Functional Behavior of NKp46-Positive Intrahepatic Natural Killer Cells Against Hepatitis C Virus Reinfection After Liver Transplantation.

abstract：BACKGROUND:Renal transplant recipients are at increased risk of developing skin cancer. It remains difficult to establish the actual influence of overimmunosuppression in the development of skin cancers. We investigated whether lymphocyte subset count may predict the risk of developing skin cancer in long-term renal tr...

journal_title：Transplantation

authors： Ducloux D,Carron PL,Rebibou JM,Aubin F,Fournier V,Bresson-Vautrin C,Blanc D,Humbert P,Chalopin JM

更新日期：1998-05-15 00:00:00

abstract：BACKGROUND:The currently used macrolide immunosuppressants, i.e., cyclosporine and tacrolimus, exert considerable nephrotoxicity. We aimed to avoid the nephrotoxic effects by applying a cyclosporine-free regimen for the induction as well as for the maintenance treatment of renal allograft recipients using mycophenolate...

journal_title：Transplantation

authors： Zanker B,Schneeberger H,Rothenpieler U,Hillebrand G,Illner WD,Theodorakis I,Stangl M,Land W

更新日期：1998-07-15 00:00:00

abstract：:As a consequence of its large volume, a microencapsulated islet graft can be implanted only into the peritoneal cavity. The graft volume can be reduced by using small capsules. However, reduction of the diameter of the capsules holds a certain risk, because with smaller capsules, more islets may be found to protrude f...

journal_title：Transplantation

authors： De Vos P,De Haan B,Pater J,Van Schilfgaarde R

更新日期：1996-10-15 00:00:00

abstract：:The mixed leukocyte culture (MLC) of peripheral blood lymphocytes (PBLs) from two prospective kidney transplant recipients and their respective donors, produced a primed cell population that functioned as suppressors. The primed cells suppressed the primary and secondary MLC when added as third components, without dem...

journal_title：Transplantation

authors： Fuller L,Kyriakides G,Flaa C,Esquenazi V,Miller J

更新日期：1980-01-01 00:00:00

abstract：:To determine the degree of graft versus host disease (GVHD) prophylaxis that might be necessary if cord blood (CB) transplantation is more widely applied, we compared human cord blood mononuclear cell (CBMC) and adult peripheral blood mononuclear cell (PBMC) proliferative responses and stimulatory capabilities; to exa...

journal_title：Transplantation

authors： Greenfeld JI,Noizat-Pirenne F,Hardy MA,Oluwole SF,Hesdorffer CA,Preti RA,De Groote D,Franchimont P

更新日期：1994-08-27 00:00:00

abstract：BACKGROUND:Intrapulmonary arteriovenous shunting (IPS), occasionally associated with advanced liver disease, may reverse after liver transplantation (LTx). Two-dimensional contrast-enhanced echocardiography, a convenient noninvasive study, has never been used to demonstrate disappearance of IPS after LTx. METHODS:For ...

journal_title：Transplantation

authors： Hasegawa T,Kamiyama M,Azuma T,Sasaki T,Okada A,Miwatani T,Matsushita T

更新日期：2000-02-27 00:00:00

abstract：BACKGROUND:We developed a nonviral gene transfer method using rapid injection of naked DNA targeting the liver and applied it in a rat model of liver transplantation. METHODS:Inbred Dark Agouti and Lewis rats were used. To test the efficacy and adverse effects of systemic or local (catheter-based) injection, different...

journal_title：Transplantation

authors： Inoue S,Hakamata Y,Kaneko M,Kobayashi E

更新日期：2004-04-15 00:00:00

abstract：:The mode of action of glucocorticosteroids as immunosuppressive and antiinflammatory agents is not fully understood. Glucocorticosteroids block synthesis of interleukin 1 by interfering with the transcription of the IL-1 beta gene. Glucocorticosteroids may also induce rapid degradation of IL-1 mRNA. In the presence of...

journal_title：Transplantation

authors： Zanker B,Walz G,Wieder KJ,Strom TB

更新日期：1990-01-01 00:00:00

abstract：:Because of the inherent difficulties in allele assignment with HLA-DR serological typing, in 1993 our organ procurement organization-based HLA laboratory replaced serology with the molecular method of polymerase chain reaction using sequence-specific primer mixes (PCR-SSP) to type for DR and DQ at a resolution level e...

journal_title：Transplantation

authors： Bryan CF,Harrell KM,Nelson PW,Pierce GE,Ross G,Shield CF 3rd,Warady BA,Aeder MI,Helling TS,Landreneau MD,Luger AM

更新日期：1996-12-27 00:00:00

abstract：INTRODUCTION:HMG-CoA reductase inhibitors play several roles in the maintenance of organ transplants. We investigated the role of pitavastatin, a potent and newly developed HMG-CoA reductase inhibitor, in cardiac allograft rejection and mechanism of graft arterial disease (GAD) suppression. METHODS:Balb/c mice hearts ...

