Ling Zhi-8: studies of a new immunomodulating agent.

abstract：BACKGROUND:It has been proposed that hyperacute rejection (HAR) of pig-to-primate vascularized xenografts is due in large part to ineffective regulation of recipient complement by pig complement regulatory proteins (CRPs), and indeed transgenic expression of human CRPs in pigs can prevent hyperacute rejection. However,...

journal_title：Transplantation

authors： Fisicaro N,Aminian A,Hinchliffe SJ,Morgan BP,Pearse MJ,D'Apice AJ,Cowan PJ

更新日期：2000-09-27 00:00:00

abstract：BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscl...

journal_title：Transplantation

authors： Zaitsu M,Yamashita K,Shibasaki S,Tsunetoshi Y,Fukai M,Ogura M,Yoshida T,Igarashi R,Kobayashi N,Umezawa K,Todo S

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Allogeneic bone marrow transplantation (BMT) and donor lymphocyte infusion (DLI) provide valuable treatments for a range of diseases. However, the therapeutic utility of BMT and DLI is reduced by the high incidence of graft-versus-host disease (GvHD) mediated by activated donor T lymphocytes directed against...

journal_title：Transplantation

authors： Georgantas RW 3rd,Bohana-Kashtan O,Civin CI

更新日期：2006-08-27 00:00:00

abstract：INTRODUCTION:Posttransplant anemia and its association with transplant outcomes have not been properly studied. METHODS:We examined 530 renal allograft recipients transplanted at our center and followed up for 31.0±14.1 months. Hemoglobin (Hb), serum bicarbonate, and creatinine; use of erythropoiesis-stimulating agent...

journal_title：Transplantation

authors： Jones H,Talwar M,Nogueira JM,Ugarte R,Cangro C,Rasheed H,Klassen DK,Weir MR,Haririan A

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:A new vascularized concordant xenotransplant model using the Chinese hamster as donor and mouse as recipient species is reported. This model takes advantage of the wealth of informative immune reagents and knockout and transgenic backgrounds available for the mouse. METHODS:Heterotopic auxillary cardiac tra...

journal_title：Transplantation

authors： Obatake M,Kushida M,Kimmel S,Clarke ID,Kim PC

更新日期：1999-06-15 00:00:00

abstract：:Acute rejection episodes still occur after kidney transplantation in spite of modern immunosuppressive protocols including combined tacrolimus, mycophenolate mofetil, and prednisolone. The authors present seven cases of biopsy-proven acute rejection after kidney transplantation refractory to conventional rejection the...

journal_title：Transplantation

authors： Kumlien G,Genberg H,Shanwell A,Tydén G

更新日期：2005-01-15 00:00:00

abstract：:Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that c...

journal_title：Transplantation

authors： Hebert MF,Zheng S,Hays K,Shen DD,Davis CL,Umans JG,Miodovnik M,Thummel KE,Easterling TR

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Langerhans cells (LCs) are self-renewing epidermal myeloid cells that can migrate and mature into dendritic cells. Recipient LCs that survive cytotoxic therapy given in preparation for allogeneic hematopoietic cell transplantation may prime donor T cells to mediate cutaneous graft-versus-host disease (GVHD)....

journal_title：Transplantation

authors： Mielcarek M,Kirkorian AY,Hackman RC,Price J,Storer BE,Wood BL,Leboeuf M,Bogunovic M,Storb R,Inamoto Y,Flowers ME,Martin PJ,Collin M,Merad M

更新日期：2014-09-15 00:00:00

abstract：BACKGROUND:Obliterative bronchiolitis poses a primary obstacle for long-term survival of lung transplant recipients and manifests clinically as bronchiolitis obliterans syndrome (BOS). Establishing a molecular level screening method to detect BOS-related proteome changes before its diagnosis by forced expiratory volume...

journal_title：Transplantation

authors： Wolf T,Oumeraci T,Gottlieb J,Pich A,Brors B,Eils R,Haverich A,Schlegelberger B,Welte T,Zapatka M,von Neuhoff N

更新日期：2011-08-27 00:00:00

abstract：:Allograft rejection results from a complex process involving both the innate and acquired immune systems. The innate immune system predominates in the early phase of the allogeneic response, during which chemokines and cell adhesion play essential roles, not only for leukocyte migration into the graft but also for fac...

journal_title：Transplantation

authors： Le Moine A,Goldman M,Abramowicz D

更新日期：2002-05-15 00:00:00

abstract：:To evaluate the pharmacokinetic properties of the new microemulsion formulation of cyclosporine (Sandimmun Neoral), a double-blind, prospective study in stable renal transplant recipients was performed. The patients were randomized on a 4:1 basis either to receive Sandimmun Neoral (n = 45) or continue on regular Sandi...

