Abstract:
BACKGROUND:The consequences of a prior human herpesvirus-8 (HHV-8) infection in kidney-transplant recipients are still partially unknown. The aim of this monocentric study was to determine the prevalence of HHV-8-seropositive patients at the time of transplantation and to identify the main clinical events of these HHV-8+ recipients. METHODS:From January 1, 1990 to December 31, 1996, antibodies to HHV-8 latent nuclear antigen were detected by indirect immunofluorescent method in serum samples collected just before kidney transplantation from 400 consecutive patients. Conventional double or triple immunosuppressive treatment was prescribed. For the group of HHV-8+ recipients, data including death rate, graft survival, and occurrence of Kaposi's sarcoma (KS) were retrospectively collected until December 31, 1998. Cofactors associated with KS were studied in univariate and multivariate analyses using a Cox model. RESULTS:Thirty-two patients (8%) had antibodies to HHV-8 in their sera at the time of transplantation. Among these 32, 3 years after transplantation, graft survival was 72%, and KS prevalence was 28% (KS incidence: 8.2/yr/100 HHV-8+ recipients). Multivariate analysis identified bacterial and/or Pneumocystis carinii infection (odds ratio: 8.6; P=0.019) and female gender (odds ratio: 5.34; P=0.047) as factors associated with KS. No KS was observed in patients without anti-HHV-8 antibodies at the time of transplantation. CONCLUSIONS:The low graft survival and the high prevalence of KS within the studied population of HHV-8+ transplant recipients are strong arguments for systematic screening of HHV-8 serologic features before transplantation, especially in patients of African origin. HHV-8+ transplant recipients should be closely monitored to severe infections.
journal_name
Transplantationjournal_title
Transplantationauthors
Francès C,Mouquet C,Marcelin AG,Barete S,Agher R,Charron D,Benalia H,Dupin N,Piette JC,Bitker MO,Calvez Vdoi
10.1097/00007890-200005150-00008subject
Has Abstractpub_date
2000-05-15 00:00:00pages
1776-9issue
9eissn
0041-1337issn
1534-6080journal_volume
69pub_type
杂志文章相关文献
TRANSPLANTATION文献大全abstract:BACKGROUND:To investigate immune reactions after reduced-intensity cord-blood transplantation (RI-CBT). MATERIALS AND METHODS:We reviewed medical records of 57 adult RI-CBT recipients. Preparative regimen comprised fludarabine, total-body irradiation, and either melphalan (n=51) or busulfan (n=6). Graft-versus-host di...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000163289.20406.86
更新日期:2005-07-15 00:00:00
abstract::: Hepatitis C virus (HCV) infection is common in solid organ allograft recipients and is a significant cause of morbidity and mortality after transplantation, so effective management will improve outcomes. In this review, we discuss the extent of the problem associated with HCV infection in donors and kidney, heart, a...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0b013e318273fec4
更新日期:2013-03-27 00:00:00
abstract:INTRODUCTION:The purpose of the current study was to investigate the capacity of CD4+, CD8+, or non-T cells to independently initiate acute rejection of allogeneic hepatocytes using reconstituted SCID, CD4 or CD8 knockout (KO) recipient mice. METHODS:Allogeneic hepatocytes (FVB/N, H-2q) were transplanted into C57BL/6....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200012270-00017
更新日期:2000-12-27 00:00:00
abstract::Over the decade between 2003 and 2012, the UK has seen major changes in how organ donation and transplantation is delivered. The number of deceased organ donors has increased from 709 (12.0 per million population [pmp]) to 1,164 (18.3 pmp); this increase has been predominantly a result of an increase in donors after c...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000438215.16737.68
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:Despite effective antiviral treatment, hundreds of kidneys from deceased donors with hepatitis C virus (HCV) are discarded annually. Little is known about the determinants of willingness to accept HCV-infected kidneys among HCV-negative patients. METHODS:At 2 centers, 189 patients undergoing initial or reev...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002099
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The innovative pure laparoscopic living donor right hepatectomy (LLDRH) procedure for liver transplantation has never been fully compared to open living donor right hepatectomy (OLDRH). We aimed to compare the donor safety and graft results of pure LLDRH to those of OLDRH. METHODS:From May 2013 to July 2017...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002834
更新日期:2019-10-01 00:00:00
abstract::Requirements for sustained engraftment of fetal liver hematopoietic stem cells were evaluated in 45 dogs. Pretransplant preparative treatment with total-body irradiation, 14.7 Gy, permitted engraftment of DLA-compatible fetal liver cells. Radiation alone was inadequate in DLA-haploidentical or DLA-mismatched transplan...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198712000-00004
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Tacrolimus (Tac) has immunosuppressant properties similar to those of cyclosporine A (CsA), but it is more potent. At present, however, its immunosuppressive activity in renal transplant recipients with ongoing chronic rejection has not been clarified. METHODS:We studied changes in kidney function, mixed ly...
