Abstract:
:Histoincompatible-complete radiation chimeras, after resolving acute graft-versus-host disease (GVHD), establish specific tolerance to host and donor alloantigens. This tolerance can be perturbed with immunosuppressive agents and infusions of small numbers of donor-type cells, with infusions of massive numbers of donor-type cells, or with infusions of a small number of donor-type cells, that were sensitized against host antigens prior to transfer. These chimeras possess T lymphocytes in the spleen that specifically suppress donor to host mixed lymphocyte reactions and adoptively transfer suppression of GVHD to secondary hosts. Nylon-wool fractionation of chimeric spleen cells restores the response of chimeric lymphocytes to host alloantigens, suggesting that transplantation tolerance is not attributable to clonal deletion but the activity of nylon-wool-adherent T suppressor spleen cells.
journal_name
Transplantationjournal_title
Transplantationauthors
Tutschka PJ,Hess AD,Beschorner WE,Santos GWdoi
10.1097/00007890-198109000-00005subject
Has Abstractpub_date
1981-09-01 00:00:00pages
203-9issue
3eissn
0041-1337issn
1534-6080journal_volume
32pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:The aim of our study was to examine, in a recent cohort of kidney transplant recipients who have received modern immunosuppressive therapy, the respective role of cold ischemia time (CIT) and delayed graft function (DGF) on acute rejection (AR) rates and long-term graft survival. METHODS:We retrospectively ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318169c29e
更新日期:2008-04-15 00:00:00
abstract::Natural killer (NK) cells effect hybrid resistance, in which parental hematopoietic cell grafts are rejected by F1 recipients. NK cells can also resist engraftment of fully MHC-mismatched allogeneic marrow. However, studies of NK cell-mediated alloresistance have relied on short-term proliferation, colony, or survival...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601150-00024
更新日期:1996-01-15 00:00:00
abstract:BACKGROUND:Neutrophilic tubulitis accompanied by intratubular neutrophil clusters in the renal allograft is a surrogate marker for urinary tract infection (UTI). Overlapping histologic findings can occur in antibody-mediated rejection, which is characterized by peritubular capillary (PTC) deposition of C4d. This study ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31819ca304
更新日期:2009-04-15 00:00:00
abstract::Antibodies against B lymphocytes were found in the serum of the majority of 59 kidney transplant recipients and of 22 eluates obtained from kidney allografts undergoing rejection. To characterize these B cell lymphocytotoxins we have used a mouse monoclonal anti-DR antibody (L227) that inhibits cytotoxicity of antibod...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198305000-00011
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND:Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks per day) are scanty. METHODS:Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with non-HD (ND) donors. RESULTS:Of 56 182 firs...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002230
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Hyperacute rejection (HAR) of pig-to-primate discordant xenografts is caused by the deposition of preexisting natural antibodies that recognize Galalpha1-3Gal (alphaGal)-terminating oligosaccharides on glycoproteins and glycolipids, followed by complement-mediated lysis of the graft's endothelium. In vitro, ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199802150-00009
更新日期:1998-02-15 00:00:00
abstract::We have done a comparative analysis of two consecutive clinical trials at our center: the first in 56 patients who received blood transfusions from their prospective donors (DST group), and the second in 36 patients who received such transfusions while they were taking Imuran in an attempt to reduce the incidence of s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198336060-00009
更新日期:1983-12-01 00:00:00
abstract::In a randomized trial conducted in 9 Ontario transplant centers, 107 cadaver kidney donors were randomized so that both kidneys were preserved either by simple cold storage (CS) or by pulsatile perfusion (PP). After exclusions and losses to follow-up, there were 90 patients in the CS group and 91 in the PP group. Tota...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Despite effective antiviral treatment, hundreds of kidneys from deceased donors with hepatitis C virus (HCV) are discarded annually. Little is known about the determinants of willingness to accept HCV-infected kidneys among HCV-negative patients. METHODS:At 2 centers, 189 patients undergoing initial or reev...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002099
更新日期:2018-04-01 00:00:00
abstract::Fine-needle aspiration biopsies were used for clinical monitoring of liver allografts; 21 patients with an inflammatory episode of acute rejection (12.0 +/- 3.3 CIU at the peak) were studied; all episodes were reversible. The inflammatory infiltrate consisted mainly of lymphoid cells, including lymphoid blasts, with i...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199011000-00011
更新日期:1990-11-01 00:00:00
abstract::The carbohydrate antigens, blood groups A and B, and the alpha-gal epitope (Galalpha1-3Gal) are major risk factors in transplantation. Transplantation across ABO barriers may result in rejection by elicited anti-blood group antibodies, accommodation where elicited anti-blood group antibodies do not reject the graft, o...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000142673.32394.95
更新日期:2004-10-27 00:00:00
abstract:BACKGROUND:In an effort to define reliable assays that might predict postimmunosuppressant-withdrawal development of chronic rejection (CR), despite conditioning for tolerance induction, we evaluated various immunological responses in nonhuman primate renal allograft recipients. METHODS:Fourteen Cynomolgus monkeys rec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000234786.26511.a4
更新日期:2006-09-27 00:00:00
abstract::Currently trials of immunosuppression in transplantation are in decline because their objectives remain focused on improving acute rejection rates and graft survival in the first 12 months. With 1 year renal graft survival rates of greater than 90% the best that can be hoped for is noninferiority trial outcomes compar...
