Simulation modeling of the impact of proposed new simultaneous liver and kidney transplantation policies.

abstract：BACKGROUND:Significant disparity exists in the United Kingdom between the need for organ transplant and supply of deceased donor organs. In the recent years, efforts to increase donation has improved the rate of mainly deceased donors after circulatory death and from older donors. The rate of donation from pediatric po...

journal_title：Transplantation

authors： Dave RV,Hakeem AR,Dawrant MJ,Ecuyer CL,Lewington AJ,Attia MS,Hostert L,Finlay E,Ahmad N

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:There are limited data on the outcome of transplant recipients with familial Mediterranean fever (FMF)-associated AA amyloidosis. The aim of the present study is to evaluate demographic, clinical, laboratory, and prognostic characteristics and outcome measures of these patients. METHODS:Eighty-one renal tra...

journal_title：Transplantation

authors： Sarihan I,Caliskan Y,Mirioglu S,Ozluk Y,Senates B,Seyahi N,Basturk T,Yildiz A,Kilicaslan I,Sever MS

更新日期：2020-08-01 00:00:00

abstract：:As a consequence of its large volume, a microencapsulated islet graft can be implanted only into the peritoneal cavity. The graft volume can be reduced by using small capsules. However, reduction of the diameter of the capsules holds a certain risk, because with smaller capsules, more islets may be found to protrude f...

journal_title：Transplantation

authors： De Vos P,De Haan B,Pater J,Van Schilfgaarde R

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:A new supercooling system using a variable magnetic field has been recently developed. Subzero nonfreezing preservation has been believed to be a beneficial method because of the lower metabolic rate. The purpose of this study was to evaluate the hemodynamic and metabolic effects of rat heart preservation in...

journal_title：Transplantation

authors： Kato H,Tomita S,Yamaguchi S,Ohtake H,Watanabe G

更新日期：2012-09-15 00:00:00

abstract：BACKGROUND:Post-lung transplant infection is one of the leading causes of morbidity and mortality. The cause and incidence are similar in many series; however, infections such as Mycobacterium tuberculosis are influenced by the epidemiologic situation. The authors present a prospective and observational study to define...

journal_title：Transplantation

authors： Bravo C,Roldán J,Roman A,Degracia J,Majo J,Guerra J,Monforte V,Vidal R,Morell F

更新日期：2005-01-15 00:00:00

abstract：BACKGROUND:A recent proposal supports the elimination of allocation points for human leukocyte antigen (HLA) mismatches (MM) in cadaveric kidney transplantation. The intent is to increase access for some racial groups that might be disadvantaged by the representation of race-specific HLA in a largely white donor pool. ...

journal_title：Transplantation

authors： Rebellato LM,Arnold AN,Bozik KM,Haisch CE

更新日期：2002-12-15 00:00:00

abstract：:Spleen cells obtained from C57BL/Ks (Ks, H-2d) mice carrying passively enhanced Sarcoma I (Sa I, H-2a) tumors were tested for alloantibody formation, lymphocyte blastogenesis, antibody-dependent cellular cytotoxicity, and cell to cell cytotoxicity. Assays were usually performed approximately 6 weeks after tumor inocul...

journal_title：Transplantation

authors： Giorgi JV,Tokuda S,Goldberg EH,Shen FW

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND:To stimulate organ donation, an organ procurement organization (OPO)-wide effort was undertaken to increase donors after cardiac death (DCD) over a 5-year period. This included commonality of protocols, pulsatile perfusion of kidneys, centralization of data and a regional allocation variance designed to mini...

journal_title：Transplantation

authors： Whiting JF,Delmonico F,Morrissey P,Basadonna G,Johnson S,Lewis WD,Rohrer R,O'Connor K,Bradley J,Lovewell TD,Lipkowitz G

更新日期：2006-05-27 00:00:00

abstract：BACKGROUND:Solitary pancreas transplants, both pancreas transplant alone (PTA) and pancreas after kidney (PAK), have higher rejection rates and lower graft survivals than simultaneous pancreas-kidney transplants (SPK). The aim of this study is to compare three different antibody induction regimens in solitary pancreas ...

journal_title：Transplantation

authors： Stegall MD,Kim DY,Prieto M,Cohen AJ,Griffin MD,Schwab TR,Nyberg SL,Velosa JA,Gloor JM,Innocenti F,Bohorquez H,Dean PG,Carpenter HA,Leontovich ON,Sterioff S,Larson TS

