Abstract:
:Despite previous attempts there is currently no suitable animal model available for xenogeneic graft versus host disease (XGVHD) mediated via human immunocompetent cells. Recently, we have developed an efficient protocol to engraft SCID mice with human peripheral blood lymphocytes (Hu-PBLs). The engraftment efficiency is extremely high, such that 100% of Hu-PBL-SCID mice die of XGVHD within 4 weeks after engraftment with Hu-PBLs (3-5 x 10(7) cells). A series of experiments was performed to investigate the mechanisms involved in the severe XGVHD. The results suggest that XGVHD was induced by human CD4+ T cells, antixenogeneic (antimouse) antibodies, and lymphokines. The SCID mouse model will be extremely valuable for the evaluation and development of immunosuppressive agents and transplantation protocols for human XGVHD.
journal_name
Transplantationjournal_title
Transplantationauthors
Sandhu JS,Gorczynski R,Shpitz B,Gallinger S,Nguyen HP,Hozumi Nsubject
Has Abstractpub_date
1995-07-27 00:00:00pages
179-84issue
2eissn
0041-1337issn
1534-6080journal_volume
60pub_type
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