Incidence of cytomegalovirus disease in cyclosporine-treated renal transplant recipients based on donor/recipient pretransplant immunity.

abstract：BACKGROUND:Intrathymic events undergoing allograft rejection remain undefined. The present study investigated the role of tumor necrosis factor-beta on acute thymic involution in rat hepatic allograft recipients during rejection. METHODS:Apoptosis and cellular phenotypic changes in the thymus were studied after hepati...

journal_title：Transplantation

authors： Yamaguchi Y,Okabe K,Miyanari N,Matsumura F,Ichiguchi O,Akizuki E,Matsuda T,Liang J,Ohshiro H,Miyayama Y,Yamada S,Mori K,Ogawa M

更新日期：1998-10-15 00:00:00

abstract：:The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indica...

journal_title：Transplantation

authors： Shelton JA,Goldberg EH

更新日期：1984-01-01 00:00:00

abstract：:The aim of this study was to analyze, in heart transplant patients, if renal function improvement after cyclosporine replacement by everolimus persists at the middle term and its predictors. We studied prospectively 56 patients in whom conversion was consecutively made. Forty-five patients completed the follow-up peri...

journal_title：Transplantation

authors： Moro López JA,Almenar L,Martínez-Dolz L,Sánchez-Lázaro I,Agüero J,Buendía F,Ortiz V,Salvador A

更新日期：2009-02-27 00:00:00

abstract：:We had previously shown in a canine model that the administration of anti-MHC class II monoclonal antibody (MAB) immediately after autologous marrow transplantation prevented hemopoietic reconstitution. Since MHC class II expression in mice differs from that in dogs we were interested in determining the effect of MHC ...

journal_title：Transplantation

authors： Huss R,Beckham C,Storb R,Deeg HJ

更新日期：1994-12-27 00:00:00

abstract：:Heart transplantation is considered nowadays the gold standard in the therapy of chronic and terminal heart insufficiency. Primary organ failure after heart transplantation is a severe complication generally related to prolonged ischemia time, poor quality of the organ, or acute rejection. All these factors can potent...

journal_title：Transplantation

authors： Beiras-Fernandez A,Weis FC,Fuchs H,Meiser BM,Reichart B,Weis M

更新日期：2006-10-27 00:00:00

abstract：BACKGROUND:The shortage of organs for liver transplantation has forced transplant centers to expand the donor pool by using donors traditionally labeled as marginal. One such example is liver transplantation using a donor with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), a disorder of late pre...

journal_title：Transplantation

authors： Briceno PJ,Ortiz JA,Manzarbeitia C,Jeon H,Munoz SJ,Rothstein KD,Araya V,Gala I,Reich DJ

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND:Osteoporosis is a well-documented complication of organ transplantation. Bisphosphonates have been shown to be effective in preventing corticosteroid-induced osteoporosis in renal transplant recipients, but data are lacking for treatment of established osteoporosis. This study reports our clinical experience...

journal_title：Transplantation

authors： Arlen DJ,Lambert K,Ioannidis G,Adachi JD

更新日期：2001-03-15 00:00:00

abstract：BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...

journal_title：Transplantation

authors： Zanker B,Schneeberger H,Rothenpieler U,Hillebrand G,Illner WD,Theodorakis I,Stangl M,Land W

更新日期：1998-07-15 00:00:00

abstract：:In a murine strain combination disparate in both H-2 antigens and minor histocompatibility antigens consisting of C57BL/6 (B6; H-2b, Mls-1b) mice as recipients and AKR/J (AKR; H-2k, Mls-1a) mice as donors, we reported that the administration of anti-TCR-alpha beta mAb nonspecifically suppresses the ability to reject a...

journal_title：Transplantation

authors： Nomoto K,Yung-Yun K,Omoto K,Umesue M,Murakami Y,Matsuzaki G,Nomoto K

更新日期：1995-02-15 00:00:00

abstract：:Until recently, islet allotransplantation for type 1 diabetic patients has been largely unsuccessful. Previous pharmacologic studies of single drugs have suggested that one factor contributing to this poor success is toxicity of immunosuppressive drugs on transplanted islets. However, no comprehensive study of agents ...

journal_title：Transplantation

authors： Paty BW,Harmon JS,Marsh CL,Robertson RP

更新日期：2002-02-15 00:00:00

abstract：BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...

journal_title：Transplantation

authors： Tsai HL,Chang JW,Wu TH,King KL,Yang LY,Chan YJ,Yang AH,Chang FP,Pan CC,Yang WC,Loong CC

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examined correlates and outcomes associated with low PA (ie, not meeting individual study's definition of being physically acti...

journal_title：Transplantation

authors： Berben L,Engberg SJ,Rossmeissl A,Gordon EJ,Kugler C,Schmidt-Trucksäss A,Klem ML,Sereika SM,De Simone P,Dobbels F,De Geest SM,B-SERIOUS consortium.

