Abstract:
BACKGROUND:Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. METHODS:At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1c) or LEW (RT1(1)) rats. Rats having undergone orthotopic liver transplantation (OLT; DA-PVG) naturally overcome rejection, whereas all OLT (DA-LEW) rats die from acute rejection within 14 days. Telomerase activity in liver allografts was measured at various intervals post OLT. RESULTS:At day 7 when the most severe rejection episode was observed in OLT (DA-LEW) and OLT (DA-PVG), the telomerase activity was significantly higher than in syngeneic OLT (DA-DA) rats, in which no rejection occurred. Telomerase activity in tolerogenic OLT (DA-PVG) livers remained elevated for at least 2 months. CONCLUSION:These results suggest that telomerase activity in allogeneic OLT livers may reflect regenerating hepatocytes or activation of lymphocytes and/or hematopoietic stem cells associated with rejection or tolerance.
journal_name
Transplantationjournal_title
Transplantationauthors
Goto S,Lin YC,Lai CY,Lee CM,Pan TL,Lord R,Chiang KC,Tseng HP,Lin CL,Cheng YF,Yokoyama H,Kitano S,Chen CLdoi
10.1097/00007890-200003150-00062subject
Has Abstractpub_date
2000-03-15 00:00:00pages
1013-5issue
5eissn
0041-1337issn
1534-6080journal_volume
69pub_type
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