journal_title：Transplantation

authors： Wahlberg J,Wilczek HE,Fauchald P,Nordal KP,Heaf JG,Olgaard K,Hansen JM,Lokkegaard H,Mueller EA,Kovarik JM

更新日期：1995-10-15 00:00:00

abstract：:Natural suppressor (NS) activity is detected in tissues undergoing intense hematopoietic regeneration. This includes the spleens of mice recovering from total lymphoid irradiation or cyclophosphamide treatment, or after induction of chronic graft-versus-host disease against minor histocompatibility antigens. NS cells ...

journal_title：Transplantation

authors： Schreiber KL,Forman J

更新日期：1993-09-01 00:00:00

abstract：:As a first step in the study of the possible relationship between the T/t and H-2 complexes, the H-2 antigenic composition of the strains carrying factors t12, tw32, tw2, tw8, t1, t0, t6, tw1, tw71, tw73, tw12, tw5, tw75, and t38 was studied by using a battery of antisera containing antibodies against inbred-derived H...

journal_title：Transplantation

authors： Hammerberg C,Klein J,Artzt K,Bennett D

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:The role of human herpesvirus (HHV)-8 in the pathogenesis of multiple myeloma and its pre-malignant state of monoclonal gammopathy is unclear. HHV-8 is transmitted by organ transplantation, representing a unique model with which to investigate primary HHV-8 infection. METHODS:The authors studied the inciden...

journal_title：Transplantation

authors： Regamey N,Hess V,Passweg J,Hess C,Steiger J,Erb P,Cathomas G,Tamm M

更新日期：2004-05-27 00:00:00

abstract：:To evaluate the efficacy of University of Wisconsin (UW) solution for lung preservation, we performed canine lung allotransplantation with lungs preserved in UW solution. Donor lungs from eight dogs were flushed with UW solution and lungs from four dogs with Euro-Collins solution, and these were preserved for 24 hr in...

journal_title：Transplantation

authors： Kawahara K,Itoyanagi N,Takahashi T,Akamine S,Kobayashi M,Tomota M

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Immunosuppressive therapy is a risk factor for the increased incidence and metastatic progression of malignancies in organ graft recipients. Transforming growth factor (TGF)-beta(1) has been associated with tumor invasion and metastasis, and we have implicated cyclosporine-associated TGF-beta(1) hyperexpress...

journal_title：Transplantation

authors： Maluccio M,Sharma V,Lagman M,Vyas S,Yang H,Li B,Suthanthiran M

更新日期：2003-08-15 00:00:00

abstract：:In a murine strain combination disparate in both H-2 antigens and minor histocompatibility antigens consisting of C57BL/6 (B6; H-2b, Mls-1b) mice as recipients and AKR/J (AKR; H-2k, Mls-1a) mice as donors, we reported that the administration of anti-TCR-alpha beta mAb nonspecifically suppresses the ability to reject a...

journal_title：Transplantation

authors： Nomoto K,Yung-Yun K,Omoto K,Umesue M,Murakami Y,Matsuzaki G,Nomoto K

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:The aim was to compare efficacy of multiple daily injections (MDI), continuous subcutaneous insulin infusion (CSII) and islet transplantation to reduce hypoglycemia and glycemic variability in type 1 diabetes subjects with severe hypoglycemia. METHODS:This was a within-subject, paired comparison of MDI and ...

journal_title：Transplantation

authors： Holmes-Walker DJ,Gunton JE,Hawthorne W,Payk M,Anderson P,Donath S,Loudovaris T,Ward GM,Kay TW,OʼConnell PJ

更新日期：2017-06-01 00:00:00

abstract：:Since calcium channel blocking agents and CsA exert an antiproliferative effect upon T cell mitogenesis, we have compared and characterized their immunosuppressive properties at the level of gene activation. Verapamil (greater than or equal to 30 microM), which blocks T cell mitogenesis and a rise in cytosolic calcium...

journal_title：Transplantation

authors： Walz G,Zanker B,Wieder K,Hadro E,Moscovitch-Lopatin M,Smith BR,Strom TB

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Living kidney donors have donation-related out-of-pocket costs (direct costs) and/or ongoing daily expenses while losing income (indirect costs). Yet there is little information about how much of a subjective burden these constitute for the donors. METHODS:From December 2003 through December 2014, we survey...

journal_title：Transplantation

authors： Wiseman JF,Jacobs CL,Larson DB,Berglund DM,Garvey CA,Ibrahim HN,Matas AJ

