Evaluation of Pefabloc as a serine protease inhibitor during human-islet isolation.

abstract：BACKGROUND:The deceased donor score (DDS), expanded criteria donor (ECD) definition, and resistive index (RI) were developed for pretransplant evaluation of donors. DDS and ECD are determined by a calculation of risk from donor variables, while RI is determined from flow characteristics of kidneys during machine preser...

journal_title：Transplantation

authors： Nyberg SL,Baskin-Bey ES,Kremers W,Prieto M,Henry ML,Stegall MD

更新日期：2005-10-15 00:00:00

abstract：:Nonadherence to immunosuppressants in renal transplant recipients is a major factor affecting graft survival, but it is difficult to detect accurately in clinical practice. Adherence was measured in 153 adult renal transplant recipients using self-report questionnaires and interview, clinician rating, and cyclosporine...

journal_title：Transplantation

authors： Butler JA,Peveler RC,Roderick P,Horne R,Mason JC

更新日期：2004-03-15 00:00:00

abstract：:Patients awaiting a renal transplant were given 1 HLA-DR antigen-matched blood in order to compare the sensitization and graft outcome of these patients with those of control patients, who had been given random blood before transplantation. No differences in sensitization, measured by the formation of HLA antibodies, ...

journal_title：Transplantation

authors： Middleton D,Martin J,Douglas J,McClelland M

更新日期：1994-10-15 00:00:00

abstract：BACKGROUND:Previous studies have shown that posttransplant total lymphoid irradiation, anti-thymocyte globulin, and an intravenous donor blood cell infusion induce tolerance to ACI heart allografts in Lewis rat hosts. METHODS:In the current study, fresh ACI monocytes and dendritic cell precursors, derived from short-t...

journal_title：Transplantation

authors： Hayamizu K,Huie P,Sibley RK,Strober S

更新日期：1998-11-27 00:00:00

abstract：BACKGROUND:Our goal was to test the intragraft mRNA expression and production of two chemokines that are potent chemoattractants for antigen-primed T cells, interferon-gamma inducible protein 10 (IP-10) and monokine-induced by IFN-gamma, (Mig), in allogeneic heart grafts. METHODS:Syngeneic or allogeneic A/J (H-2a) hea...

journal_title：Transplantation

authors： Kapoor A,Morita K,Engeman TM,Koga S,Vapnek EM,Hobart MG,Fairchild RL

更新日期：2000-03-27 00:00:00

abstract：BACKGROUND:Recipients of simultaneous kidney-pancreas transplantation receive a combination of polyclonal antithymocyte globulin (ATG), cyclosporin or tacrolimus, mycophenolate mofetil (MMF) and corticosteroids (Cs). To avoid the side effects and adverse events associated with Cs, we investigated a new immunosuppressiv...

journal_title：Transplantation

authors： Cantarovich D,Giral-Classe M,Hourmant M,Dantal J,Blancho G,Karam G,Soulillou JP

更新日期：2000-04-15 00:00:00

abstract：:The immunosuppressive effects of leflunomide and cyclosporine were evaluated in a rat neurovascularized myocutaneous allograft model. Inbred Brown-Norway and Lewis rats were served as donors and recipients, respectively. All recipients were observed for 60 days or until allograft rejection occurred. All isograft contr...

journal_title：Transplantation

authors： Yeh LS,Gregory CR,Griffey SM,Lecouteur RA,Morris RE

更新日期：1996-09-27 00:00:00

abstract：BACKGROUND:Overexposure to cyclosporine is a risk factor for chronic allograft nephropathy (CAN) and dose reduction has been advocated. The purpose of this study was to determine the impact of adding the non-nephrotoxic immunosuppressant, rapamycin, after cyclosporine dose reduction in renal-allograft recipients with C...

journal_title：Transplantation

authors： Saunders RN,Bicknell GR,Nicholson ML

更新日期：2003-03-27 00:00:00

abstract：BACKGROUND:This study aims to verify the condition of recipients of solid organs from donors with central nervous system (CNS) tumors and determine the risk of disease transmission due to transplantation. METHODS:Twenty-eight brain-dead organ donors with CNS tumors and 91 recipients who received solid organs from Janu...

journal_title：Transplantation

authors： Lee MS,Cho WH,Ha J,Yu ES,Jeong YS,Oh JS,Lee JR,Lee JM

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to examine the utility of the random urine protein to creatinine ratio (P/C) in evaluation and longitudinal management of proteinuria in adult renal transplant recipients with or without overt nephropathy in an outpatient clinic. METHODS:A total of 289 adult renal transplant re...