journal_title：Transplantation

authors： Suzuki J,Koga N,Kosuge H,Ogawa M,Haraguchi G,Maejima Y,Saiki H,Isobe M

更新日期：2007-04-27 00:00:00

abstract：:The overall incidence of malignancy in renal transplant recipients is 100-fold higher compared with age matched controls. Routine clinical evaluation therefore often includes the determination of serum tumor markers AFP, CA19-9, CEA, CA125, CA15-3, PSA, and calcitonin. We evaluated the specificity and the sensitivity ...

journal_title：Transplantation

authors： Oberbauer R,Banyai S,Schmidt A,Kornek G,Scheithauer W,Mayer G

更新日期：1996-11-27 00:00:00

abstract：BACKGROUND:Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. METHODS:At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1c) or LEW (RT1(1)) rats. Rats having undergon...

journal_title：Transplantation

authors： Goto S,Lin YC,Lai CY,Lee CM,Pan TL,Lord R,Chiang KC,Tseng HP,Lin CL,Cheng YF,Yokoyama H,Kitano S,Chen CL

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:We are presently investigating the therapeutic potential of herpes simplex-thymidine kinase-expressing donor T cells in the setting of a T cell-depleted allogeneic bone marrow transplantation. The generation, expansion, and selection of the gene-modified T cells require a 12-day ex vivo culture period in hig...

journal_title：Transplantation

authors： Contassot E,Murphy W,Angonin R,Pavy JJ,Bittencourt MC,Robinet E,Reynolds CW,Cahn JY,Hervé P,Tiberghien P

更新日期：1998-05-27 00:00:00

abstract：BACKGROUND:Liver transplant recipients for hepatitis C virus (HCV)-related cirrhosis usually remain anti-HCV-seropositive after transplantation. The aim of this study was to characterize, longitudinally, the profile of HCV-specific antibodies and cryoglobulins in liver transplant recipients with recurrent HCV infection...

journal_title：Transplantation

authors： Gane EJ,Maertens G,Ducatteeuw A,Qian KP,Lau JY,Jones H,Davies E,Naoumov NV,Williams R

更新日期：1999-01-15 00:00:00

abstract：BACKGROUND:Angiogenesis contributes to the repair process after renal ischemia/reperfusion (I/R) injury. In the present study, we tested the role of miR-21 in the angiogenesis induced by hypoxia inducible factor (HIF)-1α through inhibiting a predicted target gene thrombospondin 1 (TSP-1). METHODS:To stabilize HIF-1α, ...

journal_title：Transplantation

authors： Xu X,Song N,Zhang X,Jiao X,Hu J,Liang M,Teng J,Ding X

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Recently, peptides derived from the heavy chain of HLA-B2702 have been shown to modulate immune responses. In this study, we examined the use of these peptides for immunosuppression in a pig to mouse islet xenograft model. METHODS:Purified porcine islets were transplanted in autoimmune (non-obese diabetic) ...

journal_title：Transplantation

authors： Squiers EC,Hodell M,Tice D,Buelow R

更新日期：1998-12-15 00:00:00

abstract：BACKGROUND:Pneumocystis jiroveci pneumonia may be a life-threatening opportunistic infection in immunosuppressed solid organ transplant recipients. Despite effective treatment with high-dose trimethoprim-sulfamethoxazole and steroids, morbidity is often severe and lethality remains high. New therapeutic approaches are ...

journal_title：Transplantation

authors： Utili R,Durante-Mangoni E,Basilico C,Mattei A,Ragone E,Grossi P

更新日期：2007-09-27 00:00:00

abstract：OBJECTIVE:We compared the enzyme release from preserved and ex vivo reperfused livers after acute injury or inflammatory stimulus with organ function. METHODS:Acute injury was induced by carbon tetrachloride and inflammation was induced by turpentine oil treatments. Livers were exsanguinated and preserved for 8 or 24 ...

journal_title：Transplantation

authors： Gioli-Pereira L,Coradin K,Nagaoka MR,Borges DR,Kouyoumdjian M

更新日期：2002-10-27 00:00:00

abstract：:We have investigated retrospectively sera from 70 renal allograft recipients for the presence of antibodies binding to a preanastomosis biopsy of the donor kidney by an indirect immunoperoxidase technique. All recipients had a negative T cell lymphocytotoxic crossmatch. A positive immunoperoxidase crossmatch for kidne...

journal_title：Transplantation

authors： Evans PR,Trickett LP,Gosney AR,Hodges E,Shires S,Wilson PJ,MacIver AG,Gardner B,Slapak M,Smith JL

更新日期：1988-12-01 00:00:00

abstract：:Fox kidney and skin grafts were transplanted into dog recipients. Fox kidneys, transplanted en bloc into untreated dogs, survived 6.2 +/- 0.4 days. The skin transplants survived 5.9 +/- 1.4 days. The grafted kidneys showed almost normal function before rejection. Both skin and kidney rejection were mediated through a ...

