Immunopathological observations after xenogeneic liver perfusions using donor pigs transgenic for human decay-accelerating factor.

abstract：BACKGROUND:Kidneys from older donors are likely to have a lower nephron mass. Nevertheless they constitute a valuable source of kidney allografts. Long cold ischemic time (CIT), with or without delayed graft function (DGF), has been associated with reduced graft survival. The aim of this study was to review the experie...

journal_title：Transplantation

authors： Asderakis A,Dyer P,Augustine T,Worthington J,Campbell B,Johnson RW

更新日期：2001-08-27 00:00:00

abstract：BACKGROUND:In the development of chronic kidney allograft rejection acute rejection (AR) is the single most important risk factor. Although Cyclosporin A (CsA) medication has decreased the incidence of AR, chronic rejection (CR) is still the major reason for late allograft loss. Platelet-derived growth factor (PDGF) is...

journal_title：Transplantation

authors： Savikko J,Kallio EA,Taskinen E,von Willebrand E

更新日期：2002-02-27 00:00:00

abstract：BACKGROUND:Strong alloreactive T cell responses are a menace in transplantation surgery and their menagement requires understanding the basis of alloreactivity. Alloantigen recognition can be peptide independent, peptide specific, or peptide dependent. The mechanisms influencing each recognition pattern are largely unk...

journal_title：Transplantation

authors： Nesić D,Marić M,Santori FR,Vukmanović S

更新日期：2002-03-15 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) infection is common in kidney transplantation and is known to affect long-term patient and graft survival, as is time in renal-replacement therapy (RRT). The aim of this study was to investigate HCV in relation to time in RRT and its impact on outcome after transplantation. METHODS:A...

journal_title：Transplantation

authors： Bruchfeld A,Wilczek H,Elinder CG

更新日期：2004-09-15 00:00:00

abstract：:Cytomegalovirus remains a significant source of morbidity and mortality in immunocompromised hosts. The increased sensitivity of molecular diagnostic techniques (PCR, antigenemia) has resulted in our ability to detect viral replication earlier in the posttransplant period, before the onset of symptoms. With the advent...

journal_title：Transplantation

authors： Abecassis MM,Koffron AJ,Kaplan B,Buckingham M,Muldoon JP,Cribbins AJ,Kaufman DB,Fryer JP,Stuart J,Stuart FP

更新日期：1997-01-27 00:00:00

abstract：:Chronic graft-versus-host disease often results in a combined deficiency of humoral and cell-mediated immunity. Clinical and experimental studies have suggested that the decrease in B cell responsiveness is due to a failure of B cell production in the bone marrow, intrinsic B cell defects, excessive suppressor T cell ...

journal_title：Transplantation

authors： Schreiber KL,Forman J

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients. METHODS:Retrospective cohort study, including all actual deceased dono...

journal_title：Transplantation

authors： Coll E,Torre-Cisneros J,Calvo R,Garrido G,Matesanz R

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:Intestinal transplantation is known to be associated with a high risk of early complications and mortality. METHODS:We analyzed prospective data of 51 primary small bowel transplantations from December 1999 to August 2009 and identified perioperative factors that impact on early mortality (≤6 months after t...

journal_title：Transplantation

authors： Dopazo C,Gupte GL,Sharif K,Perera MT,Hartley J,Muiesan P,Mayer DA,Bromley P,Bennett J,Kelly DA,van Mourik I,McKiernan P,Beath SV,Mirza DF

更新日期：2012-10-27 00:00:00

abstract：:A panel of ethicists, organ procurement organization executives, physicians, and surgeons was convened by the sponsorship of the American Society of Transplant Surgeons to determine whether an ethically acceptable pilot trial could be proposed to provide a financial incentive for a family to consent to the donation of...

journal_title：Transplantation

authors： Arnold R,Bartlett S,Bernat J,Colonna J,Dafoe D,Dubler N,Gruber S,Kahn J,Luskin R,Nathan H,Orloff S,Prottas J,Shapiro R,Ricordi C,Youngner S,Delmonico FL

更新日期：2002-04-27 00:00:00

abstract：:The CD154-CD40 pathway is one of the critical costimulatory pathways that are required for full activation of T cells during alloimmune responses. Blockade of this pathway with anti-CD154 antibodies has been reported to prolong allograft survival in experimental transplantation models and to induce tolerance in some i...

journal_title：Transplantation

authors： Yamada And A,Sayegh MH

更新日期：2002-01-15 00:00:00

abstract：BACKGROUND:In France, the need for continuous monitoring of transplant center performance has recently become apparent. Cumulative sum (CUSUM) monitoring of transplantation is already been used to monitor transplant outcomes in the United Kingdom and in the United States. Because CUSUM monitoring can be applied by diff...

