Abstract:
:Complement plays important roles in both ischemia-reperfusion injury (IRI) and antibody-mediated rejection (AMR) of solid organ allografts. One approach to possibly improve outcomes after transplantation is the use of C1 inhibitor (C1-INH), which blocks the first step in both the classical and lectin pathways of complement activation and also inhibits the contact, coagulation, and kinin systems. C1-INH can also directly block leukocyte-endothelial cell adhesion. C1-INH contrasts with eculizumab and other distal inhibitors, which do not affect C4b or C3b deposition or noncomplement pathways. Authors of reports on trials in kidney transplant recipients have suggested that C1-INH treatment may reduce IRI and delayed graft function, based on decreased requirements for dialysis in the first month after transplantation. This effect was particularly marked with grafts with Kidney Disease Profile Index ≥ 85. Other clinical studies and models suggest that C1-INH may decrease sensitization and donor-specific antibody production and might improve outcomes in AMR, including in patients who are refractory to other modalities. However, the studies have been small and often only single-center. This article reviews clinical data and ongoing trials with C1-INH in transplant recipients, compares the results with those of other complement inhibitors, and summarizes potentially productive directions for future research.
journal_name
Transplantationjournal_title
Transplantationauthors
Berger M,Lefaucheur C,Jordan SCdoi
10.1097/TP.0000000000002717subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1763-1775issue
9eissn
0041-1337issn
1534-6080journal_volume
103pub_type
杂志文章,评审相关文献
TRANSPLANTATION文献大全abstract::Advances in immunosuppression have reduced the incidence of acute graft loss after transplantation, but long-term allograft survival is still hindered by the development of chronic allograft injury, a multifactorial process that involves both immunologic and nonimmunologic components. Because these components become d...
journal_title:Transplantation
pub_type: 社论,评审
doi:10.1097/TP.0b013e3181efcfbc
更新日期:2010-11-15 00:00:00
abstract:BACKGROUND:Remote ischemic preconditioning (RIPC) protects against liver ischemia reperfusion (IR) injury. An essential circulating mediator of this protection is nitric oxide (NO) induced by lower limb RIPC. One of the mechanisms through which NO generally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31824cd59d
更新日期:2012-05-15 00:00:00
abstract:BACKGROUND:Specific tolerance after combined kidney and bone marrow transplantation for multiple myeloma with end-stage renal disease through mixed lymphohematopoietic chimerism has been achieved, as evidenced by prolonged normal renal function without ongoing immunosuppression. METHODS:To achieve potent antimyeloma r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31820a3068
更新日期:2011-03-27 00:00:00
abstract:BACKGROUND:A precise understanding of immunological mechanisms is needed to prevent transplant vasculopathy. METHODS:The developing process of transplant vasculopathy was investigated by retransplanting rat cardiac allografts and measuring the expressions of 21 different genes inside the retransplanted allografts unde...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200009150-00005
更新日期:2000-09-15 00:00:00
abstract::Previously, we demonstrated that the dose-normalized tacrolimus blood concentration after renal transplantation was associated with a single nucleotide polymorphism (SNP) in the CYP3AP1 gene, probably through linkage with an SNP in the CYP3A5 gene. Individuals with at least one CYP3A5*1 allele synthesize CYP3A5 and CY...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000151766.73249.12
更新日期:2005-02-27 00:00:00
abstract:INTRODUCTION:Bone marrow cells expressing foreign MHC antigens survive poorly after transplantation. Stable mixed hematopoietic chimerism requires reconstitution with a relatively large number of foreign bone marrow cells and intensive depletion of host cells. In addition, when foreign MHC-transduced autologous bone ma...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000159871.01132.5d
更新日期:2005-05-27 00:00:00
abstract::After measurement of normal renal function, dog kidneys (n = 52) were subjected to 3, 15, or 30 min of normothermic warm ischemia (WI). After 24 hr of preservation by simple hypothermic storage (SHS) in a modified Collins solution, autotransplant was done and renal function was again measured beginning at 1 hr. Compar...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198611000-00003
更新日期:1986-11-01 00:00:00
abstract::Natural anti-carbohydrate antibodies are central to hyperacute rejection in ABO-incompatible allotransplantation and in discordant xenotransplantation. ABO-incompatible rejection has been inhibited successfully using intravenous soluble carbohydrates as antibody inhibitors. The approach has been less successful previo...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-12-15 00:00:00
abstract:BACKGROUND:This study investigated the use of deceased heart-beating donor livers offered for transplantation during a 10-year period, during which there has been an increasing disparity between organ supply and demand in the United Kingdom. METHODS:Summary data from the National Transplant Database were analyzed on a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000268072.04260.69
更新日期:2007-07-15 00:00:00
abstract::We are participating in a multicenter trial testing the efficacy of a murine monoclonal antihuman peripheral T lymphocyte antibody (OKT3.PAN) as immunosuppressive therapy for the treatment of acute cadaveric renal allograft rejection. Although clinical data indicate that administration of this antibody clears the circ...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/00007890-198411000-00009
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Hemophagocytic syndrome (HPS) is a serious hematological disorder caused by activated T lymphocytes in immunologically compromised patients. There is no report of HPS in liver transplant recipients. METHODS:Among 135 patients who underwent living-related liver transplantation between June 1990 and October 2...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200112150-00024
更新日期:2001-12-15 00:00:00
abstract::If transplantation of endocrine tissue is to become a therapy for a significant number of insulin-dependent diabetic individuals, tissue sources other than adult human islets will be required. Because human fetal pancreatic cells may offer that alternative, we have tried to find the optimal combination of tissue cultu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199312000-00011
更新日期:1993-12-01 00:00:00
abstract::The combination of pharmacokinetic and pharmacodynamic (measurement of the biological effect) monitoring of immunosuppressive drugs provides a method for the optimization of drug dosing. We chose to investigate this using mycophenolic acid (MPA), an immunosuppressive drug that mediates its effect by the inhibition of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199601150-00018