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:The emergence of a ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strain in a heart transplant recipient (HTR) coinfected by multiple HCMV strains was investigated. METHODS:A HTR with primary HCMV infection was treated with three induction courses of intravenous GCV followed by a 2-month maintenan...

journal_title：Transplantation

authors： Baldanti F,Simoncini L,Sarasini A,Zavattoni M,Grossi P,Revello MG,Gerna G

更新日期：1998-08-15 00:00:00

abstract：:Rat, hamster, and rabbit islets were transplanted into diabetic C57BL/B6 mice. The effect on islet xenograft survival of low-temperature culture of the donor islets, alpha L3T4 treatment of the recipients for seven days, and transplantation of the grafts either in the renal capsule or in the liver via the portal vein ...

journal_title：Transplantation

authors： Lacy PE,Ricordi C,Finke EH

更新日期：1989-05-01 00:00:00

abstract：:Increased susceptibility to bacterial infection is a recognized side-effect of sirolimus treatment after transplantation, which could be caused by inhibition of neutrophil activation. Blood from 24 healthy subjects was equilibrated with 0 to 50 ng/mL sirolimus or 60 microg/mL propofol. Blood was also collected from 23...

journal_title：Transplantation

authors： Gee I,Trull AK,Charman SC,Alexander GJ

更新日期：2003-12-27 00:00:00

abstract：:The mixed lymphocyte culture tests between one patient with acute lymphocytic leukemia and her mother and between another patient with aplastic anemia and his mother were found nonreactive, despite a one-haplotype difference for HL-A. Two crossovers in each family at the MLC locus or a specific defect in lymphocyte r...

journal_title：Transplantation

authors： Opelz G

更新日期：1975-01-01 00:00:00

abstract：:Patients receiving allogeneic marrow transplantation for hematologic malignancies commonly are conditioned with total body irradiation (TBI) and given methotrexate (MTX) in an attempt to prevent graft-versus-host disease. To study the effects of TBI with or without MTX on bronchoalveolar cells and proteins, we perform...

journal_title：Transplantation

authors： Springmeyer SC,Kopecky KJ,Deeg HJ,Whitehead J,Altman LC,Storb R

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:Auxiliary partial orthotopic liver transplantation (APOLT) has been an effective alternative in acute liver failure (ALF), but clinically several problems remain to be resolved. Thus, we attempt to establish an APOLT model for ALF using a large animal and demonstrate the validity of our model. METHODS:In ex...

journal_title：Transplantation

authors： Fukueda M,Ishizaki N,Hamada N,Kadono J,Kaieda M,Nakamura N,Komokata T,Sakata R

更新日期：2006-11-27 00:00:00

abstract：BACKGROUND:Islet transplantation studies with diabetic rodents frequently use treatment with diabetogens such as alloxan or streptozotocin to render hosts hyperglycemic. These chemicals produce unwanted toxic side effects, which complicate interpretations of damage produced by hyperglycemia versus direct toxin-induced ...

journal_title：Transplantation

authors： Mathews CE,Langley SH,Leiter EH

更新日期：2002-04-27 00:00:00

abstract：BACKGROUND:Cold preservation is the most practical method to maintain the viability of isolated lungs. However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature. METHODS:Human ...

journal_title：Transplantation

authors： Suzuki S,Bing H,Sugawara T,Matsuda Y,Tabata T,Hoshikawa Y,Saijo Y,Kondo T

更新日期：2004-08-27 00:00:00

abstract：BACKGROUND:CTLA4 immunoglobulin (Ig)G that binds to B7 effectively inhibits the signaling of CD28/CTLA4-B7 pathway and induces antigen specific T cell unresponsiveness in vitro and in vivo. Using CTLA4IgG, we examined induction of long-term graft survival and the mechanism of maintenance of tolerance in rat allogeneic ...