journal_title：Transplantation

authors： Alexandrine B,Savoye E,Pessione F,Cantrelle C,Jasseron C,Santin G,Bastien O,Legeai C

更新日期：2019-09-01 00:00:00

abstract：:Though the high immunosuppressive efficacy of cyclosporine has revolutionized clinical transplantation, renal, hepatic, and neural toxicities limit its therapeutic potential. One approach to this problem is to combine CsA therapy with immunosuppressive agents that act synergistically with it, thereby permitting lower ...

journal_title：Transplantation

authors： Vathsala A,Chou TC,Kahan BD

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Solid organ xenograft rejection is associated with vascular injury resulting at least in part in platelet activation, and rejected xenografts invariably demonstrate intravascular thrombosis and interstitial hemorrhage. Complement activation plays a prominent role in platelet-endothelial interaction. We teste...

journal_title：Transplantation

authors： Brandl U,Jöckle H,Erhardt M,Michel S,Burdorf L,Brenner P,Bittmann I,Rössle M,Mordstein V,Hammer C,Thein E,Reichart B,Schmoeckel M

更新日期：2007-12-27 00:00:00

abstract：:Endothelial injury plays a central role in the pathophysiologic mechanisms underlying cardiac allograft vasculopathy (CAV). Although the accelerated course of CAV and its localization to the allograft support an important role for the alloimmune response, there is considerable evidence implicating lipoprotein abnormal...

journal_title：Transplantation

authors： Valantine HA

更新日期：2003-09-27 00:00:00

abstract：BACKGROUND:Early outcomes after human immunodeficiency virus (HIV) + liver transplantation (LT) are encouraging, but data are lacking regarding long-term outcomes and comparisons with matched HIV- patients. METHODS:We examined outcomes among 180 HIV+ LT, and compared outcomes to matched HIV- counterfactuals (Scientifi...

journal_title：Transplantation

authors： Locke JE,Durand C,Reed RD,MacLennan PA,Mehta S,Massie A,Nellore A,DuBay D,Segev DL

更新日期：2016-01-01 00:00:00

abstract：:Hepatic grafts from non-heartbeating donors may alleviate the organ shortage, but they inherently suffer from warm ischemia. In the present study, we tested our hypothesis that augmentation of endogenous adenosine by inhibition of nucleoside transport with R75231 attenuates ischemic liver injury. Adult female beagle d...

journal_title：Transplantation

authors： Todo S,Zhu Y,Zhang S,Jin MB,Ishizaki N,Tanaka H,Subbotin V,Starzl TE

更新日期：1997-01-27 00:00:00

abstract：:Healthy rat islets were encapsulated in alginate-polylysine-alginate capsules measuring 0.25-0.35 mm in diameter using a modified encapsulation technique. The encapsulated islets were transplanted intraperitoneally in nonimmunosuppressed streptozotocin-induced diabetic BALB/c mice. The diabetic condition of the experi...

journal_title：Transplantation

authors： Lum ZP,Krestow M,Tai IT,Vacek I,Sun AM

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:The impact of recipient body mass index on graft and patient survival after pancreas transplantation is not well known. METHODS:We have analyzed data from all pancreas transplant recipients reported in the Scientific Registry of Transplant Recipients between 1987 and 2011. Recipients were categorized into B...

journal_title：Transplantation

authors： Bédat B,Niclauss N,Jannot AS,Andres A,Toso C,Morel P,Berney T

更新日期：2015-01-01 00:00:00

abstract：:Modified limiting dilution analysis (LDA) techniques were used to evaluate the mobilization of antigen-stimulated helper T lymphocytes (HTL) and cytotoxic T lymphocytes (CTL) following allogeneic heterotopic cardiac transplantation. These modified LDA techniques allow a quantitative comparison of T cells that have bee...

journal_title：Transplantation

authors： Bishop DK,Shelby J,Eichwald EJ

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:The spleen is considered to be an important secondary lymphoid organ where acute graft-versus-host disease (GVHD) is initiated by donor T cells that recognize host alloantigens after allogeneic bone-marrow transplantation (BMT). The influence of splenectomy on the development of GVHD prior to BMT has yet to ...

journal_title：Transplantation

authors： Clouthier SG,Ferrara JL,Teshima T

更新日期：2002-05-27 00:00:00

abstract：BACKGROUND:As opposed to most solid-organ transplant recipients, patients with acute liver failure exhibit a pretransplant health status more comparable with the general population, and any posttransplant cardiovascular risk excess should thus be more attributable to transplantation-related factors alone. METHODS:This...