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/01.tp.0000112438.46472.38
更新日期:2004-02-27 00:00:00
abstract::CD18 antibodies react with the common beta chain of the human leukocyte function antigen (LFA1)* and thus block the functions mediated by the three identified molecules in humans. A murine CD18 monoclonal antibody was infused in 8 leukemic patients receiving allogeneic T-depleted bone marrow transplantation in order t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198903000-00014
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:The management of small bowel transplantation is unique because signs of rejection can be obtained visually by endoscopy. The aim of this study was to evaluate the accuracy of endoscopic appearance in assessing histologic evidence of acute cellular rejection (ACR). METHODS:Endoscopies were performed in 66 a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31825f4410
更新日期:2012-10-15 00:00:00
abstract::Rabbit antisera to rat thoracic duct lymphocytes were examined by absorption analysis with quantitative radioimmunoassays to determine the tissue distribution of the antigens recognised and the amount of antibody against different specificities. Seven of eight sera were remarkably specific for leucocytes and one serum...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00009
更新日期:1977-04-01 00:00:00
abstract::The properties of rat liver dendritic cells (DC) were analyzed after collagenase digestion of the tissue and enrichment with density gradient centrifugation. The liver macrophages (Kupffer cells) were eliminated by adherence before the gradient centrifugation. The morphology of isolated DC in May-Grunwald-Giemsa (MGG)...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-198805000-00019
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:The majority of chronic hepatitis is ascribable to hepatitis C virus (HCV) infection, whereas the clinical impact has not been understood in kidney transplant recipients. Our current study was carried out to assess the impact of HCV infection on kidney recipients over the long-term, and to investigate the ef...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199808270-00010
更新日期:1998-08-27 00:00:00
abstract::Anti-CD3 mAbs are potent inhibitors of T cell function; however, administration of mitogenic mAb can cause significant morbidity secondary to T cell activation and cytokine release. Nonmitogenic anti-CD3 mAb is immunosuppressive in mice without inducing detectable morbidity, and may thus be preferable for in vivo T ce...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1995-12-15 00:00:00
abstract::Monoclonal antibodies to CD3 have been shown to activate T cells in vivo and in vitro but have also been shown to render T cells anergic in vitro. In this study G4.18, a mouse IgG3 mAb, was produced that appeared to recognize CD3 by its binding to all peripheral T cells, including a population not recognized by mAb to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199303000-00001
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Human leukocyte antigen (HLA) antibodies, especially those that fix complement, are associated with antibody-mediated rejection and graft failure. The C1q assay on single antigen beads detects a subset of HLA antibodies that can fix complement and precede C4d deposition. The aim of this study was to determin...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318203fd26
更新日期:2011-02-15 00:00:00
abstract::Stable renal transplant recipients (RTR) display high rates of atherosclerotic events (AE). Innate immunity and especially vascular inflammation play a role in the pathogenesis of atherosclerosis. It is illustrated both by an increased occurrence of postrenal transplant cardiovascular events in patients with elevated ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000202846.17619.a4
更新日期:2006-04-27 00:00:00
abstract:BACKGROUND:Urologic complications cause substantial morbidity in the pediatric population after renal transplantation, but their impact on graft survival and transplant costs is poorly understood. In this retrospective review, we evaluated the records of all pediatric renal transplant recipients at our center from 1995...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31818b63da
更新日期:2008-12-15 00:00:00
abstract:BACKGROUND:Human cytomegalovirus (CMV) uses different strategies to escape from human host defense reactions. Previously we have observed that infection of endothelial cells with CMV in vitro leads to enhanced activity of endothelial ectonucleotidases. These ectoenzymes are responsible for hydrolysis of extracellular a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000287598.25493.a5
