Evaluation of Flagging Criteria of United States Kidney Transplant Center Performance: How to Best Define Outliers?

Abstract:

BACKGROUND:Scientific Registry of Transplant Recipients report cards of US organ transplant center performance are publicly available and used for quality oversight. Low center performance (LP) evaluations are associated with changes in practice including reduced transplant rates and increased waitlist removals. In 2014, Scientific Registry of Transplant Recipients implemented new Bayesian methodology to evaluate performance which was not adopted by Center for Medicare and Medicaid Services (CMS). In May 2016, CMS altered their performance criteria, reducing the likelihood of LP evaluations. METHODS:Our aims were to evaluate incidence, survival rates, and volume of LP centers with Bayesian, historical (old-CMS) and new-CMS criteria using 6 consecutive program-specific reports (PSR), January 2013 to July 2015 among adult kidney transplant centers. RESULTS:Bayesian, old-CMS and new-CMS criteria identified 13.4%, 8.3%, and 6.1% LP PSRs, respectively. Over the 3-year period, 31.9% (Bayesian), 23.4% (old-CMS), and 19.8% (new-CMS) of centers had 1 or more LP evaluation. For small centers (<83 transplants/PSR), there were 4-fold additional LP evaluations (52 vs 13 PSRs) for 1-year mortality with Bayesian versus new-CMS criteria. For large centers (>183 transplants/PSR), there were 3-fold additional LP evaluations for 1-year mortality with Bayesian versus new-CMS criteria with median differences in observed and expected patient survival of -1.6% and -2.2%, respectively. CONCLUSIONS:A significant proportion of kidney transplant centers are identified as low performing with relatively small survival differences compared with expected. Bayesian criteria have significantly higher flagging rates and new-CMS criteria modestly reduce flagging. Critical appraisal of performance criteria is needed to assess whether quality oversight is meeting intended goals and whether further modifications could reduce risk aversion, more efficiently allocate resources, and increase transplant opportunities.

journal_name

Transplantation

journal_title

Transplantation

authors

Schold JD,Miller CM,Henry ML,Buccini LD,Flechner SM,Goldfarb DA,Poggio ED,Andreoni KA

doi

10.1097/TP.0000000000001373

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

1373-1380

issue

6

eissn

0041-1337

issn

1534-6080

journal_volume

101

pub_type

杂志文章
  • Successful renovascular reconstruction for renal allografts with multiple renal arteries.

    abstract:BACKGROUND:Kidney grafts with multiple renal arteries have been considered a relative contraindication because of the increased risk of complications. In the present study, we retrospectively reviewed multiple renal artery reconstruction in kidney transplantation to elucidate the usefulness of these grafts. METHODS:Fr...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000054461.57565.18

    authors: Makiyama K,Tanabe K,Ishida H,Tokumoto T,Shimmura H,Omoto K,Toma H

    更新日期:2003-03-27 00:00:00

  • Coronary calcifications detected by computed tomography are not markers of cardiac allograft vasculopathy.

    abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) still limits survival after heart transplantation. Currently available noninvasive tests are of inferior value to detect CAV, and thus invasive coronary angiography (ICA) is frequently performed. Cardiac dual-source computed tomography calcium scoring (DSCTCS) offers the ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318225281d

    authors: von Ziegler F,Kaczmarek I,Knez A,Greif M,Rümmler J,Meiser B,Reichart B,Becker C,Steinbeck G,Becker A

    更新日期:2011-08-27 00:00:00

  • Modeling the allocation system: principles for robust design before restructuring.

    abstract::The United Network for Organ Sharing is poised to resolve geographic disparity in liver transplantation and promote allocation based on medical urgency. At the time of writing, United Network for Organ Sharing is considering redistricting the organ procurement and transplantation network so that patient model for end-...

    journal_title:Transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/TP.0000000000000656

    authors: Mehrotra S,Kilambi V,Gilroy R,Ladner DP,Klintmalm GB,Kaplan B

    更新日期:2015-02-01 00:00:00

  • Direct induction of MHC class I, but not class II, expression on endothelial cells by cytomegalovirus infection.