更新日期：2001-11-27 00:00:00

abstract：BACKGROUND:Alloreactive immune responses may engage both direct and indirect antigen allorecognition. This study focuses on T-cell receptor (TCR) beta-chain usage by in vitro generated alloreactive CD4+ T cells involved in direct allorecognition pathway. METHODS AND RESULTS:We have established Lewis anti-Brown Norway ...

journal_title：Transplantation

authors： Zhai Y,Kupiec-Weglinski JW

更新日期：2003-02-27 00:00:00

abstract：BACKGROUND:Liver transplantation using ABO-incompatible grafts is rarely performed because the reported outcome is poorer than with compatible grafts. We report our positive experience with adult-to-adult living-donor liver transplant (LDLT) using ABO-incompatible grafts. METHODS:The immunosuppressive protocol consist...

journal_title：Transplantation

authors： Testa G,Vidanovic V,Chejfec G,Gangemi A,Iqpal R,Porubsky M,Pham T,Benedetti E

更新日期：2008-03-15 00:00:00

abstract：:Although the requirements for the induction of IL-2 receptor expression following lymphocyte stimulation in vitro have been well characterized, little information is available on the role of IL-2 and the IL-2 receptor in lymphocyte activation in vivo. We have established a quantitative assay for the measurement of IL-...

journal_title：Transplantation

authors： Kroczek RA,Black CD,Barbet J,Edison LJ,Shevach EM

更新日期：1987-10-01 00:00:00

abstract：:The effect of the graft-versus-host reaction in response to minor histocompatibility antigens on the antibody response to a T-dependent antigen was studied in four strains of mice. Lethally irradiated mice were transplanted with bone marrow plus graded numbers of spleen cells from H-2-compatible donors. Recipients of ...

journal_title：Transplantation

authors： Hamilton BL,Ochs HD

更新日期：1989-06-01 00:00:00

abstract：:The aim of this study was to compare the extent of in vitro T cell depletion and recovery of hematopoietic progenitor cells achieved with five methods of T cell depletion. Bone marrow samples from the same source were treated with monoclonal antibody Campath-1 (CP1) and human complement, XomaZyme-H65 (anti-T cell rici...

journal_title：Transplantation

authors： Frame JN,Collins NH,Cartagena T,Waldmann H,O'Reilly RJ,Dupont B,Kernan NA

更新日期：1989-06-01 00:00:00

abstract：:To investigate the clinical manifestations of Aspergillus infections in lung transplant recipients, we reviewed the mycology and autopsy reports of all double (DLT=93) and single (SLT=48) lung transplant recipients from November 1983 to May 1993. Positive Aspergillus cultures were identified in 22% of the recipients (...

journal_title：Transplantation

authors： Westney GE,Kesten S,De Hoyos A,Chapparro C,Winton T,Maurer JR

更新日期：1996-03-27 00:00:00

abstract：:FK506, an immunosuppresant, was isolated from Streptomyces tsukubaensis. Intramuscular administration of FK506 (0.32 mg/kg or more) 5 days a week for two weeks after grafting prolonged the acceptance time of F344 skin allograft to WKA rats. Similar results were obtained with cyclosporine at 32 mg/kg or more, but other...

journal_title：Transplantation

authors： Inamura N,Nakahara K,Kino T,Goto T,Aoki H,Yamaguchi I,Kohsaka M,Ochiai T

更新日期：1988-01-01 00:00:00

abstract：:Influenza vaccination has been strongly recommended for immunosuppressed renal transplant recipients. However, immunosuppression may lead to impaired antibody responses. We studied the antibody response to an inactivated trivalent influenza vaccine in 59 renal transplant recipients with life-sustaining kidney function...

journal_title：Transplantation

authors： Versluis DJ,Beyer WE,Masurel N,Wenting GJ,Weimar W

更新日期：1986-10-01 00:00:00

abstract：:Non-A, non-B hepatitis is a significant cause of liver disease among renal allograft recipients. In order to assess the impact and prevalence of hepatitis C in a series of renal allograft recipients, we retrospectively screened 621 consecutive patients transplanted between 1979 and 1989 and 484 cadaver organ donors re...

journal_title：Transplantation

authors： Roth D,Fernandez JA,Burke GW,Esquenazi V,Miller J

更新日期：1991-02-01 00:00:00

abstract：:Exposure to the equine-derived polyclonal antithymocyte preparation, ATGAM, frequently elicits human anti-ATGAM antibody formation. The influence of concomitant immunosuppressants on this antiantibody response has not been established. We therefore evaluated IgG antibody formation to ATGAM in 47 patients receiving ATG...

