Abstract:
BACKGROUND:Cardiac allograft vasculopathy (CAV) has an incidence of 43% at 8 years after heart transplantation with extremely limited treatment options and unclear pathogenesis. CAV constitutes a significant complication that limits the long-term survival of heart recipients. Insulin-like growth factor-1 (IGF-1) is associated with different cardiovascular diseases; however, its role in CAV pathogenesis remains unknown. METHODS:Serum samples of 10 matched recipients with CAV and 10 with no-CAV were initially screened with a protein array. Subsequently, IGF-1- and IGF-binding protein-3 (IGFBP-3) were analyzed using enzyme-linked immunosorbent assay in 44 randomly selected CAV and 50 no-CAV patients at two time points. RESULTS:The initial screening showed that IGF-1 and IGFBP-3 are differentially expressed in CAV compared with no-CAV patients (P=0.037 and P<0.0001, respectively). Subsequent enzyme-linked immunosorbent assay analyses indicated that serum IGF-1 protein concentrations were significantly lower in CAV patients (159.7±114 ng/mL) as compared with no-CAV patients (234.1±136 ng/mL; P=0.02). Serum IGFBP-3 protein concentrations were significantly lower in CAV (0.46±0.37 mg/L) as compared with no-CAV patients (1.03±0.73 mg/L; P=0.04). Multivariate logistic regression analyses showed that IGF-1 (odds ratio, 0.89; P=0.04) and IGFBP-3 (odds ratio, 0.09; P=0.03) are independent risk factors for CAV. CONCLUSION:Low IGF-1 and IGFPB-3 serum concentrations are associated with CAV. The assessment of serum IGF-1 and IGFPB-3 might be beneficial in identifying cardiac allograft recipients who are prone to develop CAV. Moreover, IGF-1 might be a useful therapy that could protect cardiac allografts against CAV.
journal_name
Transplantationjournal_title
Transplantationauthors
Aharinejad S,Salama M,Rödler S,Ehrlich M,Zuckermann A,Laufer Gdoi
10.1097/TP.0b013e31823ec10dsubject
Has Abstractpub_date
2012-02-15 00:00:00pages
309-13issue
3eissn
0041-1337issn
1534-6080journal_volume
93pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:Renal transplant patients have an increased incidence of skin cancers, predominantly on sun-exposed surfaces. Clinical observation identified some patients with an increased number of viral warts, keratoses, and skin malignancies on the side of the arteriovenous fistula. METHODS:In a population of 980 patie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200101150-00022
更新日期:2001-01-15 00:00:00
abstract:BACKGROUND:More than 30% of potential kidney transplant recipients have pre-existing anti-human leukocyte antigen antibodies. This subgroup has significantly lower transplant rates and increased mortality. Desensitization has become an important tool to overcome this immunological barrier. However, limited data is avai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000442782.98131.7c
更新日期:2014-06-27 00:00:00
abstract:BACKGROUND:Acute rejection (AR) of the transplanted kidney has been identified as the major risk factor for the development of chronic rejection and immunological graft loss. However, the clinical presentation and response to AR therapy can vary considerably between recipients. METHODS:We studied the first AR episode ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199911150-00017
更新日期:1999-11-15 00:00:00
abstract:BACKGROUND:Although it is generally considered that livers with moderate steatosis can be safely used in the setting of living-donor liver transplantation, the effect of the regenerative process of such a graft on postoperative liver function is incompletely understood. We assessed the morphologic and functional altera...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000109777.51902.09
更新日期:2004-02-15 00:00:00
abstract:BACKGROUND:We have previously demonstrated that in a concordant hamster-to-nude rat cardiac transplant model, T-independent specific B-lymphocyte and natural killer (NK)-cell tolerance could be induced, leading to long-term xenograft (Xg) survival. Here, we investigated whether the same could be achieved in a clinicall...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199907150-00024
更新日期:1999-07-15 00:00:00
abstract::Increased susceptibility to bacterial infection is a recognized side-effect of sirolimus treatment after transplantation, which could be caused by inhibition of neutrophil activation. Blood from 24 healthy subjects was equilibrated with 0 to 50 ng/mL sirolimus or 60 microg/mL propofol. Blood was also collected from 23...
