Cardiac myosin autoantibodies and acute rejection after heart transplantation in patients with dilated cardiomyopathy.

abstract：BACKGROUND:A widely held view is that any increase in the potency of an immunosuppressive agent will lead to an increase in infection and malignancy, such as life-threatening Epstein-Barr virus (EBV) induced posttransplant lymphoproliferative disorders (PTLD). We tested this paradigm by studying the effect of adding mo...

journal_title：Transplantation

authors： Birkeland SA,Andersen HK,Hamilton-Dutoit SJ

更新日期：1999-05-15 00:00:00

abstract：:Antibodies against B lymphocytes were found in the serum of the majority of 59 kidney transplant recipients and of 22 eluates obtained from kidney allografts undergoing rejection. To characterize these B cell lymphocytotoxins we have used a mouse monoclonal anti-DR antibody (L227) that inhibits cytotoxicity of antibod...

journal_title：Transplantation

authors： Nunez G,McPhaul JJ Jr,Stastny P

更新日期：1983-05-01 00:00:00

abstract：:Hematopoietic growth factors (HGF) mobilize potential tolerogenic cells in transplant donors. Fms-like tyrosine kinase 3 ligand (Flt3L) mobilizes stem cells and dendritic cells (DCs) in human and nonhuman primate blood. Blood and renal and liver biopsies were obtained from untreated and Flt3L-mobilized rhesus macaques...

journal_title：Transplantation

authors： Morelli AE,Coates PT,Shufesky WJ,Barratt-Boyes SM,Fung JJ,Demetris AJ,Thomson AW

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:End-stage renal disease (ESRD) patients with antiphospholipid antibody syndrome (APAS) remain at high risk for the development of renal thrombosis without the benefit of anticoagulation therapy. This study examines the efficacy of anticoagulation therapy in this high-risk patient population. METHOD:Of nine ...

journal_title：Transplantation

authors： Vaidya S,Gugliuzza K,Daller JA

更新日期：2004-04-15 00:00:00

abstract：INTRODUCTION:This study examines the efficacy and toxicity of sirolimus used as primary immunosuppression in combination with reduced dose tacrolimus (calcineurin inhibitor [CI]-sparing regimen) or mycophenolate mofetil (CI-free regimen) in high-risk cadaveric renal transplantation. METHODS:Seventy subjects were treat...

journal_title：Transplantation

authors： Lo A,Egidi MF,Gaber LW,Amiri HS,Vera S,Nezakatgoo N,Gaber AO

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Ischemia/reperfusion (I/R) injury is a limiting factor in liver transplantation. We have recently shown that pyruvate (PY) inhibits intestinal and renal I/R injury. This study aims to evaluate the protective effect of PY on hepatic I/R injury. METHODS:ACI rats were treated with PY, whereas control animals r...

journal_title：Transplantation

authors： Sileri P,Schena S,Morini S,Rastellini C,Pham S,Benedetti E,Cicalese L

更新日期：2001-07-15 00:00:00

abstract：BACKGROUND:To maximize the renal donor pool, cadaveric pediatric en bloc kidneys have been transplanted as a dual unit by some transplant centers. We compared the short- and long-term outcomes of adult recipients of cadaveric pediatric en bloc renal transplants versus those of matched recipients of cadaveric adult kidn...

journal_title：Transplantation

authors： Hobart MG,Modlin CS,Kapoor A,Boparai N,Mastroianni B,Papajcik D,Flechner SM,Goldfarb DA,Fischer R,O'Malley KJ,Novick AC

更新日期：1998-12-27 00:00:00

abstract：BACKGROUND:Murine umbilical cord blood cells (UCBCs) were studied for their ability to reconstitute the hematopoietic system. METHODS:On average, 150 microL of cord blood per fetus containing 1.2 to 2 x 10(4) nucleated cells were collected from day 18.5 fetal umbilical cord, and 3 to 6 x 10(3) cells per fetus were obt...

journal_title：Transplantation

authors： Migishima F,Oikawa A,Kondo S,Ema H,Morita Y,Nakauchi H,Yokoyama M,Song SY,Nishijima M,Okabe M,Shinohara N

更新日期：2003-06-15 00:00:00

abstract：BACKGROUND:Preexisting IgG antibodies to donor human leukocyte antigens (HLA) are a risk factor for rapid allograft rejection. However, non-HLA antibodies, of the IgM class, also called autoreactive antibodies, are not believed to affect graft survival. The aim of this study was to determine the incidence and clinical ...

journal_title：Transplantation

authors： Smith JD,Hamour IM,Burke MM,Mahesh B,Stanford RE,Haj-Yahia S,Robinson DR,Kaul P,Yacoub MH,Banner NR,Rose ML

更新日期：2009-03-27 00:00:00

abstract：:Previous studies in our laboratory demonstrated that several treatments that inhibited the ability of cells to stimulate the mixed lymphocyte reaction (MLR) also blocked the shedding of histocompatibility antigens and Ia antigens from murine spleen cells. In the present studies, one of these treatments, ultraviolet ra...