journal_title：Transplantation

authors： Aberg F,Jula A,Höckerstedt K,Isoniemi H

更新日期：2010-01-15 00:00:00

abstract：:The absorption of oral cyclosporine (CsA) was studied in a canine small intestinal transplantation model. Absorption of CsA was almost absent in bowel-resected dogs. Autotransplanted dogs showed a persisting malabsorption of CsA (mean peak of 687 +/- 348 ng/ml vs. 1683 +/- 154 ng/ml in control dogs). Allotransplanted ...

journal_title：Transplantation

authors： Wassef R,Cohen Z,Nordgren S,Langer B

更新日期：1985-05-01 00:00:00

abstract：:Rapamycin prolongs allograft survival and induces donor-specific tolerance in some small animal transplant models. Large animal studies, however, are limited. We studied rapamycin in a porcine renal allograft model. Donor-recipient combinations were chosen based on high response in pretransplant MLCs. Allografts were ...

journal_title：Transplantation

authors： Almond PS,Moss A,Nakhleh RE,Melin M,Chen S,Salazar A,Shirabe K,Matas AJ

更新日期：1993-08-01 00:00:00

abstract：:As a consequence of its large volume, a microencapsulated islet graft can be implanted only into the peritoneal cavity. The graft volume can be reduced by using small capsules. However, reduction of the diameter of the capsules holds a certain risk, because with smaller capsules, more islets may be found to protrude f...

journal_title：Transplantation

authors： De Vos P,De Haan B,Pater J,Van Schilfgaarde R

更新日期：1996-10-15 00:00:00

abstract：OBJECTIVE:We compared the enzyme release from preserved and ex vivo reperfused livers after acute injury or inflammatory stimulus with organ function. METHODS:Acute injury was induced by carbon tetrachloride and inflammation was induced by turpentine oil treatments. Livers were exsanguinated and preserved for 8 or 24 ...

journal_title：Transplantation

authors： Gioli-Pereira L,Coradin K,Nagaoka MR,Borges DR,Kouyoumdjian M

更新日期：2002-10-27 00:00:00

abstract：BACKGROUND:We examined whether oral administration of alloantigen could induce the prolonged survival of cardiac allografts. METHODS:Hearts from CBK (H2k+Kb) transgenic or (C57BL/10xCBA)F1 (H2bxH2k) mice were transplanted into CBA (H2k) recipients pretreated orally with 1 x 10(7) donor splenocytes in the presence or a...

journal_title：Transplantation

authors： Niimi M,Witzke O,Bushell A,Hara M,Morris PJ,Wood KJ

更新日期：2000-11-27 00:00:00

abstract：:The effect of prophylactic i.v. administration of high doses of human gamma-immunoglobulin (IgG) on kidney graft survival was investigated in rhesus monkeys treated with azathioprine and prednisolone. In nontransfused recipients not treated with IgG (controls), graft survival ranged from 9 to 22 days; if nontreated an...

journal_title：Transplantation

authors： Borleffs JC,Marquet RL,de By-Aghai Z,Dolkart RE,Persijn GG,Balner H

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Community respiratory viruses such as respiratory syncytial virus (RSV), adenovirus, influenza A, influenza B, and the parainfluenza group are frequent causes of respiratory disease in bone marrow transplant (BMT) patients. MATERIAL AND METHODS:During the period from March 1993 to August 1999, 810 samples o...

journal_title：Transplantation

authors： Raboni SM,Nogueira MB,Tsuchiya LR,Takahashi GA,Pereira LA,Pasquini R,Siqueira MM

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:The National Marrow Donor Program (NMDP) has approximately 5 million registered potential donors and continues to add more than 30,000 new recruits to the registry monthly. However, more than 30% of potential donors are not available or decline to donate at key decision points in the donation process. Althou...

journal_title：Transplantation

authors： Myaskovsky L,Switzer GE,Dew MA,Goycoolea JM,Confer DL,Abress L

更新日期：2004-03-27 00:00:00

abstract：BACKGROUND:We herein investigate critical ischemia times and the effect of novel preservation solutions such as new histidine-tryptophan-ketoglutarate (HTK-N) and TiProtec on the individual tissues of a rat limb isograft. METHODS:Orthotopic hind-limb transplantations were performed in male Lewis rats after 2 hours, 6 ...

journal_title：Transplantation

authors： Messner F,Hautz T,Blumer MJF,Bitsche M,Pechriggl EJ,Hermann M,Zelger B,Zelger B,Öfner D,Schneeberger S

更新日期：2017-09-01 00:00:00