Abstract:
:Heart transplantation is considered nowadays the gold standard in the therapy of chronic and terminal heart insufficiency. Primary organ failure after heart transplantation is a severe complication generally related to prolonged ischemia time, poor quality of the organ, or acute rejection. All these factors can potentially lead to multiorgan failure. Pharmacological and mechanical support for these patients is limited and often related to side effects. Ca sensitizers have been proposed to increase cardiac contractility without altering intracellular Ca levels, thus avoiding the side effects of Ca overload. We report two cases of heart transplanted patients suffering from acute graft failure in the early postoperative period who recovered after intravenous administration of levosimendan, a Ca sensitizer.
journal_name
Transplantationjournal_title
Transplantationauthors
Beiras-Fernandez A,Weis FC,Fuchs H,Meiser BM,Reichart B,Weis Mdoi
10.1097/01.tp.0000233845.15508.89subject
Has Abstractpub_date
2006-10-27 00:00:00pages
1101-3issue
8eissn
0041-1337issn
1534-6080pii
00007890-200610270-00015journal_volume
82pub_type
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