journal_title：Transplantation

authors： Tarumi K,Murakami M,Yagihashi A,Nakagawa I,Hirata K,Uede T

更新日期：1999-02-27 00:00:00

abstract：BACKGROUND:Pediatric liver transplant recipients have traditionally been grouped according to age. Age-based classification schemes are useful in identifying clinical problems in selected age groups and also for developing solutions to these problems. Although infants in the first 3 months of life have not traditionall...

journal_title：Transplantation

authors： Woodle ES,Millis JM,So SK,McDiarmid SV,Busuttil RW,Esquivel CO,Whitington PF,Thistlethwaite JR

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:Living kidney donors have donation-related out-of-pocket costs (direct costs) and/or ongoing daily expenses while losing income (indirect costs). Yet there is little information about how much of a subjective burden these constitute for the donors. METHODS:From December 2003 through December 2014, we survey...

journal_title：Transplantation

authors： Wiseman JF,Jacobs CL,Larson DB,Berglund DM,Garvey CA,Ibrahim HN,Matas AJ

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Osteoarthritis is the most prevalent joint disease and a frequent cause of joint pain, functional loss, and disability. Osteoarthritis often becomes chronic, and conventional treatments have demonstrated only modest clinical benefits without lesion reversal. Cell-based therapies have shown encouraging result...

journal_title：Transplantation

authors： Orozco L,Munar A,Soler R,Alberca M,Soler F,Huguet M,Sentís J,Sánchez A,García-Sancho J

更新日期：2013-06-27 00:00:00

abstract：BACKGROUND:Only four centers have reported their results with renal transplantation in human immunodeficiency virus (HIV)+ recipients on highly active antiretroviral therapy, and acute rejection (AR) rates have consistently ranged from 43% to 67%. METHODS:We examined the outcomes of eight adult HIV+ primary renal allo...

journal_title：Transplantation

authors： Gruber SA,Doshi MD,Cincotta E,Brown KL,Singh A,Morawski K,Alangaden G,Chandrasekar P,Losanoff JE,West MS,El-Amm JM

更新日期：2008-07-27 00:00:00

abstract：:Cyclosporine A administration produces an increase in renal vascular resistance and a decrease in glomerular filtration rate in both human and animal models. CsA usage in humans has also been shown to alter the ability of the kidney to adapt to alterations in renal hemodynamics. CsA alters the production of prostaglan...

journal_title：Transplantation

authors： Bunke M,Wilder L,Martin A

更新日期：1991-10-01 00:00:00

abstract：:The role of TNF in the expression of GVHD and GVHD-related immunodeficiency was studied in a well-established murine GVHD model of bone marrow transplantation across minor histocompatibility barriers (B10.BR-->GBA/J) both in vitro and in vivo. Splenocytes from animals with GVHD profoundly inhibited the proliferation o...

journal_title：Transplantation

authors： Wall DA,Sheehan KC

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Increasing clinical evidence suggests that delayed initial function secondary to ischemia/reperfusion injury alone, and particularly in combination with early episodes of acute rejection, reduces kidney allograft survival over time. METHODS:We investigated changes developing over the long term following a s...

journal_title：Transplantation

authors： Takada M,Nadeau KC,Shaw GD,Tilney NL

更新日期：1997-12-15 00:00:00

abstract：:The renal handling of cyclosporine was studied in ischemically damaged kidneys in New Zealand White rabbits and nonischemic control animals. CsA, 25 mg/kg/day, was administered intravenously for 10 days starting with the day of operation. Blood CsA (B CsA) was higher in the ischemic group compared with the controls (m...

journal_title：Transplantation

authors： Karim MS,Wood RF,Dawnay AB,Fulton PA

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Exercise training is effective in improving the cardiovascular risk profiles of nontransplanted patients, but the health benefits and potential harms of routine exercise training after solid organ transplantation are unclear. This study aims to assess the health benefits and harms of supervised exercise trai...

journal_title：Transplantation

authors： Didsbury M,McGee RG,Tong A,Craig JC,Chapman JR,Chadban S,Wong G

更新日期：2013-03-15 00:00:00