journal_title：Transplantation

authors： Pretell JO,Cone RE

更新日期：1985-02-01 00:00:00

abstract：:The success of kidney transplants is limited by the lack of robust improvements in long-term survival. It is now recognized that alloimmune responses are responsible for the majority of allograft failures. Development of novel therapies to decrease allosensitization is critical. The lack of new drug development in kid...

journal_title：Transplantation

authors： Jordan SC,Choi J,Kim I,Wu G,Toyoda M,Shin B,Vo A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Pancreas transplantation (PTX) improves lipids in patients with type 1 diabetes mellitus. However, there are patients who have persistent abnormal lipids or develop new hyperlipidemia despite PTX. One factor that may influence the lipid profile is apolipoprotein E (Apo E) genotype. Apo E polymorphism, partic...

journal_title：Transplantation

authors： Balakrishnan S,Colling C,Burkman T,Erickson J,Lyden E,Maheshwari H,Mack-Shipman L,Lane J,Larsen J

更新日期：2002-10-15 00:00:00

abstract：:To determine if cold preservation time continues to affect renal transplant outcome, prospectively collected data from 17,937 cadaveric renal transplants performed between 1982 and 1991 were analyzed. Cold preservation intervals of 1-16, 16-32, 32-48, and greater than 48 hr were studied by multi- and univariate method...

journal_title：Transplantation

authors： Peters TG,Shaver TR,Ames JE 4th,Santiago-Delpin EA,Jones KW,Blanton JW

更新日期：1995-01-27 00:00:00

abstract：BACKGROUND:In kidney transplant recipients with alemtuzumab induction maintained on mycophenolate mofetil (MMF) immunosuppression, sirolimus (SRL) promotes significant expansion of circulating CD4+CD25high regulatory T cells (Treg). This might translate into more effective protection against chronic graft injury compar...

journal_title：Transplantation

authors： Ruggenenti P,Perico N,Gotti E,Cravedi P,D'Agati V,Gagliardini E,Abbate M,Gaspari F,Cattaneo D,Noris M,Casiraghi F,Todeschini M,Cugini D,Conti S,Remuzzi G

更新日期：2007-10-27 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil (MMF) therapy compared with azathioprine has not led to improved long-term renal allograft outcomes perhaps as MMF dose is limited by tolerability and dose reduction is associated with inferior graft outcome. The consequences, however, of dose reduction of mycophenolate mofetil relative...

journal_title：Transplantation

authors： Shah S,Collett D,Johnson R,Raftery M,Rudge C,Yaqoob MM

更新日期：2008-10-27 00:00:00

abstract：:A prospective study of intentional stopping of steroids 6 months after transplantation was done with 29 pediatric renal transplant recipients with a mean age of 10.4 +/- 3.4 years. Immunosuppression consisted of cyclosporine and methylprednisolone. We stopped giving MP to 24 children: to twenty after six months, four ...

journal_title：Transplantation

authors： Ghio L,Tarantino A,Edefonti A,Mocciaro A,Giani M,Guerra L,Berardinelli L,Vegeto A

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Several technical modifications in portal vein (PV) reconstruction have shown excellent outcomes in pediatric liver transplantation (LT); however, which procedure is the best for PV reconstruction of the hypoplastic PV in pediatric LT remains unclear. METHODS:One hundred sixteen pediatric patients aged 1 or...

journal_title：Transplantation

authors： Sakamoto S,Uchida H,Kitajima T,Shimizu S,Yoshimura S,Takeda M,Hirata Y,Fukuda A,Kasahara M

更新日期：2020-01-01 00:00:00

abstract：:A murine monoclonal antihuman T cell antibody is described that is pan-T in that it reacts with all T cells, including those from thymus, but not with B cells or other cells, except for a small subpopulation of null cells. Biochemical analysis demonstrated that the antigen detected is a glycoprotein, Mr 50,000 daltons...

journal_title：Transplantation

authors： Thurlow PJ,Lovering E,d'Apice AJ,McKenzie IF

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:Localization of inflammatory stimuli may direct lung allografts to different phenotypes of chronic dysfunction, such as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS). We hypothesized that airway stimulation with lipopolysaccharide (LPS) in rats leads to airway-centered infla...

journal_title：Transplantation

authors： Takahagi A,Sato M,Chen-Yoshikawa TF,Miyamoto E,Saito M,Gochi F,Hamaji M,Yoshizawa A,Terasaki Y,Urushiyama H,Aoyama A,Sonobe M,Date H

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Current histological methods cannot accurately determine the survival rate of human pancreatic islets following portal vein infusion. This is due, in part, to the low number of infused islets relative to the whole liver. In this study, we assessed the ability of confocal laser scanning microscopy (CLSM) to t...