journal_title:Transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.TP.0000093995.08240.49
更新日期:2003-12-27 00:00:00
abstract:BACKGROUND:This study is designed to examine a possible association of cardiopulmonary bypass (CPB) support and outcome of lung transplantation in a well-balanced group of emphysema patients. METHODS:We performed a retrospective analysis of 62 consecutive primary bilateral lung transplantations for emphysema. Risk fac...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200205270-00017
更新日期:2002-05-27 00:00:00
abstract::Consecutive patients transplanted between January 1984 and December 1988 were followed until August 1992 to detect fatal and nonfatal thromboembolic complications, including sudden death, acute and chronic myocardial infarction, pulmonary and peripheral embolisms, stroke, and thrombophlebitis. The probability of devel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199603150-00015
更新日期:1996-03-15 00:00:00
abstract:BACKGROUND:Previous reports have established the feasibility of using livers from controlled, non-heart-beating donors (CNHBD) with good immediate graft function. This has been largely borne out of necessity because of the donor shortage. METHODS:Retrospective database review for the last 7 years (1995-2002), encompas...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000128327.95311.e3
更新日期:2004-07-27 00:00:00
abstract:BACKGROUND:Posttransplantation bone disease is a well-described phenomenon; among its etiology is immunosuppressant-induced bone disease. Mycophenolate mofetil (MMF) has emerged as a promising new immunosuppressant. Our study was designed to investigate the effect of MMF on in vivo bone mineral metabolism. METHODS:Twe...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199801270-00025
更新日期:1998-01-27 00:00:00
abstract::Pseudoaneurysms of the hepatic artery are a rare complication of liver transplantation. Early diagnosis and treatment are essential to avoid life-threatening hemorrhage. Conventional treatment consists of surgical resection and vascular reconstruction or transarterial coil embolization. More recently, percutaneous thr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000063936.94587.10
更新日期:2003-05-27 00:00:00
abstract:BACKGROUND:Previous studies have shown that posttransplant total lymphoid irradiation, anti-thymocyte globulin, and an intravenous donor blood cell infusion induce tolerance to ACI heart allografts in Lewis rat hosts. METHODS:In the current study, fresh ACI monocytes and dendritic cell precursors, derived from short-t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199811270-00004
更新日期:1998-11-27 00:00:00
abstract:BACKGROUND:In kidney transplant recipients with alemtuzumab induction maintained on mycophenolate mofetil (MMF) immunosuppression, sirolimus (SRL) promotes significant expansion of circulating CD4+CD25high regulatory T cells (Treg). This might translate into more effective protection against chronic graft injury compar...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.tp.0000284808.28353.2c
更新日期:2007-10-27 00:00:00
abstract::Ranolazine is a new drug with a novel mode of action as a metabolic modulator and membrane stabilizer. In this prospective randomized double-blind trial, a porcine model of renal autotransplantation was used to assess the effects of this drug during preservation and reperfusion of kidneys cold-stored for 24 hr in phos...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199011000-00004
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs and the migration of dendritic cells into afferent lymphatic vessels. Antigen presentation, T cell recruitment, and expansion of regulatory cells are crucial events in establish...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181826a97
更新日期:2008-08-27 00:00:00
abstract:BACKGROUND:Modification of the aminoacid sequence of peptides derived from the HLA class I heavy chain in combination with computer rational design resulted in the development of a peptide, RDP1258, with enhanced immunosuppressive activity. METHODS:We evaluated the activity of this peptide, analyzing infiltrate by imm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199906270-00017
更新日期:1999-06-27 00:00:00
abstract::To determine if cold preservation time continues to affect renal transplant outcome, prospectively collected data from 17,937 cadaveric renal transplants performed between 1982 and 1991 were analyzed. Cold preservation intervals of 1-16, 16-32, 32-48, and greater than 48 hr were studied by multi- and univariate method...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-01-27 00:00:00
