Correlates and Outcomes of Low Physical Activity Posttransplant: A Systematic Review and Meta-Analysis.

abstract：:Infection remains one of the major complications of nonspecific immunosuppression in renal transplant patients and accounts for significant morbidity and mortality. The incidence of infectious complications has been shown to be related to the degree of immunosuppression and correlated with the total steroid dosage, us...

journal_title：Transplantation

authors： Salama AD,Rogers T,Lord GM,Lechler RI,Mason PD

更新日期：1997-01-15 00:00:00

abstract：BACKGROUND:This 36-month, randomized, parallel-group study compared safety and efficacy of two doses of everolimus with mycophenolate mofetil (MMF) in de novo renal-transplant recipients. METHODS:Renal-allograft recipients received 1.5 mg/day or 3 mg/day of everolimus or 2 g/day of MMF, plus full-dose cyclosporine (Cs...

journal_title：Transplantation

authors： Lorber MI,Mulgaonkar S,Butt KM,Elkhammas E,Mendez R,Rajagopalan PR,Kahan B,Sollinger H,Li Y,Cretin N,Tedesco H,B251 Study Group.

更新日期：2005-07-27 00:00:00

abstract：BACKGROUND:Cardiovascular disease remains epidemic in transplant recipients, despite aggressive treatment of cardiovascular risk factors. Thus, novel risk factors could play a role in the genesis of cardiovascular events in this population. METHODS:We evaluated the impact of early posttransplant anemia on cardiovascul...

journal_title：Transplantation

authors： Djamali A,Becker YT,Simmons WD,Johnson CA,Premasathian N,Becker BN

更新日期：2003-09-15 00:00:00

abstract：BACKGROUND:Recent evidence has suggested that inconsistencies in human-islet yields after collagenase digestion are attributed to the activation of endogenous enzymes of the cadaveric donor pancreas. Inhibition of protease activity by Pefabloc (0.4 mM; Roche Biochemicals Inc., Indianapolis, IN) has recently been shown ...

journal_title：Transplantation

authors： Rose NL,Palcic MM,Helms LM,Lakey JR

更新日期：2003-02-27 00:00:00

abstract：:Human peripheral blood leukocyte (PBL)-reconstituted severe combined immunodeficient (SCID) mice (Hu-PBL-SCID) were used as a model to study xenograft rejection in humans. SCID mice were reconstituted with human PBL using a protocol that included a booster injection with anti-human CD3 antibody-primed cells. This prot...

journal_title：Transplantation

authors： Shiroki R,Naziruddin B,Shishido S,Duffy BF,Howard T,Mohanakumar T

更新日期：1997-03-27 00:00:00

abstract：OBJECTIVES:Recent studies demonstrated that prolactin (PRL) has beneficial effects on beta cells for islet transplantation. We examined the effect of human recombinant PRL (rhPRL) supplementation to the culture media to determine its potential use in the context of clinical islet transplantation. MATERIALS AND METHODS...

journal_title：Transplantation

authors： Yamamoto T,Mita A,Ricordi C,Messinger S,Miki A,Sakuma Y,Timoneri F,Barker S,Fornoni A,Molano RD,Inverardi L,Pileggi A,Ichii H

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the efficacy of cariporide (a sodium-hydrogen exchanger inhibitor), BMS180448 (a pharmacologic ischemic preconditioning agent), and the combination thereof, as adjuvant therapies for extended cardiac allograft preservation. METHODS:A porcine model of donor brain death ...

journal_title：Transplantation

authors： Ryan JB,Hicks M,Cropper JR,Garlick SR,Kesteven SH,Wilson MK,Feneley MP,Macdonald PS

更新日期：2003-09-15 00:00:00

abstract：BACKGROUND:Composite tissue allotransplantation (CTA) has been recently introduced as a potential treatment for tissue loss secondary to burns, injuries, or resections. However, the optimal strategies to prevent CTA rejection remain undefined. Presently, no CTA model exists to evaluate human-specific immunosuppressants...

journal_title：Transplantation

authors： Cendales LC,Xu H,Bacher J,Eckhaus MA,Kleiner DE,Kirk AD

更新日期：2005-11-27 00:00:00

abstract：BACKGROUND:Remote ischemic preconditioning (RIPC) protects against liver ischemia reperfusion (IR) injury. An essential circulating mediator of this protection is nitric oxide (NO) induced by lower limb RIPC. One of the mechanisms through which NO generally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pat...

journal_title：Transplantation

authors： Abu-Amara M,Yang SY,Quaglia A,Rowley P,Tapuria N,Fuller B,Davidson B,Seifalian A

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:Graft coronary arteriosclerosis (GCA) is the major limiting factor for long-term survival after heart transplantation. In this study, we investigated the effect of Multiglycosidorum tripterygii (MT) on GCA and platelet-derived growth factor A (PDGF-A) mRNA expression of transplanted hearts. METHODS:Two grou...

