstract：BACKGROUND:Generation of non-human primate regulatory T cells (Treg) with alloantigen (alloAg) specificity would allow their testing in preclinical transplant models. Low recovery of Treg from peripheral blood limits their potential utility. In small animals and humans, conventional myeloid dendritic cells (DC) have be...

journal_title：Transplantation

authors： Zahorchak AF,Raimondi G,Thomson AW

更新日期：2009-11-15 00:00:00

abstract：:Allogeneic lymphocyte cytotoxicity (ALC) describes the elimination of allogeneic lymphocytes in vivo by an NK-related activity. There is evidence that ALC is demonstrable between donor and recipient when these are incompatible at MHC gene loci alone. Since ALC is a property of T cell-deficient nude rats, the role of t...

journal_title：Transplantation

authors： Ager A,Fajumi J,Sparshott SM,Ford WL,Butcher GW

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC IPV (I...

journal_title：Transplantation

authors： Rayar M,Tron C,Jézéquel C,Beaurepaire JM,Petitcollin A,Houssel-Debry P,Camus C,Verdier MC,Dehlawi A,Lakéhal M,Desfourneaux V,Meunier B,Sulpice L,Bellissant E,Boudjema K,Lemaitre F

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Urologic complications cause substantial morbidity in the pediatric population after renal transplantation, but their impact on graft survival and transplant costs is poorly understood. In this retrospective review, we evaluated the records of all pediatric renal transplant recipients at our center from 1995...

journal_title：Transplantation

authors： Englesbe MJ,Lynch RJ,Heidt DG,Thomas SE,Brooks M,Dubay DA,Pelletier SJ,Magee JC

更新日期：2008-12-15 00:00:00

abstract：BACKGROUND:Bone marrow transplantation (BMT) is effective treatment for many hematologic disease, but performed in a population with a high endemic hepatitis B virus carrier rate, the incidence of liver function impairment and fulminant hepatitis (FH) is expected to be raised. METHODS:Forty-three hepatitis B virus car...

journal_title：Transplantation

authors： Chen PM,Chiou TJ,Fan FS,Liu JM,Hsieh RK,Yen CC,Wang WS,Liu JH

更新日期：1999-06-15 00:00:00

abstract：:Spodoptera frugiperda (Sf9) insect cells secreted a class I MHC RT1.Aa heavy chain protein when infected with baculovirus that bore a construct that contained a honeybee melittin secretion (ms) signal attached to RT1.Aa cDNA. The RT1.Aa heavy chain protein in the culture supernatant and cell lysate immunoprecipitated ...

journal_title：Transplantation

authors： Wang M,Stepkowski SM,Wang ME,Tian L,Qu X,Tu Y,He G,Kahan BD

更新日期：1996-02-15 00:00:00

abstract：:The influence of continuous immunosuppression on the immune system of 2 neonates born to heart-lung transplant recipients was analyzed. T cells, T cell subpopulations, B cells and cyclosporine levels were measured in maternal and cord blood at the time of delivery. Cyclosporine, both parent compound, and metabolites w...

journal_title：Transplantation

authors： Rose ML,Dominguez M,Leaver N,Lachno R,Yacoub MH

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Frequencies of alloreactive T cells determined by limiting dilution assays (LDA) may not adequately reflect the donor-reactive immune status in transplant recipients. To reevaluate LDA frequencies, we developed a flow cytometry test for direct determination of alloreactive T-cell frequencies and compared the...

journal_title：Transplantation

authors： De Haan A,Van Der Gun I,Van Der Bij W,De Leij LF,Prop J

更新日期：2002-08-27 00:00:00

abstract：:The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indica...

journal_title：Transplantation

authors： Shelton JA,Goldberg EH

更新日期：1984-01-01 00:00:00

abstract：:Non-A, non-B hepatitis is a significant cause of liver disease among renal allograft recipients. In order to assess the impact and prevalence of hepatitis C in a series of renal allograft recipients, we retrospectively screened 621 consecutive patients transplanted between 1979 and 1989 and 484 cadaver organ donors re...

journal_title：Transplantation

authors： Roth D,Fernandez JA,Burke GW,Esquenazi V,Miller J

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:The effect of cyclosporine A (CsA) on polyomavirus BK virus (BKV) replication remains unclear. The aim of this in vitro study was to investigate the effect of CsA on BKV replication in human uroepithelial cells. METHODS:After infection of a human renal proximal tubular cell line, HK-2 with BKV, BKV viral lo...