    abstract::MHC expression on endothelial cells after cytomegalovirus infection was investigated using double antibody radioimmunoassays and immunofluorescence flow cytometry. After CMV infection there was an increase in class I and beta 2 microglobulin expression. This increase corresponds to the percentage of cells that are inf...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198909000-00024

    authors: van Dorp WT,Jonges E,Bruggeman CA,Daha MR,van Es LA,van Der Woude FJ

    更新日期:1989-09-01 00:00:00

  • Induction of immune alterations and successful renal transplantation with a simplified method of donor-specific blood transfusion.

    abstract::We developed a new and simplified donor-specific blood transfusion (DSBT) protocol for prospective kidney transplant recipients from one-haplotype-mismatched related donors. Prospective kidney donors gave 450 ml of blood in a quad-pack unit, and the blood was stored in a blood bank. Twenty-five patients were transfuse...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198411000-00012

    authors: Cheigh JS,Suthanthiran M,Kaplan M,Evelyn M,Riggio RR,Fotino M,Schechter N,Wolf CF,Stubenbord WT,Stenzel KH

    更新日期:1984-11-01 00:00:00

  • Galectin-3-mediated xenoactivation of human monocytes.

    abstract:BACKGROUND:Delayed xenograft rejection (DXR) remains a roadblock to successful xenotransplantation. A feature of DXR is early recruitment of monocytes to the xenograft. Naïve human monocytes can recognize and adhere to unstimulated porcine aortic endothelial cells (PAEC) more than human aortic endothelial cells, partly...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318191e6b4

    authors: Greenwald AG,Jin R,Waddell TK

    更新日期:2009-01-15 00:00:00

  • The effect of agents which modulate levels of the cyclic nucleotides on human lymphotoxin secretion and activity in vitro.

    abstract::The ability of concanavalin-A (Con-A) to activate lymphocytes to secrete human lymphotoxin (LT) was tested in the presence of agents known to modify the intracellular levels of cyclic nucleotides (cAMP and cGMP). Lymphocytes were treated with these agents at different stages of activation: (1) during the first encount...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197510000-00010

    authors: Prieur AM,Granger GA

    更新日期:1975-10-01 00:00:00

  • Long-term results of liver transplantation in familial amyloidotic polyneuropathy type I.

    abstract:BACKGROUND:The aim of this article is to report our experience regarding the survival and the evolution of polyneuropathy of the extremities and autonomic dysfunction in 18 liver transplant patients with familial amyloidotic polyneuropathy type I after a mean follow-up of more than 2.5 years for 13 patients. METHODS:T...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199708270-00017

    authors: Parrilla P,Ramirez P,Andreu LF,Bueno SF,Robles R,Miras M,Acosta F,Viader-Farre D,de Mingo P,Bermejo J,Garrido SF,Munar-Ques M

    更新日期:1997-08-27 00:00:00

  • Induction of increased graft-versus-host disease by mouse spleen cells sensitized in vitro to allogeneic tumor.

    abstract::The aim of our study was to sensitize cells in vitro, follow their proliferative and cytotoxic responses, and determine their ability to cause lethal graft-versus-host disease (GVHD). C57BL/6 (H2b) spleen cells were incubated with irradiated BALB/C (H2d) Moloney lymphoma cells (LSTRA) in mixed leukocyte culture condit...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-197612000-00008

    authors: Einstein AB Jr,Cheever MA,Fefer A

    更新日期:1976-12-01 00:00:00

  • Clinical Trials for Immunosuppression in Transplantation: The Case for Reform and Change in Direction.

    abstract::Currently trials of immunosuppression in transplantation are in decline because their objectives remain focused on improving acute rejection rates and graft survival in the first 12 months. With 1 year renal graft survival rates of greater than 90% the best that can be hoped for is noninferiority trial outcomes compar...