journal_title:Transplantation
pub_type:
doi:10.1097/TP.0000000000001648
更新日期:2017-07-01 00:00:00
abstract::The study purpose was to identify risks, benefits and costs associated with an expanded donor protocol. The protocol design evaluated organs rescued using expanded donor criteria and weighed all costs associated with doing so. Costs were measured against conditions experienced with expanded and traditional criteria an...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199560120-00021
更新日期:1995-12-27 00:00:00
abstract:BACKGROUND:Kidney grafts with multiple renal arteries have been considered a relative contraindication because of the increased risk of complications. In the present study, we retrospectively reviewed multiple renal artery reconstruction in kidney transplantation to elucidate the usefulness of these grafts. METHODS:Fr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000054461.57565.18
更新日期:2003-03-27 00:00:00
abstract:BACKGROUND:The use of liver allografts from an older donor (OD) (age>50 years) is a widespread strategy to manage the disparity between supply and demand of organs for liver transplantation. This study determines the effect of OD allografts on fibrosis progression and graft survival after liver transplantation in patie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000095896.07048.BB
更新日期:2004-01-15 00:00:00
abstract:BACKGROUND:Although the clinical features of early hepatic artery thrombosis (HAT) are well defined, the features of delayed (more than 4 weeks after transplantation) hepatic artery thrombosis are less clearly defined. The aim of our study was to identify risk factors, clinical presentation, and outcome of management o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200106150-00018
更新日期:2001-06-15 00:00:00
abstract:BACKGROUND:The role of changes in peri-operative blood lactate levels in recipients of living-related liver transplants has not yet been clarified. METHODS:Forty-three recipients were included in this study. Blood lactate, plasma total bilirubin, aminotransferase, body temperature, and gastric mucosal PCO2 levels were...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200005270-00028
更新日期:2000-05-27 00:00:00
abstract::Although it has long been appreciated that establishment of chimerism is important in the acquisition and maintenance of allograft tolerance, the importance of this relationship has been reemphasized recently. Using the exquisite sensitivity of the polymerase chain reaction we have studied qualitatively and quantitati...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199511270-00012
更新日期:1995-11-27 00:00:00
abstract:BACKGROUND:In France, foreign patients, whether resident or not in France, can register on the national waiting list under certain conditions. We compared waiting time to kidney transplantation, the level of HLA matching and graft cold ischemia time between foreign patients and French patients living in mainland France...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000205182.96861.3a
更新日期:2006-04-27 00:00:00
abstract:BACKGROUND:Donor hepatectomy with maximal safety while preserving graft viability is of principal concern in living donor liver transplantation. There are compelling reasons for avoiding blood transfusion, even with autologous blood, to avoid the potential risks it imposes on healthy donors. This study aims to describe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200006270-00018
更新日期:2000-06-27 00:00:00
abstract:BACKGROUND:Posttransplantation measurement of soluble CD30 (sCD30) may be useful for identifying kidney graft recipients at risk of impending graft rejection in the early posttransplantation period. METHODS:We measured plasma sCD30 levels and evaluated the levels in relation to the diagnosis of rejection. RESULTS:Rec...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000044702.18327.66
更新日期:2003-02-15 00:00:00
abstract:BACKGROUND:Scientific Registry of Transplant Recipients report cards of US organ transplant center performance are publicly available and used for quality oversight. Low center performance (LP) evaluations are associated with changes in practice including reduced transplant rates and increased waitlist removals. In 201...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001373
更新日期:2017-06-01 00:00:00
abstract::We examined graft and patient survival rates of 47,146 patients in the United Network for Organ Sharing registry following transplants between donors and recipients who were cytomegalovirus (CMV) antibody negative and positive. CMV positivity increased with age to about 80% in patients over 60. Seropositivity was seen...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/00007890-199607150-00007
更新日期:1996-07-15 00:00:00
abstract:OBJECTIVES:Recent studies demonstrated that prolactin (PRL) has beneficial effects on beta cells for islet transplantation. We examined the effect of human recombinant PRL (rhPRL) supplementation to the culture media to determine its potential use in the context of clinical islet transplantation. MATERIALS AND METHODS...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181d98af1
更新日期:2010-06-15 00:00:00
abstract::Donor graft major histocompatibility complex class I antigens are targets for both allogeneic and xenogeneic rejection. Mice homozygous for beta 2-microglobulin gene disruption express reduced amounts of surface MHC class I antigens. Liver cells from such mutant mice were transplanted into isogeneic, allogeneic, and x...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199304000-00046
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Whether kidney transplant recipients who were treated for a malignant tumor before transplantation are at an increased risk of developing a tumor posttransplantation has not been adequately quantified and characterized. METHODS:We studied more than 270 000 patients on whom pretransplant and posttransplant m...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002459
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Although graft local infusion (GLI) treatment via the portal vein or the hepatic artery has been the pivotal strategy in ABO incompatible (ABOi) living donor liver transplantation (LDLT) in Japan, the procedure is associated with a high rate of catheter-associated complications. METHODS:A new ABOi-LDLT prot...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181adcae6
更新日期:2009-08-15 00:00:00
abstract::Two patients with Fanconi's anemia treated for 5 years with oxymetholone developed hepatic function abnormalities in association with hepatic tumors demonstrated by isotope liver-spleen scan or abdominal echogram. The lesions resolved over a period of 26 months after allogeneic marrow transplantation, and the patients...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198405000-00006
更新日期:1984-05-01 00:00:00
abstract::The incidence of malignant disease (renal cancer and skin cancer excluded) was analyzed in 934 renal transplant patients from one center, transplanted between 1965 and 1981, and followed through 1983. National Cancer Registry data were used for statistical comparison. Cancers of the lip, vulva, and anus and malignant ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00