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Defining the clinical relevance of donor-specific HLA-antibodies detected by single-antigen flow-beads (SAFB) is important because these assays are increasingly used for pretransplant risk assessment and organ allocation. The aims of this study were to investigate to which extent HLA-DSA detected by SAFB rep...

journal_title：Transplantation

authors： Amico P,Hönger G,Mayr M,Steiger J,Hopfer H,Schaub S

更新日期：2009-06-15 00:00:00

abstract：:Subsets of T cells have been identified by the expression of different isoforms of CD45. Some T cells expressing CD45RA (gp220) have been characterized as "naive" in their response to antigens including alloantigens, whereas T cells expressing CD45RO (gp180) have been characterized as "memory" T cells. To examine the ...

journal_title：Transplantation

authors： Ibrahim S,Dawson DV,Sanfilippo F

更新日期：1995-03-15 00:00:00

abstract：BACKGROUND:Clinical studies suggest that the immunosuppressant mycophenolate mofetil is associated with anemia. However, the mechanism for this is not known. Here, we studied the effect of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil, on erythropoiesis in vitro. METHODS:Both UT-7 cells and p...

journal_title：Transplantation

authors： Pile T,Kieswich J,Harwood S,Yaqoob MM

更新日期：2011-12-27 00:00:00

abstract：:Unstimulated whole saliva and serum samples were collected from ten allogeneic bone marrow transplant recipients before and after bone marrow transplantation, seven donors, and from twenty healthy individuals. Two patterns with regard to salivary IgA were found after transplantation. In five patients, a short-lasting ...

journal_title：Transplantation

authors： Norhagen-Engström G,Hammarström L,Lönnqvist B,Söder PO,Smith CI

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to identify pretransplantation and posttransplantation indicators for the development of diabetes mellitus in the first 2 months after renal transplantation and to examine the influence of a cyclosporine A (CsA)-based versus a tacrolimus-based immunosuppressive regimen on these r...

journal_title：Transplantation

authors： Sato T,Inagaki A,Uchida K,Ueki T,Goto N,Matsuoka S,Katayama A,Haba T,Tominaga Y,Okajima Y,Ohta K,Suga H,Taguchi S,Kakiya S,Itatsu T,Kobayashi T,Nakao A

更新日期：2003-11-15 00:00:00

abstract：BACKGROUND:The prevalence of renal posttransplantation amputation and its impact on allograft and patient survival have not been widely reported. METHODS:We used an incident cohort of patients who underwent renal transplantation between June 2004 and September 2009. Amputation data were obtained using Medicare institu...

journal_title：Transplantation

authors： Brar A,Jindal RM,Sumrani N,John D,Mondal Z,Tedla F,Salifu MO

更新日期：2013-05-27 00:00:00

abstract：:The immunological events mediated by, and antigen specificity of, allograft-bound lymphocytes (ABLs) are poorly understood. To further define the role of antibody-mediated rejection, a rejected allograft from a patient with primary anti-TBM disease was sterilely minced and pressed through a microscreen. The ABLs were ...

journal_title：Transplantation

authors： Jordan SC,Barkley SC,Lemire JM,Sakai RS,Cohen A,Fine RN

更新日期：1986-02-01 00:00:00

abstract：:Total lymphoid irradiation (TLI) induces a unique state of immunosuppression. Although permanent bone marrow chimerism has been obtained in rodents prepared by TLI, uniform marrow engraftment has been more difficult to obtain in larger mammals. Accordingly, studies were performed to assess the immunologic perturbation...

journal_title：Transplantation

authors： Lowry RP,Carpenter CB,Gurley KE,Merrill JP

更新日期：1983-07-01 00:00:00

abstract：:Allograft recipients who have preformed antibodies to MHC determinants or develop these antibodies post-transplantation have a higher incidence of cellular rejection and graft loss. It is unclear whether this association is an etiologic one or whether the presence of these antibodies solely identifies individuals with...

journal_title：Transplantation

authors： Hosenpud JD,Shipley GD,Morris TE,Hefeneider SH,Wagner CR

更新日期：1993-02-01 00:00:00

abstract：INTRODUCTION:Patients after solid organ transplantation are at an increased risk for microbial infections. Due to therapeutic immunosuppression, the response to active immunizations may be reduced. The serological efficacy of pneumococcal and influenza vaccination was studied in heart transplant recipients. PATIENTS A...

journal_title：Transplantation

authors： Dengler TJ,Strnad N,Bühring I,Zimmermann R,Girgsdies O,Kubler WE,Zielen S

更新日期：1998-11-27 00:00:00