    journal_title:Transplantation

    pub_type:

    doi:10.1097/TP.0000000000001648

    authors: OʼConnell PJ,Kuypers DR,Mannon RB,Abecassis M,Chadban SJ,Gill JS,Murphy B,Nickerson PW,Schold JD,Stock PG,Seron D,Alloway RR,Bromberg JS,Budde K,Jordan SC,Legendre C,Lefaucheur C,Sarwall M,Segev DL,Stegall MD,Tull

    更新日期:2017-07-01 00:00:00

  • Comparison of University of Wisconsin and St Thomas' Hospital solutions on endothelium-derived hyperpolarizing factor-mediated function in coronary micro-arteries.

    abstract:BACKGROUND:It is controversial whether coronary endothelial function is impaired after cold exposure to University of Wisconsin (UW) or St. Thomas' Hospital (ST) solution during heart transplantation. We therefore examined the effects of cold storage of coronary micro-arteries with UW or ST solution on endothelium-deri...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Ge ZD,He GW

    更新日期:2000-07-15 00:00:00

  • Nondepleting anti-CD4 monoclonal antibody enhances the ability of oral alloantigen delivery to induce indefinite survival of cardiac allografts: oral tolerance to alloantigen.

    abstract:BACKGROUND:We examined whether oral administration of alloantigen could induce the prolonged survival of cardiac allografts. METHODS:Hearts from CBK (H2k+Kb) transgenic or (C57BL/10xCBA)F1 (H2bxH2k) mice were transplanted into CBA (H2k) recipients pretreated orally with 1 x 10(7) donor splenocytes in the presence or a...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-200011270-00021

    authors: Niimi M,Witzke O,Bushell A,Hara M,Morris PJ,Wood KJ

    更新日期:2000-11-27 00:00:00

  • Continuous venovenous hemofiltration with dialysis in combination with total hepatectomy and portocaval shunting. Bridge to liver transplantation.

    abstract::Children who experience acute liver failure following liver transplantation will have multiple organ failure and a high rate of mortality unless emergency retransplantation can be performed. Transplant hepatectomy with portocaval shunting has been described as a bridge to transplantation in the most severe cases, as w...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199607150-00026

    authors: Hammer GB,So SK,Al-Uzri A,Conley SB,Concepcion W,Cox KL,Berquist WE,Esquivel CO

    更新日期:1996-07-15 00:00:00

  • Heart rate after cardiac transplantation-lessons from the tortoise and the shrew.

    abstract::There is a striking consistency in the total number of heart beats accrued over a lifetime across a range of animal species despite vast differences in size. Moreover, an inverse relationship is observed between heart rate and lifespan, leading to speculation that elevated heart rate could significantly affect longevi...

    journal_title:Transplantation

    pub_type: 社论,评审

    doi:10.1097/TP.0b013e31826bc42a

    authors: Critchley WR,Yonan N,Shaw SM,Fildes JE

    更新日期:2013-01-27 00:00:00

  • T cells are necessary and critical for xenograft rejection in new concordant cardiac xenotransplant model.

    abstract:BACKGROUND:A new vascularized concordant xenotransplant model using the Chinese hamster as donor and mouse as recipient species is reported. This model takes advantage of the wealth of informative immune reagents and knockout and transgenic backgrounds available for the mouse. METHODS:Heterotopic auxillary cardiac tra...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199906150-00016

    authors: Obatake M,Kushida M,Kimmel S,Clarke ID,Kim PC

    更新日期:1999-06-15 00:00:00

  • Induction of vascular adhesion molecules during rejection of human cardiac allografts.

    abstract::Adhesion of leukocytes to vascular endothelium is a necessary step leading to the migration of cells into underlying tissues. Vascular adhesion molecules regulate this process and may play an important role in graft rejection. Immunocytochemical studies have been used to investigate the expression of vascular adhesion...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199209000-00013

    authors: Taylor PM,Rose ML,Yacoub MH,Pigott R

    更新日期:1992-09-01 00:00:00

  • Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group.