journal_title：Transplantation

authors： Chaussy C,Hammer C,von Scheel J,Pielsticker K,Sollinger HW,Pfeifer KJ,Pongratz H,Brender W

更新日期：1975-08-01 00:00:00

abstract：:Since June 1979, percutaneous transluminal angioplasty (PTA) has been the procedure of choice for renal transplant artery stenosis (RTAS) at the Hospital of the University of Pennsylvania. Of 241 renal allograft recipients, 17 (7%) when studied by arteriogram because of suspected RTAS proved to have significant stenos...

journal_title：Transplantation

authors： Grossman RA,Dafoe DC,Shoenfeld RB,Ring EJ,McLean GK,Oleaga JA,Freiman DB,Naji A,Perloff LJ,Barker CF

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:The impact of the age of the donor on the outcome of living related liver transplantation is yet to be clarified. METHODS:During October 14, 1996 and December 20, 1999, 34 living related liver transplantations were performed. Of these, 26 cases were performed using the extended left lobe graft, which were c...

journal_title：Transplantation

authors： Ikegami T,Nishizaki T,Yanaga K,Shimada M,Kishikawa K,Nomoto K,Uchiyama H,Sugimachi K

更新日期：2000-12-27 00:00:00

abstract：BACKGROUND:Assays of drug blood levels are used for therapeutic immunosuppressive drug monitoring (pharmacokinetics, PK). We monitored lymphocyte functions (pharmacodynamics, PD) in allograft recipients treated with mycophenolic acid (MPA) to determine its mechanisms and the relationships among dose levels, PK, PD, and...

journal_title：Transplantation

authors： Gummert JF,Barten MJ,van Gelder T,Billingham ME,Morris RE

更新日期：2000-10-15 00:00:00

abstract：BACKGROUND:The clinical symptoms, histological findings, and treatments for antibody-mediated rejection (AMR), which is the leading cause of graft loss in adult ABO-incompatible liver transplantation (ABO-I-LT), have rarely been discussed. METHODS:We performed adult living donor ABO-I-LT on six patients. We used anti-...

journal_title：Transplantation

authors： Morioka D,Togo S,Kumamoto T,Takeda K,Matsuo K,Inayama Y,Yamanaka S,Tanaka K,Endo I,Maegawa J,Shimada H

更新日期：2008-01-27 00:00:00

abstract：:Natural killer (NK) cells effect hybrid resistance, in which parental hematopoietic cell grafts are rejected by F1 recipients. NK cells can also resist engraftment of fully MHC-mismatched allogeneic marrow. However, studies of NK cell-mediated alloresistance have relied on short-term proliferation, colony, or survival...

journal_title：Transplantation

authors： Lee LA,Sergio JJ,Sykes M

更新日期：1996-01-15 00:00:00

abstract：:In human organ transplantation, the correct diagnosis of rejection may be difficult using clinical and/or histopathologic criteria, and immunologic assays should therefore be considered. We have applied monoclonal antibodies in 2-color flow cytometric (FACS) analysis to study phenotypic patterns of kidney-infiltrating...

journal_title：Transplantation

authors： Tötterman TH,Hanås E,Bergström R,Larsson E,Tufveson G

更新日期：1989-05-01 00:00:00

abstract：:The proliferation and differentiation of donor hematopoietic progenitor cells in bone marrow transplantation (BMT) recipients is influenced by hematopoietic growth factors, which could derive from either T cells or adherent stromal bone marrow cells, or both. In this study of 20 BMT recipients, we asked whether T lymp...

journal_title：Transplantation

authors： Thomas S,Clark SC,Rappeport JM,Nathan DG,Emerson SG

更新日期：1990-04-01 00:00:00

abstract：:The complement system plays a major role in hyperacute rejection of discordant xenografts. In an immediately vascularized xenograft of a porcine organ to a primate, natural antibodies bind to the vascular endothelium of the graft, triggering activation of complement via the classical pathway. One consequence of antibo...

journal_title：Transplantation

authors： Dalmasso AP,Platt JL

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Inasmuch as cryopreservation can facilitate clinical islet transplantation by providing a means of storing supplemental islets in order to augment marginally adequate grafts, protocols are needed to allow for a minimal loss in viable beta cells. By replacing the cryoprotectant dimethyl sulfoxide (DMSO) with ...

journal_title：Transplantation

authors： Korbutt GS,Rayat GR,Ezekowitz J,Rajotte RV

更新日期：1997-10-15 00:00:00

abstract：:Nuclear imaging is used to evaluate renal allografts demonstrating delayed function after transplantation. Interpretation of the nuclear scan in the context of clinical data, provides helpful information in the management of the transplant recipient. The better quality of images obtained with technetium-99m mercaptoac...

journal_title：Transplantation

authors： Mange KC,Scheff A,Brayman K,Mozley D,Grossman RA,Naji A,Aradhye S

更新日期：1997-11-27 00:00:00