更新日期:1996-01-15 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion (I/R) injury is a multifactorial phenomenon that occurs during the transplant event and frequently compromises early graft function after liver transplantation (LT). Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regul...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a20398
更新日期:2013-11-27 00:00:00
abstract::Hepatocyte transplantation is an investigational alternative to orthotopic liver transplantation to treat liver based inborn errors of metabolism. We report successful hepatocyte transplantation in a 4-year-old girl with infantile Refsum disease. Hepatocytes were isolated from the left liver segment of two male donors...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000077420.81365.53
更新日期:2003-08-27 00:00:00
abstract::Heterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during heart transplantations and also to study remodeling of the myocardium due to volume unloading. We provide a unique review on the latter and present a summary of the ex...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001585
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Conversion from tacrolimus to cyclosporin has not previously been reported as routine clinical practice, but only as indicated by rejection or adverse effects. METHODS:The safety and metabolic outcome of elective conversion from tacrolimus to cyclosporin was examined in 19 recipients of cadaver renal transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:2000-07-15 00:00:00
abstract::This study was undertaken to examine the humoral immune response against endothelial antigens of the donor kidney in human renal allograft recipients. Sera from 61 transplant recipients who received 62 grafts were studied for the presence of circulating endothelial antibodies (CEAb) using an indirect immunofluorescenc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197903000-00007
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Imported pancreata accumulate cold ischemia time (CIT), limiting utilization and worsening outcomes. Flow cytometric crossmatching (FXM) is a standard method to assess recipient and donor compatibility, but can prolong CIT. Single-antigen bead assays allow for detection of recipient donor-specific HLA antibo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001125
更新日期:2016-05-01 00:00:00
abstract::Until recently, islet allotransplantation for type 1 diabetic patients has been largely unsuccessful. Previous pharmacologic studies of single drugs have suggested that one factor contributing to this poor success is toxicity of immunosuppressive drugs on transplanted islets. However, no comprehensive study of agents ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200202150-00007
更新日期:2002-02-15 00:00:00
abstract::The following findings were noted among 45 bone marrow transplant recipients. The patients without cytomegalovirus (CMV) infection or chronic graft-versus-host disease (GVHD) showed normal lymphocyte stimulation in vitro by concanavalin A (Con A) more than 3 months after transplantation, and normal stimulation by phyt...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198504000-00008
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:In 2006, Northwestern Medicine implemented a culturally targeted and linguistically congruent Hispanic Kidney Transplant Program (HKTP). The HKTP has been associated with a reduction in Hispanic/Latino disparities in live donor kidney transplantation. This paper assessed the financial feasibility of implemen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000003269
更新日期:2020-04-09 00:00:00
abstract::The development of erythrocytosis following renal transplantation has been reported to be caused by a number of factors. These include acute and chronic rejection, hydronephrosis and renal artery stenosis. In this study, seven patients were noted to have erythrocytosis with hematocrits ranging between 53.5 and 66%. Se...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1979-12-01 00:00:00
abstract::Serologic evidence of resolved hepatitis B virus (HBV) infection (HBV surface antigen negative, anti-HBV core antibody [HBc] positive) in a liver donor can be regarded as an occult infection with episomal HBV in the liver. The purpose of this study was to evaluate the safety of anti-HBc-positive living donors. Between...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000047030.38665.0D
更新日期:2003-02-15 00:00:00
abstract::Kidney transplantation in elderly patients is a good therapeutic option, but the incidence of infections compared to younger patients must be studied. Case and control study was performed with 40 cases (patients older than 65) and 40 controls (younger than 65) receiving a kidney transplant between January 2000 and Aug...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000173822.05877.d7
更新日期:2005-10-15 00:00:00
abstract:BACKGROUND:Reactivation of cytomegalovirus (CMV) is frequently observed in recipients of solid organs and bone marrow transplants and is associated with increased risk of acute and chronic allograft rejection, opportunistic infection, graft failure, and patient mortality. The molecular mechanisms by which reactivation ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181b242a7
更新日期:2009-09-15 00:00:00
abstract::The study purpose was to identify risks, benefits and costs associated with an expanded donor protocol. The protocol design evaluated organs rescued using expanded donor criteria and weighed all costs associated with doing so. Costs were measured against conditions experienced with expanded and traditional criteria an...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199560120-00021
更新日期:1995-12-27 00:00:00
abstract::To determine the importance of static lung inflation during storage, graft performance was evaluated at different levels of intratracheal pressure and varying ischemic intervals. Lewis rat lungs were perfused with low-potassium Euro-Collins and stored for 4 or 8 hr either in atelectasis (4 hr: group I; 8 hr: group IV,...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199612270-00004
更新日期:1996-12-27 00:00:00
abstract::Modification of pathogenic antibodies for autoimmune diseases illuminated the biologic relevance of B cells, plasma cells, and pathogenic antibodies in autoimmunity. They have also rejuvenated interest in how B cells mediate multiple effector functions that include antibody production, antigen presentation to T cells,...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000002462
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The impact of community-acquired respiratory virus (CARV) infections on bronchiolitis obliterans syndrome (BOS) and outcome after lung transplantation (LTx) and diagnostic techniques were prospectively evaluated. METHODS:A single-center prospective cohort study was performed in LTx-outpatients between Octob...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181a4857d
更新日期:2009-05-27 00:00:00