journal_title：Transplantation

authors： Hachida M,Zhang XL,Lu H,Hoshi H,Koyanagi H

更新日期：1998-06-15 00:00:00

abstract：:The improvement of graft survival over the past decade has mainly been due to the development of more highly specific immunosuppressive agents, such as cyclosporine (CsA) and FK506. CsA and FK506 inhibit T cell activation by interfering with the calcium-mediated pathway, one of two pathways needed for T cell activatio...

journal_title：Transplantation

authors： Geiselhart L,Conti DJ,Freed BM

更新日期：1996-06-15 00:00:00

abstract：:A series of three synthetic peptides spanning H-2E alpha k chain residues (90-110), (110-130), and (130-150) were synthesized and purified. Mice representative of H-2E- (B6, B10, B10.M, B10.Q, B10.S) and H-2E+ (B10.D2, B10.K, B10.RIII) were immunized with individual peptides and lymph node cells challenged in vitro. B...

journal_title：Transplantation

authors： Krco CJ,Beito TG,David CS

更新日期：1992-11-01 00:00:00

abstract：:Pulmonary endothelium is considered the compartment most susceptible to preservation damage. This investigation was designed to analyze the efficacy of an original, University of Parma low-potassium-albumin solution (SPAL UP) on cultured human pulmonary artery endothelial cells (HPAEC) and to compare its effects with ...

journal_title：Transplantation

authors： Spaggiari L,Rusca M,Carbognani P,Alfieri R,Urbani S,Cattelani L,Petronini P,Solli P,Borghetti AF,Bobbio P

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:Donor hepatectomy and liver implantation time reduce long-term graft and patient survival after liver transplantation. It is not known whether these surgical times influence early outcomes after liver transplantation. METHODS:This single-center study evaluated the effect of donor hepatectomy and implantatio...

journal_title：Transplantation

authors： Gilbo N,Fieuws S,Meurisse N,Nevens F,van der Merwe S,Laleman W,Verslype C,Cassiman D,van Malenstein H,Roskams T,Sainz-Barriga M,Pirenne J,Jochmans I,Monbaliu D

更新日期：2020-05-28 00:00:00

abstract：BACKGROUND:The leflunomide analog, FK778, is a selective pyrimidine synthesis inhibitor. In rodent models, FK778 is efficacious in the prevention of allograft and xenograft rejection, and a combination of FK778 and cyclosporine has synergistic immunosuppressive efficacy. METHODS:Heterotopic renal transplantation was p...

journal_title：Transplantation

authors： Kyles AE,Gregory CR,Griffey SM,Bernsteen L,Pierce J,Lilja HS,Morris RE

更新日期：2003-04-27 00:00:00

abstract：INTRODUCTION:Organ donation after brain death (DBD) has declined in the United Kingdom, whereas donation after cardiac death (DCD) has increased markedly. We sought to understand the reasons for the decline in DBD and determine whether the increase in DCD was a major factor. METHODS:The UK Transplant Registry was anal...

journal_title：Transplantation

authors： Summers DM,Counter C,Johnson RJ,Murphy PG,Neuberger JM,Bradley JA

更新日期：2010-12-27 00:00:00

abstract：:Antithymocyte globulin (ATG) has been used successfully for induction therapy as well as for treatment of established allograft rejection. However, this therapy has often been associated with problems of overimmunosuppression and increased costs. In a randomized clinical trial, we compared the immunosuppressive benefi...

journal_title：Transplantation

authors： Abouna GM,al-Abdullah IH,Kelly-Sullivan D,Kumar MS,Loose J,Phillips K,Yost S,Seirka D

更新日期：1995-06-15 00:00:00

abstract：BACKGROUND:The UK Kidney Fast-Track Scheme (KFTS) was introduced in 2012 to identify kidneys at high risk of discard and to rapidly facilitate transplantation. A retrospective analysis of kidneys transplanted through the KFTS was undertaken. METHODS:UK Transplant Registry data were collected on deceased donor kidneys ...

journal_title：Transplantation

authors： Callaghan CJ,Mumford L,Pankhurst L,Baker RJ,Bradley JA,Watson CJE

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:CTLA4IgG that binds to B7 effectively inhibits the signaling of CD28/B7 pathway and induces antigen-specific T-cell unresponsiveness in vitro and in vivo. We examined whether the development of obliterative bronchiolitis in a murine heterotopic airway transplantation model is T cell dependent and whether CTL...

journal_title：Transplantation

authors： Yamada A,Konishi K,Cruz GL,Takehara M,Morikawa M,Nakagawa I,Murakami M,Abe T,Todo S,Uede T