journal_title：Transplantation

authors： Kimball JA,Pescovitz MD,Book BK,Norman DJ

更新日期：1995-12-27 00:00:00

abstract：BACKGROUND:MicroRNA-155 (miR-155) is known to be involved in autoimmune diseases, inflammation, and transplantation. However, its role in a warm hepatic ischemia-reperfusion (IR) model has not been fully elucidated. METHODS:Partial hepatic IR was performed in wild-type and miR-155-deficient mice treated with or withou...

journal_title：Transplantation

authors： Li Y,Ma D,Wang Z,Yang J

更新日期：2017-07-01 00:00:00

abstract：:Crigler-Najjar type 1 disease (CNS1) is the result of a genetic defect, leading to complete functional loss of an enzyme which glucuronidates bilirubin. As a consequence, unconjugated bilirubin accumulates and may cause kernicterus, the most serious complication in adolescents. Phototherapy effectively adjusts bilirub...

journal_title：Transplantation

authors： Schauer R,Lang T,Zimmermann A,Stangl M,Da Silva L,Schildberg FW,Rau HG

更新日期：2002-01-15 00:00:00

abstract：:Short-term outcomes of solid organ transplantation have improved dramatically over the past several decades; however, long-term survival has remained static over the same period, and chronic rejection remains a major cause of graft failure. The importance of donor, or "passenger," lymphocytes to the induction of toler...

journal_title：Transplantation

authors： Prosser AC,Kallies A,Lucas M

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Increased use of pediatric deceased donor kidneys could enlarge the deceased donor kidney pool. Kidney transplant outcomes from small pediatric donors were compared with those from ideal kidney (IK) and expanded criteria kidney (ECK) donors to understand the optimal use of pediatric donor kidneys. METHODS:K...

journal_title：Transplantation

authors： Suneja M,Kuppachi S,Katz D,Hunsicker L

更新日期：2019-12-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) has recently been associated with endothelial cell injury. The potential clinical significance was explored here in an autopsy review. Thirty-seven allogeneic bone marrow recipients were identified in the autopsy files at The Johns Hopkins Hospital with no evidence of systemic in...

journal_title：Transplantation

authors： Wojno KJ,Vogelsang GB,Beschorner WE,Santos GW

更新日期：1994-01-01 00:00:00

abstract：:Loss of bile ducts is a characteristic feature of chronic rejection in the liver allograft (also known as irreversible rejection and vanishing bile-duct syndrome). Typically, this occurs as a progressive lesion resulting in irreversible damage and graft failure requiring retransplantation. In this study, we describe 6...

journal_title：Transplantation

authors： Hubscher SG,Buckels JA,Elias E,McMaster P,Neuberger J

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:The pathogenesis of acute pulmonary xenograft injury has not yet been determined. The present study evaluates the role of complement in mediating pulmonary xenograft dysfunction by using cobra venom factor (CVF) to deplete recipient complement and transgenic swine, which express human regulators of complemen...

journal_title：Transplantation

authors： Yeatman M,Daggett CW,Parker W,Byrne GW,Logan JS,Platt JL,Davis RD

更新日期：1998-04-27 00:00:00

abstract：BACKGROUND:The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepa...

journal_title：Transplantation

authors： Arnault I,Bao YM,Sebagh M,Anjo A,Dimicoli JL,Lemoine A,Delvart V,Adam R

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Extensive third degree burn wounds can be permanently covered by the transplantation of autologous cultured keratinocytes. Many modifications to Green and colleagues' original technique have been suggested, including the use of a fibrin matrix. However, the properties of the cultured cells must be assessed u...

journal_title：Transplantation

authors： Ronfard V,Rives JM,Neveux Y,Carsin H,Barrandon Y

更新日期：2000-12-15 00:00:00

abstract：:The interactions of rapamycin (Rapa), CsA, and donor-specific transfusion (DST) were examined in an ACI to Lewis rat heterotopic cardiac allograft model. Survival data were truncated at 175 days for the purpose of statistical comparisons. Vehicle (Veh)-treated animals rejected at a mean of 7.3 +/- 0.2 days. Treatment ...

journal_title：Transplantation

authors： Davies CB,Madden RL,Alexander JW,Cofer BR,Fisher RA,Anderson P

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Immunosuppressive drugs that target T cells are useful for prolonging allograft survival. The anti-CD3 immunotoxin FN18-CRM9 has been shown to effectively prolong renal allograft survival in a rhesus monkey model of transplantation. However, immunotoxin-treated monkeys showed increased levels of inflammatory...

journal_title：Transplantation

authors： Hamawy MM,Tsuchida M,Manthei ER,Dong Y,Fechner JE,Knechtle JS

更新日期：1999-09-15 00:00:00