    abstract:BACKGROUND:Sirolimus (rapamycin) is a potent immunosuppressant with a mechanism of action different from cyclosporine (CsA) or tacrolimus. METHODS:In 11 European centers, first cadaveric renal allograft recipients were randomized to CsA (n=42) or sirolimus (n=41). Dosing of these agents was concentration-controlled an...

    journal_title:Transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007890-199904150-00017

    authors: Groth CG,Bäckman L,Morales JM,Calne R,Kreis H,Lang P,Touraine JL,Claesson K,Campistol JM,Durand D,Wramner L,Brattström C,Charpentier B

    更新日期:1999-04-15 00:00:00

  • Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion.

    abstract::Liver transplantation is currently the only established treatment of end-stage liver disease, but it is limited by a severe shortage of viable donor livers. Donors after cardiac death (DCD) are an untapped source that could significantly increase the pool of available livers. Preservation of these DCD livers by conven...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318192df6b

    authors: Tolboom H,Pouw RE,Izamis ML,Milwid JM,Sharma N,Soto-Gutierrez A,Nahmias Y,Uygun K,Berthiaume F,Yarmush ML

    更新日期:2009-01-27 00:00:00

  • Increased hyaluronan in acutely rejecting human kidney grafts.

    abstract::The glycosaminoglycan hyaluronan is not only involved in cellular differentiation and migration but may also play a role in several inflammatory diseases. We have previously demonstrated an increased local production of hyaluronan in chronically rejected kidneys and the correspondingly affected renal vessels. In this ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199306000-00025

    authors: Wells A,Larsson E,Hanás E,Laurent T,Hällgren R,Tufveson G

    更新日期:1993-06-01 00:00:00

  • Neutrophilic tubulitis as a marker for urinary tract infection in renal allograft biopsies with C4d deposition.

    abstract:BACKGROUND:Neutrophilic tubulitis accompanied by intratubular neutrophil clusters in the renal allograft is a surrogate marker for urinary tract infection (UTI). Overlapping histologic findings can occur in antibody-mediated rejection, which is characterized by peritubular capillary (PTC) deposition of C4d. This study ...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e31819ca304

    authors: Gupta G,Shapiro R,Girnita A,Batal I,McCauley J,Basu A,Tan H,Randhawa P

    更新日期:2009-04-15 00:00:00

  • Interference of angiotensin-converting enzyme inhibitors on erythropoiesis in kidney transplant recipients: role of growth factors and cytokines.

    abstract:BACKGROUND:Recent data indicate that factors other than erythropoietin (EPO), such as insulin-like growth factor 1 (IGF-1), can promote erythropoiesis in vitro and correct the anemia of chronic renal failure in vivo. IGF-1 is produced by the liver under growth hormone control, as well as by other sources, including the...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199709270-00021

    authors: Morrone LF,Di Paolo S,Logoluso F,Schena A,Stallone G,Giorgino F,Schena FP

    更新日期:1997-09-27 00:00:00

  • Functional recovery of chronic paraplegic pigs after autologous transplantation of bone marrow stromal cells.

    abstract:BACKGROUND:Bone marrow stromal cells (BMSC) transplantation offers promise in the treatment of chronic paraplegia in rodents. Here, we report the effect of this cell therapy in adult pigs suffering chronic paraplegia. METHODS:Three months after spinal cord injury, autologous BMSC in autologous plasma was injected into...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0b013e318186198f

    authors: Zurita M,Vaquero J,Bonilla C,Santos M,De Haro J,Oya S,Aguayo C

    更新日期:2008-09-27 00:00:00

  • Focal acute tubular necrosis in a renal allograft.

    abstract::Nuclear imaging is used to evaluate renal allografts demonstrating delayed function after transplantation. Interpretation of the nuclear scan in the context of clinical data, provides helpful information in the management of the transplant recipient. The better quality of images obtained with technetium-99m mercaptoac...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199711270-00023

    authors: Mange KC,Scheff A,Brayman K,Mozley D,Grossman RA,Naji A,Aradhye S

    更新日期:1997-11-27 00:00:00

  • In Vivo Costimulation Blockade-Induced Regulatory T Cells Demonstrate Dominant and Specific Tolerance to Porcine Islet Xenografts.