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:Uterus transplantation is a treatment for absolute uterine infertility and can be performed with living and deceased donors. Given the safety and increased utilization of robotic assistance with other gynecologic and transplant donor operations, we adopted a robot-assisted approach to donor hysterectomy. Thi...

journal_title：Transplantation

authors： Johannesson L,Koon EC,Bayer J,McKenna GJ,Wall A,Fernandez H,Martinez EJ,Gupta A,Ruiz R,Onaca N,Testa G

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Current grading systems in acute graft-versus-host disease (GVHD) are not able to identify patients with poor prognosis at time of onset, because they take into account maximal grade. The aim of this study was to evaluate potential predictors for overall survival at disease onset. METHODS:The study sample w...

journal_title：Transplantation

authors： Robin M,Porcher R,de Castro R,Fisher G,de Latour RP,Ribaud P,Petropoulou AD,Rocha V,Devergie A,Mary JY,Socié G

更新日期：2009-11-15 00:00:00

abstract：BACKGROUND:Donor hepatectomy with maximal safety while preserving graft viability is of principal concern in living donor liver transplantation. There are compelling reasons for avoiding blood transfusion, even with autologous blood, to avoid the potential risks it imposes on healthy donors. This study aims to describe...

journal_title：Transplantation

authors： Chen CL,Chen YS,de Villa VH,Wang CC,Lin CL,Goto S,Wang SH,Cheng YF,Huang TL,Jawan B,Cheung HK

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:It has been proposed that hyperacute rejection (HAR) of pig-to-primate vascularized xenografts is due in large part to ineffective regulation of recipient complement by pig complement regulatory proteins (CRPs), and indeed transgenic expression of human CRPs in pigs can prevent hyperacute rejection. However,...

journal_title：Transplantation

authors： Fisicaro N,Aminian A,Hinchliffe SJ,Morgan BP,Pearse MJ,D'Apice AJ,Cowan PJ

更新日期：2000-09-27 00:00:00

abstract：BACKGROUND:Functionally relevant polymorphisms in genes of the Th1 and Th2-inflammatory pathway influence the susceptibility to acute rejection (AR), chronic allograft nephropathy (CAN), and subclinical rejection (SR) as well as graft survival after renal transplantation. Because these findings have not been validated,...

journal_title：Transplantation

authors： Brabcova I,Petrasek J,Hribova P,Hyklova K,Bartosova K,Lacha J,Viklický O

更新日期：2007-10-27 00:00:00

abstract：:Cross sensitization between the products of the H-2K and H-2D loci has been demonstrated by an experimental design in which recipients were sensitized with tissue bearing determinants controlled by one locus (e.g., H-2K), and then challenged with skin grafts expressing determinants controlled by the other locus (e.g.,...

journal_title：Transplantation

authors： Murphy DB,Shreffler DC

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization...

journal_title：Transplantation

authors： Pruett TL,Clark MA,Taranto SE

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Nephrotoxicity is a major side effect of calcineurin inhibitors (CNI). Earlier we reported 8% of our heart transplant recipients reaching end-stage renal failure (ESRF). Now, with an extended follow up of 20 years, we re-evaluated the development of ESRF and studied its influence on survival and the impact o...

journal_title：Transplantation

authors： van de Wetering J,Weimar CH,Balk AH,Roodnat JI,Holweg CT,Baan CC,van Domburg RT,Weimar W

更新日期：2006-12-27 00:00:00

abstract：BACKGROUND:We recently demonstrated that inhibition of inducible nitric oxide synthase (iNOS) ameliorated severe acute lung allograft rejection. This study used a rat lung transplant model to determine (1) the time course and cellular localization of iNOS expression during the histological progression of unmodified acu...

journal_title：Transplantation

authors： Worrall NK,Boasquevisque CH,Botney MD,Misko TP,Sullivan PM,Ritter JH,Ferguson TB Jr,Patterson GA

更新日期：1997-04-27 00:00:00

abstract：BACKGROUND:Immunosuppression involves the nature of the immunosuppressive agents and individual differences in patient factors. We investigated whether the effect of mycophenolate mofetil (MMF) is measurable using an in vitro measure of immunocompetence and related its effects to cyclosporine (CsA) in vitro. METHODS:L...

journal_title：Transplantation

authors： Ogawa N,Nagashima N,Nakamura M,Shalabi A,Maley WR,Burdick JF

更新日期：2001-08-15 00:00:00

abstract：BACKGROUND:The influence of donor hematopoietic cell microchimerism on organ allograft survival has been studied largely in vascularized transplant models. Here, we examine the impact of donor bone marrow (BM) cells administered intravenously together with transient systemic tacrolimus therapy on microchimerism, the su...

journal_title：Transplantation

authors： Khanna A,Steptoe RJ,Antonysamy MA,Li W,Thomson AW

更新日期：1998-02-27 00:00:00