Abstract:
:Sensitized patients awaiting renal transplantation have a markedly reduced probability of receiving a crossmatch (XM)-negative renal allograft, and, even if transplanted with a negative complement-dependent cytotoxicity (CDC)-XM, they are at an increased risk of antibody-mediated humoral rejection with early graft loss. We report here for the first time on the effectiveness of a single pretransplant plasma exchange session in rendering a positive complement-dependent cytotoxicity-XM negative and, in combination with anti-CD20 therapy, allowing successful renal transplantation in two sensitized deceased-donor kidney allograft recipients. In a third patient with high donor-specific reactivity, the therapy was unsuccessful. Plasma exchange treatments were continued during the posttransplant period until stable allograft function was achieved. Both patients showed good graft outcome at 27 and 21 months after transplantation with serum creatinine values of 1.60 and 1.25 mg/dL, respectively.
journal_name
Transplantationjournal_title
Transplantationauthors
Beimler JH,Morath C,Schmidt J,Ovens J,Opelz G,Rahmel A,Zeier M,Süsal Cdoi
10.1097/TP.0b013e318198a376subject
Has Abstractpub_date
2009-03-15 00:00:00pages
668-71issue
5eissn
0041-1337issn
1534-6080pii
00007890-200903150-00008journal_volume
87pub_type
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