journal_title：Transplantation

authors： Torng S,Rigatto C,Rush DN,Nickerson P,Jeffery JR

更新日期：2001-10-27 00:00:00

abstract：:Donor-specific blood transfusion (DSBT) in animals and humans can either promote subsequent renal graft survival or lead to sensitization and graft rejection. Using a rat renal allograft model, we have examined whether the effects of DSBT on renal allograft outcome and IgG alloantibody responses are linked to the host...

journal_title：Transplantation

authors： Wasowska B,Baldwin WM 3rd,Howell DN,Sanfilippo F

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Obliterative bronchiolitis (OB), chronic allograft rejection of the lung, is a major cause of morbidity and mortality after lung transplantation. Previous studies using the heterotopic mouse trachea model of chronic airway rejection have shown a T cell infiltrate composed of CD4+ and CD8+ T cells. The goal o...

journal_title：Transplantation

authors： Neuringer IP,Walsh SP,Mannon RB,Gabriel S,Aris RM

更新日期：2000-02-15 00:00:00

abstract：BACKGROUND:Co-stimulatory blockade has been shown to prolong allograft survival in different transplant models. We investigated the effect of combining humanized anti-CD80 and anti-CD86 monoclonal antibodies (mAb) with sirolimus in cynomolgus monkey renal transplant recipients. METHODS:After renal transplantation, gro...

journal_title：Transplantation

authors： Bîrsan T,Hausen B,Higgins JP,Hubble RW,Klupp J,Stalder M,Celniker A,Friedrich S,O'Hara RM,Morris RE

更新日期：2003-06-27 00:00:00

abstract：:Renal transplant recipients are at risk of severe morbidity and mortality from CMV disease. We have undertaken routine surveillance for CMV shedding on 133 transplant recipients, using a rapid culture technique, in order to assess the incidence of CMV infection and disease in these patients and to assess the prognosti...

journal_title：Transplantation

authors： Pillay D,Ali AA,Liu SF,Kops E,Sweny P,Griffiths PD

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Primary hyperoxaluria type-1 (PH1) is an autosomal recessive disease characterized by excessive oxalate production by hepatocytes caused by the deficiency of peroxisomal alanine-glyoxylate aminotransferase (AGT) activity. Persistent hyperoxaluria causes nephrocalcinosis and urolithiasis, leading to renal fai...

journal_title：Transplantation

authors： Jiang J,Salido EC,Guha C,Wang X,Moitra R,Liu L,Roy-Chowdhury J,Roy-Chowdhury N

更新日期：2008-05-15 00:00:00

abstract：BACKGROUND:The timing of an acute rejection may have a variable impact on renal allograft survival. To determine whether the time of first acute transplant rejection (ATR) is an independent predictor of long-term allograft survival, we studied 31,600 first cadaveric renal transplants that were functional on the first t...

journal_title：Transplantation

authors： Leggat JE Jr,Ojo AO,Leichtman AB,Port FK,Wolfe RA,Turenne MN,Held PJ

更新日期：1997-05-15 00:00:00

abstract：BACKGROUND:A striped pattern of fibrosis has been described in the kidneys of patients undergoing long-term cyclosporine or tacrolimus therapy. This lesion is frequently misconstrued as being specific for drug toxicity. METHODS:We performed clinicopathologic correlation on 18 patients with striped fibrosis identified ...

journal_title：Transplantation

authors： Dell'Antonio G,Randhawa PS

更新日期：1999-02-15 00:00:00

abstract：:Loss of renal mass has been associated with the development of glomerular sclerosis in animals and human beings. The pathophysiology of this renal injury is unknown, but glomerular sclerosis in animals can be aggravated or accelerated following exposure to nephrotoxic antibodies, puromycin aminoglycoside or renal irra...

journal_title：Transplantation

authors： Parfrey PS,Hollomby DJ,Gilmore NJ,Knaack J,Schur PH,Guttmann RD

更新日期：1984-10-01 00:00:00

abstract：:A major impediment to the wider application of clinical liver transplantation is the paucity of acceptable organs. Most centers refuse organs that come from donors who are hepatitis B core antibody positive because of a fear of transmission of hepatitis B virus (HBV) infection to the recipient. The risk related to the...

journal_title：Transplantation

authors： Van Thiel DH,De Maria N,Colantoni A,Friedlander L

更新日期：1999-08-27 00:00:00

abstract：BACKGROUND:Although used for more than 20 years, optimal dosing strategies of most immunosuppressants have never been determined. Tacrolimus, one of the newer agents used in solid-organ transplantation, is gaining increasing popularity because of its ability to reverse refractory rejection in cyclosporine-treated patie...

journal_title：Transplantation

authors： Baran DA,Galin I,Sandler D,Segura L,Cheng J,Courtney MC,Correa R,Chan M,Fallon JT,Spielvogel D,Lansman SL,Gass AL