journal_title：Transplantation

authors： Li YJ,Weng CH,Lai WC,Wu HH,Chen YC,Hung CC,Yang CW,Tian YC

更新日期：2010-02-15 00:00:00

abstract：:Polymerase chain reaction (PCR) amplification of CMV DNA recovered from bronchial alveolar lavage (BAL) and peripheral blood samples was compared with tissue culture, cytology, and/or histology for the earlier detection of CMV pneumonitis in 12 recipients of single-lung or heart/lung transplants. In patients with conf...

journal_title：Transplantation

authors： Buffone GJ,Frost A,Samo T,Demmler GJ,Cagle PT,Lawrence EC

更新日期：1993-08-01 00:00:00

abstract：:Heterologous anti-immunoglobulin is a potent immunosuppressive agent that prolongs H-2- and H-3-incompatible skin graft survival. In conjunction with antithymocyte serum, anti-immunoglobulin promotes greater graft life than either antiserum used alone, without evidence of toxicity to recipient animals. Combination tre...

journal_title：Transplantation

authors： Constantian MB,Couser WG,Mannick JA

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:Conflicting data have been reported about the effect of Toxoplasma serostatus on mortality after heart transplantation. Either a positive or a negative recipient Toxoplasma serostatus was found to be associated with increased mortality. METHODS:We evaluated the effects of T. gondii infection on survival of ...

journal_title：Transplantation

authors： van Hellemond JJ,van Domburg RT,Caliskan K,Birim O,Balk AH

更新日期：2013-12-27 00:00:00

abstract：BACKGROUND:Delayed xenograft rejection (DXR) remains a roadblock to successful xenotransplantation. A feature of DXR is early recruitment of monocytes to the xenograft. Naïve human monocytes can recognize and adhere to unstimulated porcine aortic endothelial cells (PAEC) more than human aortic endothelial cells, partly...

journal_title：Transplantation

authors： Greenwald AG,Jin R,Waddell TK

更新日期：2009-01-15 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor. Currently, liver transplantation may be the optimal treatment for HCC in cirrhotic patients. Patient selection is currently based on tumor size. We developed a program to offer liver transplantation to selected patients with HCC...

journal_title：Transplantation

authors： Victor DW 3rd,Monsour HP Jr,Boktour M,Lunsford K,Balogh J,Graviss EA,Nguyen DT,McFadden R,Divatia MK,Heyne K,Ankoma-Sey V,Egwim C,Galati J,Duchini A,Saharia A,Mobley C,Gaber AO,Ghobrial RM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:New insights into mechanisms of injury in orthotopic liver transplantation (OLT) often come from experiments in small animal models. Mice are particularly suitable because of the growing availability of gene-altered animals and specific antibodies. A validated model of OLT in mice is not available and, in pa...

journal_title：Transplantation

authors： Tian Y,Rüdiger HA,Jochum W,Clavien PA

更新日期：2002-11-15 00:00:00

abstract：BACKGROUND:We hypothesized that tissue-engineered contractile cardiomyocyte sheets without a scaffold would show histological and electrical integration with impaired myocardium, leading to the regeneration of infarcted myocardium. METHODS:Neonatal rat cardiomyocytes were cultured on Poly(N-isopropylacrylamide)-grafte...

journal_title：Transplantation

authors： Miyagawa S,Sawa Y,Sakakida S,Taketani S,Kondoh H,Memon IA,Imanishi Y,Shimizu T,Okano T,Matsuda H

更新日期：2005-12-15 00:00:00

abstract：BACKGROUND:In an effort to improve outcomes associated with living kidney donation, the Kidney Diseases Improving Global Outcomes (KDIGO) assembled a Work Group to develop comprehensive guidelines addressing the evaluation and care of living kidney donors. We conducted this systematic review to inform guideline develop...

journal_title：Transplantation

authors： Slinin Y,Brasure M,Eidman K,Bydash J,Maripuri S,Carlyle M,Ishani A,Wilt TJ

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Given growth in kidney transplant waitlists and discard rates, donor kidney acceptance is an important problem. We used network analysis to examine whether organ procurement organization (OPO) network centrality affects discard and outcomes. METHODS:We identified 106,160 deceased donor kidneys recovered for...

journal_title：Transplantation

authors： Butala NM,King MD,Reitsma W,Formica RN,Abt PL,Reese PP,Parikh CR

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:In patients with acute liver failure (ALF) of unknown cause, viral infections are believed to be involved. This study investigates the involvement of human herpesvirus-6 (HHV-6). METHODS:Thirty-two patients with ALF who underwent transplantations during a 6-year period were studied for viruses in biopsies f...

journal_title：Transplantation

authors： Härmä M,Höckerstedt K,Lautenschlager I

更新日期：2003-08-15 00:00:00