journal_title：Transplantation

authors： Sui F,Tang W,Karunananthan J,Qi C,Li J,He N,Kandeel F,Li J

更新日期：2020-06-01 00:00:00

abstract：:Hemorrhagic cystitis (HC) is a major cause of morbidity after BMT; we have analyzed its incidence, risk factors, and complications in 977 patients undergoing BMT between 1974 and 1988. Despite vigorous hydration and frequent voiding in all patients receiving cyclophosphamide, 135/977 (15% by Kaplan-Meier projection) d...

journal_title：Transplantation

authors： Sencer SF,Haake RJ,Weisdorf DJ

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:HLA-G is a nonclassical MHC class I molecule and its physiological expression restricted to placental extravillous trophoblasts contributes to maternal tolerance to the semiallogeneic fetus. Aberrant expression of HLA-G in human organ grafts has been proposed to contribute to graft acceptance. METHODS:We st...

journal_title：Transplantation

authors： Moroso V,van Cranenbroek B,Mancham S,Sideras K,Boor PP,Biermann K,de Vogel L,de Knegt RJ,van der Eijk A,van der Laan LJ,de Jonge J,Metselaar HJ,Joosten I,Kwekkeboom J

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:We have previously shown successful engraftment of allogeneic hematopoietic stem cells (HSCs) when transplanted across the major histocompatibility antigen barriers if transplanted along with a preparation of facilitator cells (osteoblasts). We have investigated whether or not fully allogeneic HSCs from heal...

journal_title：Transplantation

authors： El-Badri NS,Wang BY,Steele A,Cherry,Marikar Y,Mizobe K,Good RA

更新日期：2000-09-27 00:00:00

abstract：:To evaluate the pharmacokinetic properties of the new microemulsion formulation of cyclosporine (Sandimmun Neoral), a double-blind, prospective study in stable renal transplant recipients was performed. The patients were randomized on a 4:1 basis either to receive Sandimmun Neoral (n = 45) or continue on regular Sandi...

journal_title：Transplantation

authors： Wahlberg J,Wilczek HE,Fauchald P,Nordal KP,Heaf JG,Olgaard K,Hansen JM,Lokkegaard H,Mueller EA,Kovarik JM

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:Recent insights suggest that endothelial cell (EC) activation plays a major role in renal ischemia-reperfusion (I/R) injury. Interactions between ECs and pericytes via signaling molecules, including angiopoietins, are involved in maintenance of the vascular integrity. Experimental data have shown that enhanc...

journal_title：Transplantation

authors： de Vries DK,Khairoun M,Lindeman JH,Bajema IM,de Heer E,Roest M,van Zonneveld AJ,van Kooten C,Rabelink TJ,Schaapherder AF,Reinders ME

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:The clinical significance of HLA-directed antibodies newly detected after transplantation (HT) is controversial. METHODS:Seventy-one HT recipients consented to enroll. Mean follow-up time was 28 months (range 6-48). Panel reactive antibody (PRA) analysis was performed on posttransplant sera (2 weeks, 1, 2, ...

journal_title：Transplantation

authors： Tambur AR,Pamboukian SV,Costanzo MR,Herrera ND,Dunlap S,Montpetit M,Heroux A

更新日期：2005-10-27 00:00:00

abstract：BACKGROUND:Cold preservation is the most practical method to maintain the viability of isolated lungs. However, rapid cooling may affect pulmonary endothelial function. We examined the effects of microtubule stabilization with paclitaxel on pulmonary endothelial barrier integrity under cold temperature. METHODS:Human ...

journal_title：Transplantation

authors： Suzuki S,Bing H,Sugawara T,Matsuda Y,Tabata T,Hoshikawa Y,Saijo Y,Kondo T

更新日期：2004-08-27 00:00:00

abstract：BACKGROUND:Early and late complications related to the pancreas after simultaneous kidney-pancreas transplantation (SKPT) frequently result in graft loss. The authors describe a surgical rescue technique that allows salvage of the pancreatic graft when surgical complications appear after the transplant. METHODS:Of 158...

journal_title：Transplantation

authors： Orsenigo E,Cristallo M,Socci C,Castoldi R,Fiorina P,Invernizzi L,Caldara R,Secchi A,Di Carlo V

更新日期：2003-01-27 00:00:00

abstract：:Millions of people want to donate their organs after they die for transplantation, and many of them have registered their wish to do so or told their family and friends about their decision. For most of them, however, this wish is unlikely to be fulfilled, as only a small number of deaths (1% in the United Kingdom) oc...

journal_title：Transplantation

authors： Shaw D,Georgieva D,Haase B,Gardiner D,Lewis P,Jansen N,Wind T,Samuel U,McDonald M,Ploeg R,ELPAT Working Group on Deceased Donation.

更新日期：2017-03-01 00:00:00

abstract：:The case studies of four patients with post-transplantation calcinosis are presented. Three of the four patients died of inanition and sepsis secondary to infection of extensive soft tissue ulcers and diffuse cutaneous vascular calcification with gangrene. The fourth patient survived following removal of all four para...

journal_title：Transplantation

authors： Perloff LJ,Spence RK,Grossman RA,Barker CF

更新日期：1979-01-01 00:00:00