更新日期：2002-10-27 00:00:00

abstract：:Cell surface markers of isolated graft-infiltrating cells (GIC) were studied, and functional in vitro assays performed in 8 cases of acute irreversible rejection of human renal allografts. The GIC were mostly activated T cells (OKT11+, OKT3+, Ia+), with predominance of the cytotoxic/suppressor T cell phenotype (OKT8+)...

journal_title：Transplantation

authors： Charpentier BM,Bach MA,Lang P,Martin B,Fries D

更新日期：1987-07-01 00:00:00

abstract：:Since chemotaxis is an important mechanism by which leukocytes are recruited to allografts during rejection, the effect of immunosuppressant agents on in vitro chemotactic responses of neutrophils, monocytes, and lymphocytes was studied. Cyclosporine caused profound inhibition of lymphocyte chemotaxis to three differe...

journal_title：Transplantation

authors： Adams DH,Wang LF,Neuberger JM,Elias E

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Monocarboxylate transporter (MCT)-1, a member of a family of molecules, transports monocarboxylates such as lactate. Inhibiting MCT-1 leads to long-term graft survival in rodent heart transplantation and induces tolerance. We evaluated an MCT-1 inhibitor, AS2495674, in a rat heart transplant model and analyz...

journal_title：Transplantation

authors： Cho KS,Yamada T,Wynn C,Behanna HA,Hong IC,Manaves V,Nakanishi T,Hirose J,Abe Y,Jiang H,Tamura K,Saita Y

更新日期：2010-12-27 00:00:00

abstract：:A laparoscopic live-donor nephrectomy was performed on a 40-year-old man. The kidney was removed intact via a 9-cm infraumbilical midline incision. Warm ischemia was limited to less than 5 min. Immediately upon revascularization, the allograft produced urine. By the second postoperative day, the recipient's serum crea...

journal_title：Transplantation

authors： Ratner LE,Ciseck LJ,Moore RG,Cigarroa FG,Kaufman HS,Kavoussi LR

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:In transplantation, novel methods are required to augment the supply of donor organs. We report the first domino liver transplant in which a patient with familial amyloid polyneuropathy (FAP) received an orthotopic split liver graft, and her explanted liver was donated to another patient. Three successful li...

journal_title：Transplantation

authors： Stangou AJ,Heaton ND,Rela M,Pepys MB,Hawkins PN,Williams R

更新日期：1998-06-15 00:00:00

abstract：BACKGROUND:An artificial neural networks (ANNs) model was developed to predict 5-year graft survival of living-donor kidney transplants. Predictions from the validated ANNs were compared with Cox regression-based nomogram. METHODS:Out of 1900 patients with living-donor kidney transplant; 1581 patients were used for tr...

journal_title：Transplantation

authors： Akl A,Ismail AM,Ghoneim M

更新日期：2008-11-27 00:00:00

abstract：BACKGROUND:In this report, we compare the long-term outcome of pediatric liver transplantation (LTx) patients maintained with tacrolimus-based and with cyclosporine (CsA)-based immunosuppressive therapy. We examine long-term patient and graft survival, the incidence of rejection, and immunosuppression-related complicat...

journal_title：Transplantation

authors： Jain A,Mazariegos G,Kashyap R,Green M,Gronsky C,Starzl TE,Fung J,Reyes J

更新日期：2000-08-27 00:00:00

abstract：BACKGROUND:Renal ischemia-reperfusion (I/R) injury is unavoidable in kidney transplantation and frequently influences both short- and long-term allograft survival rates. One of the major events in I/R injury is the generation of cytotoxic oxygen radicals. Recently, hydrogen gas has been reported to display antioxidant ...

journal_title：Transplantation

authors： Abe T,Li XK,Yazawa K,Hatayama N,Xie L,Sato B,Kakuta Y,Tsutahara K,Okumi M,Tsuda H,Kaimori JY,Isaka Y,Natori M,Takahara S,Nonomura N

更新日期：2012-07-15 00:00:00

abstract：:Murine lymphoid cells sensitized against allografts express two types of cytotoxicity measured in vitro in short-term assays of 2 to 3 hr by 51Cr release. One type of cytotoxicity is specific against target cells carrying the sensitizing alloantigens, and the other type is nonspecific against both syngeneic and unrela...

journal_title：Transplantation

authors： Bonavida B,Bradley TP

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:We sought to determine the risk factors, molecular epidemiology, antibiotic therapy, and outcomes of bacteremia because of extensively drug-resistant (XDR) Pseudomonas aeruginosa in solid organ transplant (SOT) recipients. METHODS:All episodes of bacteremia occurring in SOT recipients were prospectively doc...

journal_title：Transplantation

authors： Bodro M,Sabé N,Tubau F,Lladó L,Baliellas C,González-Costello J,Cruzado JM,Carratalà J

更新日期：2015-03-01 00:00:00