abstract:BACKGROUND:The full potential of pancreatic islet transplantation (PIT) has not been realized because of the difficulties associated with islet isolation, particularly when associated with a remote islet isolation center. Herein, we describe the principles of pancreatic procurement for PIT, which have allowed us to ach...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000128910.41921.4b
更新日期:2004-08-15 00:00:00
abstract::To determine the extent to which pretransplant immunity resulting from natural infection protects against cytomegalovirus (CMV) disease, we analyzed CMV serology on 153 kidney donor and recipient pairs and followed transplant patients to determine incidence and severity of CMV disease. The overall incidence of CMV dis...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198508000-00010
更新日期:1985-08-01 00:00:00
abstract::The incidence of interstitial pneumonitis (IP) was reviewed in 70 consecutive patients who received autologous marrow transplants for hematologic malignancies. All patients were treated with total-body irradiation (TBI), with or without other chemotherapeutic agents. Seven patients (10%) developed IP, 3 were due to cy...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198611000-00015
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Recurrent nephrotic syndrome (NS) is a severe problem after renal transplantation in patients with congenital nephrotic syndrome of the Finnish type (NPHS1). The NPHS1 kidneys do not express nephrin, and antibodies against this major glomerular filter protein have been observed in NPHS1 children with recurre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000262569.27890.64
更新日期:2007-05-27 00:00:00
abstract::For maximum use of left liver plus caudate lobe grafts, the short hepatic vein draining the caudate lobe should be reconstructed. We devised a new venoplasty technique. On the graft side, a wide venous orifice with a long cuff was formed by gathering the left, middle, and short hepatic veins using a conduit vein graft...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000244729.39485.7c
更新日期:2007-01-27 00:00:00
abstract:BACKGROUND:Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model. METHODS:We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829b07e1
更新日期:2013-09-15 00:00:00
abstract::The possible ability of the mixed-epidermal-cell-lymphocyte reaction (MECLR) to detect alloreactivities in HLA-identical MLR negative siblings has been investigated before grafting in 30 donor-recipients pairs and their families. Results indicate that recipients' epidermal cells (EC) can induce proliferative responses...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198603000-00007
更新日期:1986-03-01 00:00:00
abstract::Islets were isolated using neutral red as a dye to exclude lymphatic and acinar impurities in the transplant preparation. In a one donor-one recipient model, intraportally transplanted isogeneic islets survived indefinitely. Mean graft survival could be prolonged from 5 to 90 days, using a 3-dose rejection prophylaxis...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198604000-00003
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine diphosphate-ribose) polymerase (PARP) is a single-stranded DNA repair enzyme that induces apoptosis and necrosis after DNA damage caused by reactive oxygen species. We evaluate...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000305
更新日期:2014-09-27 00:00:00
abstract:BACKGROUND:One of the alternative options to simultaneous pancreas-kidney transplantation (SPKT) for type I diabetics with renal failure is sequential transplant of a living donor kidney followed by a deceased donor pancreas transplant (pancreas after living donor kidney transplant [PALK]). We retrospectively compared ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181dd3587
更新日期:2010-06-27 00:00:00
abstract:BACKGROUND:Transplant recipients who develop COVID-19 may be at increased risk for morbidity and mortality. Determining the status of antibodies against SARS-CoV-2 in both candidates and recipients will be important to understand the epidemiology and clinical course of COVID-19 in this population. While there are multi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003524
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it. METHODS:First,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199905150-00012
更新日期:1999-05-15 00:00:00
abstract:UNLABELLED:LBNF1 cardiac allografts (Tx) are rejected within 36 hr in LEW rats sensitized with BN skin Tx 7 days earlier, compared to 8-day rejection in unmodified hosts. Treatment with cyclosporine or ART-18, an anti-interleukin 2 receptor (IL-2[R]) mAb monoclonal antibody, abrogates accelerated rejection and prolongs...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199102000-00004
更新日期:1991-02-01 00:00:00