    abstract:BACKGROUND:Although islet xenotransplantation is a promising therapy for type 1 diabetes, its clinical application has been hampered by cellular rejection and the requirement for high levels of immunosuppression. The aim of this study was to determine the role of Foxp3 regulatory T (Treg) cells in costimulation blockad...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001482

    authors: Wu J,Hu M,Qian YW,Hawthorne WJ,Burns H,Liuwantara D,Alexander SI,Yi S,O'Connell PJ

    更新日期:2017-07-01 00:00:00

  • Histologic grading of acute allograft rejection in pancreas needle biopsy: correlation to serum enzymes, glycemia, and response to immunosuppressive treatment.

    abstract:BACKGROUND:Allograft rejection continues to be the most common cause of graft failure in technically successful pancreas transplants. Early diagnosis and treatment of rejection is essential for long-term graft survival. Pancreas graft biopsies are now used routinely for the diagnosis of acute allograft rejection. The c...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-199812270-00030

    authors: Papadimitriou JC,Drachenberg CB,Wiland A,Klassen DK,Fink J,Weir MR,Cangro C,Schweitzer EJ,Bartlett ST

    更新日期:1998-12-27 00:00:00

  • The nonessential role of a humoral antibody response in acute rat cardiac allograft rejection. An ultrastructural tracer study in an adoptive transfer model.

    abstract::Progressive microvascular endothelial damage is a characteristic feature of fulminant acute cardiac allograft rejection in the rat. Serial ultrastructural tracer studies using i.v. administered colloidal carbon and horseradish peroxidase have been performed in an adoptive transfer model to determine the role of cellul...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/00007890-198402000-00013

    authors: Lowry RP,Forbes RD

    更新日期:1984-02-01 00:00:00

  • Respiratory tract viral infections in bone marrow transplant patients.

    abstract:BACKGROUND:Community respiratory viruses such as respiratory syncytial virus (RSV), adenovirus, influenza A, influenza B, and the parainfluenza group are frequent causes of respiratory disease in bone marrow transplant (BMT) patients. MATERIAL AND METHODS:During the period from March 1993 to August 1999, 810 samples o...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/01.TP.0000072012.26176.58

    authors: Raboni SM,Nogueira MB,Tsuchiya LR,Takahashi GA,Pereira LA,Pasquini R,Siqueira MM

    更新日期:2003-07-15 00:00:00

  • Ten-year results of a randomized trial comparing tacrolimus versus cyclosporine a in combination with mycophenolate mofetil after heart transplantation.

    abstract:BACKGROUND:Long-term results of prospective randomized trials comparing triple immunosuppressive strategies combining tacrolimus (TAC) or cyclosporine A (CsA) with mycophenolate mofetil (MMF) and steroids after heart transplantation (HTX) are rarely published. Therefore, we collected long-term follow-up data of an inte...

    journal_title:Transplantation

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/TP.0b013e318277e378

    authors: Guethoff S,Meiser BM,Groetzner J,Eifert S,Grinninger C,Ueberfuhr P,Reichart B,Hagl C,Kaczmarek I

    更新日期:2013-02-27 00:00:00

  • Accept or Decline? An Analytics-Based Decision Tool for Kidney Offer Evaluation.

    abstract:BACKGROUND:When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for futu...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:10.1097/TP.0000000000001824

    authors: Bertsimas D,Kung J,Trichakis N,Wojciechowski D,Vagefi PA

    更新日期:2017-12-01 00:00:00

  • CD4 Th2 cells do not functionally suppress CTL generation in neonatal tolerant mice.

    abstract::Injecting semiallogeneic CAF1 spleen into BALB/c newborn mice renders mice tolerant, and the majority of mice show prolonged survival of tolerogen-bearing A/J skin grafts. Moreover, graft survival is associated with enhanced Th2 cytokine responses and graft rejection with Th1 cytokine responses. To further delineate t...

    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

    authors: Gao Q,Chen N,Field EH

    更新日期:1995-12-15 00:00:00