更新日期:2007-11-27 00:00:00
abstract:BACKGROUND:In previous studies of cynomolgus monkey lung allograft recipients, we demonstrated significant immunosuppressive efficacy but reduced tolerability after combined treatment with high doses of microemulsion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin). The current study was designed to com...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200002270-00005
更新日期:2000-02-27 00:00:00
abstract:BACKGROUND:Organ scarcity continues in solid organ transplantation, such that the availability of organs limits the number of people able to benefit from transplantation. Medical advancements in managing end-stage organ disease have led to an increasing demand for multiorgan transplant, wherein a patient with multiorga...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002788
更新日期:2020-02-01 00:00:00
abstract::A comparative study of 24 hr preservation at 4 degrees C of excised rat livers with Euro-Collins and hydroxyethyl starch-free University of Wisconsin (UWm) solutions has been conducted based on the assessment of (1) the cellular energy status determined by 31P NMR spectroscopy and (2) cellular injury estimated from th...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199210000-00006
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Renal transplant patients have an increased incidence of skin cancers, predominantly on sun-exposed surfaces. Clinical observation identified some patients with an increased number of viral warts, keratoses, and skin malignancies on the side of the arteriovenous fistula. METHODS:In a population of 980 patie...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200101150-00022
更新日期:2001-01-15 00:00:00
abstract:BACKGROUND:If pancreas transplantation is a validated alternative for type 1 diabetic patients with end-stage renal disease, the management of patients who have lost their primary graft is poorly defined. This study aims at evaluating pancreas retransplantation outcome. METHODS:Between 1976 and 2008, 569 pancreas tran...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0b013e318271d795
更新日期:2013-01-27 00:00:00
abstract:BACKGROUND:Whether cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) at prophylaxis cessation predicts D+/R+ kidney transplants at risk of late-onset CMV infection after receiving distinct induction therapies is still not well characterized. METHODS:We prospectively assessed CMV-specific CMI predicting late-...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002421
更新日期:2018-11-01 00:00:00
abstract::A study was designed to determine if cold preservation induces an increase in lymphocyte adherence to liver sinusoids on reperfusion. Rat livers were stored at 1 degree C in University of Wisconsin solution for 45 min, 8 hr, or 30 hr, and then reperfused for 90 min at 37 degrees C in an isolated perfused rat liver app...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-199109000-00004
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:The objectives of this study are to investigate the impact of cytomegalovirus (CMV) donor (D)/recipient (R) serostatus on kidney transplant outcomes in recipients who received CMV prophylaxis and to investigate the association of individual antiviral agents (acyclovir, ganciclovir, and valganciclovir) with o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3181f7c053
更新日期:2010-11-27 00:00:00
abstract:BACKGROUND:Registry databases offer the statistical power to analyze differences in graft survival rates that may not be detected in randomized clinical trials. This study analyses 2-year graft survival using tacrolimus (tac) or cyclosporine (CsA) with mycophenolate mofetil (MMF) and steroids. METHODS:Data reported to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000079965.62765.1A
更新日期:2003-07-15 00:00:00
abstract::Rapamycin prolongs allograft survival and induces donor-specific tolerance in some small animal transplant models. Large animal studies, however, are limited. We studied rapamycin in a porcine renal allograft model. Donor-recipient combinations were chosen based on high response in pretransplant MLCs. Allografts were ...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Knowledge on the reinnervation of transplanted organs is scarce, and the aim of the study was therefore to evaluate to what degree syngeneic pancreas grafts were reinnervated in rats. METHODS:Syngeneic pancreatico-duodenal transplantations were performed in normoglycemic Wistar-Furth rats. Native and transp...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-200101150-00002
更新日期:2001-01-15 00:00:00