Telomerase activity in rat liver allografts.

Abstract:

BACKGROUND:Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. METHODS:At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1c) or LEW (RT1(1)) rats. Rats having undergone orthotopic liver transplantation (OLT; DA-PVG) naturally overcome rejection, whereas all OLT (DA-LEW) rats die from acute rejection within 14 days. Telomerase activity in liver allografts was measured at various intervals post OLT. RESULTS:At day 7 when the most severe rejection episode was observed in OLT (DA-LEW) and OLT (DA-PVG), the telomerase activity was significantly higher than in syngeneic OLT (DA-DA) rats, in which no rejection occurred. Telomerase activity in tolerogenic OLT (DA-PVG) livers remained elevated for at least 2 months. CONCLUSION:These results suggest that telomerase activity in allogeneic OLT livers may reflect regenerating hepatocytes or activation of lymphocytes and/or hematopoietic stem cells associated with rejection or tolerance.

journal_name

Transplantation

journal_title

Transplantation

authors

Goto S,Lin YC,Lai CY,Lee CM,Pan TL,Lord R,Chiang KC,Tseng HP,Lin CL,Cheng YF,Yokoyama H,Kitano S,Chen CL

doi

10.1097/00007890-200003150-00062

subject

Has Abstract

pub_date

2000-03-15 00:00:00

pages

1013-5

issue

5

eissn

0041-1337

issn

1534-6080

journal_volume

69

pub_type

杂志文章
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    pub_type: 杂志文章

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    更新日期:2001-08-15 00:00:00

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    journal_title:Transplantation

    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1097/00007890-198404000-00013

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:

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  • Successful use of an enhanced immunosuppressive protocol with plasmapheresis for ABO-incompatible mismatched grafts in liver transplant recipients.

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    pub_type: 杂志文章

    doi:10.1097/00007890-199504150-00011

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    更新日期:1995-04-15 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/TP.0000000000000583

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    pub_type: 杂志文章

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    pub_type: 杂志文章,随机对照试验

    doi:10.1097/TP.0b013e318277e378

    authors: Guethoff S,Meiser BM,Groetzner J,Eifert S,Grinninger C,Ueberfuhr P,Reichart B,Hagl C,Kaczmarek I

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    journal_title:Transplantation

    pub_type: 杂志文章

    doi:

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