Abstract:
:Cell-mediated cytotoxicity directed toward pancreatic islets plays a significant role in the pathogenesis of type 1 diabetes mellitus. Histologically, autoimmune insulitis appears as mononuclear infiltrates that precede actual beta cell loss. Experimental studies by Bartlett et al. on the BB rat model suggest that whole pancreas transplants are not susceptible to recurrent autoimmune diabetes. To test this hypothesis on clinical grounds, we evaluated the islets in pancreatectomies and percutaneous needle biopsies from 55 whole pancreas allografts. In this material, islet inflammation was never seen independently of allograft rejection, but was always associated with inflammation of the surrounding acinar structures. The degree of islet inflammation and the occasional presence of islet necrosis correlated well with the degree of rejection and only occurred in the higher grades of the latter (grades III-V). We did not observe isolated insulitis as a histological indication of selective cell-mediated cytotoxicity against beta cells.
journal_name
Transplantationjournal_title
Transplantationauthors
Drachenberg CB,Papadimitriou JC,Weir MR,Klassen DK,Hoehn-Saric E,Bartlett STdoi
10.1097/00007890-199612270-00014subject
Has Abstractpub_date
1996-12-27 00:00:00pages
1770-2issue
12eissn
0041-1337issn
1534-6080journal_volume
62pub_type
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